Acne.org Products
26 minutes ago, nikki_gargin said:Is the USA hasnt president Trump made some changes to speed up the whole research to market of drugs? Or is that just a rumour?
He has made some changes most notably allowing for patients on life support flexibility to try experimental drugs. Hopefully he will make some more changes as time comes.
On 8/8/2018 at 8:33 PM, FromScarredtoFree said:He has made some changes most notably allowing for patients on life support flexibility to try experimental drugs. Hopefully he will make some more changes as time comes.
Why? People act like the FDA just decided to be pains in the butts. There are very good reasons the FDA approval process exists.
3 hours ago, Sniffy said:Does anyone know what Dr Sun is doing on a day to day basis? Like how is he making money, does he have a side job at 7/11 or something?
He was at Johns Hopkins. Now he's probably just trying to get sunogel some funding.
5 hours ago, Sniffy said:Does anyone know what Dr Sun is doing on a day to day basis? Like how is he making money, does he have a side job at 7/11 or something?
I don't see why anyone should or would know that information. He moved on to Columbia after JHU and then started Sunogel. I imagine he makes money in a variety of ways stemming from his research expertise (i.e. serving on advisory panels, being an independent verifier of data etc.) But yes, his primary focus is getting funding for Sunogel.
I mostly agree with @FastMediaabout the FDA. Gene manipulation is definitely something that should not be taken lightly. However, the FDA also has a lot of corruption and bureaucracy that makes it work inefficiently and at times suspiciously in regards to which products come to market when. I do think they should ease up on regulations in terms of allowing patients (who are thoroughly and properly informed of the risks of course) to test products prior to approval. Not just obvious life threatening situations, but things like we seek here as well. Of course, some of that regulation is to protect the consumer, but a big part of it is there to protect the researchers/businesses investigating the product. If someone died using a gene manipulation treatment, that would effectively destroy the company and likely the researchers careers.
6 hours ago, FastMedia said:Why? People act like the FDA just decided to be pains in the butts. There are very good reasons the FDA approval process exists. He was at Johns Hopkins. Now he's probably just trying to get sunogel some funding.
I agree that the FDA is important but if someone is on their deathbed they should have a right to decide whether they want an experimental treatment without the FDA's approval. I'm not saying that we should throw out the FDA approval process but if we can speed up the time it takes it could potentially save lives.
Yeah I talked to a scientist at MIT who works in Tissue Bioengineering.
He said the type of things that would lead to total scar remodeling won't be a reality for another 50 years.
That's what he said and I challenged him talking about all the exciting research and he said this is all research for it to first even be found there would need to be several quantum jumps in terms of finding sources with which to actually generate enough cells from stem cells and they're not even close to doing that yet. And then for it to be developed into a therapeutic device or application would take us way past 2040. He said there are tons of unethical start-ups who are promising all sorts of things but they're just pie in the sky hopes that they'll get enough funding to last through the next decade till they can try and post some new discovery. He even said the ugly truth about hair cloning and regeneration is that its at least 20-30 years away.
I just thought it you guys should hear this from a scientist directly involved in the university level research on skin remodeling. THis at least helps me take a deep breath and stop following this thread which I have been very active in previously. I'm sorry I cannot post something more optimistic but I'm posting what I've heard. Its a tough pill to swallow, but at least it helps me accept my scars and stop wasting the rest of life hoping for something that won't come in time for me to still enjoy my youth, which is already half gone anyway. I've been with this thread since 2007 and now 11 years later with no single improvement whatsoever, its time to realize why and stop hoping. Sometimes its just better to know when to quit. Sorry guys.
1 hour ago, Rez77 said:Yeah I talked to a scientist at MIT who works in Tissue Bioengineering.
He said the type of things that would lead to total scar remodeling won't be a reality for another 50 years.
That's what he said and I challenged him talking about all the exciting research and he said this is all research for it to first even be found there would need to be several quantum jumps in terms of finding sources with which to actually generate enough cells from stem cells and they're not even close to doing that yet. And then for it to be developed into a therapeutic device or application would take us way past 2040. He said there are tons of unethical start-ups who are promising all sorts of things but they're just pie in the sky hopes that they'll get enough funding to last through the next decade till they can try and post some new discovery. He even said the ugly truth about hair cloning and regeneration is that its at least 20-30 years away.
