Oral Retinoid
Reviews
3.9
2791 Reviews
Oral Retinoid
Efficacy
87%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Note: Use with EXTREME CAUTION: Causes severe birth defects and fetal death.
Oral Retinoid
Side Effects
High
Oral Retinoid
Acne.org’s Real World Take
The nuclear option. It works reliably and provides long-term remission of acne, and even severe acne, in about ⅔ of people who properly take an adequate dosage. However, it permanently and irreversibly changes the skin and the body forever and users may experience long-term side effects for the rest of their lives. It’ll nuke it, but there is no going back.
Oral Retinoid
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Read All About Isotretinoin (Accutane®)
Compare To Other Treatments
5
37.1%
4
33.4%
3
15.5%
2
7.3%
1
6.6%

Used Isotretinoin (Accutane®)? Rate It:

Choose from 1 to 5 stars
June 20, 2018
Isotretinoin (Accutane) Experience
Honest Review of Isotretinoin: I suffered with cystic acne throughout middle school / high school, during which I had been taking many different types of antibiotics and topical creams. I found that the antibiotics (or Tetracyclines) never seemed to defeat my stubborn / persistent acne, so my dermatologist finally gave me permission to take Accutane. I started taking Accutane in my junior year of high school, initially starting at 40mg and slowly moving up to 60mg. I went through 2 weeks of initial breakouts, but the improvements became noticeable within the first 2 months. In fact it completely cleared up my cystic acne and black heads around 3 months! I stayed on the medication for 6 months until my skin was 100% clear, and at that point I felt like I defeated the long battle with my acne. However fast forward to my first year of university, my acne unfortunately came back :( I knew instantly that my skin was acting abnormal, so within a couple months of struggling with acne cream and store bought acne treatments, I decided to go back on Accutane. ROUND TWO. During the second treatment I didn't notice the same improvements - my skin did not respond the same way it did to my first round. All it did was dry me out and lessen the severity of my breakouts by a small amount. I stayed on the medication for 4 months and never ended the treatment with clear skin. I am currently 19 years old and my skin is a lot different than it was when I was first prescribed Accutane. My biggest struggle today is small bumpy white heads along my jaw / lower cheek and chin. I'm currently beginning my journey with spironolactone in hopes that I'll never have to take a oral drug for acne again. SUMMARY: - Accutane works great for cystic acne (completely got rid of mine, but now I struggle with a different type of acne). - Accutane is NOT 100% effective. - Accutane is not guaranteed to provide lasting results (mine only lasted 1 year). - Accutane is a short term solution to manage an internal / hormonal issue (digestive, air quality, sex hormones, allergies). Go see a doctor to understand the root cause of your acne!!! Side Effects: dryness (mainly lips and nose) Treatment Length: 1st round: 6 months. 2nd round: 4 months. Initial Breakout: yes. Products Used While On Accutane: - Cetaphil moisturizer - Cetaphil cleanser - Dr Jart+ cicapair cream - Vaseline (lips)' - All natural cold pressed oils (jojoba, sea buckthorn, avocado oil) - used in alternation and in moderation. - AHA skin exfoliator
June 3, 2018
Accutane
My experience with accutane was probably the best thing that ever happened to me. I'm 17y.o. and suffered from acne since I was 10. At forst it was mild but then it started getting worse. My problem area was mostly around the mouth and every month when i was in ovulation i got lots of cysts on the chin. I've tried everything and when i lost hope my dermatologist decided to put me on accutane. I took the pill in February March April May and June(30/30/30/20/10mg).This was honestly the best decision i have ever done because besides the side effects i saw my skin getting better with each dose and guys there is nothing better then gaining more and more confidence each day and recieving compliments on an area which was the thing you tried to make perfect 7 years out of 17. The feeling is just magical! I hope that it wont come back so wish me luck. If you are struggling with acne try it, it makes wonders and the side effects are even not that bad. Hope I helped!
August 22, 2018
I am going on accutane (dont know starting dosage yet) but I am not worried about the dryness but I am extremely worried about the mental side effects!
May 3, 2018
Takes time but oh so worth it!!
