Okay I just want to summarize what we know so far about scar-free healing.

1) Dextran hydrogel:

John Hopkins University

Gemstone Biotherapeutics

- In Maryland

http://www.gemstonebio.com

If you want to contact Gemstone: [email protected]

If you want to contact Dr. Sharon Gerecht: [email protected]

If you want to contact CEO George Davis: https://www.linkedin.com/in/george-davis-3377992a/

Excerpt from an article about Gemstone:
"Dr. Harold Brem, chief, Division of Wound Healing & Regenerative Medicine at Winthrop University Hospital and leader of the Winthrop Wound Healing Center and his diverse and dynamic team of clinicians and support staff are now actively engaged in pre-clinical study with us, which will lead to product refinement and enhancements as well as establishing a seamless path to First-In-Human clinical trials at Winthrop."

You can call Winthrop's Clinical Trials Center at: 516-663-9582.

http://www.haroldbrem.org/research/current-clinical-trials/patient-research-info/index.html

- However, None of the trials are related to scar free healing.

- Winthrop is in Mineola, NY.

Another excerpt from Gemstone:

Our efforts moving into 2017 will focus on:

• Finalizing our scale-up manufacturing planincluding synthesis cost optimization,
• Conversion and irradiation optimization as well as finalizing a packaged, sterilized, GMP-validated product,
• Completing FDA enabling studies,
• Submitting for 510(k) FDA clearance and
• Initiating First-In-Human studies.

"As we continue to work diligently toward regulatory approvals and First-In-Human trials for our innovative advanced wound care solutions"

Moreover, this article is what confuses me: http://www.prweb.com/releases/2015/07/prweb12856816.htm

"All third-degree burns treated with Gemstone Bios advanced hydrogel technology achieved complete wound closure after two weeks, compared to only 14 percent of the control-treated wounds. "

"The technology works by eliciting an earlier and more controlled inflammatory response, which stimulates rapid neovascularization, i.e. blood vessel formation, and supports efficient dermal reconstruction to close the wounds with minimal scarring. The regenerated skin demonstrated characteristics of uninjured skin. Wounds treated with the technology produced increased amounts of the dermal proteins collagen and elastin, which help to minimize scarring and strengthen the repaired tissue. These wounds were reinnervated throughout, with nerve fibers extending through the center of the reconstructed skin."

Our core hydrogel technology, the foundation for our biosynthetic scaffold product, facilitated a superior wound healing response by accelerating skin regeneration, said Dr. Laura Dickinson, Gemstone Bios director of research and development. Third-degree burns, which normally heal with thick distorted scars with permanent sensory loss, were healed with complete re-epithelialization (wound closure) and nerve ingrowth.

....... says nothing about healing scar-free. So idk.
____________________________________________________________________________________________________________________________

2) Sunogel:
Sunogel Biotechnologies Inc
- In Maryland
Contact sunogel at: [email protected] OR [email protected]
Contact Guoming Sun- founder of sunogel: https://www.linkedin.com/in/guoming-sun-b8963110/

I'm pretty Dr. Sun has a direct e-mail, I just couldn't find it.

On 3/8/2017 at 5:19 PM, 34erer34 said:

http://www.redorbit.com/news/health/1113415545/compound-scar-tissue-prevention-082216/

Another promising treatment

I'm quoting myself. This is nano technology that would basically stop scars from forming but the research is looking to improve appearance and functionality of scars. This works to stop fibrosis resulting in more functional skin. The aussie's are really some of the best when it comes to skin tech. A researcher said they are looking at a cream based delivery system for the nanotechnology. Seems pretty cool to me. They have already tested it on keloid cells and it worked, next is animal models then human trials. Nanotech seems promising because they can more precisely trigger what they want at a cellular level.

5 hours ago, CollegeKidd said:

Okay I just want to summarize what we know so far about scar-free healing.

1) Dextran hydrogel:

John Hopkins University

Gemstone Biotherapeutics

- In Maryland

http://www.gemstonebio.com

 

If you want to contact Gemstone: [email protected]

If you want to contact Dr. Sharon Gerecht: gerecht:jhu.edu

If you want to contact CEO George Davis: https://www.linkedin.com/in/george-davis-3377992a/

 

Excerpt from an article about Gemstone:
"Dr. Harold Brem, chief, Division of Wound Healing & Regenerative Medicine at Winthrop University Hospital and leader of the Winthrop Wound Healing Center and his diverse and dynamic team of clinicians and support staff are now actively engaged in pre-clinical study with us, which will lead to product refinement and enhancements as well as establishing a seamless path to First-In-Human clinical trials at Winthrop."