I just thought it you guys should hear this from a scientist directly involved in the university level research on skin remodeling. THis at least helps me take a deep breath and stop following this thread which I have been very active in previously. I'm sorry I cannot post something more optimistic but I'm posting what I've heard. Its a tough pill to swallow, but at least it helps me accept my scars and stop wasting the rest of life hoping for something that won't come in time for me to still enjoy my youth, which is already half gone anyway. I've been with this thread since 2007 and now 11 years later with no single improvement whatsoever, its time to realize why and stop hoping. Sometimes its just better to know when to quit. Sorry guys.
you seem to always be the bearer of bad news huh , let me ask you a question.
Who is this tissue bioengineer you allegedly spoke with Rez ? ( His name , position within the team/ company etc )
Also if this would be the case only until 50 years then how is it a
That Skin TE which is considered a overall failure by this community able to regenerate hairs and sweat glans within the newly formed tissue ? ( And this product is considered a fail due to the cosmetic appearance )
On a scientific level scientist have discovered that they can turn stem cells into fat cells which in turn will regenerate skin without scarring , explain to me how you equate some random bioengineer scientist ( who you talked to , the biggest troll and pessimist in this community ) to a legit discovery , explain please.
we will have scarless healing way earlier then what your pal proposed.
4 hours ago, Rez77 said:Yeah I talked to a scientist at MIT who works in Tissue Bioengineering.
He said the type of things that would lead to total scar remodeling won't be a reality for another 50 years.
That's what he said and I challenged him talking about all the exciting research and he said this is all research for it to first even be found there would need to be several quantum jumps in terms of finding sources with which to actually generate enough cells from stem cells and they're not even close to doing that yet. And then for it to be developed into a therapeutic device or application would take us way past 2040. He said there are tons of unethical start-ups who are promising all sorts of things but they're just pie in the sky hopes that they'll get enough funding to last through the next decade till they can try and post some new discovery. He even said the ugly truth about hair cloning and regeneration is that its at least 20-30 years away.
I just thought it you guys should hear this from a scientist directly involved in the university level research on skin remodeling. THis at least helps me take a deep breath and stop following this thread which I have been very active in previously. I'm sorry I cannot post something more optimistic but I'm posting what I've heard. Its a tough pill to swallow, but at least it helps me accept my scars and stop wasting the rest of life hoping for something that won't come in time for me to still enjoy my youth, which is already half gone anyway. I've been with this thread since 2007 and now 11 years later with no single improvement whatsoever, its time to realize why and stop hoping. Sometimes its just better to know when to quit. Sorry guys.
First of all, I want to congratulate you for accepting your scars. A lot of people on here should do the same and live their life.
You have contributed in the past and sometimes it seemed that your scars caused you a great deal of distress. Accepting them, will help you tremendously.
I agree with you that scarless wound healing can take decades but its not because scientists don't have the capacity right now to do so. As you mentioned, it's because of the time it takes to develop a method, drug or device that can take so long. Clinical trials to product development takes on average 10 years provided the clinical trials don't fail. A lot of time, the clinical trials stop because they don't have the funds to continue.
Scientists are already using gene therapy, as experimental treatments. They are already growing human organs in labs for transplantation. They are using stem cells to cure certain types of diseases in young children. We have come a long way.
Scars are for the most part aesthetic. Its only normal to attempt to find functional cures to disease using tissue engineering first.
I truly believe within the next decade, a topical cream or drug will exist that will improve the overall appearance of scars. Right now, we have none.
Tissue engineering is only one facet of scarless healing. There is still nanotechnology, bioprinting, the drug market etc. Even if we find a way to prevent scars which there are tons of companies looking into we can excise our scars and have scar free skin. I high doubt Rez77 spoke to a random scientist at MIT because they would know that medicine develops unpredictably. I saw in my friends nursing textbook that it said a Hepatitis C cure would be near impossible and it was written two years ago. Now we have a Hepatitis C cure. A trend I've noticed on this board is that the older scar sufferers are extremely negative and volatile because they don't want to believe that while they wasted their whole life worrying about scars (Which is an extremely stupid thing to worry about BTW) a younger person can have their scars removed and still live the rest of their life happy.