I've never written a review on anything before but during my Accutane journey, reading the positive reviews were one of the major reasons I kept pushing through. I thought I better add to this collection in hopes it helps someone someday too! Background: I am a 24 year old female with a greasy complexion. I have battled acne since I have been about 15 years old. I have tried it all: birth control, antibiotics, every cream, lotion, and wash imaginable for little to no effect. I began to get progressively worse hormonal acne (I noticed I would heavily breakout around that time of the month). Just when I was getting these multiple breakouts under control, it would be that time again and the vicious cycle would repeat. I have always been a confident woman, and while this acne didn't utterly destroy me, I understood the hurt of looking into the mirror and seeing an inflamed, sore, bumpy face staring back at me. I knew it was time to bring in the big guns. First Steps: I knew quite a bit about Accutane already, as I'm sure anyone who is a chronic acne sufferer has endlessly searched Google for remedies and has come across this controversial drug as well. I am also a nurse so I have heard and seen this drug in my workplace. I knew I had to suggest it to my doctor. DO YOUR RESEARCH PEOPLE! Read the ins and outs of the drug, read positive and negative reviews, read about timelines, side effects, precautions, dosing, etc and just get educated! Try to form an opinion about Accutane for yourself without being too bias one way or the other. When you go see your doctor with confidence of starting the drug, they will be more willing to make a plan with you. My family doctor (who does not specialize in dermatology but has the capabilities of prescribing Accutane) was extremely receptive in prescribing me it after I talked to her about it and proved I was educated on the matter. She sent me for baseline bloodwork and a pregnancy test, and then I booked a follow-up appointment with her for the following week. Dosing: After reading multiple peer-reviewed articles and journals, I discovered the cumulative goal dose of Accutane to prevent relapse is 120-150 mg/kg. I am approximately 75 kg, therefore I required 9000-11250 mg total Accutane over my treatment course. The recommended daily dose is 0.5-1.0 mg/kg. Typically you start low, then increase dosage monthly as your body becomes more tolerant. My 6 month Accutane dosing was as follows: Month 1 - 30 mg/day (900 mg total) Month 2 - 40 mg/day (1200 mg total) Month 3 - 60 mg/day (1800 mg total) Month 4 - 60 mg/day (1800 mg total) Month 5 - 60 mg/day (1800 mg total) Month 6 - 60 mg/day (1800 mg total) For a cumulative dose of 9300 mg total. Journey: After 1 month, there was absolutely NO change to my acne. The only noticeable changes were the dry lips. This wasn't a surprise to me, so onward we go! Month 2, still hardly no change. Just more of the negative side effects - dryer lips, eyes, and skin. Keep going, keep going. Month 3 and 4 were the toughest months in this journey by far, and from reading tons of other reviews, it sounds like this is the common trend. Anyone who knows anything about Accutane has read about "the purge". Basically, the drug is healing your skin from the inside out so all the breakouts that begin to happen during this time were already going to happen eventually anyway, but the Accutane makes them all happen and heal at the same time. This was a tough time for me. I felt others were noticing my nasty breakouts more than even before I had started the drug. Not to mention, my skin was so dry that attempting to cover up with makeup almost made it look more awful. One of the only things that made me continuing taking my pills was reading review after review to KEEP GOING BECAUSE IT WILL GET BETTER! I thought over and over that I must be in that small group of people that Accutane doesn't work for. But I kept going and am I ever happy I did! By the end of month 4 I started noticing big changes (and GOOD changes!) My face was clearing and the remaining pimples seemed quite superficial, no more deep cysts! Month 5 and 6 were amazing! Day by day, my face was clearer! Washing your face and not feeling any bumps is one of the best feelings in the entire world for an acne sufferer. Not to mention, as the acne healed, the dryness let up a bit. I have finally wrapped up my journey just a couple weeks ago and I am fully comfortable heading out makeup free. I am happy, confident, and so proud of myself that I pushed through. Side Effects: The only side effects I had were dryness/flakiness/redness. My face, lips, eyes, and back of hands got hit the hardest. I changed my face wash to Cetaphil and moisturizer to CeraVe. I used Aquaphor on my lips and hands. And I used Systane eye drops. If you have taken anything from this review, it's to push through your Accutane journey. You're going to want to give up, you're going to think it's not going to work, you're likely going to get worse acne temporarily before it gets better. KEEP GOING!!!! I did and am so grateful for reviews such as these for telling me to do so.
August 22, 2018
I have a question, how you said about "the purge". What you noticed/were told was that the skin was breaking out (worse) due to the skin healing from the inside out so that was 1, speeding up the acne process and 2, the healing process again from inside out? I am going on accutane and am just preparing myself, thanks in advance!
September 27, 2019

Thank you for the review. I had a huge purge month 1. Things for slowly better. Then now starting month four I’m breaking out so bad again. Worried wasn’t going to work. But your review gave me hope. 

