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More about Excaliard (EXC 001):
http://www.xconomy.com/san-diego/2009/10/2...linical-trials/
http://www.xconomy.com/san-diego/2009/10/2...nical-trials/2/
I suppose some might be sick of hearing it, but scar free healing has been done 
Decorin at 200nM completely brings fiberblast proliferation static. If the fiberblast proliferation is static, the fiberblasts cant create scar.
Perhaps I should carry this message as a footnote.
I suppose some might be sick of hearing it, but scar free healing has been done
Decorin at 200nM completely brings fiberblast proliferation static. If the fiberblast proliferation is static, the fiberblasts cant create scar.
Perhaps I should carry this message as a footnote.
LOL , yes.
I do not believe that he is so easy the one of the treatment without scar, with decorin I do not only believe that it is sufficient.
We need less tgf b1 b2, more tgf b3. and other things.
I suppose some might be sick of hearing it, but scar free healing has been done
Decorin at 200nM completely brings fiberblast proliferation static. If the fiberblast proliferation is static, the fiberblasts cant create scar.
Perhaps I should carry this message as a footnote.
LOL , yes.
I do not believe that he is so easy the one of the treatment without scar, with decorin I do not only believe that it is sufficient.
We need less tgf b1 b2, more tgf b3. and other things.
Fiberblasts over express collagen when we are wounded (i.e. scar)
Fiberblasts are made static with 200nM decorin. <<-- No scar can be created as the fiberblasts are static.
Your normal tissues do not suffer with mass apoptosis (cell death) when decorin is at 200nM and can actually heal.
IMO the logic clearly shows scar free healing has been done.
I suppose some might be sick of hearing it, but scar free healing has been done
Decorin at 200nM completely brings fiberblast proliferation static. If the fiberblast proliferation is static, the fiberblasts cant create scar.
Perhaps I should carry this message as a footnote.
LOL , yes.
I do not believe that he is so easy the one of the treatment without scar, with decorin I do not only believe that it is sufficient.
We need less tgf b1 b2, more tgf b3. and other things.
Fiberblasts over express collagen when we are wounded (i.e. scar)
Fiberblasts are made static with 200nM decorin. <<-- No scar can be created as the fiberblasts are static.
Your normal tissues do not suffer with mass apoptosis (cell death) when decorin is at 200nM and can actually heal.
IMO the logic clearly shows scar free healing has been done.
Is there any paper documenting scar free healing with decorin? Its main purpose seems to be hypertrophic scarring, which could be resolved with one visit at dermabrasion, and muscle healing.
As for these juvistas, the results are pathetic. It seems like the only way to deal with this is to wait for limb regeneration, where there will be no question that it would work perfectly for any scar. It anoys to hear of 'regeneration' in the same sentence with 'reduced scarring', there shouldnt be any scarring.
http://www.newscientist.com/article/dn4218...ewer-scars.html
memory to have to read that news in the 2003
'Holy grail' drug can help scars heal, new research shows'
http://www.telegraph.co.uk/science/science...arch-shows.html
I cannot believe to sell the things that say
I suppose some might be sick of hearing it, but scar free healing has been done
Decorin at 200nM completely brings fiberblast proliferation static. If the fiberblast proliferation is static, the fiberblasts cant create scar.
Perhaps I should carry this message as a footnote.
LOL , yes.
I do not believe that he is so easy the one of the treatment without scar, with decorin I do not only believe that it is sufficient.
We need less tgf b1 b2, more tgf b3. and other things.
Fiberblasts over express collagen when we are wounded (i.e. scar)
Fiberblasts are made static with 200nM decorin. <<-- No scar can be created as the fiberblasts are static.
Your normal tissues do not suffer with mass apoptosis (cell death) when decorin is at 200nM and can actually heal.
IMO the logic clearly shows scar free healing has been done.
Is there any paper documenting scar free healing with decorin? Its main purpose seems to be hypertrophic scarring, which could be resolved with one visit at dermabrasion, and muscle healing.
As for these juvistas, the results are pathetic. It seems like the only way to deal with this is to wait for limb regeneration, where there will be no question that it would work perfectly for any scar. It anoys to hear of 'regeneration' in the same sentence with 'reduced scarring', there shouldnt be any scarring.
