Acne.org Products
Another reason why these companies are emphasizing their focus on burns might be that they do not want to dilute the sense of urgency that comes with life-threatening conditions like severe burns by too frequently mentioning significantly less medically serious things like acne scars and other cosmetically undesirable things. It is implied that, if a technology is capable of regenerating full-thickness skin with all the appendages after excisions deep enough to cut out third degree burns, it will work for any other scarring that exists within the range of depth of third degree burns. It's mostly not a question of 'prioritizing' some conditions over others, but a question ofsolving the most difficult problem, and thereby solving underlying problems in the process.
For example, if you have the technology to get water from 0 degrees to 100 degrees, you wouldn't say, 'now I just need to figure out how to get water at temperatures 99 degrees, 98 degrees, 97 degrees and so forth' - you have already figured out how to set the temperature for the entire range between 0 degrees and 100 degrees by figuring out how to get water to 100 degrees. Sure, the technology would probably need to be optimized for some scars, but if SkinTE or Sunogel work for third degree burns they will work for acne scars.
17 hours ago, RickeyDog1989 said:Another reason why these companies are emphasizing their focus on burns might be that they do not want to dilute the sense of urgency that comes with life-threatening conditions like severe burns by too frequently mentioning significantly less medically serious things like acne scars and other cosmetically undesirable things. It is implied that, if a technology is capable of regenerating full-thickness skin with all the appendages after excisions deep enough to cut out third degree burns, it will work for any other scarring that exists within the range of depth of third degree burns. It's mostly not a question of 'prioritizing' some conditions over others, but a question ofsolving the most difficult problem, and thereby solving underlying problems in the process.
For example, if you have the technology to get water from 0 degrees to 100 degrees, you wouldn't say, 'now I just need to figure out how to get water at temperatures 99 degrees, 98 degrees, 97 degrees and so forth' - you have already figured out how to set the temperature for the entire range between 0 degrees and 100 degrees by figuring out how to get water to 100 degrees. Sure, the technology would probably need to be optimized for some scars, but if SkinTE or Sunogel work for third degree burns they will work for acne scars.
Exactly. Along with that, and working with it, is the concept of greatest unmet need. 3rd degree burns, and other indications that result in complete loss of the skin layers, represent the greatest need by far.
BTW, I reached out to Dr. Sun again about Sunogel following the news about PolarityTE testing on humans. To my surprise, he responded almost immediately and Im trying to set up a call for this week.
I have 8 questions Id like to ask him but feel free to offer up some suggestions.
1. What is the current status of Sunogel and the hydrogel? When do you anticipate it will be a commercialized product?
2. Has it been tested on humans (aside from the picture of Sun's own finger) and if so can you share any results? If not, when are you planning to tests on patients?
3. Will the hydrogel as presently designed achieve the same results across all parts of the body?
4. Is there a plan for a pilot study or clinical trial or are you going straight to market?
5. This next one requires a little more info. I did some research and it turns out a patent was issued for the work Sun was a part of at Gerecht's lab for the Dex-AE in May of this year.
Sun's product is DexIEMEI'm guessing an innovation of the original that achieved better results (Gemstone was founded on the Dex-AE but they didn't get perfect regeneration in pigs).
So, my question would be: How does the issued patent for Dex-AE affect your ability to protect your intellectual property and successfully bring DexIEME to market?
6. If trials are going to be done will it be listed on clinicaltrials.gov or will you attempt to get FDA approval and just do a pilot study?
7. Do you believe that your hydrogel can achieve perfect regeneration in humans across all types of wounds and scarring?
8. Since hair follicles are so heavily implicated in skin regeneration across a wide variety of studies, what happens if you apply the hydrogel to a part of the body where hair does not grow?
This article is from a few months ago, but still relevant and good news:
The fact they plunked down $21 million is a great sign that they're serious about ramping up production and believe in the product. It mitigates a lot of my fears that I was having about their ability to meet demand should the product work as well.
One question I would like to ask is whether the regenerated skin will be like the original skin in the specific region treated, or be generally the same anywhere. For example, if someone lost their eyebrows due to burns in the eyebrow regions, would the regenerated skin in those regions regrow hair in a similar shape as the skin prior to being burned? Or would the regenerated skin look similar to regenerated skin in some other regions with less hair, like arms?
24 minutes ago, RickeyDog1989 said:One question I would like to ask is whether the regenerated skin will be like the original skin in the specific region treated, or be generally the same anywhere. For example, if someone lost their eyebrows due to burns in the eyebrow regions, would the regenerated skin in those regions regrow hair in a similar shape as the skin prior to being burned? Or would the regenerated skin look similar to regenerated skin in some other regions with less hair, like arms?
