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19 hours ago, Rez77 said:3 years away from human trials. The technology is not realizable yet though either which they don't directly
say in this article. I would say clinical application at your local cosmetic surgeon maybe 10-15 years? Maybe....lol I guess that's the optimism of youth as you are truly a college kid. 10-15 years before clinical application (clinical as in at your doctor's office)
I thought someone here said they plan on starting trials in 2017. It's not optimism, I'm just simply following a timeline that's been shared with the public.
Oh my god guys, you have to get with the program. GO to something like futuretimeline they post all sorts of crap --for example, they have posted and this is based on the scientific studies by real researchers that we will have "stem cell regeneration of teeth" in 2017 which is a month away by the way lol. Now yes there ARE labs working on trying to figure this stuff out. And they may say "human trials will begin blah blah" but it's all just to keep them funded!!!!! FUNDED!!!!!
THIS THREAD STARTED in 2007!!!! THERE HAS BEEN ZERO. COUNT IT ZERO progress in the past 10 years even though we had labs back then predicting revolutionary advancement in this stuff in terms of stem cells, gene editing, 3D printing blah blah blah.
NONE OF THAT IS ACTUALLY AVAILABLE. There's a thread on reddit where scientists discuss tissue regeneration. By their most conservative estimates actually engineering or producing basic human tisses for actual use is50 YEARS AWAY!!!!
FIFTY YEARS. FIVE. ZERO. I wonder when this thread will die out, cause it really should. You guys are wasting your life here. And I was one of the originals reading this thread back in 2007!!! 10 YEARS AGO. MIC DROP.
Lol, why are we wasting our lifes? We visit this thread from once a day to even once a year.
Scar-free regeneration will happen, but we're just looking for news. To follow the science is bad?
Dude, if don't like it, just don't visit the thread. Here are adults that can do whatever they want.
I can understand Rez's frustration and realism about the situation. But why is it impossible to believe that scar-free healing might actually be possible in the very near future? It's not like we're talking about anything THAT absurd ya know? And there has been scientific proof now that it basically is possible. It just depends on awareness and funding to speed up the process I believe.
1 minute ago, scarred2468 said:It's definitely possible but we need more info. I'll call gemstone again today and ask about how it will be approved
Yes, call him and let him know that there are tons of other people who are interested in the process. Try and get him to check this thread and maybe he'll understand that there are people who are so happy and optimistic about what he has done so far and who would love to help with everything as much as possible
1 hour ago, scarred2468 said:No luck, I already left them a message before but I'll try again tomorrow
On 12/5/2016 at 7:33 PM, Binga said:
Guys I'd love to join you in the optimism but the above story right here demonstrates what an impossibility (or possibility in our lifetime ) this is. Look at how at the very same university they're discussing gene regulators and the possibility of these or proteins functioning in scar healing. There are literally infinite combinations of these genes involved. This is just at this stage totally hypothetical research that will take decades. Don't you think they'd mention the hydrogel that has already supposedly solved the friggin problem according to you guys at the very same university. These sorts of stories were around in 2007. Science functions at literally glacial time horizons.
I'm depressed latest dermatological conference on acne scarring doesn't even mention anything to do with regeneration --so the best there is is the same old shit which doesn't do shit.
16 minutes ago, Rez77 said:Guys I'd love to join you in the optimism but the above story right here demonstrates what an impossibility (or possibility in our lifetime ) this is. Look at how at the very same university they're discussing gene regulators and the possibility of these or proteins functioning in scar healing. There are literally infinite combinations of these genes involved. This is just at this stage totally hypothetical research that will take decades. Don't you think they'd mention the hydrogel that has already supposedly solved the friggin problem according to you guys at the very same university. These sorts of stories were around in 2007. Science functions at literally glacial time horizons.
I'm depressed latest dermatological conference on acne scarring doesn't even mention anything to do with regeneration --so the best there is is the same old shit which doesn't do shit.
I hope this isn't true.