You can call Winthrop's Clinical Trials Center at: 516-663-9582.

http://www.haroldbrem.org/research/current-clinical-trials/patient-research-info/index.html

- However, None of the trials are related to scar free healing.

- Winthrop is in Mineola, NY.

Another excerpt from Gemstone:

Our efforts moving into 2017 will focus on:

• Finalizing our scale-up manufacturing planincluding synthesis cost optimization,
• Conversion and irradiation optimization as well as finalizing a packaged, sterilized, GMP-validated product,
• Completing FDA enabling studies,
• Submitting for 510(k) FDA clearance and
• Initiating First-In-Human studies.

"As we continue to work diligently toward regulatory approvals and First-In-Human trials for our innovative advanced wound care solutions"

Moreover, this article is what confuses me: http://www.prweb.com/releases/2015/07/prweb12856816.htm

"All third-degree burns treated with Gemstone Bios advanced hydrogel technology achieved complete wound closure after two weeks, compared to only 14 percent of the control-treated wounds. "

"The technology works by eliciting an earlier and more controlled inflammatory response, which stimulates rapid neovascularization, i.e. blood vessel formation, and supports efficient dermal reconstruction to close the wounds with minimal scarring. The regenerated skin demonstrated characteristics of uninjured skin. Wounds treated with the technology produced increased amounts of the dermal proteins collagen and elastin, which help to minimize scarring and strengthen the repaired tissue. These wounds were reinnervated throughout, with nerve fibers extending through the center of the reconstructed skin."

Our core hydrogel technology, the foundation for our biosynthetic scaffold product, facilitated a superior wound healing response by accelerating skin regeneration, said Dr. Laura Dickinson, Gemstone Bios director of research and development. Third-degree burns, which normally heal with thick distorted scars with permanent sensory loss, were healed with complete re-epithelialization (wound closure) and nerve ingrowth.

....... says nothing about healing scar-free. So idk.
____________________________________________________________________________________________________________________________

2) Sunogel:
Sunogel Biotechnologies Inc
- In Maryland
Contact sunogel at: [email protected] OR [email protected]
Contact Guoming Sun- founder of sunogel: https://www.linkedin.com/in/guoming-sun-b8963110/

I'm pretty Dr. Sun has a direct e-mail, I just couldn't find it.

From Sunogel's Facebook:
September 1, 2015: Recently, we were able to regenerate complete skin structure on acute deep wounds, including on scarred tissues.
__________________________________________________________________________________________________

3) Brooklyn start-up Suneris is creating a hydrogel, as well.

...........this is all the main info we have thus far.

But guys, we need to contact these companies and contact these people if we ever want news on what is going on. If anyone is interested in participating in clinical trials or inquiring about them I suggest we all reach out in one form or another.

Thank you for the summary on the hydrogels. I had never heard of Suneris, so that's really helpful.

2 hours ago, 34erer34 said:

On 3/8/2017 at 7:19 PM, 34erer34 said:

http://www.redorbit.com/news/health/1113415545/compound-scar-tissue-prevention-082216/

Another promising treatment

I'm quoting myself. This is nano technology that would basically stop scars from forming but the research is looking to improve appearance and functionality of scars. This works to stop fibrosis resulting in more functional skin. The aussie's are really some of the best when it comes to skin tech. A researcher said they are looking at a cream based delivery system for the nanotechnology. Seems pretty cool to me. They have already tested it on keloid cells and it worked, next is animal models then human trials. Nanotech seems promising because they can more precisely trigger what they want at a cellular level.

Yeah, the lysil oxidase approach (as well as the other, as far as I can tell more helpful, lysil hydroxylase 2b approach) interferes with what I've learned is the final stage of scar formation, cross-linking. Which, like regenerating elastin and collagen in hydrogels, and the conversion of myofiroblasts in the adipocyte conversion approach, are all essential pieces of the puzzle.

On 3/8/2017 at 2:21 PM, mjg713 said:

This is the Press Release BirchBio sent me about completion of the first clinical trial: http://birchbiomed.ca/completion-of-clinical-trial/ . So it definitely completed Phase 1 and is in Phase 2 right now. However, the Press Release does not clearly state whether it did indeed completely regenerate skin in the clinical trial.