It does not that way
New treatment of scars and wounds by regeneration of all skin layers coming soon
https://www.polarityte.com/products/skinte
QuoteSkinTE, regenerated full-thickness, organized skin and hair follicles in third degree burn wounds. The findings represent the first known successful regeneration of skin and hair in full-thickness swine wound models, the standard animal model for human skin. The Company expects to initiate a human clinical trial evaluating the autologous homologous SkinTE construct in the third quarter of 2017. In pre-clinical models of full-thickness burns and wounds, SkinTE demonstrated scar-less healing, hair follicle growth, immediate complete wound coverage, and the progressive regeneration of all skin layers including epidermis, dermis and hypodermal layers
PolarityTE announced that the company has continued to expand its R&D and biomedical manufacturing capabilities and moved its corporate headquarters to a 200,000 sq ft multi-facility PolarityTE Campus. Slated to open in early 2018, the new Polarity corporate campus will centralize core company departments related to basic biomedical R&D, pre-clinical research, as well as provide another site for the manufacturing of the now commercially available SkinTE product. With the expansive addition of the new PolarityTE campus, we hope to meet the impressive demand we have already received for SkinTE, while allowing us to grow our company, develop our core pipeline tissues and further evolve our technology platforms at an even more accelerated rate, said Dr. Denver Lough, Chief Executive Officer of PolarityTE.
12 hours ago, RickeyDog1989 said:One question I would like to ask is whether the regenerated skin will be like the original skin in the specific region treated, or be generally the same anywhere. For example, if someone lost their eyebrows due to burns in the eyebrow regions, would the regenerated skin in those regions regrow hair in a similar shape as the skin prior to being burned? Or would the regenerated skin look similar to regenerated skin in some other regions with less hair, like arms?
I'd like to know this too. How about beard etc.? Will the regeneration recognize the environment so to speak, or will it maintain characteristics from the biopsy? The latter basically means you have your crotch in your face.
For some reason I had a clear view of this issue, but now I got unsure again.
13 hours ago, RickeyDog1989 said:One question I would like to ask is whether the regenerated skin will be like the original skin in the specific region treated, or be generally the same anywhere. For example, if someone lost their eyebrows due to burns in the eyebrow regions, would the regenerated skin in those regions regrow hair in a similar shape as the skin prior to being burned? Or would the regenerated skin look similar to regenerated skin in some other regions with less hair, like arms?
Yeah, I've thought about this as well and will ask. Here's an article that talks a bit about how cells recognize neighboring cells in order to determine their location and regenerate (in normal every day life, not after a wound):
https://blog.cirm.ca.gov/tag/skin-stem-cells/
I'm guessing the research done so far indicates that the cells just know where they are in respect to neighboring skin/cells and heal appropriately. A mystery of the body that serves our needs well in this case. I will definitely ask about this though.
1 hour ago, Ps93 said:PolarityTE announced that the company has continued to expand its R&D and biomedical manufacturing capabilities and moved its corporate headquarters to a 200,000 sq ft multi-facility œPolarityTE Campus. Slated to open in early 2018, the new Polarity corporate campus will centralize core company departments related to basic biomedical R&D, pre-clinical research, as well as provide another site for the manufacturing of the now commercially available SkinTE„ product. œWith the expansive addition of the new PolarityTE campus, we hope to meet the impressive demand we have already received for SkinTE, while allowing us to grow our company, develop our core pipeline tissues and further evolve our technology platforms at an even more accelerated rate, said Dr. Denver Lough, Chief Executive Officer of PolarityTE.
This was just annouced 15 min ago.It can only be a good sign I guess
You beat me to it! 
Yes, this is a fantastic sign in my opinion. If they were all smoke and mirrors like say, Renovo, I don't think PolarityTE would be buying a 200k sqft facility. I like the fact that SkinTE is already being used and this is happening as well. That to me indicates early results are at least promising and emboldening them to move forward with scaling up their operation. It could be this was all planned beforehand, but again, that's a sizable investment and one that would be unnecessary if they were just trying to make a quick buck.
I should have mentioned this in my earlier post, but there is another question that I would like you to ask, if it's not too much. Is there a limit to the size (width and depth) of wounding that can be regenerated without scarring? If so, what is the limit?
49 minutes ago, RickeyDog1989 said:I should have mentioned this in my earlier post, but there is another question that I would like you to ask, if it's not too much. Is there a limit to the size (width and depth) of wounding that can be regenerated without scarring? If so, what is the limit?
Good question. I think PolarityTE has no size limit, but I am curious about Sunogel.
1 hour ago, RickeyDog1989 said:I should have mentioned this in my earlier post, but there is another question that I would like you to ask, if it's not too much. Is there a limit to the size (width and depth) of wounding that can be regenerated without scarring? If so, what is the limit?
I can definitely ask this. My guess about depth is that it can (in theory) regenerate everything down to the hypodermis. If a part of the body has damage beneath that (i.e. muscle) it probably wouldn't provide optimal results.