April 29, 2018
We'll see how this goes
I haven't been on Claravis long but I'm on 40mg. I'm 27 and I have had mild-moderate acne on only my face for my entire adult life, it's very much hormonal and my face/hair has always been oily. Multiple doctors tried to sell me on accutane and I refused for years, I finally gave up. I have tried everything you can think of, I'm currently on spironolactone, hormonal birth control pills, and use aczone. . . I was using all 3 prior to accutane and my skin looks the best it has in years. I also moved from Florida to the PNW and this helped my skin because I spend less time in the sun, sweaty and hot. I mostly am just tired of having elaborate facial routines and ruining my clothes/towels/sheets with acne products/bleaching. My doctor reduced my dose of spironolactone while on accutane. I gave up drinking altogether but I have never been much of a drinker, I also have a medical background and value my liver too much to mix medications and alcohol. I did a TON of research prior to starting accutane and ordered: chapstick, lotion, aquaphor, eye drops, hydrating shampoo, thicker moisturizer, new sunscreen. . . and came prepared for battle with dry skin. I also take my accutane with fish oil pills and some version of fatty food. I have always drank lots of water, exercise every day, eat pretty good and wear sunscreen every day (I'm incredibly fair skinned). 5 days in and thus far, my only side effect has been dry lips (I managed them with aquaphor and chapstick with sunscreen),and a pressure headache which improved with Tylenol. Here is to hoping this jazz works, I hate messing with my hormones, I just want my face to not have new spots, old spots, and scars. . . all those chemical peels and microneedling only work for removing scars if you can prevent new break outs.
April 6, 2018
My Isotretinoin journey
Hi, I wanted to leave a review after finishing isotretinoin over a 8 month period. I read so many reviews that helped so want to do my bit... So...a bit about me: I'm a 28 year old female who had suffered from mild acne since my teens. My acne really wasn't that bad, hence most people wouldn't have defined it as acne. More or less, I had 2-3 active pimples at any given time, which meant I thought it could be easily treated with over the counter treatments. These never worked. My frustration grew. When I was 27 I went to a doctor in London (where I had moved one year prior from Australia). I explained to the doc that I still broke out and given my age, it was becoming a problem because it should have cleared up. I had been on various birth control pills, had an ultrasound for polycystic ovaries, but none of that had worked. I was referred to a dermatologist on the NHS. When I met with the derm she suggested accutane. I was very hesitant because I'd heard so many bad things about the side effects. I have had depression and wasn't keen to start medication that might affect my mood. She explained that if I went on anti-biotics, the chances were that the acne would return once I got off, so accutane was my best bet and I could start on a very low dose to reduce symptoms of side effects. After doing a lot of research I decided to give it a shot. I am 6ft tall and weighed 8-kg, so I was going to need more than your average girl. I still only started on 20mg per day. After 2 weeks or so I started getting dry lips, but they weren't too bad. I continued on the 20mg for a couple of months (no real improvement in my skin, and in fact it was getting worse). I upped to 40mg, but still no improvement and again...it was getting worse. I was obviously very upset, but the derm said I should still persevere and we upped it to 60mg, coupled with some steroids to combat the inflammation. It was at that point where I saw massive improvements. I stopped breaking out and was able to see the light at the end of the tunnel. I stayed on 60mg for a few months before going up to 80mg as I wanted the course to finish as soon as possible. My lips were dry, but I didn't get the skin peeling or other major side effects. What I did notice though was that my hair became very VERY dry. I have long hair and was losing more hair than I usually did. Fortunately, my mood was OK and if I was down, it was probably due to my living/work situation. After 8.5 months I finished the course and after a week or so my lips got better. It's now been 3 months since taking it and I haven't had a single pimple or break out. My scalp has started to produce oil again, which I hope will fix my hair, but I have just started taking hair loss/strengthening supplements called Nourkrin and I hope that will help improve the health of my scalp and hair. In a nutshell: It was disappointing at the beginning, but I am so glad I stuck with it as I now get compliments on my skin (this had literally never happened ever in my life). I still have faint red marks on my skin from the old scars (my skin is very sensitive so when I used to get pimples they'd leave marks which lasted for very long periods of time). I may consider laser treatment to deal with these residual marks, but I suspect they will fade with more time. Hoping the supplements improve the condition of my hair which has been the worst casualty of isotretinoin.
