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4 hours ago, mjg713 said:I read an article about the hydrogel recently that stated that when they did the pig experiment it did not produce sebaceous glands or grow hair. Did they redo the experiment to fix this? if not i'm assuming this can mean a possible not so good result for humans if they can't regenerate these characteristics in pigs?
Dono Kasino Indro
2 hours ago, rudy1986 said:6 hours ago, mjg713 said:I read an article about the hydrogel recently that stated that when they did the pig experiment it did not produce sebaceous glands or grow hair. Did they redo the experiment to fix this? if not i'm assuming this can mean a possible not so good result for humans if they can't regenerate these characteristics in pigs?
Dono Kasino Indro
Sorry, what does this mean?
16 hours ago, mjg713 said:I read an article about the hydrogel recently that stated that when they did the pig experiment it did not produce sebaceous glands or grow hair. Did they redo the experiment to fix this? if not i'm assuming this can mean a possible not so good result for humans if they can't regenerate these characteristics in pigs?
Wow, I hope thats not true..
anyone noticed that dextran hydrogel, Gerecht hydrogel research has made progress.
The research now is primarily based on combining chemical compounds and stem cells.
Besides promoting tissue repair there seems to be some issues with infection etc spreading because of open environment. Also a few other issues. Also a lot of research on applications here in Leiden university there is research going on for hearth tissue (scar)repair with hydrogel which has been successful in pigs.
It all sounds promising though I thought it was at a standstill it is still going (slow)
I am keeping a close eye on this the coming years.
9 hours ago, rudy1986 said:Please cite a statement which said "doesn't produce sebaceous gland"
http://www.prweb.com/releases/2015/07/prweb12856816.htm Read the last paragraph that says "The technology previously demonstrated similar positive results when evaluated in mice, including the regeneration of complex dermal features such as hair follicles and sebaceous glands." This means that it was regenerated in mice but not in the pig trial. I am unsure how good this will work for humans now. It also keepsreferring to the wound being closed with "minimal scarring" which means thatthere is still some scarring, which means that is technically not full regeneration.
2 hours ago, mjg713 said:http://www.prweb.com/releases/2015/07/prweb12856816.htm Read the last paragraph that says "The technology previously demonstrated similar positive results when evaluated in mice, including the regeneration of complex dermal features such as hair follicles and sebaceous glands." This means that it was regenerated in mice but not in the pig trial. I am unsure how good this will work for humans now. It also keepsreferring to the wound being closed with "minimal scarring" which means thatthere is still some scarring, which means that is technically not full regeneration.
To me it looks like the same regeneration happened it pigs as in mice. Am I wrong? Yes it does mention minimal scarring..I dont know exactly what that mean. But this was one year ago - I wonder what kind of progress is getting a long.
http://www.bristol.ac.uk/news/2016/july/scar-free-healing.html Things like this confuse me. On one hand we have people so confident that something like the hydrogel will work and help achieve scarless healing. On the other hand, we have foundations like this start that aim to achieve scarless healing in a "generation". That definitely does not seem very optimistic.
http://www.baystreet.ca/viewarticle.aspx?id=442873 Interesting video on spray-on skin.
God I hate this fucking thread. There is nothing to be gained by pondering non-existing treatments/cures except added frustration and discouragement. Unless it gives people a sense of false hope and security.
I wish it would just die out. Ironically, this is the longest thread on the scar treatment forum and will continue to be unless "scarless healing" becomes a reality.
12 minutes ago, scarredandsad34 said:God I hate this fucking thread. There is nothing to be gained by pondering non-existing treatments/cures except added frustration and discouragement. Unless it gives people a sense of false hope and security.
I wish it would just die out. Ironically, this is the longest thread on the scar treatment forum and will continue to be unless "scarless healing" becomes a reality.
That actually is an existing treatment, just not in the US.
11 hours ago, mjg713 said:http://www.baystreet.ca/viewarticle.aspx?id=442873 Interesting video on spray-on skin.