And guys I want to believe like you guys do but no one is even talking about regeneration in the actual dermatological circles.
And clinical practice is even further 20 years behind. Look at all these latest "results" of all these doctors doing multiple modality treatments and remember the pics are all doctored with light angling and such and they still look like absolute shit. I am so depressed over this. One they figure out how to solve acne scarring they will figure out the fountain of youth. You think that's gonna happen in our lifetimes?
https://www.realself.com/acne-scars-treatment/before-and-after-photos#media-photo-200602-98897-28
This is probably the best they can do right now. And it's with the MOST ANCIENT of the technologies. I'm so friggin depressed.
Well, I am no genius when it comes to skin research, but skin regeneration wouldnt mean the fountain of youth as I see it. You will still regenerate the skin of your age. We are talking about skin defects...like scars etc.
And honestly I dont think we are decades away. There is a lot of focus on skin regeneration now, and it is like computer science. Its a technology - so it is like a snowball running. It will get faster and faster.
I think there will be a good enough solution in about 5-10 years. Good enough = no more anxiety because of acne scars.
Until then try some needling, subscision etc., and stay in shape - mentally and physically. Finish your education, get an apartment, and prepare for an even better life.
Be a champion.
10 hours ago, Frasier said:Well, I am no genius when it comes to skin research, but skin regeneration wouldnt mean the fountain of youth as I see it. You will still regenerate the skin of your age. We are talking about skin defects...like scars etc.
And honestly I dont think we are decades away. There is a lot of focus on skin regeneration now, and it is like computer science. Its a technology - so it is like a snowball running. It will get faster and faster.
I think there will be a good enough solution in about 5-10 years. Good enough = no more anxiety because of acne scars.
Until then try some needling, subscision etc., and stay in shape - mentally and physically. Finish your education, get an apartment, and prepare for an even better life.
Be a champion.
I totally agree with this. Great advice. I think it will be closer to 10 years that we'll have a "no anxiety" solution, but yes prepare for life.
I am no means a expert on skin regeneration and have been following this topic for years. Back in the day they had Isologen,lasers....you name it to try to reduce acne scars. I have spent 1000's of dollars already and still have scars. I had my best results using a skin tightner. Like the products from skin biology.....they don't get rid of scarring but improve the appearance.You might also try wetting backing soda and scrubbing your face with it.It is almost the same process as microdermabrasion and doesn't cost hardly anything. I think it might be years and hope i am wrong but hope is eternal!
Imagine if the new hydrogels really work. If a scaffold solution won't work, perhaps a different crosslink pattern would work, or a massive cocktail of growth factors and inhibitors, there's already tons of research on various mechanisms that affect scarring. I'm going into biotech regardless but if they work it would allow me to focus on a topic less-impossibly-difficult. Or would allow me to tackle hair loss and shit, I'd rather not try to tackle too many things at once. Just remember that even though it seems impossible, it most certainly is not. Early fetuses do it all the time, it can be done. It's going to happen, hope it happens soon.
https://www.instagram.com/p/BNsda1ZhUBn/
My doctor is planning to use subcision, fat grafting and amniotic fluid from child birth in my next session. Will see how it goes.
21 hours ago, Binga said:https://www.instagram.com/p/BNsda1ZhUBn/My doctor is planning to use subcision, fat grafting and amniotic fluid from child birth in my next session. Will see how it goes.
This place got horrible reviews on yelp.
On 12/1/2016 at 0:23 PM, mjg713 said:On 12/1/2016 at 0:18 PM, scarred2468 said:If the two hydrogels are similar, maybe it's possible that sunogel and gemstone are competing. I hope they both go at it quick. But we don't even know what sunogel's thing is or if it's any different from gemstone
Why are you so concerned about sunogel? seems like Gemstone is on track for clinical trials, and that is great news.
This is such good news!! I can't wait to start my life all over..