October 25, 2018
Hello! Has your hair returned to its natural oil state? I have quite dry wavy/curly hair and am really worried about making it even drier and frizzier! Thank you
March 29, 2018
Helped for Awhile
So I don't know if my review is going to help, for I was on Accutane 20 years ago. However, maybe it will help some people who are currently starting out on Accutane or are in treatment. Some background: I had suffered with acne since the age of 14, but acne got progressively worse in my 20's. I found out much later down the road it was hormonal acne. I tried so many treatments, from otc products to prescription-strength medications and finally got fed-up at the age of 25. The Accutane rules were a bit different back then - not quite as strict. For women, you still had to take a pregnancy test, but only once a month as opposed to two (I know this because I almost went on it again but bailed out at the last minute). You still had to be on two forms of birth control and get monthly blood work (I think it was for liver testing?). I don't recall having to go through such a strict clearance to pick up a prescription every month, but my memory could be off. Anyway, the first month or so, my acne did get worse before it got better. My skin got very dry and my lips were ridiculously chapped and dry, to the point where they were cracked, bleeding, and peeling. People even asked what was wrong with my lips. No amount of lip balm seemed to help. To this day, 20 years later, I have perpetually dry lips. Luckily, lip products have come a long way since then and they now have a lot of great overnight lip masks that you can use (thank you Sephora!). But regular Aquaphor works very well. My vision also became very blurry and I remember my eyes being dry. I can't recall any other side effects off the top of my head. But after awhile, I began to see amazing progress. By the end of the treatment, my skin was beautiful and clear. Not a pimple to be found anywhere! My skin stayed clear for three wonderful years. And then gradually returned. I was so disappointed. As I mentioned earlier, I never did do a second round of Accutane. It was around the time that I wanted to have kids and I was too scared to. And when I tried a new dermatologist, she did not recommend it and put me on another regimen instead. I really, truly, hope it works for you long-term. I will never forget those three years of beautiful skin. It was worth the side effects to experience that. It changed my skin texture, cleared up the marks on my face, everything. It was truly life-changing for me. I hope it is for you too!
March 13, 2018
Before I begin Accutane
I'm just about to start Accutane, however I am a male and I'm 17 years old, I've been told I have moderate/severe acne but in other cases some people tell me I have hormonal acne just like my brother did who was the same as me, however cleared up when he was 19-20 and he's now 22 and never gets a pimple. I get my acne along my jawline, neck, around the lower mouth, chin... let's say the lower parts of my face mainly but also on my chest and back! I weigh 73kg and my dermo is putting me on 20mg to start with, the reason being is because I have a wedding to go to in 6 weeks and I was scared I would face the initial break out just before the wedding and I didn't want to have dry flaky skin also. He told me because of my weight i'd be fine on 20mg and I should not break out for the wedding, he asked me to get back to him in 6 weeks for results. I want to know whether I should listen and go ahead or is it best to wait, will I most likely break out because I'm not going to lie I am so scared and sonscience about what's going to happen!! PLEASE HELP ME!!!!
March 5, 2018
Excited to start my course of treatment
Going to start with 5 stars and retract once I've actually experienced treatment. I haven't personally started isotretinoin yet. I was primed to start back in August 2017 before finding out I was pregnant and my treatment plan put on delay. After reading all the reviews (which have been extremely helpful), I've decided the benefits out weight the risks. Thanks everyone for sharing your experiences and I will check back here once I start my treatment (within about six months) and give my honest review. P.S. Moderate/Severe itchy cystic (keloid-type) acne in jawline area.
April 29, 2018
Was it a planned pregnancy? I was amazed when I was reading up on Accutane how many women get pregnant after finishing Accutane and have to go back on it after their baby is born. . . the hormonal changes make them break out. So maybe you dodged a bullet!
March 4, 2018
Accutane and initial breakout
My doctor prescribe me accutane 20mg a day as i am having severe acne, its an end of 2nd week and i am experiencing initial breakouts dnt know why my doctor prescribe me this for 20 days and call me again for checkup, Is really accutane works?? coz m still having breakouts every new fay with a new pimple on face
March 2, 2018
Accutane
what are side effects if taking cold medicines or drinking alcohol ocassionally?
April 29, 2018
From what I have read, cold medicines and alcohol are metabolized in your liver and so is Accutane. So you're just making it work harder. Many people have also said they get drunk faster and on less alcohol while on Accutane. I honestly would say it's ill-advised to drink while on Accutane but you do you. I personally decided not to drink while on Accutane. I also figure most drugs have some metabolic process in the kidneys too and I want my liver to work with my kidneys as much as possible. My liver and I have this loving relationship because I want it to stick around and it has more documented medical functions than the human brain.

Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.