This has been discussed further up. It is not as good as it seems apperantly. Too bad 
On 27-7-2016 at 11:27 PM, scarredandsad34 said:God I hate this fucking thread. There is nothing to be gained by pondering non-existing treatments/cures except added frustration and discouragement. Unless it gives people a sense of false hope and security.
I wish it would just die out. Ironically, this is the longest thread on the scar treatment forum and will continue to be unless "scarless healing" becomes a reality.
I still check this thread every now and then for news that people share. It's a nice way of seeing what's come along in terms of progress. So the thread has its function for me.
I'd love for scarless healing to come along. It would certainly be beneficial to me. Having damage reversed would be a weight off of my shoulders and a worry less. But that said, I'm not necessarily in agony. I just focus on my work mostly and find I have a peace of mind most of the time.
What is everyones opinion on what the success rate of the hydrogel will be? Also factor in we now have 3D printed skin in the mix which seems to hold promise. Personally I think we are very close to permanently fixing small areas of scarring (whether acne, traumatic, or surgical). I do however think that large areas of scarring will be a lot more difficult to treat and may take a bit longer to fully perfect.
Maybe I'm delusional, but I truly believe that the dextran hydrogel or sunogel or whatever it is does completely regenerate human skin. BUT WE NEED HUMAN TRIALS AND STUFF IN AMERICA TAKES FOREVER.
Also, where did we hear that human clinical trials will begin toward the end of 2016? Because it's getting near the end of 2016 and I haven't heard any updates. I would even volunteer to participate in the trials if that was an option. Lol I'm desperate
On July 27, 2016 at 5:40 PM, mjg713 said:On July 27, 2016 at 5:27 PM, scarredandsad34 said:God I hate this fucking thread. There is nothing to be gained by pondering non-existing treatments/cures except added frustration and discouragement. Unless it gives people a sense of false hope and security.
I wish it would just die out. Ironically, this is the longest thread on the scar treatment forum and will continue to be unless "scarless healing" becomes a reality.
That actually is an existing treatment, just not in the US.
where is this an existing treatment ? If that is true wouldn't people be traveling there having the treatment and reporting back? Are there even any existing trials being done overseas for scarless healing? I would certainly travel.
On July 31, 2016 at 7:44 PM, mjg713 said:What is everyones opinion on what the success rate of the hydrogel will be? Also factor in we now have 3D printed skin in the mix which seems to hold promise. Personally I think we are very close to permanently fixing small areas of scarring (whether acne, traumatic, or surgical). I do however think that large areas of scarring will be a lot more difficult to treat and may take a bit longer to fully perfect.
the skin gun does not even seem close to doing anything at all. Maybe they are trying to raise $ for trials but by the time they do other things could replace that technology and make it obsolete. Seems lime an amazing product but they have been stuck in the same place for years. A lot of great technology never makes it to market
Hey guys I would like to know what you think of this: http://www.thepharmaletter.com/article/mallinckrodt-to-acquire-stratatech-gaining-rights-to-skin-substitute . It is suppose to be on the market by 2020, it is marketed for 3rd degree burns but i'm pretty positive it can be used for scarring. It seems very similar to the dextran hydrogel in which it covers the damaged area and promotes tissue regeneration. I read something that said out of 28 trials 27 of them were fully epithelized and the last one was 85% epithelized, this seems really promising and i think we are getting really close.
12 hours ago, mjg713 said:Hey guys I would like to know what you think of this: http://www.thepharmaletter.com/article/mallinckrodt-to-acquire-stratatech-gaining-rights-to-skin-substitute . It is suppose to be on the market by 2020, it is marketed for 3rd degree burns but i'm pretty positive it can be used for scarring. It seems very similar to the dextran hydrogel in which it covers the damaged area and promotes tissue regeneration. I read something that said out of 28 trials 27 of them were fully epithelized and the last one was 85% epithelized, this seems really promising and i think we are getting really close.
