Tretinoin / Benzoyl Peroxide (Twyneo®)

Topical Retinoid / Topical Antibacterial
Compare To Other Treatments

What Is It?

Tretinoin / Benzoyl Peroxide (Twyneo®) is a topical medication combining two active ingredients: tretinoin, a retinoid, and benzoyl peroxide, an antimicrobial and peeling agent. Tretinoin works by promoting skin cell turnover to prevent acne formation, while benzoyl peroxide kills bacteria and helps clear pores.


Strength of Evidence
Average 61% reduction in acne after 12 weeks
  1. Del Rosso, J. Q., Sugarman, J., Levy-Hacham, O. & Mizrahi, R. Efficacy and safety of encapsulated benzoyl peroxide 3% and encapsulated tretinoin 0.1% (E-BPO/E-ATRA) cream in acne vulgaris: Results from two randomized, controlled pivotal clinical trials. 14, (2021).
  2. Webster, G. F., Sugarman, J., Levy-Hacham, O. & Toledano, O. Microencapsulated benzoyl peroxide and tretinoin for the treatment of acne vulgaris: results from a phase 2 multicenter, double-blind, randomized, vehicle-controlled study. Skinmed 18, 343–351 (2020).
  3. Pariser, D. et al. Tretinoin gel microsphere pump 0.04% plus 5% benzoyl peroxide wash for treatment of acne vulgaris: morning/morning regimen is as effective and safe as morning/evening regimen. J Drugs Dermatol 9, 805–813 (2010).
  4. Shalita, A. R. et al. Compared efficacy and safety of tretinoin 0.1% microsphere gel alone and in combination with benzoyl peroxide 6% cleanser for the treatment of acne vulgaris. Cutis 72, 167–172 (2003).

Side Effects

Low-medium side effects and adverse reactions's Real World Take

Similar to adapalene + benzoyl peroxide (Epiduo®), this is a way of using a topical retinoid (in this case tretinoin) along with benzoyl peroxide. However, studies thus far show very unimpressive results. Comes with side effects for the first weeks and can bleach fabric. Note: When used correctly, benzoyl peroxide on its own can completely clear the skin.


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