Acne.org Products
Yeh and a video on youtube with a patient giving a talk. When you see the bits that have skinTE vs grafted you see what a difference it makes to peoples lives. It is the stem cells from the hairs that do the magic in the biopsy. Then when the new skin regrows the hairs, it matures and changes in time. I think with this woman it was 7 months before she had 'proper skin'. It takes a long time to get the results.
Its actually tissue expansion in vivo. Thats what they say.
7 hours ago, nikki_gargin said:Yeh and a video on youtube with a patient giving a talk. When you see the bits that have skinTE vs grafted you see what a difference it makes to peoples lives. It is the stem cells from the hairs that do the magic in the biopsy. Then when the new skin regrows the hairs, it matures and changes in time. I think with this woman it was 7 months before she had 'proper skin'. It takes a long time to get the results.
Its actually tissue expansion in vivo. Thats what they say.
What SkinTE does or will become some day is a substitute to skin grafts. Instead of cutting parts of healthy skin from other body parts to cover large wounds that won't heal, doctorslay down some stem cellsthat they harvest from another part of the body. Thesecells grow and cover the wound by proliferating from the center instead of normal wound contracture. Either way, there is a noticeacle gap between uninjured skin and the wound edges once the healing stage has occurred. The body will tend to close the wound by contraction and the new skin that grows the center will eventually meet creating a scarred edge.
That's the potential of SkinTE. Recell is similar in many ways and with SkinTE you risk life-threatening infections. ReCell claimed total skin regeneration in the beginning and propagated pictures on the Net about their miracle product.
SkinTE is doing the same thing as ReCell. They have posted pics on their website. The new skin doesn't look scar free from what I see. Some of those pics could also be altered.I keep seeing fine lines of scarred edges. Over time, I suppose the scars only get better. It's a better alternative than skin grafts as opposed to current methods.The media has us believing that SkinTE is great and wonderful. That's the media for you propagating false info or stretching the truth.
I read about that woman who unfortunately got burned at around 75% of her bodyand how this product supposedly regenerated her skin. The reality is that SkinTE suppressed scarring to some extent but that woman will be marked from that event in some form or another forever.
Acne sufferers cannot be considered for this. Acne scarring is different as it results mostly in atrophic or pitted skin and not contracture or hypertrophic scarring from cuts, burns or lacerations. In the same way, FS2 will not help with atrophic scarring. Most products or research currently conducted focuses on raised scars as there is nothing out there to enhance their appearance. Silicon sheets offer little. With pitted skin, there is simply much more money to made by injecting non permanent fillers or lasers.
20 hours ago, MyBeautifulScars said:I read about that woman who unfortunately got burned at around 75% of her bodyand how this product supposedly regenerated her skin. The reality is that SkinTE suppressed scarring to some extent but that woman will be marked from that event in some form or another forever.
It didn't suppressscarring. that's what fs2 does so SkinTE by logic does not do that. its basically like uncooked cake mixture. the cake rises in the oven (wound bed). Its in vivo tissue expansion,their words, but it makes more sense now to me what they do as I have had tissue expanders myself. Iread about the mechanisms on why that works in creating % increase in skin surface, not a mere stretch. Even in tissue expanders it takes a year for the epidermis and dermis to return to normal, asthe epidermis thickens and dermis thinsduring expansion. Dermis does thicken again, but never to normal and the epidermis goes back to normal 100%.
SkinTE is going through all these biological changes while in the wound. it takes over a year before no further changes will take place. That woman has been told pigment should start coming back. so we will see. its the fact it replaces a donor functioning dermis that is impressive. The Dermis is the problem in scaring. I was told by a plastic surgeon on email that skinTE is "thin". which supports its tissue expansion in vivo.
but it depends on how big the wound in which it is covering. obviously like for like will be same dermis depth. a small harvest for a whole arm will end up aTHIN DERMISand look weird and 'old almost' which is what we are seeing esp that replacement SFTG on dark skin? it is FT Skin, just thin.it does work, its just the dermis does not recover from expansion.