You need to be a registered user to read the article. To those that can read it; what do you think? Does it look promising?
3 hours ago, Frasier said:16 hours ago, mjg713 said:Hey guys I would like to know what you think of this: http://www.thepharmaletter.com/article/mallinckrodt-to-acquire-stratatech-gaining-rights-to-skin-substitute . It is suppose to be on the market by 2020, it is marketed for 3rd degree burns but i'm pretty positive it can be used for scarring. It seems very similar to the dextran hydrogel in which it covers the damaged area and promotes tissue regeneration. I read something that said out of 28 trials 27 of them were fully epithelized and the last one was 85% epithelized, this seems really promising and i think we are getting really close.
You need to be a registered user to read the article. To those that can read it; what do you think? Does it look promising?
3 hours ago, JackDoe said:To those that can read it; just post it here.
Not sure why the article is for registered users only now, when I discovered it it was available to everyone. Here is a link to Stratatechs main site: http://www.stratatechcorp.com/about/index.php . This product was made initially for the military and is in its last phase for FDA approval and looks extremely promising, please read it everyone.
Seems interesting, but I still see scars and different skin texture. New skin looks shiny and red.Possibly, this issue disappears with time. I'm on Accutane now and my skin over the whole body looks exactly the same as in the picture (shiny (not oily) and a bit red).
Btw, guys, look at this thread: http://www.acne.org/messageboard/topic/361779-pulsed-electric-fields-pef/
10 minutes ago, JackDoe said:Seems interesting, but I still see scars and different skin texture. New skin looks shiny and red.Possibly, this issue disappears with time. I'm on Accutane now and my skin over the whole body looks exactly the same as in the picture (shiny (not oily) and a bit red).
Btw, guys, look at this thread: http://www.acne.org/messageboard/topic/361779-pulsed-electric-fields-pef/
I mean it is hard to tell by the picture and there is a possibility it doesn't stay like that. The fact of the matter is that the skin was fully re-epithelized on a full thickness wound without the need for a skin graft, I have yet to see any product do this ever. It also seems as though it works very similarly as the hydrogel. I don't think you can compare the skin to being on accutane when this is a wound closure of a third degree burn. I still think this is a great sign of progress.
http://www.eurekalert.org/pub_releases/2016-03/bs-git021916.php
Something to keep up hope.
I know the feeling of people right now is pessimistic, but again we have to keep the faith that something will happen
in the future if not there wouldn't be a reason for living.
On 8/15/2016 at 1:10 AM, mjg713 said:I mean it is hard to tell by the picture and there is a possibility it doesn't stay like that. The fact of the matter is that the skin was fully re-epithelized on a full thickness wound without the need for a skin graft, I have yet to see any product do this ever. It also seems as though it works very similarly as the hydrogel. I don't think you can compare the skin to being on accutane when this is a wound closure of a third degree burn. I still think this is a great sign of progress.
It does look like p good progress! I'd happily trade the disgusting scars on my body for those tbh. Also, I think it'd be easier to manage/reduce the graft scarring w dermarolling etc. I've seen surgical scars get amazing results from micro needling. Good stuff though I'm more interested in the hydrogel. Here's to hoping that they've started human trials and are getting great results!
55 minutes ago, agelessfrost said:It does look like p good progress! I'd happily trade the disgusting scars on my body for those tbh. Also, I think it'd be easier to manage/reduce the graft scarring w dermarolling etc. I've seen surgical scars get amazing results from micro needling. Good stuff though I'm more interested in the hydrogel. Here's to hoping that they've started human trials and are getting great results!
Exactly! if anything this experiment proves that the hydrogel concept should work and get even better results! It just seems like we really are so close, I just wish that Gemstone Biotherapeutics or whoever is in charge of hydrogel would update us more often. Human trials should have started already correct? I even read on Reddit that "secret" human trials were already being done. Hydrogel has been in fruition since 2011, so they already have been tweaking with it for 5 years. The good news is since it is a "device", FDA approval will be no more than a year.