To update on this, Susan has emailed me today. She stated that the FS2 prevented any scarring from forming in the first place AND it promoted the breakdown of existing scars. I think this is very exciting news!

What exactly does this mean, 4 cell types?

Your question was regarding phase 1, correct, the phase 1 clinical study in humans? It's true as you mentioned that the press release and e-mail you received say two different things.

We all know to take everything we hear with a grain of salt. She could just be exaggerating or unintentionally misrelaying the results. But if what she said is true, it's over.

That's all we need. We have received the description of a perfect solution.

44 minutes ago, scarred2468 said:

Thank you for the summary on the hydrogels. I had never heard of Suneris, so that's really helpful.

Yeah, the lysil oxidase approach (as well as the other, as far as I can tell more helpful, lysil hydroxylase 2b approach) interferes with what I've learned is the final stage of scar formation, cross-linking. Which, like regenerating elastin and collagen in hydrogels, and the conversion of myofiroblasts in the adipocyte conversion approach, are all essential pieces of the puzzle.
Your question was regarding phase 1, correct, the phase 1 clinical study in humans? It's true as you mentioned that the press release and e-mail you received say two different things.

We all know to take everything we hear with a grain of salt. She could just be exaggerating or unintentionally misrelaying the results. But if what she said is true, it's over.

That's all we need. We have received the description of a perfect solution.

Yes, it was regarding Phase 1 which was completed in 20 human volunteers. Phase 2 is starting soon and I suggested someone in the forum who lives in Canada or who can travel there should sign up, what's there to lose? Actually after reading the press release carefully is does state: "In addition to showing effectiveness in preventing scarring and promoting the breakdown of existing scars''. Which is indeed what she emailed me. I guess she could be exaggerating, but I don't understand what the purpose would be and that would mean the press release is lying. I specifically asked her if it prevented scarring and regenerated normal skin and she confirmed it. I'm just hoping for the best and that it is able to be clinically used in the near future.

From that response you got alone, there is reason to get excited. I don't think we've ever been told that something outright worked.

8 minutes ago, scarred2468 said:

From that response you got alone, there is reason to get excited. I don't think we've ever been told that something outright worked.

Yes, I definitely agree. Although I wish it were classified a a device and not a drug so it would get here sooner. Also would be nice to see some before and after photos.

mjg713 are you planning on signing up for trials?

Don't forget about The Scar Free Foundation

13 hours ago, acastro0069 said:

mjg713 are you planning on signing up for trials?

I am not because I believe it is located in Canada and I won't be able to travel. It is ideal for anyone who lives in Canada though or a state close by.

13 hours ago, JackDoe said:

Don't forget about The Scar Free Foundation

Forget about this, they are aiming for scar free healing by 2045 when we already have viable methods now.

On 3/10/2017 at 4:57 PM, mjg713 said:

I am not because I believe it is located in Canada and I won't be able to travel. It is ideal for anyone who lives in Canada though or a state close by. Forget about this, they are aiming for scar free healing by 2045 when we already have viable methods now.

well there you go if the scar free foundation is predicting 2045 --trust me they're being conservative. you think they don't know about hydrogels? of course they do. also forget the wakeforest stuff it's all just "in theory" right now, nothing real. so just give up on it all. go for dermabrasion, fillers and fat. That's like 10 grand. You guys on this board realize that if there IS scar free technology it's gonna cost you a few hundred grand right? I hope you're all rich.

4 hours ago, Rez77 said:

well there you go if the scar free foundation is predicting 2045 --trust me they're being conservative. you think they don't know about hydrogels? of course they do. also forget the wakeforest stuff it's all just "in theory" right now, nothing real. so just give up on it all. go for dermabrasion, fillers and fat. That's like 10 grand. You guys on this board realize that if there IS scar free technology it's gonna cost you a few hundred grand right? I hope you're all rich.

What a childish statement. First you say that it wont happen then you say that if there is scar free technology it will cost a few hundred grand. It doesnt even make sense. Get a grip.

okay fine i'm willing to listen. can someone give me like a timeline when we will really have something that could be called a breakthrough. pLEASE. my life depends on this.

One example is BirchBio's FS2 anti-scarring cream. I emailed Susan from the company and she stated in Phase 1 of Clinical Trials in humans it prevented scarring from ever forming and broke down existing scars. It is in Phase 2 now of clinical trials, so i'm not sure what an actual timeline to market would be.