2 hours ago, Anish004 said:sorry but when u dont have significant scarring than why u are on this forum ???
do u have any other type of scarring ???
Yeah I have a surgical scar.
i have a donor skin graft scar as well. But I dont care about that.
Why would I waste my time here if I didnt have a scar I wanted gone. Plus I told you this before. You dont listen to no one Anish just blab blab
1 hour ago, nikki_gargin said:Yeah I have a surgical scar.
i have a donor skin graft scar as well. But I dont care about that.
Why would I waste my time here if I didnt have a scar I wanted gone. Plus I told you this before. You dont listen to no one Anish just blab blab
Women are under immense pressure these days to look amazingly beautiful. Clothes arequite revealing, so unsightly body scars can cause a lot of anguish for younger girls, basically the trend right now is to reveal almost everything by hiding the bare minimum.
As a guy,we arealso are under immense pressure to look extremely masculine with amazing skin to attract the opposite sex.I have many scars from childhood and sport related injuries on my knees, hands and face. A few others on other parts of my body but the ones that truly disgust me are the horrendous scarsI have developed from my horrible case of cystic acne, folliculitis and hidredinitis frommy teenage years and that I continue to sporadically suffer from in my early thirties. They bring back painful memories of sleepless nights, low self-esteem and embarrassment.
My back, shoulders, upper arms, jawline, thighs and buttocks have a bunch of slightly raised white scars which are pretty noticeable under certain lighting. My face has a few pock marks but they are not so noticeable.
I find it extremely frustrating that in this day and age, we cannot cure acneand all these other skin diseases. People are left with pretty noticeable disfigurement. My back looks as if I was a victim of an acid attack and I'm pretty much tired of it. My armpits, groin and buttockshave deep holes from healedboils. Type hidredinitis on Google and you will be pleasantly surprised.
I needa doctor to strip my current skin away and make me a new skin suit, lol.Unfortunately the way things are going, nobody wants to find cures, they rather treat. Scarring is nature's way for mammals to heal. If we can't find a cure to stop pimples from forming, how can we find a way to reprogram scar tissue into normal looking skin?
The truth is they probably know how to stop scar formation but it will take a long time before they release it for public use. So here I am playing the waiting game hoping to rid myself offmy white marks and pot holes to look normal one day.
FS2 looks promising. It improves existing scars and apparently stops scars in new wounds. Olx101 is even more promising because it reprograms scar tissue DNA. Hopefully these two will not fail clinical trialsand in 5 years time, they will be truly available for me to take advantage of for a small price. SkinTE looks awful and dangerous. Sunogel is all talk, no show. Other startups are promising things but again little to show for it. I don't know what the researchers at UCI are doing after they released a paper promising scarless healing two years ago.And off course, we have microcoring which also seems like a waste of money. Most people will not throw money away to remove scars after 1000 treatments.
Anyways, we should enjoy life to the fullest right now before we become to old and our scars probably become level with the rest of our skin or look even worse. In any case, scars will be the least of our concerns by then.
17 hours ago, MyBeautifulScars said:Women are under immense pressure these days to look amazingly beautiful. Clothes arequite revealing, so unsightly body scars can cause a lot of anguish for younger girls, basically the trend right now is to reveal almost everything by hiding the bare minimum.
As a guy,we arealso are under immense pressure to look extremely masculine with amazing skin to attract the opposite sex.I have many scars from childhood and sport related injuries on my knees, hands and face. A few others on other parts of my body but the ones that truly disgust me are the horrendous scarsI have developed from my horrible case of cystic acne, folliculitis and hidredinitis frommy teenage years and that I continue to sporadically suffer from in my early thirties. They bring back painful memories of sleepless nights, low self-esteem and embarrassment.
My back, shoulders, upper arms, jawline, thighs and buttocks have a bunch of slightly raised white scars which are pretty noticeable under certain lighting. My face has a few pock marks but they are not so noticeable.