Also, skin will be the first thing people in regenerative medicine will try to regenerate completely if we want to eventually regenerate organs and limbs. This is because the skin, liver, and uterus are the only organs that can regenerate themselves to a degree. If Rez77 really spoke to a scientist at MIT without a doubt he would have told him this.
Also scars are not only an aesthetic problem. Scarring of organs is a huge problem in medicine. Feasiblyif we can prevent or remove scars around organs we can use that same technology on the skin. There is a huge amount of research funding in Pulmonary Fibrosis, Cystic Fribrosis, etc.
23 hours ago, Rez77 said:Yeah I talked to a scientist at MIT who works in Tissue Bioengineering.
He said the type of things that would lead to total scar remodeling won't be a reality for another 50 years.
That's what he said and I challenged him talking about all the exciting research and he said this is all research for it to first even be found there would need to be several quantum jumps in terms of finding sources with which to actually generate enough cells from stem cells and they're not even close to doing that yet. And then for it to be developed into a therapeutic device or application would take us way past 2040. He said there are tons of unethical start-ups who are promising all sorts of things but they're just pie in the sky hopes that they'll get enough funding to last through the next decade till they can try and post some new discovery. He even said the ugly truth about hair cloning and regeneration is that its at least 20-30 years away.
I just thought it you guys should hear this from a scientist directly involved in the university level research on skin remodeling. THis at least helps me take a deep breath and stop following this thread which I have been very active in previously. I'm sorry I cannot post something more optimistic but I'm posting what I've heard. Its a tough pill to swallow, but at least it helps me accept my scars and stop wasting the rest of life hoping for something that won't come in time for me to still enjoy my youth, which is already half gone anyway. I've been with this thread since 2007 and now 11 years later with no single improvement whatsoever, its time to realize why and stop hoping. Sometimes its just better to know when to quit. Sorry guys.
I semi agree with you. Mostly in the fact that it's going to be a while before we have true scarless healing. I think it's more likely that we see vastly improved skin grafts, scarring improvement first. SkinTe, Recell etc... are all making significant waves in these areas. And I hope they succeed on that front. It's sure better than having horrific scars. I mean seeing what recell did with mesh grafting is nothing short of amazing. Baby steps, but it'll come some day.
22 hours ago, FromScarredtoFree said:Also, skin will be the first thing people in regenerative medicine will try to regenerate completely if we want to eventually regenerate organs and limbs. This is because the skin, liver, and uterus are the only organs that can regenerate themselves to a degree. If Rez77 really spoke to a scientist at MIT without a doubt he would have told him this.
I've heard bone can also regenerate.
On 8/12/2018 at 3:16 PM, FromScarredtoFree said:Tissue engineering is only one facet of scarless healing. There is still nanotechnology, bioprinting, the drug market etc. Even if we find a way to prevent scars which there are tons of companies looking into we can excise our scars and have scar free skin. I high doubt Rez77 spoke to a random scientist at MIT because they would know that medicine develops unpredictably. I saw in my friends nursing textbook that it said a Hepatitis C cure would be near impossible and it was written two years ago. Now we have a Hepatitis C cure. A trend I've noticed on this board is that the older scar sufferers are extremely negative and volatile because they don't want to believe that while they wasted their whole life worrying about scars (Which is an extremely stupid thing to worry about BTW) a younger person can have their scars removed and still live the rest of their life happy.
Also, skin will be the first thing people in regenerative medicine will try to regenerate completely if we want to eventually regenerate organs and limbs. This is because the skin, liver, and uterus are the only organs that can regenerate themselves to a degree. If Rez77 really spoke to a scientist at MIT without a doubt he would have told him this.
Also scars are not only an aesthetic problem. Scarring of organs is a huge problem in medicine. Feasiblyif we can prevent or remove scars around organs we can use that same technology on the skin. There is a huge amount of research funding in Pulmonary Fibrosis, Cystic Fribrosis, etc.
Good points. I think the amount of startups and universities tackling the scarring issue is a really good sign.