In terms of width/length, not sure. I'll ask if I can get Sun on the phone.
56 minutes ago, Neo_232323232323 said:How is Skinte utilized? Is it in sheet form, injection, spray or what?
It's a paste that is processed from a skin biopsy of healthy tissue from the patient. It is then applied onto a wound bed, which is covered with a dressing that creates a water barrier.
It would be great if Skin TE or Sunogel worked but seeing is believing. I think surgical scarring and burn victims are where the most money will be generated. Since Accutane came out.....years ago.....i have not seen a lot of faces with acne scars anymore. Accutane doesn't work for everybody though....me included so it would be nice if something finally worked.....it looks great on paper...but do they work?
39 minutes ago, nikkigirl said:It would be great if Skin TE or Sunogel worked but seeing is believing. I think surgical scarring and burn victims are where the most money will be generated. Since Accutane came out.....years ago.....i have not seen a lot of faces with acne scars anymore. Accutane doesn't work for everybody though....me included so it would be nice if something finally worked.....it looks great on paper...but do they work?
Yes, seeing is believing as with anything in life.
I disagree that the most money would be made on surgical scarring and burns. The cosmetic market would dwarf both if the products work. Surgeries and 3rd degree burns aren't that common, but everyone walking on this planet has scar they'd like to remove.
I get being cautious about these products working and we should definitely await results before getting too excited. But all signs point to at least PolarityTE being ready to ramp up production and bring SkinTE to a large market. That means something and with testing already underway and the purchase of their facility, things are looking good. Again, I seriously doubt PolarityTE would have purchased that facility if the early results from the first patients were anything less that very promising. If they weren't, there'd be no reason to assume more risk (i.e. an extremely expensive operations facility).
Do you guys think SkinTE will be able to get rid of hyperpigmentaton?
In theory they have to excise all layers of the skin and regenerate it fully so the hyperpigmentation should go away
Actually potentially it could get rid of hypopigemntation (white spots) too because the news skin should have melanocytes in it
18 hours ago, nikkigirl said:It would be great if Skin TE or Sunogel worked but seeing is believing. I think surgical scarring and burn victims are where the most money will be generated. Since Accutane came out.....years ago.....i have not seen a lot of faces with acne scars anymore. Accutane doesn't work for everybody though....me included so it would be nice if something finally worked.....it looks great on paper...but do they work?
I didn't take Accutane therefore, I have a billion small slightly white raised scars on my upper arms, shoulder blades, sides of my back and I'm in my late twenties. I suffered from severe forms of body acne like acne conglobata which developped to acne fulminans. That causes joint pain. It took years for it for clear naturally. Antibiotics did help a little but I didn't take Accutane because my parents were horrified by the side effects. Later on since scars developped, I made a few lifestyle changes and my acne cleared. No need for Accutane because scars had already formed. I still do get breakouts so I believe Accutane would not work for me either.
Also, my face has a few craters from cystic acne but they are slightly noticeable. Not many people as teenagers or in their early adult years take Accutane, so you still have many people out there plagued with facial craters from acne, measles or even chicken pox.
Also, people develop prominent scarring more than others. I for once don't get severe scarring but I do develop scars nonetheless.
It would be nice if they could eradicate acne altogether to eliminate scarring in the first place.
8 hours ago, Anonymouz1 said:I didn't take Accutane therefore, I have a billion small slightly white raised scars on my upper arms, shoulder blades, sides of my back and I'm in my late twenties. I suffered from severe forms of body acne like acne conglobata which developped to acne fulminans. That causes joint pain. It took years for it for clear naturally. Antibiotics did help a little but I didn't take Accutane because my parents were horrified by the side effects. Later on since scars developped, I made a few lifestyle changes and my acne cleared. No need for Accutane because scars had already formed. I still do get breakouts so I believe Accutane would not work for me either.Also, my face has a few craters from cystic acne but they are slightly noticeable. Not many people as teenagers or in their early adult years take Accutane, so you still have many people out there plagued with facial craters from acne, measles or even chicken pox.
Also, people develop prominent scarring more than others. I for once don't get severe scarring but I do develop scars nonetheless.
It would be nice if they could eradicate acne altogether to eliminate scarring in the first place.
That would be ideal. Even though my scars aren't from acne, I feel your pain.
Let's all keep an eye on PolarityTE and Sunogel and hold them to their burden.
10 hours ago, SimpleMutton said:Do you guys think SkinTE will be able to get rid of hyperpigmentaton?
In theory they have to excise all layers of the skin and regenerate it fully so the hyperpigmentation should go awayActually potentially it could get rid of hypopigemntation (white spots) too because the news skin should have melanocytes in it
hypopigmemtation can be treated by Recell also...but if u dont mind i tell you that ginger is a gift from mother nature for hypopigmentation....even in scar tissue also it regenrates melanocytes to some extent