Platelet-rich Plasma

Compare To Other Treatments

What Is It?

Platelet-rich plasma is a procedure in which a medical professional extracts the patient’s own blood just before the start of the treatment. Then, after putting the blood into a machine to isolate plasma from the blood, the plasma is injected into the skin in order to encourage the production of collagen and elastin under scars, which helps create a smoother skin surface. 

The procedure is normally repeated 3 times, with about 1 month between treatments, and you should see gradual results with each session. And after your last session, your skin should continue to improve.

Good or Excellent Response

Strength of Evidence
1
2
3
4
5
23% of patients achieved a good (>50%) or excellent (>75%) improvement in scarring after 4 sessions

Moderate Response

Strength of Evidence
1
2
3
4
5
71% of patients achieved at least a moderate (>25%) improvement in scarring after 4 sessions
▸ Based on These Clinical Studies & Trials
▾ Based on These Clinical Studies & Trials
 
  1. Sindhu, B., Naidu, C., Babu, S. & Teja, R. Microneedling vs microneedling with PRP in atrophic acne scars treatment. Journal of Cardiovascular Disease Research 14, (2023).
  2. Gandhi, R. N. & Makhecha, M. B. A split face study to compare the efficacy of platelet rich plasma versus normal saline injections in acne scars and to assess the utility of ultrabiomicroscopic sonography in evaluation of treatment response. J Cutan Aesthet Surg 15, 375–380 (2022).
  3. Diab, N. A. F., Ibrahim, A. M. & Abdallah, A. M. Fluid platelet-rich fibrin (PRF) versus platelet-rich plasma (PRP) in the treatment of atrophic acne scars: A comparative study. Arch Dermatol Res (2022) doi:10.1007/s00403-022-02511-3.
  4. Mumtaz, M. et al. Comparing the efficacy of intra-dermal platelet rich plasma (PRP) versus 50% trichloracetic acid (TCA) using CROSS technique for atrophic acne scars. J Coll Physicians Surg Pak 31, 55–59 (2021).
  5. Pooja, T., Gopal, K. V. T., Rao, T. N., Devi, B. G. & Kumar, S. A. A randomized study to evaluate the efficacy fractional CO2 laser, microneedling and platelet rich plasma in post-acne scarring. Indian Dermatol Online J 11, 349–354 (2020).
  6. Nassar, S. O., Eltatawy, R. A. R. & Hassan, G. F. R. Safety and efficacy of platelet-rich plasma vs carboxytherapy in the treatment of atrophic scars: a comparative clinical and histopathological study. Dermatol Ther 33, e13942 (2020).
  7. Hassan, A. S., El-Hawary, M. S., Abdel Raheem, H. M., Abdallah, S. H. & El-Komy, M. M. Treatment of atrophic acne scars using autologous platelet-rich plasma vs combined subcision and autologous platelet-rich plasma: a split-face comparative study. J Cosmet Dermatol 19, 456–461 (2020).
  8. Elfar, N. N. & Hasby, E. A. Efficacy and safety of plasma gel as a new modality in treatment of atrophic acne scars. Int J Dermatol 59, 620–626 (2020).
  9. El-Hawary, E. E., Nassar, S., Hodeib, A. A., Shareef, M. M. & Fawzy, M. M. Ablative fractional carbon dioxide laser and autologous platelet-rich plasma in the treatment of atrophic acne scars: a comparative clinico-immuno-histopathological study. Lasers Surg Med (2020) doi:10.1002/lsm.23306.
  10. Meena, M. K., Meena, D., Kachhawa, D. & Mehta, R. D. To evaluate the efficacy and safety of platelet rich plasma (PRP) in the treatment of acne scarring in different skin phototypes. IJMBS 3, 110–116 (2019).
  11. Gulanikar, A. & Vidholkar, R. Efficacy of platelet-rich plasma in acne scars. Clinical Dermatology Review 3, 109 (2019).
  12. El-Taieb, M. A. et al. Fractional erbium-YAG laser and platelet-rich plasma as single or combined treatment for atrophic acne scars: a randomized clinical trial. Dermatol Ther (Heidelb) 9, 707–717 (2019).
  13. Ibrahim, Z. A., El-Ashmawy, A. A. & Shora, O. A. Therapeutic effect of microneedling and autologous platelet-rich plasma in the treatment of atrophic scars: a randomized study. J Cosmet Dermatol 16, 388–399 (2017).
  14. Nofal, E., Helmy, A., Nofal, A., Alakad, R. & Nasr, M. Platelet-rich plasma versus CROSS technique with 100% trichloroacetic acid versus combined skin needling and platelet rich plasma in the treatment of atrophic acne scars: a comparative study. Dermatologic Surgery 40, 864–873 (2014).
 

Side Effects

Low-Medium
Low-medium side effects and adverse reactions

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