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13 hours ago, gueste said:
Cool stuff.
I guess it seems like.. the verteporfin research spawned different teams..
One with FAKI. In which he says the onlything not fully regenerating is the hair. (Which most of us dont give a **** about).
And the other team is working with verteporfin.. if there evenis such a group, havent heard any wordfrom that side since their originalresearch was published.
From a profit perspective, verteporfin doesnt make much sense to pursue, Im not sure how patentable the use case will beand is damn expensive.
FAKI on the other hand, can become a proprietary device, and potentially cheaper to make. At the cost of the consumers wasted life.
Its hard to ignore the words of a Stanford post doc student, when he says his device completely eliminates scarring. Red flags go off, but its hard to pin point a motive, other than him just hyping up his research.
7 hours ago, Scars4Life said:Cool stuff.
I guess it seems like.. the verteporfin research spawned different teams..
One with FAKI. In which he says the onlything not fully regenerating is the hair. (Which most of us dont give a **** about).
And the other team is working with verteporfin.. if there evenis such a group, havent heard any wordfrom that side since their originalresearch was published.
From a profit perspective, verteporfin doesnt make much sense to pursue, Im not sure how patentable the use case will beand is damn expensive.
FAKI on the other hand, can become a proprietary device, and potentially cheaper to make. At the cost of the consumers wasted life.
Its hard to ignore the words of a Stanford post doc student, when he says his device completely eliminates scarring. Red flags go off, but its hard to pin point a motive, other than him just hyping up his research.
I personally care to have regenerated hair follicles as i lost eyelashes due to my eye issues ( inflammation etc ) but this is incredible news none the less , the future is getting brighter
absolutely irrelevant today,butfunny still. Remember that PolarityTE hype back in 2017? They are still alive lol
On 12/20/2021 at 2:34 AM, gueste said:Someone emailed Dr. Chen who is the co-author of the verteporfin study and lead author of the faki + hydrogel study!
I don't understand that very well. or Google translates incorrectly. so we can't get rid of the scars we have with verteporfin? Do they need to do more research to find out?
It just means that they need to cut out the scar before using the drug -- that is, the drug won't dissolve an existing scar if injected into the scar, but if you create a new wound by cutting out the scar, it will heal scarlessly.
BTW, that email is not about Verteporfin but a more experimental drug that is a FAKI inhibitor, preventing the body from sensing tension. The end result is similar and the drug could potentially work in combination with Verteporfin for even better results.
We haven't had any updates on Verteporfin specifically but they should be coming soon.
It's a little confusing because both projects are from Stanford and have many of the same scientists working on scarless healing, but they're two different projects. One involves Verteporfin, and another involves a FAKI inhibitor. The email is talking about the latter.
On 1/1/2022 at 10:44 AM, k95 said:It just means that they need to cut out the scar before using the drug -- that is, the drug won't dissolve an existing scar if injected into the scar, but if you create a new wound by cutting out the scar, it will heal scarlessly.
BTW, that email is not about Verteporfin but a more experimental drug that is a FAKI inhibitor, preventing the body from sensing tension. The end result is similar and the drug could potentially work in combination with Verteporfin for even better results.
We haven't had any updates on Verteporfin specifically but they should be coming soon.
It's a little confusing because both projects are from Stanford and have many of the same scientists working on scarless healing, but they're two different projects. One involves Verteporfin, and another involves a FAKI inhibitor. The email is talking about the latter.
understandably. Thank you. but when verteporfin publishes new data
On 12/28/2021 at 12:33 AM, Scars4Life said:I guess it seems like.. the verteporfin research spawned different teams..
I've been looking into this and the faki hydrogel has been in development since 2017. At least, they have had funds since 2017. There are patents filed since 2019 about using this method. They know what stops scarring, and wanted to repurpose a drug(Verteporfin) so it would be easily accessible. The FAKI research has been before the verteporfin research.
The link to the FAKI project summary: https://doctrc.org/wp-content/uploads/2021/08/Gurtner.pdf
Hoping that we can see some results with verteporfin. Just have to find a surgeon that will be willing to try it since most surgeons are only going to wait for clinical studies to be published which is reasonable.
I have a science background nothing to do with this area but from what I can tell the current trial from Mr Chen is just an advancement on from theVerteporfin drug. By means of a way of efficiently applying it and making a feasible economic path onwards. So therefore if the main base of the drug isVerteporfin and that is already FDA approved then the trials change from having to prove it is safe to proving it is effective. This dramatically shortens the time needed for approval, I was wondering if anyone has contact with a member of the study and can ask them how close they are to there initial plan of starting the human trial of the product by the third quarter of 2022. From this point if all good you should expect approximately 2 years until full approval. However means of production would not be granted till approval, depending on the legal patents, it may take 1-2 years to reach full scale production and if they manage to get full hair regrowth then you are looking at billions added to the potential market. Therefore the chance of months after approval the scale of production being able to cope with demand is near impossible therefore probably encouraging huge prices in the short run or making it near impossible for the cosmetic user to gain access until production is increased.
This mayalso be interesting. Trying to get more info
Dr Fiona Woods is working on a scarless healing cream:PXS-6302
First human trials for scar-less wound healing cream(uwa.edu.au)
I was wondering if anyone has any information on the mouse, pig or human verteporfin trials. As was wondering what kinda dosages are expected and how if they say to inject into wound edges is that still applicable to large scale burns.
3 hours ago, Scarsmakemewanttodie said:I was wondering if anyone has any information on the mouse, pig or human verteporfin trials. As was wondering what kinda dosages are expected and how if they say to inject into wound edges is that still applicable to large scale burns.
For verteporfin, we only have the mouse study. I dont think the dosage from the mouse study would be a goodreference. I wish the pig study would have been published by now so we would have a clear picture.
I dont know if the wound edges would be applicable to large scale burns but Longaker said he hopes to use this treatment for burns also.
I found this inside of the April paper by Dr Longaker, and if I'm not mistaken it works out to 0.03mg per wound which to me seems massively insignificant. Let me know if anyone else gets anything else from this.
I've sat and done some maths for approximate pricing for verteporfin injection in order to see its financial viability for myself and you guys.
So to start the ratio of drug to solvent is 1:1000, therefore for every 1mg of verteporfin you will need 0.999ml of solvent (phosphate buffer saline) and that will provide you 0.001ml of verteporfin.
As stated above they injected 30uL of verteporfin in to each scar of 20mm diameter and that works out to be 30ml of solution injected and 30mg of verteporfin. So the first expense would be the price of injection and due to such a large quantity this would have to be a staggered process with multiple days of injection within the 30 days of healing. And not to frighten you but the cost of a professional injector or a dermatologist is in the region of a 100 dollars a trip and your looking at roughly 15 trips! Totalling 1500 dollars as the fixed costs.
The variable cost of the drug is 20 dollars per mg and you need 30mg for 2cm. So the price of a 2cm scar for just the drug is $600 dollars. Which works out at $30 per mm of scaring and I don't even want to work out the price for a potential full face application for deep full ablation laser.
So in the case of myself who was 5cm worth of excisable scars, I am looking at roughly $3000 dollars and in the grand scheme of things that doesn't sound to bad. But I can see the price of the drug rising once approval happens.
Also this has been 20mins work so please correct me if you notice any errors or glaring oversights!