Antiandrogen
Reviews
4.1
1330 Reviews
Antiandrogen
Efficacy
68%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Antiandrogen
Side Effects
High
Antiandrogen
Acne.org’s Real World Take
“Spiro” has been shown to work in a real and noticeable way most of the time. However, messing with hormones is messing with hormones and it’s best to proceed with caution.
Antiandrogen
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Read All About Spironolactone
Compare To Other Treatments
5
51%
4
28%
3
10.1%
2
4.9%
1
6.1%

Used Spironolactone? Rate It:

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July 15, 2018
Great
Works wonders if you have slightly high testosterone levels(girls). Also ladies if you have rly heavy long periods which i did, it makes them so much lighter and shorter! Mine now last from 2-3 days and are very light!
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June 12, 2018
Works for hormonal acne
I have had mild-moderate acne along my cheeks, jawline, and neck for years. It was controlled to varying degrees depending on my level of stress with topical treatments, but I was looking to make better progress. A friend suggested spironolactone given the distribution of my acne. I was prescribed 100mg daily. I stopped getting frequent whiteheads/cystic acne after the first month (see my album!) but I hyperpigment easily so it has been taking a long time for the dark marks to fade. I now take 100mg every other day and this seems to be maintaining my skin well. I haven't had active acne in months at this point. The only side effect I really noticed was dry mouth in the morning and (possibly) more frequent urination. I'm grateful I gave this a try!
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November 23, 2018

After a few months, I wasn’t convinced it was actually making me urinate more than usual. 