4 hours ago, Rez77 said:

okay fine i'm willing to listen. can someone give me like a timeline when we will really have something that could be called a breakthrough. pLEASE. my life depends on this.

There have been fundamental science breakthroughs in the last few years regarding scarring ; plenty of articles are available on Pubmed and NCBI website. Recently University of Pennsylvania and University of California (I think?) reasearchers have found that it was possible to regenerate skin by inducting a differenciation of myofibroblasts into adipocytes to heal wounds without any scars "Type no more scars on google". Scars were a complex issue to understand before because of the molecular mechanism behind it ; we definitely understand it better than ever and we have clearly identified ways to regulate it. Unfortunately, clinical applications are more complex to develop because of all the process (trials, etc.) But I'm sure that by 10 years, more efficient treatments will be avalaible to treat scarring due to ;

1) the pace of science advances
2) the number of scars sufferers worldwide ; burn victims, acne, injuring ... a LOT of people, rich or poor. It's not like a rare disease where 1 person/a billion people is suffering from it. Therefore, researches are a lot motivated due to the large pool of people seeking for treatments.

To give you an idea ; a lot of major discoveries in cellular biology that I was studying in my university classes were achieved in the 1990s so It's not surprising that scarring was not totally understood at the beginning of the 21st century.

Plus ; for those who are not believing in total skin rejuvenation, you have to understand that scarring was at first an adaptation in the evolution of mammals to avoid infection in wounds with a faster healing process. It's a result of "natural selection" and therefore, we can return back to "the initial skin rejuvenation process" before that natural selection occurred by re-regulating the scarring mechanism.

2 hours ago, Davrak said:

There have been fundamental science breakthroughs in the last few years regarding scarring ; plenty of articles are available on Pubmed and NCBI website. Recently University of Pennsylvania and University of California (I think?) reasearchers have found that it was possible to regenerate skin by inducting a differenciation of myofibroblasts into adipocytes to heal wounds without any scars "Type no more scars on google". Scars were a complex issue to understand before because of the molecular mechanism behind it ; we definitely understand it better than ever and we have clearly identified ways to regulate it. Unfortunately, clinical applications are more complex to develop because of all the process (trials, etc.) But I'm sure that by 10 years, more efficient treatments will be avalaible to treat scarring due to ;

1) the pace of science advances
2) the number of scars sufferers worldwide ; burn victims, acne, injuring ... a LOT of people, rich or poor. It's not like a rare disease where 1 person/a billion people is suffering from it. Therefore, researches are a lot motivated due to the large pool of people seeking for treatments.

To give you an idea ; a lot of major discoveries in cellular biology that I was studying in my university classes were achieved in the 1990s so It's not surprising that scarring was not totally understood at the beginning of the 21st century.

Plus ; for those who are not believing in total skin rejuvenation, you have to understand that scarring was at first an adaptation in the evolution of mammals to avoid infection in wounds with a faster healing process. It's a result of "natural selection" and therefore, we can return back to "the initial skin rejuvenation process" before that natural selection occurred by re-regulating the scarring mechanism.

thanks brother. honestly just hearing your impressive scientific knowledge and clear writing I'm impressed by you and you're turning me into a believer. I'm already 40. So the idea that this could happen and I could remove these acne scars would just be a dream come true. If it could happen before I turn 45 I'd be pretty thrilled.

I wish there were even more people posting here, we've had some good discussions and have learned a lot recently.

3 hours ago, Rez77 said:

thanks brother. honestly just hearing your impressive scientific knowledge and clear writing I'm impressed by you and you're turning me into a believer. I'm already 40. So the idea that this could happen and I could remove these acne scars would just be a dream come true. If it could happen before I turn 45 I'd be pretty thrilled.

Keep it up! At least, anti-aging treatments are exploding right now ; guessing the age of people will only become harder and harder.

The "slowdown" behind development of efficient scar treatments is maybe because of lasers ; they were first discovered really efficient to treat varieties of skin problems as wrinkles and brown spots and they became overrated by marketing and laser companies for treating scars ; $$ also for doctors. But now, there's clearly evidence that they do not do much for scarring globally ... except for the fractional CO2 devices maybe, but still, they can be risky and restricted for many people.

