Acne.org ProductsThe following side effects are expected to occur with the use of sarecycline. Contact your doctor if these symptoms are severe and/or do not go away:
How Common (based on clinical studies)
| Nausea | Up to 4.6% of all users |
| Headache | Up to 2.8% of all users |
| Nasopharyngitis | Up to 2.8% of all users |
| Vomiting | Up to 2.1% of all users |
| Vaginal mycotic infection | Up to 0.8% of all users |
| Vaginal candidiasis | Up to 0.6% of all users |
| Dizziness | Less than 1% of all users |
| Photosensitivity | Less than 1% of all users |
| Abdominal discomfort | Unknown |
If you experience any of the following side effects, stop using sarecycline immediately and contact your doctor or get emergency medical care right away:
- Rash that occurs alongside fever and swollen glands in the neck or elsewhere
- Trouble breathing or swallowing
- Reappearance of sore throat, fever, and/or other symptoms of infection
- Swelling of the eyes, lips, tongue, throat, or face
- A sudden appearance of swelling and rash (known as hives)
- Chest pain
Sarecycline may also cause other side effects that are not mentioned here. Contact your doctor if you experience any other troublesome symptoms when using sarecycline.
References
- DailyMed (2024). Sarecycline. [online] Available at: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b200957c-3004-4988-be97-9fd619a83649. [Accessed 16 Nov. 2024]
- Moore A, Green LJ, Bruce S, Sadick N, Tschen E, Werschler P, Cook-Bolden FE, Dhawan SS, Forsha D, Gold MH, Guenthner S, Kempers SE, Kircik LH, Parish JL, Rendon MI, Rich P, Stein-Gold L, Tyring SK, Weiss RA, Nasir A, Schmitz C, Boodhoo TI, Kaoukhov A, Berk DR. Once-Daily Oral Sarecycline 1.5 mg/kg/day Is Effective for Moderate to Severe Acne Vulgaris: Results from Two Identically Designed, Phase 3, Randomized, Double-Blind Clinical Trials. Journal of Drugs in Dermatology. 17(9), 987-996 (2018).
- Leyden JJ, Sniukiene V, Berk DR, Kaoukhov A. Efficacy and Safety of Sarecycline, a Novel, Once-Daily, Narrow Spectrum Antibiotic for the Treatment of Moderate to Severe Facial Acne Vulgaris: Results of a Phase 2, Dose-Ranging Study. Journal of Drugs in Dermatology. 17(3), 333-338 (2018).
- Elrosasy A, Abo Zeid M, AlEdani EM, Aboali AA, Fayoud AM, Ibraheem K, Alwaili MA, Selim S, Zabady AH. Sarecycline for moderate to severe acne: a promising narrow-spectrum antibacterial drug. Naunyn Schmiedebergs Arch Pharmacol. 2024
- Xiong CY, Yang YM, Zhou Y, He TS, Luo XW, Wang J, Mao CX. Systematic analysis of the adverse effects of commonly used clinical tetracycline drugs based on the FAERS database. Expert Opin Drug Saf. 19, 1-9 (2024).