On 12/6/2016 at 4:03 AM, CollegeKidd said:I can understand Rez's frustration and realism about the situation. But why is it impossible to believe that scar-free healing might actually be possible in the very near future? It's not like we're talking about anything THAT absurd ya know? And there has been scientific proof now that it basically is possible. It just depends on awareness and funding to speed up the process I believe.
Nah, I'm not going to believe someone deluded by depression and frustration. Scarless healing will happen soon. The hydrogel has reported to regrow hair, a feat only possible when skin is fully repaired and unscathed (a.k.a, no more scarring). Again, both the hydrogels are listed as medical devices as opposed to drugs, so human trials and fda approval will take a lesser amount of time ( it's been mentioned throughout the forum - look for seabs' posts that medical devices take a year for approval).
Honestly, I don't get why the skeptics keep coming back to trash the board, and why the mods still allow them to post. Just read through the thread and look out for answers by seabs', rudy, and many others who will bring actual, reputable info to the group, as opposed to depressed ramblings.
13 hours ago, agelessfrost said:Nah, I'm not going to believe someone deluded by depression and frustration. Scarless healing will happen soon. The hydrogel has reported to regrow hair, a feat only possible when skin is fully repaired and unscathed (a.k.a, no more scarring). Again, both the hydrogels are listed as medical devices as opposed to drugs, so human trials and fda approval will take a lesser amount of time ( it's been mentioned throughout the forum - look for seabs' posts that medical devices take a year for approval).
Honestly, I don't get why the skeptics keep coming back to trash the board, and why the mods still allow them to post. Just read through the thread and look out for answers by seabs', rudy, and many others who will bring actual, reputable info to the group, as opposed to depressed ramblings.
Not trying to trash you but Seabs said the same thing donkey years ago (Scarless healing near the horizon), but it never happened.
What i'm afraid is that even if they have this technology they will not reveal it to public.
I am a skeptic...i have been here many years.......hope is eternal but nothing has ever been really dramatic in the scar reduction field.....i have spent thousands on about everything....and nothing works.....I hope you kids do get a treatment that is truly scar less but after years of high hopes..i have about givin' up! The worse thing is nobody cares about how acne and acne scarring effects a humans life. It is really bad when you feel so bad about yourself that you become anti-social.You go to a psychiatrist and they laugh you off. Someday i hope people realize the effect that acne and acne scarring has on the human mind.
Also, some criticisms of the dextran hydrogel study ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248550/ ):
The markers they used to measure skin regeneration kind of suck. The three they use are: epithelial maturation, dermal differentiation, and hair follicle quantity. Epithelial maturation is measured in "degrees" which is already vague. Dermal differentiation is also expressed in degrees, but is related to the type of skin structures that form from the healing process. Using the hydrogel, sebacious glands and hair regenerate, which is a good thing and obviously necessary for scarless healing. But that leads us to this problem. Hair follicles and sebacious glands can form even in scar tissue. I have hair growing out of an obvious red fibrous scar near my eyebrow, you don't need a hydrogel for that. In this experiment, hair follicles increased 5-fold versus control (10 vs 2) but the amount of hair itself or the presence of sebacious glands doesn't mean that the healed wound is scarless. What should have also been measured in ddition were the levels of collagen and elastin, the ratios off collagen types, skin/scar color, etc. We don't have evidence that the healed wound is scarless.
I am frustrated because if my information is correct, Guoming Sun and Gemstone are trying to approve hydrogels of he same basic type that they both made studies about: the "acellular hydrogel in a porcine model" one and the dextran hydrogel one. So if it's taken over 5 years, they should have spent this time to make it perfect. Maybe they are, but I doubt it. They haven't even started clinical trials. So I don't understand what that 5 years was spent for if the product is functionally the same. Sunogel is aiming high, as it says on the website, so I'd love to believe that these people are samaritans and are perfecting this stuff but it's probably otherwise.
On the bright side, the gels can be infused with chemicals and growh factors for additional efficacy but that's more years down the road. Hopefully the 21st century cures act will help with that. It passed by the way.