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[Sticky] Scarless Healing

 
MemberMember
12
(@hydrogel)

Posted : 06/24/2015 1:59 pm

The cure for young adults who have acne related scarring will be definitively hear by 2060. So I estimate many of us will be in our late 60s or 70s or a bit younger.

 

The problem is that the cure for sagging old skin and eradicating wrinkles and such that will be covering our acne scars by that time won't be available until 3100.

 

Humans born in 2060 will on average be living 110 years, so even they won't survive long enough to see a real cure. Ugh the future looks bleak for this.

 

Dude that's way off lmao! We're conducting antiaging and regenerative medicine today that has greater than a 50-percent chance of being publicly viable in the next 25 years or less. Thus, halting or reversing the aging process will more or less take care of any skin wrinkles. Additionally, I think by the time we've reached that point, there'll surely be substantial advances in cosmetic surgery that can more-or-less address those issues. Do some research on Aubrey de Grey and the SENS foundation, as well as Google's Calico Laboratories. I can assure you, you'll live to live to see the day of perfect, wrinkle-free, scar-free skin (and possibly live few extra hundred years in the process). :D

 

http://www.sens.org/

 

http://www.calicolabs.com/

 

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MemberMember
378
(@rez77)

Posted : 06/24/2015 2:44 pm

 

The cure for young adults who have acne related scarring will be definitively hear by 2060. So I estimate many of us will be in our late 60s or 70s or a bit younger.

 

The problem is that the cure for sagging old skin and eradicating wrinkles and such that will be covering our acne scars by that time won't be available until 3100.

 

Humans born in 2060 will on average be living 110 years, so even they won't survive long enough to see a real cure. Ugh the future looks bleak for this.

 

Dude that's way off lmao! We're conducting antiaging and regenerative medicine today that has greater than a 50-percent chance of being publicly viable in the next 25 years or less. Thus, halting or reversing the aging process will more or less take care of any skin wrinkles. Additionally, I think by the time we've reached that point, there'll surely be substantial advances in cosmetic surgery that can more-or-less address those issues. Do some research on Aubrey de Grey and the SENS foundation, as well as Google's Calico Laboratories. I can assure you, you'll live to live to see the day of perfect, wrinkle-free, scar-free skin (and possibly live few extra hundred years in the process). :D

 

http://www.sens.org/

 

http://www.calicolabs.com/

 

 

 

Well I do like your optimism. But I fear it's misguided. The most accurate prediction engine of at what point such medical developments will be available is futurtimeline.com These are conducted by rigorous scientists and futurologists. They predict anti-aging therapies may only begin to be a reality past 2060 and we would need that before we can heal scars fully because most of us will be so old it won't even matter if we have scars they'll be underneath our wrinkles!

 

http://www.futuretimeline.net/21stcentury/2060-2069.htm#.VYsH5xNVhHx

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MemberMember
12
(@hydrogel)

Posted : 06/24/2015 8:36 pm

 

The cure for young adults who have acne related scarring will be definitively hear by 2060. So I estimate many of us will be in our late 60s or 70s or a bit younger.

 

The problem is that the cure for sagging old skin and eradicating wrinkles and such that will be covering our acne scars by that time won't be available until 3100.

 

Humans born in 2060 will on average be living 110 years, so even they won't survive long enough to see a real cure. Ugh the future looks bleak for this.

 

Dude that's way off lmao! We're conducting antiaging and regenerative medicine today that has greater than a 50-percent chance of being publicly viable in the next 25 years or less. Thus, halting or reversing the aging process will more or less take care of any skin wrinkles. Additionally, I think by the time we've reached that point, there'll surely be substantial advances in cosmetic surgery that can more-or-less address those issues. Do some research on Aubrey de Grey and the SENS foundation, as well as Google's Calico Laboratories. I can assure you, you'll live to live to see the day of perfect, wrinkle-free, scar-free skin (and possibly live few extra hundred years in the process). :D

 

http://www.sens.org/

 

http://www.calicolabs.com/

 

 

 

Well I do like your optimism. But I fear it's misguided. The most accurate prediction engine of at what point such medical developments will be available is futurtimeline.com These are conducted by rigorous scientists and futurologists. They predict anti-aging therapies may only begin to be a reality past 2060 and we would need that before we can heal scars fully because most of us will be so old it won't even matter if we have scars they'll be underneath our wrinkles!

 

http://www.futuretimeline.net/21stcentury/2060-2069.htm#.VYsH5xNVhHx

 

Well, perhaps we should all give up then, huh?

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MemberMember
378
(@rez77)

Posted : 06/24/2015 9:28 pm

I actually think forgetting about all this for a couple decades could be a really good idea.