I find it extremely frustrating that in this day and age, we cannot cure acneand all these other skin diseases. People are left with pretty noticeable disfigurement. My back looks as if I was a victim of an acid attack and I'm pretty much tired of it. My armpits, groin and buttockshave deep holes from healedboils. Type hidredinitis on Google and you will be pleasantly surprised.
I needa doctor to strip my current skin away and make me a new skin suit, lol.Unfortunately the way things are going, nobody wants to find cures, they rather treat. Scarring is nature's way for mammals to heal. If we can't find a cure to stop pimples from forming, how can we find a way to reprogram scar tissue into normal looking skin?
The truth is they probably know how to stop scar formation but it will take a long time before they release it for public use. So here I am playing the waiting game hoping to rid myself offmy white marks and pot holes to look normal one day.
FS2 looks promising. It improves existing scars and apparently stops scars in new wounds. Olx101 is even more promising because it reprograms scar tissue DNA. Hopefully these two will not fail clinical trialsand in 5 years time, they will be truly available for me to take advantage of for a small price. SkinTE looks awful and dangerous. Sunogel is all talk, no show. Other startups are promising things but again little to show for it. I don't know what the researchers at UCI are doing after they released a paper promising scarless healing two years ago.And off course, we have microcoring which also seems like a waste of money. Most people will not throw money away to remove scars after 1000 treatments.
Anyways, we should enjoy life to the fullest right now before we become to old and our scars probably become level with the rest of our skin or look even worse. In any case, scars will be the least of our concerns by then.
I too would wait for fs2 for 5 years rather than skinte in 1 year. less invasive as you say and bit more precise in what they do. I googledhidredinitis, looks painful and scars full thickness by the looks of it?I see what you mean by looking like burns too.I suppose the scarsare caused by the inflammation and infection from the puss? my scar is not coverable with clothesunfortunately, I'm in bit of a desperate situation to be honest but im trying real hard to stay logical and not emotional about it. that's why im on a acne forum, no where else seems to care about their scars as much as the acne forum LOL plus this is one of the top google searches for scarless healing!
oh and when im old my scar will droop and be able to be covered by clothes again LOL what a piss take.
anything that does work however will still require work of the patient. even fs2 will take months to appreciate in the healing process. I think MyBeautifulScars that if scars are over 2 years old you will get minimum change with fs2 unless you start from fresh wound. So still might require pain and patience on your part. Mine too in my case.
http://upenn.technologypublisher.com/technology/27026
check this out guys.
3 hours ago, hopfullady said:http://upenn.technologypublisher.com/technology/27026
check this out guys.
costareils (can be spelling mistake).he showed in 2017 that hairfollicles promote scarless healing now this here is written "class of compounds" promote scarless healing.and also approved by FDA for systemic use.
what this all means ??
13 hours ago, hopfullady said:http://upenn.technologypublisher.com/technology/27026
check this out guys.
Sound very promising
I read the articles about scarless wound healing and some information is confusing.
While Sunogel claimsto be able to achieve perfect skinregeneration on deep wounds or on pre-existing scars by excisingthe scarred skin, Cotsarelis and his team claim to be able to achieve scarless skin regenerationonly on fresh wounds, but not on pre-existing scars.
However, I am asking myself why Cotsarelis'method could not be used for pre-existing scars? Why wouldn'tit be possible to excise the scarred skin and let it scarlessly regenerate by inducing hair follicles?
https://www.zmescience.com/medicine/healing-without-scarring-04432/
2 hours ago, tweet_007 said:I read the articles about scarless wound healing and some information is confusing.
While Sunogel claimsto be able to achieve perfect skinregeneration on deep wounds or on pre-existing scars by excisingthe scarred skin, Cotsarelis and his team claim to be able to achieve scarless skin regenerationonly on fresh wounds, but not on pre-existing scars.
However, I am asking myself why Cotsarelis'method could not be used for pre-existing scars? Why wouldn'tit be possible to excise the scarred skin and let it scarlessly regenerate by inducing hair follicles?
https://www.zmescience.com/medicine/healing-without-scarring-04432/
lol
20 hours ago, tweet_007 said:I read the articles about scarless wound healing and some information is confusing.
