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6 weeks sounds too long for a wound to heal. and what is mesh?
I'm thinking that the mesh is the saline soaked acell sheets which would degrade like the powder under the gauze...
Ah, yes that thought sort of crossed my mind as well. But the sheet isn't a mesh, Im thinking.
That doesn't look like a mesh to me...but you may be right. Maybe I can ask around on Spencer Kobren's forum.
I'm also thinking that if Hitzig meant the ACell sheets, he would have referred to it as "sheet" or "ACell sheet" and not as "mesh". But I'm not 100% sure.
I'm percieving a mesh as in something constructed with materials, e.g. a balloon newspaper paper mesh, were you paste over a balloon, the mesh dries, you bust the baloon, you then painted something on the mesh...
I'm percieving a mesh as in something constructed with materials, e.g. a balloon newspaper paper mesh, were you paste over a balloon, the mesh dries, you bust the baloon, you then painted something on the mesh...
Like this? 
I'm percieving a mesh as in something constructed with materials, e.g. a balloon newspaper paper mesh, were you paste over a balloon, the mesh dries, you bust the baloon, you then painted something on the mesh...
Like this?
http://www.pinataboy.com/makeaheart.html
Yes, something woven together with materials to make a mesh.
I'm percieving a mesh as in something constructed with materials, e.g. a balloon newspaper paper mesh, were you paste over a balloon, the mesh dries, you bust the baloon, you then painted something on the mesh...
Like this?
http://www.pinataboy.com/makeaheart.html
Yes, something woven together with materials to make a mesh.
I dunno I still think it's more likely that he meant some kind of medical mesh and not the ACell sheets...but that would be strange if you think about it indeed as the mesh won't dissolve in the wound contrary to the ACell sheets.
Btw, here's the description of that Xeroform moisturizing gauze:
Non-adherent dressing with 3% Bismuth Tribromophenate in a petrolatum blend on fine mesh gauze. Clings and conforms to all body contours. Sterile.
I'm percieving a mesh as in something constructed with materials, e.g. a balloon newspaper paper mesh, were you paste over a balloon, the mesh dries, you bust the baloon, you then painted something on the mesh...
Like this?
http://www.pinataboy.com/makeaheart.html
Yes, something woven together with materials to make a mesh.
I dunno I still think it's more likely that he meant some kind of medical mesh and not the ACell sheets...but that would be strange if you think about it indeed as the mesh won't dissolve in the wound contrary to the ACell sheets.
Btw, here's the description of that Xeroform moisturizing gauze:
Non-adherent dressing with 3% Bismuth Tribromophenate in a petrolatum blend on fine mesh gauze. Clings and conforms to all body contours. Sterile.
I thinking that now too. The worry I'd have is something outside of the nature of ECM denaturing the ECM. e.g. The human body does not produce Petrolatum, so perhaps you need some purposeful moist medical mesh constructed in a woven mesh keeping the ECM intact and the gause trapping the moisture etc.
Well I went to see my doctor today and he has refused to give me enalapril unfortunately.
I showed him the medical paper with the keloid and hypertrophic scars and he didn't even look at it, he just read the title and said "stretch marks are completely different to keloid and hypertrophic scars so it won't work at all". Personally I think he was talking rubbish, he really sounded like he didn't have a clue what he was talking about. I thought all types of scarring was very similar in nature, is this not true? Surely suppressing TGF-B1 would be beneficial to all scars. I tried explaining how ACE inhibitors work to help scars and it just went way over his head. I pushed him a little further and eventually he said "even if it does work it would be bad medical practice for me to prescribe you them as its only a research paper".
So basically he won't give me enalapril and he doesn't really know anything about scarring in general so he really didn't help at all.
Are keloid and hypertrophic scars that different from stretch marks? Are they so different that blocking TGF-B1 wouldn't help at all?
Well I went to see my doctor today and he has refused to give me enalapril unfortunately.
I showed him the medical paper with the keloid and hypertrophic scars and he didn't even look at it, he just read the title and said "stretch marks are completely different to keloid and hypertrophic scars so it won't work at all". Personally I think he was talking rubbish, he really sounded like he didn't have a clue what he was talking about. I thought all types of scarring was very similar in nature, is this not true? Surely suppressing TGF-B1 would be beneficial to all scars. I tried explaining how ACE inhibitors work to help scars and it just went way over his head. I pushed him a little further and eventually he said "even if it does work it would be bad medical practice for me to prescribe you them as its only a research paper".
So basically he won't give me enalapril and he doesn't really know anything about scarring in general so he really didn't help at all.
Are keloid and hypertrophic scars that different from stretch marks? Are they so different that blocking TGF-B1 wouldn't help at all?
I remember someone asking the Bulgarian Research Dermatologist, a.k.a. BRD and "bird" if the stem cell thing would work for stretch marks in the same way it supposedly would help scars. And he said that the only way to completely get rid of stretch marks is to have a treatment that can actually remodel tissue and that that was still far off...but with lots and lots of research and gene therapy...it would some day in the very, very, very distant future be a reality. So with that, he contradicted himself when he initially claimed that the stem cell thing can "get people's skin back the way it was" meaning that it can actually remodel skin. Anyway, I digress. I think what works for e.g. hypertrophic scars would have work for stretch marks too, in the sense that a wound is a wound so after an excision if you block TGF-B1 you should suppress scar formation to whatever extent. So theoretically, it should do good in my mind... 