 

2007: "Im unsure if many people here have heard of this product but seems to be quite promising, and not like another 20 years away either. The crux of it seems to be that after an operation, (not specifically acne scar revision) but similar, the companies lead product juvista is injected into the wound margins and scarring is significantly reduced. They appear to have other products as well in the pipeline for internal scarring also. If u were going to have an excision or similar this seems the way to go. Anyways definately worth checking out!!!

 

http://www.renovo.co...tent.asp?c_id=9 "

 

 

That was seven years ago....

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MemberMember
68
(@rudy1986)

Posted : 06/25/2015 3:42 am

Rickrolled is very catchy song..

 

Listen to the song and you could forget your scarring.

 

THats the logic you are arguing

 

No factual basis..

just stick with gemstone portfolio.. its our last hope. Dont bother on current treatments

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MemberMember
24
(@jackdoe)

Posted : 06/25/2015 5:04 am

Give up? No. But instead of waiting for something that may never come, you should try other methods. Some people are getting great results with things such as subcision +suction, dermarolling, single needling, tca cross, etc. Dermarolling not working? Maybe try a different topical. OR maybe your dermaroller was crappy. Or perhaps you were too impatient and dermarolled your face way too frequently, not giving your face a long enough break before attacking it again. Or maybe you didn't keep your face moisturized well enough. Or maybe look at your diet. Are you getting all the necessary nutrients your body requires to heal? Are you eating enough healthy fats? Fat soluble vitamins, water soluble vitamins, enough minerals? Too much junk food? Maybe you have a food allergy/sensitivity that's preventing your body to focus on healing, or hormones aren't working quite right effecting the way your body heals. Been on antibiotics? Perhaps your body's gut flora/ stomach acid is too weak to break down food and absorb nutrients properly. Perhaps your exercising too hard, doing to much strenuous cardio that's stealing all the energy to heal, or maybe your not exercising enough and you have a static blood flow. There's a million different factors that affect healing including stress and depression. Don't be reckless, but go experiment with different tactics and keep going, and do something that makes you happy while waiting for a miracle cure.

e up then, huh?

 

I like it. The good post.

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MemberMember
68
(@rudy1986)

Posted : 06/25/2015 5:25 am

What about my post then roach?

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MemberMember
24
(@jackdoe)

Posted : 06/25/2015 6:19 am

What about my post then roach?

 

I can't just wait. No doubt, the hydrogel is last hope to cure, but if I can improve my things by that time, then I'm gonna do everything in my power.

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MemberMember
24
(@jackdoe)

Posted : 06/25/2015 12:29 pm

Does anyone know answeres to these questions?

 

Maldition, You have been showing a lot of interest towards making this hydrogel. I thought I will share whatever I have read so far -

 

They said "We dissolved Dex-AE/PEGDA at the ratio of 60/40 and 80/20 (means Dex-AE80% and PEGDA20%)

into phosphate-buffered saline (PBS) containing 0.1% (wtwt)

2-methyl-1-[4-(hydroxyethoxy)phenyl]-2-methyl-1-propanone

(Irgacure 2959, Ciba). The mixture was pipetted into a sterile

mold (70-L volume per well) to obtain discs measuring 8 mm

in diameter by 2 mm in thickness and photopolymerized (approximately 10 mWcm2

of UV light for 10 min; Black-Ray, UVP).

We removed the resulting hydrogels from the mold and immersed

them in sterile PBS solution before application onto wounds."

 

The above steps has two ratios - one is 60/40 and other is 80/20. 80/20 ratio is shown to be more effective in skin re-generation in mice.

 

The wounds, after applying the hydrogel on them were covered with dressings which are easily available in market.

 

From what I read and what I imagine, we would need the following to give any realistic shot at preparing the hydrogel -

 

1) Dex-AE (Dextan Allyl Iso cynatae Ethylamine) (needs dextran, other chemicals and lab setup to be synthesized) - This is not available in market and needs to be synthesized in a lab. Looks to be a possible but little complicated and time consuming procedure. The following paper by Dr.Sun discusses the procedure. There are many variables in this preparation procedure depending on which, some properties of final Dex-AE synthesized may vary. I don't know which variant of the Dex-AE was used in the experiment with Mice. If anybody does, I would be glad to know.

 

Synthesis, characterization of biodegradable dextranallyl isocyanateethylamine/polyethylene glycoldiacrylate hydrogels and their in vitro release of albumin

 

http://www.sciencedi...144861706000221

 

 

2) PEGDA/Poly ethylene glycol diacrylate - The good news is PEGDA is available in the market (available in sigmaaldrich.com and it looks like anyone can order this), but the bad news is Sigma provides three variants of it, based on molecular weight I guess (Mn250, Mn575 and Mn700). Again, i don't know which one of these, if one of these was used in the experiment with Mice. Another alternative is what they did at JHU lab - they synthesized their own PEGDA. The above paper discusses the synthesis of PEGDA too and it looks like there are not many variants in the procedure, so it should be fairly less complicated.

