Holdontohope that guy with the hair transplant scar looks like it has gotten substantially smaller although it was very large to begin with. From look at the pictures I saw three different stretched looking surgical scars which look the same size rather than one large one so I think its easier to tell the difference that occurs. I definately agree with the fact sutures will worsen it but I think delivery method of Acell is something that will only get better as doctors are allowed to play around with it.

It scabbed very nicely actually. This is a really large wound though, that's gotta hurt!

I agree with Tom, it definitely looks a little smaller.

Is it possible for his hair to grow again in the treated scar with Acell ?

Is it possible for his hair to grow again in the treated scar with Acell ?

That we do not know yet. That is what many on the hairloss forums are waiting to find out. Many speculate that, no, there will not be follicle regeneration, but there's a little bit of hope for that. We just don't know yet, but will soon.

Also, as far as the wound appearing smaller on the Acell blog, I believe that's just wound contracture.... Anyways, I'm excited to see how things progress.

I have been studying that bottom picture very closely and if you look at the above two train track type scars it is clear that in the acell treated scar that the stitch marks are not visable. I think that acell would need to be repeated on scars to achieve best results.

Is it possible for his hair to grow again in the treated scar with Acell ?

I expect it to, from what I've learned, ecm, that is not artificially made or denatured by chemical additives, ultra violet, metal rims etc. regenerates what soft tissues are supposed to be there on every animal and mammal. The scalp is no different to other parts of the body when it comes to ecm. Also in the past ecm has had no problem in regenerating follicles on other tissues in the body.

Is it possible for his hair to grow again in the treated scar with Acell ?

 

I expect it to, from what I've learned, ecm, that is not artificially made or denatured by chemical additives, ultra violet, metal rims etc. regenerates what soft tissues are supposed to be there on every animal and mammal. The scalp is no different to other parts of the body when it comes to ecm. Also in the past ecm has had no problem in regenerating follicles on other tissues in the body.

 

Kirk, can you please site specific sources (a link would be awesome) of where "in the past ecm has had no problem in regenerating follicles on other tissues in the body."

Also, could you please site your sources that support your statement, "ecm, that is not artificially made or denatured by chemical additives, ultra violet, metal rims etc. regenerates......"

I'd like to educate myself as much as possible on ecm, and it would be much appreciated. Thanks.

Iran invests $2.5 billion in stem cell research:

http://www.cnn.com/2006/WORLD/meast/11/16/...n.iranstemcell/

This is awesome. It's what we need.

Is it possible for his hair to grow again in the treated scar with Acell ?

 

I expect it to, from what I've learned, ecm, that is not artificially made or denatured by chemical additives, ultra violet, metal rims etc. regenerates what soft tissues are supposed to be there on every animal and mammal. The scalp is no different to other parts of the body when it comes to ecm. Also in the past ecm has had no problem in regenerating follicles on other tissues in the body.

 

 

Kirk, can you please site specific sources (a link would be awesome) of where "in the past ecm has had no problem in regenerating follicles on other tissues in the body."

 

Also, could you please site your sources that support your statement, "ecm, that is not artificially made or denatured by chemical additives, ultra violet, metal rims etc. regenerates......"

 

I'd like to educate myself as much as possible on ecm, and it would be much appreciated. Thanks.

 

Everything I've read tells me it will regenerate tissue that is supposed to be there, every little bit of information I have on it. Take for example the collagen laminin (laminin 511) a component of the ecm. Take for example it has regenerated hair on animals, take for example it has regenerated genitalia on humans, fingers, tendons, skin, bladders. I also have hundreds of sources saved and I know one or two of them have mentioned hair regeneration that have been concerned with ecm. Anyway read Dr Jones own web comment, he explains that it has regenerated hair follicles on other parts of the body.

http://www.drrobertjones.com/newsletter/news-2008-11.html

Kirk:

Do you have any other sources that site ecm as regenerating hair follicles in HUMANS? Animals are very different in the way that they heal. Many heal better and faster than humans. Someone posted on one of the hairloss forums - as a response to mass speculation that Acell might regenerate human hair on the head - and told of how her dog had degloving injuries on one or two of his legs down to the fatty layer. All the skin had been removed, yet without any help at all from tissue regeneration products, her dog's wounds closed up and fur regenerated. I would not use the fact that Acell has regenerated fur on animals as substantial evidence that it will regenerate follicles on humans. Do I hope you're right? Hell yes, I do. But I am still very very skeptical.