But if I remember correctly excision isn't an option for you, right? So I don't know how you'd have to approach your situation but purely theoretically it should work the same, I think.
...he didn't even look at it, he just read the title and said "stretch marks are completely different to keloid and hypertrophic scars so it won't work at all".
That's pretty soon to just dismiss it like that. The least he could do is read it and if then he'd still feel the same...
...eventually he said "even if it does work it would be bad medical practice for me to prescribe you them as its only a research paper".
I can see where he was coming from there. Still it wouldn't hurt to look into it, though.
I remember someone asking the Bulgarian Research Dermatologist, a.k.a. BRD and "bird" if the stem cell thing would work for stretch marks in the same way it supposedly would help scars. And he said that the only way to completely get rid of stretch marks is to have a treatment that can actually remodel tissue and that that was still far off...but with lots and lots of research and gene therapy...it would some day in the very, very, very distant future be a reality. So with that, he contradicted himself when he initially claimed that the stem cell thing can "get people's skin back the way it was" meaning that it can actually remodel skin. Anyway, I digress. I think what works for e.g. hypertrophic scars would have work for stretch marks too, in the sense that a wound is a wound so after an excision if you block TGF-B1 you should suppress scar formation to whatever extent. So theoretically, it should do good in my mind...
Well that is very depressing to hear lol. I guess my doctor is right. It did seem strange how he just instantly dismissed it as soon as he read the title. He then went on to try and explain what keloid and hypertrophic scars are briefly and he did a terrible job explaining it which is why I thought he didn't know what he was talking about.
Excision for me isn't an option at all as I just have a ridiculous amount of stretch marks. Literally 1000s all over my body. I would literally have to have the vast majority of my skin removed. Not only that but the cost would be insane. Completely impossible.
I just don't understand how stretch marks or acne scars are that different from keloid or hypertrophic scars. I would love a detailed explanation so we knew what we are working with. I just don't see how TGF-B1 suppression can help one type of scar but not another.
Thank you very much for your reply it really is appreciated.
Well that is very depressing to hear lol. I guess my doctor is right. It did seem strange how he just instantly dismissed it as soon as he read the title. He then went on to try and explain what keloid and hypertrophic scars are briefly and he did a terrible job explaining it which is why I thought he didn't know what he was talking about.
Excision for me isn't an option at all as I just have a ridiculous amount of stretch marks. Literally 1000s all over my body. I would literally have to have the vast majority of my skin removed. Not only that but the cost would be insane. Completely impossible.
I just don't understand how stretch marks or acne scars are that different from keloid or hypertrophic scars. I would love a detailed explanation so we knew what we are working with. I just don't see how TGF-B1 suppression can help one type of scar but not another.
Thank you very much for your reply it really is appreciated.
BRD was only telling half the truth in hindsight. He had me going initially but later he turned out to be telling us something which wasn't the whole truth. At least that's how I see it... So I wouldn't let his uttering about regeneration only being possible in the year 5000, if you will, affect you too much.
Have you heard the interview with Hitzig? In it, he describes something which he is testing with, namely injections of fillers along with/mixed with ACell. He's testing it on people who have wrinkles, if I remember correctly, in order to have the sub-epidermal tissue regrow which is now sort of missing, causing the wrinkles. This, if it turns out to be working, could very well be a way that you can be helped as well, I assume, as it is only concerned with sub-epidermal layers and I think stretch marks only concern the dermis? In any case you wouldn't have to have EVERYTHING cut out...as I'm sure they can find a way to leave the epidermis as good as intact while they find some way to injure the area underneath in order to get the whole regeneration process going? I dunno, just thinking out loud...
Hey how many comments show up under the audio interview on your end, people?
http://www.iahrs.org/news/spencer-kobren-i...y-hitzig-acell/
I posted something and it says it's "awaiting moderation". So it seems they sort of blocked it? Or does it show up on your computers, regardless?
Hey how many comments show up under the audio interview on your end, people?
http://www.iahrs.org/news/spencer-kobren-i...y-hitzig-acell/
I posted something and it says it's "awaiting moderation". So it seems they sort of blocked it? Or does it show up on your computers, regardless?
Just one comment.
Hey how many comments show up under the audio interview on your end, people?
http://www.iahrs.org/news/spencer-kobren-i...y-hitzig-acell/
I posted something and it says it's "awaiting moderation". So it seems they sort of blocked it? Or does it show up on your computers, regardless?
Just one comment.
Ah, they really blocked it then. Hm. I wonder why.
I'm percieving a mesh as in something constructed with materials, e.g. a balloon newspaper paper mesh, were you paste over a balloon, the mesh dries, you bust the baloon, you then painted something on the mesh...
Like this?
http://www.pinataboy.com/makeaheart.html
Yes, something woven together with materials to make a mesh.