14 hours ago, Lapis lazuli said:I've heard bone can also regenerate.
I was talking about soft tissue organs but you are right bone also regenerates.
Also another point I wanted to make is what if new technology comes in a few years that isn't "scarless" healing per se. Everyone on this forum agrees that acne scars are a cosmetic problem, so what if a new treatment comes along that can camouflage or or flatten scar tissue to the point that it isn't visible. Personally I had filler done and it worked very well to me to the point where I can't see my scars when I shine a flashlight on my face, but I realize filler might not work for everyone because of tethering, atrophy, fat loss, and other variations. But what if the next big filler can flatten scar tissue or change skin pigmentation. Fillers are one of the biggest beauty trends now and a ton of money is going into research. Also there are so many companies fighting for the top spot and currently researching the next generation of fillers like Juvederm, Restalyn, Beletero Ect. While scarless healing is a great thing to strive for, most people on this forum don't need it because we don't have issues with scars like contractures or lack of sweat glands. Most of the problems are from the cosmetic results of our scars and as such we only need a cosmetic level solution.
10 hours ago, FromScarredtoFree said:I was talking about soft tissue organs but you are right bone also regenerates.Also another point I wanted to make is what if new technology comes in a few years that isn't "scarless" healing per se. Everyone on this forum agrees that acne scars are a cosmetic problem, so what if a new treatment comes along that can camouflage or or flatten scar tissue to the point that it isn't visible. Personally I had filler done and it worked very well to me to the point where I can't see my scars when I shine a flashlight on my face, but I realize filler might not work for everyone because of tethering, atrophy, fat loss, and other variations. But what if the next big filler can flatten scar tissue or change skin pigmentation. Fillers are one of the biggest beauty trends now and a ton of money is going into research. Also there are so many companies fighting for the top spot and currently researching the next generation of fillers like Juvederm, Restalyn, Beletero Ect. While scarless healing is a great thing to strive for, most people on this forum don't need it because we don't have issues with scars like contractures or lack of sweat glands. Most of the problems are from the cosmetic results of our scars and as such we only need a cosmetic level solution.
Most of us here have cosmetic scars resulting from moderate to severe acne. Finding a way to remove these scars is what most of us hope for. We don't necessarily need scarless healing.
When it comes to fillers, they work well for depressed type scars like rolling or boxcar. There is fat loss in rolling scars. Also, there's too little collagen in these atrophic type scars like boxcar or ice picks. Fillers help with these voids and even out the skin. Fillers are however temporary not permanent. They don't work well on ice pick scars. Most of us have ice pick scars. There's a new method right now that has to be approved by the FDA where they inject your own body's collagen to inject into these depressions. They are trying to develop a permanent filler. This might help greatly.
Also, many people with facial acne develop severe body acne on the chest, neck, shoulders, back and upper arms. Acne on these areas tends to be aggressive and widespread. After the pimples heal, the skin is covered by scar tissue mostly hypertrophic or atrophic. Fillers can help for atrophic scars but it doesn't make sense to get fillers on depressed acne scars on your back.
Fillers do nothing on hypertrophic or keloid scars. Keloids tend to cause severe disfigurement, excess hypertrophic scar tissue. Steroid injections flatten hypertrophic scars. Keloids tend to return after being manipulated even worse than before.
For some individuals, acne can leave them disfigured especially if they develop keloids. We can't truly say acne scars are purely cosmetic.
On 8/12/2018 at 4:49 AM, Rez77 said:Yeah I talked to a scientist at MIT who works in Tissue Bioengineering.
He said the type of things that would lead to total scar remodeling won't be a reality for another 50 years.
That's what he said and I challenged him talking about all the exciting research and he said this is all research for it to first even be found there would need to be several quantum jumps in terms of finding sources with which to actually generate enough cells from stem cells and they're not even close to doing that yet. And then for it to be developed into a therapeutic device or application would take us way past 2040. He said there are tons of unethical start-ups who are promising all sorts of things but they're just pie in the sky hopes that they'll get enough funding to last through the next decade till they can try and post some new discovery. He even said the ugly truth about hair cloning and regeneration is that its at least 20-30 years away.