As far as using Dr. Jones, this is what he said on his Acell blog concerning follicle regeneration (I've added the asterisks for emphasis): "It caught my interest because in veterinary use it not only regenerates skin, but regenerates skin with normal hair follicles."

He also said, "Further, Acell has been approved for wound care in humans, and in patients where it has been used, the hair follicles regenerate as well as the skin." I have no idea where he is getting this, as Mike Manning himself said only a week and a half ago that they do not know if Acell will regenerate hair in humans, but they certainly hope it will and will be disappointed if it doesn't.

Kirk, do you have any other sources that follicle regeneration with ecm used on humans?

Also, you said that either ecm, or one of its components - laminin - "has regenerated genitalia on humans." That's quite a thing to say without siting sources.

If you cannot post a link online, I would be immensely grateful if you could send me via personal email the actual sources that site this. I've PM'd you with my personal email address.

thanks.

New Acell photos from Dr. Jones - 1 week post-op

http://www.drrobertjones.com/acell.html

I typed up a response and some how my browser went back a page and I lost it all. Fuck.

Also I put this in some where in some context on my last post, the scarring regeneration response is similar in all animals that scar, and the regeneration response is similar in all animals that scar and regenerate.

Regarding laminin, I never said Laminin regenerated genitalia, I said ECM did (maybe it brought about pubic hair). I highlighted Laminin (laminin511) as it is a component in ECM that I advised you to look up a couple of weeks ago with regards to hair. My thinking would be you would see laminin highlighted and I would not have write up and expand saying I talked to you a couple of weeks ago about its apparent use in hair regeneration.

Holdontohope I never said I have any sources that said they regenerate hair on humans, I said I have hundreds, (I actually have over a thousand now, many of them on ecm) and Iam sure Iave read ECM has regenerated hair.

And if none of them said they regenerated hair, I would still know an ECM that is not cross linked denatured (denatured = information pages in a book glued together) would regenerate hair, basically because our tissues are intelligent in that they know what to regenerate locally if they have the nearby factors, they using ECM will regenerate the nearby factors to the local state. Basically by using the ECM scaffold, which acts like a 3d micro book of information.

You would not have your hair now if you had no ECM, you would not have your eyes, your skin, your bones. In fact you would not exist if you had no ECM and if you were running out of ECM or had a problem with it I guess your tissues would become fibrotic.

What is ECM from what I know: ECM is central to regeneration of every tissue you have, every creature has, and though people are trying to replicate the factors in regeneration, it is a 3d scaffold, with micro factors that is basically impossible to recreate in the lab.

Skin and other tissues are clever and literate in the 3d scaffold they micro read it, cross linked the more fibrotic, the less cross linked more regenerative, they have done so probably from the earliest ancestor stage of all the creatures on this biosphere, tissues react to it and use it over time to recreate tissue, humans are not yet literate in it, and humans could never recreate and operationalize these 3d micro processes on a micro scale over time. Also how impractical would it be to artificially operationalize the ECM material role, can you imagine someone being on hand to micro probe a morphing tissue in the ecm role?

These are only 2 days post-op.

These are only 2 days post-op.

Presss CTRL + F5 on your keyboard to refresh the page.

http://www.drrobertjones.com/acell.html

Thats a huge chunk of skin excised, if it can regenerate( with hair follicles a plus ), I dont see why it cant be used for acne scars

I only wish some things were done differently with this to help the outcome faster and with what I think would be better results:

- I would advocate using Acell with no sutures at all, if that's possible.

- I think the wound should be kept moist - moist wound environments, if kept sterile, heal much better and faster than dryer wound environments....

- I think that LLLT (Low Level Laser Therapy) should be used daily to enhance wound healing and decrease scarring

- I would have like to see a layer of Acell laid over the entire wound, not just within the wound, so as to ensure that all edges of the wound were touching the ECM.

Whatever... too late for that!

- I would have like to see a layer of Acell laid over the entire wound, not just within the wound, so as to ensure that all edges of the wound were touching the ECM.

This is what Manning had suggested to me when I asked how Acell might be used best. He said that the wound should remain covered for two weeks with a scaffold and bandage and that Acell should be applied EOD.

I only wish some things were done differently with this to help the outcome faster and with what I think would be better results:

 

- I would advocate using Acell with no sutures at all, if that's possible.