Here is a something that shows scar free healing(Fibroblasts proliferation in wounds create scar):
At decorin concentrations of 100 nM and 200 nM, fibroblast proliferation was completely inhibited (P < 0.001), and the expected temporal increase in absorbance units was completely abolished, indicating a static population (Figure 1).
All scarring is the same, it is a collagen wall that stops your tissues from regenerating.
Regarding muscles, when you exercise your muscles get flooded with decorin, to stop fibrosis.
Hey Seabs
I read that article, specifically speak of the test-tube fibroblasts,but in action in the human skin already he is but complicated.
For so many companies that to gain trillions with the regeneration of skin, nonserious easy to create decorin in 200nm? I believe they have tried that it already.
Hopefully you are right and he is easy, and it leaves something easy but fast.
Has one spoken in this topic of the suppression of the gene 21?
http://www.guardian.co.uk/science/2010/mar...21-heal-no-scar
Hey Seabs
I read that article, specifically speak of the test-tube fibroblasts,but in action in the human skin already he is but complicated.
For so many companies that to gain trillions with the regeneration of skin, nonserious easy to create decorin in 200nm? I believe they have tried that it already.
Hopefully you are right and he is easy, and it leaves something easy but fast.
When you continue to research, you‚„ll maybe see learn some of these things and more:
Scarring is merely collagen over expression that leaves a scar wall that stops regeneration. Over proliferation of fiberblasts is what produces over expression of collagen (see were that leads ) The scar free healing concept was proven years ago, when atala kept the fibrils slender and produced a bladder etc. The body will heal itself to the tissue state if the fibrils on collagen remain slender (It has been doing this over evolution). You will see people employ future sounding statements to catch your imagination.
There are ways to get scar free healing when scarred. Dissolve the scar;
remove the scar and apply ‚œnon denatured ECM‚„ (I do not mean the marketing term of denatured. Note what I mean by non denatured ECM, is ECM that the body doesn‚„t reject the ECM, and because it doesn‚„t reject it you get no scar whatso ever the body resorbs the ECM and the body uses the fibrils like it does in you non wounded tissues. );
Remove the scar and use something that stops the over expression of collagen, like decorin. etc.
http://books.google.com/books?id=ZEkCzBfMX...ion&f=false
"Lack of fibrous scarring is the primary feature of fetal wound healing. Even for longer periods, HA content in fetal wounds is still higher than that in adult wounds, which suggests that HA may, at least in part, reduce collagen deposition and therefore leading to reduced scarring.[65] This suggestion is in agreement with the research of West et al., who showed that in adult and late gestation fetal wound healing, removal of HA results in fibrotic scarring.[66] Though the exact role of HA in skin scarring is still under investigation, based on all the facts that have been observed, it must be a great contributor to the less fibrous scarring."
http://books.google.com/books?id=ZEkCzBfMX...ion&f=false
"Lack of fibrous scarring is the primary feature of fetal wound healing. Even for longer periods, HA content in fetal wounds is still higher than that in adult wounds, which suggests that HA may, at least in part, reduce collagen deposition and therefore leading to reduced scarring.[65] This suggestion is in agreement with the research of West et al., who showed that in adult and late gestation fetal wound healing, removal of HA results in fibrotic scarring.[66] Though the exact role of HA in skin scarring is still under investigation, based on all the facts that have been observed, it must be a great contributor to the less fibrous scarring."
Exact, in the embryo this one surrounded with acid hyaluronic.
They've been saying this for years...if only it was true...i woulda faught my way onto the trials tests!!
"The findings, published in the Lancet, show that on average the drug increased healing by five per cent more than standard wound care by six months, and by eight per cent by the end of the first year. "
Not a great amount of improvement over standard wound care practices? caveat: have not verified this information and only relied from the news article posted previously.
"The study also found that as well as enhancing the appearance of the scar the drug also improved the structure of the skin."
Be interesting to see how this plays out...but I have seen promises of scarless healing for several years, only to be continuously disappointed.
Thanks for posting!