What Is It?
Tretinoin / Benzoyl Peroxide (Twyneo®) is a topical medication combining two active ingredients: tretinoin, a retinoid, and benzoyl peroxide, an antimicrobial and peeling agent. Tretinoin works by promoting skin cell turnover to prevent acne formation, while benzoyl peroxide kills bacteria and helps clear pores.
Efficacy
Strength of Evidence
Average 61% reduction in acne after 12 weeks
Side Effects
Low-Medium
Low-medium side effects and adverse reactions
Acne.org's Real World Take
Similar to adapalene + benzoyl peroxide (Epiduo®), this is a way of using a topical retinoid (in this case tretinoin) along with benzoyl peroxide. However, studies thus far show very unimpressive results. Comes with side effects for the first weeks and can bleach fabric. Note: When used correctly, benzoyl peroxide on its own can completely clear the skin.