I just thought it you guys should hear this from a scientist directly involved in the university level research on skin remodeling. THis at least helps me take a deep breath and stop following this thread which I have been very active in previously. I'm sorry I cannot post something more optimistic but I'm posting what I've heard. Its a tough pill to swallow, but at least it helps me accept my scars and stop wasting the rest of life hoping for something that won't come in time for me to still enjoy my youth, which is already half gone anyway. I've been with this thread since 2007 and now 11 years later with no single improvement whatsoever, its time to realize why and stop hoping. Sometimes its just better to know when to quit. Sorry guys.
Do you think somebody could create a thin fake skin to cover your face that could let the pores breathe or just use a day.....take off and wash.
Hi! This is my first post here. I've been suffering from acne scars for a year now. I was thinking about acne scars and why the lost fat doesn't regenerate as it would be optimal and came across this: https://www.skininc.com/skinscience/physiology/Study-Finds-Fat-Cells-Can-Eliminate-Skin-Scarring-410392825.html
Hope that they find the solution soon so we can maybe heal our scars and skin back to what it used to be. I would like to hear your opinions aboutthis topic!
17 hours ago, Simp said:Hi! This is my first post here. I've been suffering from acne scars for a year now. I was thinking about acne scars and why the lost fat doesn't regenerate as it would be optimal and came across this: https://www.skininc.com/skinscience/physiology/Study-Finds-Fat-Cells-Can-Eliminate-Skin-Scarring-410392825.html
Hope that they find the solution soon so we can maybe heal our scars and skin back to what it used to be. I would like to hear your opinions aboutthis topic!
Welcome to the board and thank you for posting something relevant to scarless healing.
While this research has been discussed prior, I don't know if many new members know about it so it's a good refresher. Dr. Sun of Sunogel and Cotsarelis have had discussions about their research. Notably, Cotsarelis (according to Dr. Sun) was shocked by how Sunogel's hydrogel got hair follicle regeneration with the native color of the hair while Cotsarelis' mice had hair return, but it was white.
I haven't heard much from Pilkus and Cotsarelis' team since this was reported last year but let's hope they've kept going.
3 hours ago, golfpanther said:Welcome to the board and thank you for posting something relevant to scarless healing.While this research has been discussed prior, I don't know if many new members know about it so it's a good refresher. Dr. Sun of Sunogel and Cotsarelis have had discussions about their research. Notably, Cotsarelis (according to Dr. Sun) was shocked by how Sunogel's hydrogel got hair follicle regeneration with the native color of the hair while Cotsarelis' mice had hair return, but it was white.
I haven't heard much from Pilkus and Cotsarelis' team since this was reported last year but let's hope they've kept going.
Dr. Sun needs a team around him. I think that and money are what are holding him back. The biggest silver lining is that he tested it on a scar. The only thing I wish he could do is test it on an older scar.
https://www.utoronto.ca/news/u-t-researchers-develop-portable-3d-skin-printer-repair-deep-wounds
3D skin printing will soon be a reality replacing current skin grafts. It is still not scarless healing but a step closer.
On 14/08/2018 at 11:06 PM, nikkigirl said:On 12/08/2018 at 9:49 AM, Rez77 said:Yeah I talked to a scientist at MIT who works in Tissue Bioengineering.
He said the type of things that would lead to total scar remodeling won't be a reality for another 50 years.
That's what he said and I challenged him talking about all the exciting research and he said this is all research for it to first even be found there would need to be several quantum jumps in terms of finding sources with which to actually generate enough cells from stem cells and they're not even close to doing that yet. And then for it to be developed into a therapeutic device or application would take us way past 2040. He said there are tons of unethical start-ups who are promising all sorts of things but they're just pie in the sky hopes that they'll get enough funding to last through the next decade till they can try and post some new discovery. He even said the ugly truth about hair cloning and regeneration is that its at least 20-30 years away.
I just thought it you guys should hear this from a scientist directly involved in the university level research on skin remodeling. THis at least helps me take a deep breath and stop following this thread which I have been very active in previously. I'm sorry I cannot post something more optimistic but I'm posting what I've heard. Its a tough pill to swallow, but at least it helps me accept my scars and stop wasting the rest of life hoping for something that won't come in time for me to still enjoy my youth, which is already half gone anyway. I've been with this thread since 2007 and now 11 years later with no single improvement whatsoever, its time to realize why and stop hoping. Sometimes its just better to know when to quit. Sorry guys.