While Sunogel claimsto be able to achieve perfect skinregeneration on deep wounds or on pre-existing scars by excisingthe scarred skin, Cotsarelis and his team claim to be able to achieve scarless skin regenerationonly on fresh wounds, but not on pre-existing scars.
However, I am asking myself why Cotsarelis'method could not be used for pre-existing scars? Why wouldn'tit be possible to excise the scarred skin and let it scarlessly regenerate by inducing hair follicles?
https://www.zmescience.com/medicine/healing-without-scarring-04432/
no it means you couldn't stick a hair in a scar and it would turn normal. its just saying needs to be a wound bed. accident or created its still the same.
I was reading up onCotsarelis work on skin regeneration. The lead author of his paperand a prof atUCI Dr. Plikus stated that skin regeneration could essentially be done by injecting pure BMP in the scar tissue through a small insulin like needle. If it works maybe we will see that once they figure out how they can makemoney from it.
I also believe cotsarelis work seems like itsmore geared towards hair regeneration for alopecia. Treating male and female balding. Which of course isimportant.
A quote from the above paper. Plikus, an assistant professor of developmental & cell biology at UCI, said, In culture conditions, exposure of human fibroblasts derived from keloids, a type of skin scar, to either pure BMP or to human hair follicles is sufficient to drive their reprogramming toward new adipocytes. This shows that our findings from mice are translatable to humans.
1 hour ago, hopfullady said:I was reading up onCotsarelis work on skin regeneration. The lead author of his paperand a prof atUCI Dr. Plikus stated that skin regeneration could essentially be done by injecting pure BMP in the scar tissue through a small insulin like needle. If it works maybe we will see that once they figure out how they can makemoney from it.
I also believe cotsarelis work seems like itsmore geared towards hair regeneration for alopecia. Treating male and female balding. Which of course isimportant.
A quote from the above paper. Plikus, an assistant professor of developmental & cell biology at UCI, said, In culture conditions, exposure of human fibroblasts derived from keloids, a type of skin scar, to either pure BMP or to human hair follicles is sufficient to drive their reprogramming toward new adipocytes. This shows that our findings from mice are translatable to humans.
We are aware ofthe work going on at UCI. The discovery was made in 2017 and they published a paper on how they were able to transform fibroblasts, which heal mammalian wounds, into adipose tissue or fatty tissue. The paper was published in early 2018.
Fibroblasts will proliferate initially into the wound site and start laying collagen. This collagen will eventually fill in the wound. However, it is of inferior quality and aligned only in one direction as compared to the basket weave pattern seen in uninjured skin. This tissue is called granulation tissue. In minor wounds, fibroblasts vanishand turn into adipose tissue, thus no scar remains after several months or years.
Researchers at UCI found a way to transform granulationissue to trigger BMP signals. This will induce hair regeneration thus restoreand regenerateskin. The fibroblasts then vanish and granulation tissue transforms into fat tissue. How they do this, they will not tell off course. They are awaiting to patent their discovery most likely and conduct further testing. Patents are generally good for 100 years, so they can't keep the secret forever.
They got a 5 million US dollar grant to continue their research in September 2018 and in early 2019, they found that many types of fibroblasts participate in wound healing.
Cotsarelis has been promising a cure for male pattern for several years but nothing has come of it. Current drugs used to treat male pattern baldness come with a wide sort of side effects with the most important being feminization. Many guys will develop gynecomastia, breast tissue, and suffer from low testosterone. Impotenceis a major issue for many individuals.
Thesedrugs are marketed under different names.These properly named "testosterone blockers" are used for treating transgender individuals.So most guys will not even risk it and shave their headsunless of course the person suffers from gender dysphoria.