February 19, 2018
Spironolactone is the only treatment that worked
I've been taking Spiro for 9 years now and it has been the only thing that has kept my moderate acne away. I never had cystic acne but had many painful pimples and pustules. Prior to Spiro I tried topicals, oral antibiotics, and even Accutane. I tried different things for over a decade and none of it worked. The only acne scars I have, I got while taking Accutane, which made my skin flare up terribly. I was also constantly sick to my stomach the entire month and a half I took Accutane. If you're an adult female and still suffer with acne, please try Spironolactone before resorting to Accutane. The side effects of Spiro are minimal, if any, and it's very effective at combating hormonal acne. I had to ask my dermatologist to prescribe it to me. She didn't believe it would work. Thankfully, she was wrong.
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March 9, 2018
April 4, 2018
Hello Silver12 how long did it take for Spirronlactone to take effect on your skin
February 9, 2018
Game Changer for Hormonal Acne
I have tried almost every type of acne treatment there is out there. Spironolactone is the only thing that made a real difference. Not only do I rarely have acne, but when I get a spot it goes away quickly! It's important that your dermatologist starts you off on a low dose. I started with 25 mg. Then went to 25 mg twice a day. Then 50 mg twice a day. You should be drinking a lot of water while on this--I drink like four liters a day. I personally didn't have any side effects besides having to pee a lot--could just be the water though. Also, you will gain weight easily if you have a high intake of potassium. I also take Junel Fe 1.5/3.0 for both birth control and acne/hormonal control. Everyone should know that this will make your birth control less effective, so think about using another form of birth control in addition.
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April 4, 2018
Hello Silver12 how long did it take for Spirronlactone to take effect on your skin
December 6, 2017
Not a fan...so far
I tried Spironolactone back in 2014 when my doctor recommended it. She felt I had hormonal acne, and I believe we had tried antibiotics, creams and other topicals in the past. When I was in my early 20s I was on accutane which was amazing except for the fact my hair thinned out a great deal, and there was a lot of shedding and a little bit of dryness (the corners of my lips would crack). Anyways fast forward to now I decided to give Spironolactone another try because I had been doing peels, and doxycycline with some results but I do not like to be on antibiotics because I feel like they interfere with my sleep pattern. Mind you I had been on antibiotics in the past before I tried Accutane. So I think I have almost been on this again for a month but I restarted it on November 11th (I had some pills left over from last time), and I let my doctor know I would like to retry it again. She prescribed 50 mg tabs to be taken once daily, and gave me 3 months worth. At this point I don't think I will make the month mark if I continue to display the clinical signs I have. For the last 3 days I have had hives/red welts all over my body. Saturday they were just on my back where my sports bra made contact, and lower lumbar region, on Sunday I had welts I believe it was on my chest and neck, and on my back, Monday I had them appear on my tummy area, but specifically around my arm pits, and flank area. I noticed getting itchy after yoga last night. I usually start getting a rash, and hives and welts when I am relaxing and about to go to sleep. I am a veterinarian so I know why the drug is used so I figure I get a weird reaction due to a drop in blood pressure. Anyway, this happened the last time I tried Spironolactone 3 years ago. What activated the itchy reaction was eating spicy food. Another weird side effect when I first began this medication is I had a lot of acid reflux. I believe it was because I was not taking it with food all the time. I am taking it with food this time, and I no longer have an urgency to burp. That is the best way to describe that side effect from a few years ago. I know a few days ago over the weekend I had some spicy chicken. Well that seemed to activate things again, and I believe that is why I get hives, and welts all over my body while on this medication. Most people will say don't eat spicy food. I have not eaten any spicy food since Sunday. So when I had a reaction this afternoon just sitting and reading I was very surprised. Today I only took a 1/2 tab of the 50 mg tab. I know it takes awhile for the drug to clear from your system. At this point I am thinking about either alternating days, or stopping all together again. The itching is very uncomfortable, and in order to stop it I have to take an anti-histamine, and apply soothing topicals (hylatopica + vanos ointment). What I would prefer is something natural to cure my natural acne. I have taken dramatic steps to change my diet in the last few months. I eat a small amount of dairy (just cheese), drink cashew milk, and I use almond yogurt. I also try to eat a whole food diet with fruits and veggies. My biggest enemy is soda probably which I love. I am considering replacing soda with juicing because I used my mom's over thanksgiving and absolutely loved it. I did recently see that someone on here recommended using apple cider vinegar as a toner, and because I prefer a natural remedy I am currently trying that to see what results I get. I am so tired of these cystic breakouts on the side of my face, and chin. They take so long to go away and then when they do they leave really bad scars that take forever to fade. Would I recommend spironolactone? not if you have a sensitive system like mine. I don't think they tested it enough to be honest. My dermatologist said she has not had any patients have a similar reaction to mine.
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July 22, 2017
Took about 9 weeks, but worth the wait!
