What Is It?
Tretinoin / Benzoyl Peroxide is a newly approved medication. Details coming soon. Until then, here is a link to information on Tretinoin / Benzoyl Peroxide from the U.S. National Library of Medicine.
Strength of Evidence
Average 61% reduction in acne after 12 weeks
- Del Rosso, J. Q., Sugarman, J., Levy-Hacham, O. & Mizrahi, R. Efficacy and safety of encapsulated benzoyl peroxide 3% and encapsulated tretinoin 0.1% (E-BPO/E-ATRA) cream in acne vulgaris: Results from two randomized, controlled pivotal clinical trials. 14, (2021).
- Webster, G. F., Sugarman, J., Levy-Hacham, O. & Toledano, O. Microencapsulated benzoyl peroxide and tretinoin for the treatment of acne vulgaris: results from a phase 2 multicenter, double-blind, randomized, vehicle-controlled study. Skinmed 18, 343–351 (2020).
- Pariser, D. et al. Tretinoin gel microsphere pump 0.04% plus 5% benzoyl peroxide wash for treatment of acne vulgaris: morning/morning regimen is as effective and safe as morning/evening regimen. J Drugs Dermatol 9, 805–813 (2010).
- Shalita, A. R. et al. Compared efficacy and safety of tretinoin 0.1% microsphere gel alone and in combination with benzoyl peroxide 6% cleanser for the treatment of acne vulgaris. Cutis 72, 167–172 (2003).
Low-medium side effects and adverse reactions
Acne.org's Real World Take
Similar to adapalene + benzoyl peroxide (Epiduo(R)), this is a way of using a topical retinoid (in this case tretinoin) along with benzoyl peroxide. However, studies thus far show very unimpressive results. Comes with side effects for the first weeks and can bleach fabric. Note: When used correctly, benzoyl peroxide on its own can completely clear the skin.