Do you think somebody could create a thin fake skin to cover your face that could let the pores breathe or just use a day.....take off and wash.
I was wondering this! Like a micro thin sheet makeup type thing. Would be cool
For what it's worth, another "scarless healing" discovery by chinese scientists:
https://punchng.com/substance-in-toad-skin-could-promote-scarless-healing-study/
I just wanted to offer a quick counter point to this alleged MIT scientist. I attend UC Berkeley and today while I was talking to my former biochemistry professor(who holds a Nobel prize btw) about research he started talking to me about how quick medicine is advancing these days because of things like the internet and technology. He told me that what we will have in twenty years will make what we are using now look like leeches in the Middle Ages. He showed me a paper about a pig heart being regenerated and implanted successfully in China. People don't seem to realize that science doesn't have a linear trajectory. It grows exponentially. For hundreds of years the Church prevented people from studying science. Only recently has the internet allowed professors and researchers around the world to communicate and overcome language barriers. A lot of us take things like google translate for granted, but imagine how hard it would be to read and understand a scientific paper in a completely different language. Science is hard enough to understand without the language barrier.
EarlierI gave an example about the Hepatitis C cure. Did you guys know that we were so sure that it was incurable that we spend millions of dollars a year trying to find a vaccine to prevent it? Yet here we are now with a cure.To the people who say "but look! we still haven't cured cancer!" that's not entirely true. Cancer survival rates have been increasing every year and many types of cancers are curable and survivable now that were not before.
Another thing I want to talk about is evolution. Smaller animals and amphibians as Al3forever pointed out do not scar and can completely regenerate appendages in some cases. Why can't humans do this? Well a small animal can hide for a week or two from predators while it is wounded and wait for its skin to heal. This obiviously does not work well for humans or larger mammals because if they are wounded they cannot hide. Thus, evolution has selected for humans to close wounds as quickly as possible. Scarring is a sort of mutation in the natural healing process. But with gene therapy, we can temporarily inhibit these genes and potentially regenerate our skin like smaller animals. This can be achieved through gene silencing therapy, which the FDA recently approved the first drug of a week ago. We know the FOXN1A gene is responsible for scarring. All we need to do is find a way to silence it. OLX101 has already started a clinical trial to silence the scarring gene.
Edit: If anyone wants my professors name I will gladly message it to you. I'd rather not post his name online without his permission but if you want to talk to him yourself I won't get in your way:)
Well, I only agree with one thing, that medicine today is very primitive. Humans are good when it comes to surgery, but it has lots of limitations what can be achieved with it. We have lots of medicine that was discovered by pure luck, that we don't really understand how and why it even works (like accutane). Just by luck, the medicine has some side effects that treat the symptoms of, for example, autoimmune diseases. Until humanity really understands entire DNA/gene system and can edit them at will like in software with a debugger, no major breakthrough will be achieved. All those buzzword articles about some company doing something with genes really don't lead to anything fruitful in the end. 20 years ago there were also articles how cancer and baldness will be cured and how some company is very close to it already.
Lots of medicine is discovered by mistake and that's a good thing. Costarelis made his breakthrough scar discovery while he was studying hair loss. Penicillin was discovered by mistake and it changed the world. To say that we don't know how accutane works doesn't really make sense. It permanently shrinks sebum glands therefore slowing acne bacteria production.
Are you aware that we already have gene therapy now that is FDA approved? Luxturna is a gene therapy for hereditary blindness that was FDA approved. CRISPR is slowly becoming ready for humans. We don't know everything about genes but we know a lot more than we used to and we learn more everyday.
Also I don't get why people say there is no cure for cancer or baldness. I discussed cancer in my previous post but there are many drugs that are effective in stopping balding and hair transplants are very effective. What do you mean by cure? Do you think there will be a magic pill that will make acne scars disappear? Probably not. Will it be cheap? Also probably not. But I think there will be some sort of solution within 10 years.