I'll start with my acne regimine. I wash my face twice a day with Cetaphil Acne Prone Skin foam wash, followed by Cetaphil Acne Prone Skin moisturizer. At night I take Spironolactone 100mg, and put a pea-sized amount of tretinoin 0.025% on the affected areas. Some mornings I'll use Dermalogica daily microfoliant to exfoliate, if needed. In the mornings I follow the moisturizer with SunBum zinc based facial sunscreen. The Cetaphil moisturizer does have 30spf sunscreen in it, but it does not contain zinc or titanium, which is incredibly important in protecting skin. Sticking to this routine has given me incredible results. I've struggled with adult acne for about a year and a half. It has always been hormonal acne on my jawline, usually cystic, but some whiteheads on my chin as well. It's taken 9 weeks for me to have smooth skin, but it's definitelty worth the wait! Now that the acne is gone I'm going to be working with the dermatologist to deal with the old acne scars, which have noticeably improved as well. I'm very excited to finally have clear skin again, especially before heading back to college at the end of August. Something else that's helped my acne a lot is switching to only drinking water. It's improved both my moods and my skin. I love spironolactone!
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February 6, 2017
Spiro- 3 weeks in
Hi! This is the first time I have ever posted a review on here, but I am really excited to be trying Spiro finally. I have been experiencing breakouts since I was 14 (I am now 23) and literally have tried absolutely everything in the book. Some treatments temporarily cleared me up but initially dried out my skin so much they ended up causing even more breakouts. Finally I decided that my breakouts must be hormonal, possibly a sympton of PCOS. I have been on ortho tri cylen lo for about a year and it has helped reduce some of the breakouts but not all. That's when my gyno recommended trying Spiro. I am currently taking 50 mg a day and am 3 weeks in. I know it takes much longer than this to see the full results but so far it hasn't been that bad. I had a little bit of a breakout the first week I took it- but as of right now it seems to be clearing my skin. Has anyone had the initial breakout come after the first month of taking it? Also my skin is dryer than normal right now but I'm hoping that evens out once my body adjusts to the Spiro even more. I will right another review in a few weeks with an update! Good luck to everyone trying this- I'm praying it works.
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January 19, 2017
Desperate...
First of all, I apologize for my English which is not very good because I am French. I am 23 years old, I have been taking the Jasmine pill for 5 years and I have never had acne in my teens. Since June, acne has invaded my face only but very importantly with medium-sized white buttons and a rough set. All summer I lived the hell you trying all the parapharmacie creams ... In September I went to see a dermatologist who put me under Doxiciline and, from the first week, I had practically nothing any more I did not believe ... Then every week I had hundreds of small pimples that grew on the chin and lower cheeks. The dermatologist believing that I was having an allergic reaction to the sun, prescribed cortisone cream ... Indeed it worked rather well, but it came back every week again and again until the day it no longer had any effect .. . I started to develop acne on the forehead and days again. I therefore go back to consult this dermatologist who made me do a biopsy (thinking that it could be a mushroom of the repeated use of cortisone cream) which demonstrated the absence of fungi. I also did a hormonal blood test showing no abnormality either ... She did not know what to do for me ... So she sent me to a colleague who specializes in acne. My acne covered my face, forehead and cheeks with a grainy set, buttons bigger than others not piercing and an oily layer. This new dermatologist then prescribed Spironolactone in addition to my 4th generation Jasmine pill to control androgens. After 5 weeks at 100mg no results except that the oily aspect has disappeared. My skin is always covered with this grainy layer with pimples at the bottom of the cheeks and in the middle of the forehead. As for the side effects that this medicine gives me I would say that I go to the toilet every hour but it is not really annoying (well it would not be if I had good results on my skin ...). I lost 2kg being already very lean it is all the same boring ... So I drink a lot of water to compensate for this loss. After 5 weeks at 100mg without results, I went back to see the dermatologist who passed me at 150mg a day ... It is now a week that I take this dose, and I really feel tired, dizzy, nauseated ... If the results on my face would be visible I will take on me without problem. But you forget no results. Always this rough coat and those bigger buttons on the front and lower cheeks. And still as many tears every day for two months now ... Do you think this is normal that after 6 weeks under Spironolactone there are no results? I see your opinions and this drug is prescribed to adult women having acne with big cysts which is not my type of acne. Can Spironolactone work on my type of acne? While knowing that I have no visible hormonal disorder on the blood tests ... Thank you for your answers ...
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January 23, 2017
It took 5 months for me to see clearing. 6 weeks probably not enough time, plus also every time I upped the dose it got worse before better. Give it more time. I don't know about your type of acne and spiro unfortunately.
January 23, 2017
Thank you so much for your answer Girlvle ! I took Spiro for 8 weeks and no results for that moment... Have a good evening :)
January 31, 2017
Hey even I am on my third month. Just completed the second one I think we should wait.let's be positive. :)
July 11, 2016
Wish I was pleased as everybody else...
I have extremely oily skin with mild-to-moderate acne that fluctuates. I was put on Spironolactone to try and help regulate my breakouts and it really only made me break out in places that are considered to be "hormonal breakout areas" like my jawline, neck and shoulders. It helped mildly with the smoothness of my face but I would still get breakouts around my period. Since I stopped taking it, my jaw and neck don't have any breakouts and the condition of my face remains as it was. I haven't seen enough of a miracle with this product that would make me keep using it.
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May 2, 2016
Great
This stuff works so well. I'm on 100 mg a day and combined with the pill, I've seen major improvement. My skin still breaks out, but it's 80% better than it was! I will agree with other posters that you will feel the need to go to the bathroom ALL the time. To me, it's worth it to have better skin. Drink lots of water!!
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December 11, 2017
How long do you think it took?

Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.