I dunno I still think it's more likely that he meant some kind of medical mesh and not the ACell sheets...but that would be strange if you think about it indeed as the mesh won't dissolve in the wound contrary to the ACell sheets.
Btw, here's the description of that Xeroform moisturizing gauze:
Non-adherent dressing with 3% Bismuth Tribromophenate in a petrolatum blend on fine mesh gauze. Clings and conforms to all body contours. Sterile.
I thinking that now too. The worry I'd have is something outside of the nature of ECM denaturing the ECM. e.g. The human body does not produce Petrolatum, so perhaps you need some purposeful moist medical mesh constructed in a woven mesh keeping the ECM intact and the gause trapping the moisture etc.
Now I think we had it wrong. lol Because later on in the interview he says that someone put solely "mesh" on a wound only to find out it didn't work. So with "mesh" he's referring to ACell sheets there. haha So confusing. Why doesn't he just say "ACell sheet" like everyone else! 
Hi every one,
The latest news on the Renovo page-it made my day!
www.renovo.com/documents/renovo_74B64.pdf
Hey Cambree! Nice to hear you're doing OK.
"Professor Mark WJ Ferguson, CEO, Renovo Group plc commented ‚Å“This trial has been extremely
successful. Not only have we established that we have a new formulation that is suitable for further
evaluation in children, ideally as a single administration, but we have also reconfirmed that the
500ng/100Ž¼l/linear cm of wound margin dose of Juvista in our ongoing EU Phase III trial (REVISE) was appropriately selected as it demonstrated the greatest level of efficacy."
That's pretty cool. Have you seen the Phase III trial photo earlier in the thread? It shows some nice improvement of a rather large scar.
Have you heard the interview with Hitzig? In it, he describes something which he is testing with, namely injections of fillers along with/mixed with ACell. He's testing it on people who have wrinkles, if I remember correctly, in order to have the sub-epidermal tissue regrow which is now sort of missing, causing the wrinkles. This, if it turns out to be working, could very well be a way that you can be helped as well, I assume, as it is only concerned with sub-epidermal layers and I think stretch marks only concern the dermis? In any case you wouldn't have to have EVERYTHING cut out...as I'm sure they can find a way to leave the epidermis as good as intact while they find some way to injure the area underneath in order to get the whole regeneration process going? I dunno, just thinking out loud...
With regards to stretch marks I reckon, and I may be wrong on this point here, that this injection would only work with light stretch marks. For the the heavier ones you would have to create a wound.
Yes, there is the pic of juvista on trial 3:
is it just me or does anybody else also thinks that placebo already had a dense scarring while compared to the juvista group hence its only natural to have better result with juvista as it was applied on already a superficial scar compared to placebo.
Have you heard the interview with Hitzig? In it, he describes something which he is testing with, namely injections of fillers along with/mixed with ACell. He's testing it on people who have wrinkles, if I remember correctly, in order to have the sub-epidermal tissue regrow which is now sort of missing, causing the wrinkles. This, if it turns out to be working, could very well be a way that you can be helped as well, I assume, as it is only concerned with sub-epidermal layers and I think stretch marks only concern the dermis? In any case you wouldn't have to have EVERYTHING cut out...as I'm sure they can find a way to leave the epidermis as good as intact while they find some way to injure the area underneath in order to get the whole regeneration process going? I dunno, just thinking out loud...
With regards to stretch marks I reckon, and I may be wrong on this point here, that this injection would only work with light stretch marks. For the the heavier ones you would have to create a wound.
Yeah, I guess you'd have to.
Yes, there is the pic of juvista on trial 3:
is it just me or does anybody else also thinks that placebo already had a dense scarring while compared to the juvista group hence its only natural to have better result with juvista as it was applied on already a superficial scar compared to placebo.
I agree. Still, the scar treated with Juvista looks pretty good to me...but it's true that the placebo scar started out worse than the Juvista one. It's kind of a bad comparison they made, I agree.
as much as i crave for a treatment to work, i cant honestly feel excited about the results on the basis of clinical trial done in aforementioned pictures since the matching has not been done correctly,its hard to explain the significence of improvement Juvista has produced while compared to placebo in above pic and raises the question on the reliability of the trial.
although i seriously hope there should be more to it then just one pic.
we all are very desperate to find some cure, at the same time we all are very susceptible to be taken advantage of.
Yes, there is the pic of juvista on trial 3:
is it just me or does anybody else also thinks that placebo already had a dense scarring while compared to the juvista group hence its only natural to have better result with juvista as it was applied on already a superficial scar compared to placebo.
I agree.
Hi,
If you were to scrutinise the footnote at the bottom, it says that the first set of pictures were at the 7mth mark. The 2nd set of pictures shows further improvement (for both placebo and Juvista) at the 12 mth mark. If you were to think abt it, I think what they were trying to get across with this demonstration is the fact that Juvista already improved the scar to a remarkable degree after half a year. Of course, the implicit reference point here is the fact that both scars ought to have similar baseline qualities prior to surgical intervention for the comparison to be sound and effective. This seems to bear out what they are trying to say in the description-"Sections of mature linear scar were randomized to receive..."
The pictures prior to intervenion are unfortunately missing.
MH