- I think the wound should be kept moist - moist wound environments, if kept sterile, heal much better and faster than dryer wound environments....

- I think that LLLT (Low Level Laser Therapy) should be used daily to enhance wound healing and decrease scarring

- I would have like to see a layer of Acell laid over the entire wound, not just within the wound, so as to ensure that all edges of the wound were touching the ECM.

 

Whatever... too late for that!

Maybe someone should suggest these things to Dr. Jones for his next acell trial.

After Franklin's tower made his last post, I sent a similar message over to Dr. Jones, informing him of Acell's recommendations for wound care, etc.

After Franklin's tower made his last post, I sent a similar message over to Dr. Jones, informing him of Acell's recommendations for wound care, etc.

Nice one

I only wish some things were done differently with this to help the outcome faster and with what I think would be better results:

 

- I would advocate using Acell with no sutures at all, if that's possible.

- I think the wound should be kept moist - moist wound environments, if kept sterile, heal much better and faster than dryer wound environments....

- I think that LLLT (Low Level Laser Therapy) should be used daily to enhance wound healing and decrease scarring

- I would have like to see a layer of Acell laid over the entire wound, not just within the wound, so as to ensure that all edges of the wound were touching the ECM.

 

Whatever... too late for that!

I would advocate cutting the suture out now if possible, and I think the use of the word sterile should be forgotten, as ECM already has antibacterial (perhaps even bacterial regulation) properties and there are even products being designed with ecm to fight infection. I suspect there are a lot of sterilization products that would denature the material.

I have an image of an over zealous dermatologist thinking default, thinking sterile, sterilize, where he applies cream after cream on the ecm wound, that maybe looks like it is inflamed, completely denaturing the process.

To quote Dr. Jones:

"The scar was excised, the wound was rinsed with saline, and acell powder was generously applied to the exposed tissue. Two layers of Acell Wound Sheets were applied over the powder and the sheets were held in place with 5-0 gut."

ACell is being laid over the entire wound, however, if the sheet was left on, YOU WOULDN'T BE ABLE TO SEE ANYTHING.

However, I do see a bit of a problem with the scab kind of interfering with the healing process. It seems that the scab impedes the application of ACell.

However, I do see a bit of a problem with the scab kind of interfering with the healing process. It seems that the scab impedes the application of ACell.

This is why hope recommends keeping a moist healing environment. First hand (kind of a pun), I have experience with a very large wound healing on my palm where I did not bandage it and it was exposed to water every day during healing. It barely scabbed and two weeks later it had healed without a trace. It would be an excellent idea to dress the treated wound with saline once every few days and re-bandage with a waterproof covering.

However, I do see a bit of a problem with the scab kind of interfering with the healing process. It seems that the scab impedes the application of ACell.

This is why hope recommends keeping a moist healing environment. First hand (kind of a pun), I have experience with a very large wound healing on my palm where I did not bandage it and it was exposed to water every day during healing. It barely scabbed and two weeks later it had healed without a trace. It would be an excellent idea to dress the treated wound with saline once every few days and re-bandage with a waterproof covering.

 

Spoke with Manning today. He said that Dr. jones is being guided by Acell's VP during the entire process. He also mentioned that if the wound seems to be drying out too much that they could always revise the wound as many times as they need and still continue to have a scarless recovery.

He said that he is 100% confident that there will be no scar and it's just a question of whether or not the skin will regenerate hair. But he is hopefull that it will.

However, I do see a bit of a problem with the scab kind of interfering with the healing process. It seems that the scab impedes the application of ACell.

This is why hope recommends keeping a moist healing environment. First hand (kind of a pun), I have experience with a very large wound healing on my palm where I did not bandage it and it was exposed to water every day during healing. It barely scabbed and two weeks later it had healed without a trace. It would be an excellent idea to dress the treated wound with saline once every few days and re-bandage with a waterproof covering.

 

 

Spoke with Manning today. He said that Dr. jones is being guided by Acell's VP during the entire process. He also mentioned that if the wound seems to be drying out too much that they could always revise the wound as many times as they need and still continue to have a scarless recovery.

 

He said that he is 100% confident that there will be no scar and it's just a question of whether or not the skin will regenerate hair. But he is hopefull that it will.

 

WOOT! This is one important step. Do you have any idea about the recovery time though?