Almost all guys will suffer from hair loss at some point in their lives. The lucky ones will start gracefully balding at an advanced age which by then off course no longer matters. You can blame DHT, a byproduct of testosterone which seems to kill hair follicles on the head. Further research suggests that other factors also play a role. For young guys losing their hair is a blow but Ithink most women don't really care. Society has accepted it and most men do as well eventually, it's part of growing old. Hair transplants are quite popular and many men will opt for this.
This to say that if anything comes from this research, it will be in many years from now just because Cotsarelis has still to deliver on his promises.
Hey, Iknow the date the research was published. I wasnt introducing the paper to anyone as Ive read this thread and this work is significantly discussed here. I was just stating that according to Plikus it seems like this method can be achieved through the injection of pure BMP into scar tissue. To show that if this is proven and they figure out how to translate it properly it could be simply applied. And Ido agree while reading a lot of cotsarelis research that hehas yet to deliver. Which is unfortunate for us.
In essence, pure BMPs can act as a substitute for hair follicles," says Maksim Plikus.
This could theoretically simply occur via an injection which passes the signal molecules directly into the scar, for example by using a small insulin syringe as currently also used for Botox applications, says Plikus.
And reading the new paper published earlier this year, I realize that thisis a continued work in progress. A very long work in progress.But it also states that possibly delivery of blood derived progenitors to woundscould be simply administered. Which is something thats fascinating if it ever comes to fruition. Gotta keep the hope alive!
On 5/27/2019 at 1:45 AM, hopfullady said:And reading the new paper published earlier this year, I realize that thisis a continued work in progress. A very long work in progress.But it also states that possibly delivery of blood derived progenitors to woundscould be simply administered. Which is something thats fascinating if it ever comes to fruition. Gotta keep the hope alive!
Have you looked into stem cells in fat grafting scars? Sounds similar and actually inthe market now
Tick tok on the clock......this thread is almost 12 years old and i still have not seen anything that vastly improves acne scarring. Lot of Docs like to take people's money like they did mine.I know that there are some very intelligent people here but still i have seen nothing that works really good.I am just doing the cheep treatment...dermarolling. It doesn't cost much and i don't have to waste the thousands of dollars for no improvement in my scars.
2 minutes ago, nikkigirl said:Tick tok on the clock......this thread is almost 12 years old and i still have not seen anything that vastly improves acne scarring. Lot of Docs like to take people's money like they did mine.I know that there are some very intelligent people here but still i have seen nothing that works really good.I am just doing the cheep treatment...dermarolling. It doesn't cost much and i don't have to waste the thousands of dollars for no improvement in my scars.
is dermarolling working for u ???
12 hours ago, nikkigirl said:Tick tok on the clock......this thread is almost 12 years old and i still have not seen anything that vastly improves acne scarring. Lot of Docs like to take people's money like they did mine.I know that there are some very intelligent people here but still i have seen nothing that works really good.I am just doing the cheep treatment...dermarolling. It doesn't cost much and i don't have to waste the thousands of dollars for no improvement in my scars.
I agree 100%. I also do dermarolling myself.
https://yaledailynews.com/blog/2018/12/04/researchers-discover-new-skin-regeneration-mechanism/
Apparently, this is how researchers at UCI were able to change scar tissue into normal looking skin.
23 hours ago, MyBeautifulScars said:https://yaledailynews.com/blog/2018/12/04/researchers-discover-new-skin-regeneration-mechanism/
Apparentemente, questo e il modo in cui i ricercatori dell'UCI sono stati in grado di cambiare tessuto cicatriziale in una pelle dall'aspetto normale.
Molto interessante ma per poter portare a termine questa ricerca ci vorra davvero molto tempo vista l'estrema complessita
On 6/1/2019 at 8:55 PM, MyBeautifulScars said:https://yaledailynews.com/blog/2018/12/04/researchers-discover-new-skin-regeneration-mechanism/
Apparently, this is how researchers at UCI were able to change scar tissue into normal looking skin.
That is amazing if successful on humans. Isnt itthat the hair follicle triggersadipose cells to appear and then regeneration occurs from there in another paper?