This phenomenon can be referred to the first cancer treatments by first chemotherapies ; there was a wide target of cancers by this method, but the efficiency was quite so so ... Now, we are heading to more specific treatments for each cancer, which are way more efficient of course. (In certain cases, the chemotherapy is more specific to avoid killing healthy cells)

I juste think that Lasers were seen as the overrated promise for scars, unfortunately, because they were treating other skin conditions with effectiveness : I guess we're now heading to much more selective (and efficient) treatments to treat and eliminate scars, ultimately.

I think people need to calm down a bit. I am new here and realize this thread has been ongoing for a number of years. However, it does take a long time for something to get FDA approved. We are just now starting to see the fruits of this labor. I think there is reason to be optimistic that we have options now such as the hydrogel and the FS2 anti scarring cream. The hydrogel is backed by Johns Hopkins and enters human trials this year and if successful would be approved very quickly after that. The FS2 is in clinical stage 2 and classified as a drug so would take a little longer. I believe we will see scar free healing in the near future and there are already universities looking to regenerate a limb by 2030 such as UCONN. The biggest hurdle will be the FDA process depending on which route successfully gets us there.

I hope that we will be able to get a really goodacne scar treatment in 5 years. And a great one in 10 years. I think that would be a realistic perspective.

I am getting fed up by lasers, creams, needling, subscicions, peels,suctioning etc. All this is very time consuming and put too much stress on my life. Does it even help? Not sure.

Personally I believe 3d printing might be the way to go. But it is still some years away.

44 minutes ago, Frasier said:

I hope that we will be able to get a really goodacne scar treatment in 5 years. And a great one in 10 years. I think that would be a realistic perspective.

I am getting fed up by lasers, creams, needling, subscicions, peels,suctioning etc. All this is very time consuming and put too much stress on my life. Does it even help? Not sure.

Personally I believe 3d printing might be the way to go. But it is still some years away.

I don't have acne scars but have researched the topic a lot. I don't believe there is a such thing as a "really good" treatment. Everything that exists right now has pretty much given lackluster results. I think the only treatment that would be worth it is full skin regeneration/scarless healing and nothing less.

42 minutes ago, mjg713 said:

1 hour ago, Frasier said:

I hope that we will be able to get a really goodacne scar treatment in 5 years. And a great one in 10 years. I think that would be a realistic perspective.

I am getting fed up by lasers, creams, needling, subscicions, peels,suctioning etc. All this is very time consuming and put too much stress on my life. Does it even help? Not sure.

Personally I believe 3d printing might be the way to go. But it is still some years away.

I don't have acne scars but have researched the topic a lot. I don't believe there is a such thing as a "really good" treatment. Everything that exists right now has pretty much given lackluster results. I think the only treatment that would be worth it is full skin regeneration/scarless healing and nothing less.

Well, thats exactly what I said. I hope that there will be a good treatment in 5 years and a great one in 10 years.

If you go on Gemstone's facebook you can see some questions they just answered. They're not necessarily positive responses.

http://www.popularmechanics.com/science/a24656/scar-free-healing/
https://www.pennmedicine.org/news/news-releases/2017/january/using-fat-to-help-wounds-heal-without-scars

^This is good news, however. I guess

20 hours ago, CollegeKidd said:

If you go on Gemstone's facebook you can see some questions they just answered. They're not necessarily positive responses.

http://www.popularmechanics.com/science/a24656/scar-free-healing/
https://www.pennmedicine.org/news/news-releases/2017/january/using-fat-to-help-wounds-heal-without-scars

^This is good news, however. I guess

Sorry that's just another "this might be of some use in 10 years" information. but thanks for sharing anyway.

There are so many issues with acne scars. There's the scar tissue itself. There's the disfigurement of the skin. There's a loss of volume in various places, loss of fat and collagen especially as you age in the acne scars. I mean my temples and upper cheaks are disfigured by ice-pick and rolling scars. The thick skin on my nose has HYPERTROPHIC scarring. I'm a fucking mess. My face looks like minced meat. THERE WILL HAVE TO BE ONE HELL OF A FUCKING CURE FOR IT TO HELP ME.

On 3/16/2017 at 3:30 AM, CollegeKidd said:

If you go on Gemstone's facebook you can see some questions they just answered. They're not necessarily positive responses.

http://www.popularmechanics.com/science/a24656/scar-free-healing/
https://www.pennmedicine.org/news/news-releases/2017/january/using-fat-to-help-wounds-heal-without-scars

^This is good news, however. I guess

I just checked their facebook and can't find anything of the sort. What kind of questions were they asked and how did they respond?