3) Phosphate buffered Saline.

4)Photoinitiator - 2-methyl-1-[4-(hydroxyethoxy)phenyl]-2-methyl-1-propanone (Irgacure 2959, Ciba) - Looks like available in Ciba

5) UV light source ( I don't know what wavelength was the light source, if the wavelength mattered at all - Again, i would be glad to know if someone already knows this)

6) A bio tech student/scientist who has access to a state of the art bio tech lab facility and who would be ready to do this.

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MemberMember
24
(@jackdoe)

Posted : 06/26/2015 12:29 am

Guys, seriously, I find a doc and some labs and I'm gonna show em the papers. If you know anything that may be helpful, please let me know.

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MemberMember
68
(@rudy1986)

Posted : 06/26/2015 4:58 am

You will ruin your own face if you do so

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MemberMember
24
(@jackdoe)

Posted : 06/26/2015 6:47 am

I can't ruin the ruins.

 

Help me or not, I'll do it anyway.

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MemberMember
378
(@rez77)

Posted : 06/27/2015 12:38 am

I can't ruin the ruins.

 

Help me or not, I'll do it anyway.

 

 

Show don't tell. Talk is cheap.

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MemberMember
12
(@hydrogel)

Posted : 06/27/2015 1:34 am

I'm just gonna start wearing a really cool mask in public :D Problem solved

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0
(@Anonymous)

Posted : 06/27/2015 9:09 am

I'm sure this has already been posted, but I'll post it again. According to the Gemstone Facebook page:

This month Baltimore startup Gemstone Biotherapeutics has raised $1.6 million as it races to bring to market a synthetic material for healing wounds.

The financing round was led by founding investor Gamma 3 LLC in Baltimore. The new funding brings Gemstones total seed funding to $2.45 million.

and on April 30th they posted:

Firming up plans for regulatory submittal and first in human trials. Will update accordingly.

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MemberMember
29
(@cycloverid)

Posted : 06/27/2015 3:30 pm

Here's another article about electrical currents regenerating skin:

 

http://www.bizjournals.com/boston/blog/health-care/2015/06/mgh-researchers-use-common-technology-to.html

 

œYou stick your finger in a fire, you burn it and get a scar. With this you don™t end up with scarring, said Dr. Martin Yarmuch, director of the MGH Center for Engineering in Medicine and one of the researchers. œThat™s the key here. From an academic standpoint, it™s interesting to observe it. From an application standpoint, you get scar-less results.

 

Specifically the technology is called 'pulsed electrical fields' for anyone interested.

 

I've never seen a study this optimistic about electricity being used for scarring. Add this to the growing list of treatments that would be non-invasive, probably very cheap, and with the potential to heal skin without scarring. I'm going to look up the paper that this article refers to.

 

Here's a quote on the same story, different article: ( http://www.massgeneral.org/about/pressrelease.aspx?id=1822 )

"Our results show that the procedure is safe, does not lead to scarring and increases skin metabolism and cell proliferation, says Martin Yarmush, MD, PhD, director of the MGH Center for Engineering in Medicine and corresponding author of the paper. œWe now need to investigate the impact of PEF treatment on aged skin, as well as on skin with other forms of damage, and we are looking for funding to help us design, build and test a device for clinical application.

 

I hope someone funds them :)

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MemberMember
68
(@rudy1986)

Posted : 06/29/2015 4:07 am

Scarring myth:

 

Whenever you are wounded: apply egg yolk

 

No scar would occur

 

Reference : thoughty2 youtube

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MemberMember
21
(@repola)
MemberMember
21
(@repola)

Posted : 06/29/2015 5:18 pm

It is very disturbing, I hate when they say, might, may, would, most of the scientific papers have this words but it is only smoke. Science is something testable, verifiable. This is only bullshit.

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MemberMember
16
(@pursuit-of-happyness)

Posted : 06/29/2015 8:41 pm

Because " in painful reality ", you need clinical trials , you have FDA obstruction and you needs investors "money" !!!

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MemberMember
68
(@rudy1986)

Posted : 06/29/2015 8:47 pm

"Whether the same could be true of existing scars isnt clear yet"

 

That quote drives me insane

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MemberMember
24
(@jackdoe)

Posted : 07/01/2015 1:09 am

One of these days I'm gonna give the papers to the doctor. Your last chance to make a contribution. If there is anything to say, now is the time. Thank you all!

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MemberMember
24
(@jackdoe)

Posted : 07/02/2015 3:36 am

Rudy, if the hydrogel promotes scar free healing, but without complete regeneration, what is it then?

 

ab5dd285205353d9b17b05ea3a4de67b.jpeg

 

Seabs said if a wound covers in under 14 days then it won't be a scar. Rudy said that rete don't exist on scars. But what I see in the picture then?

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MemberMember
68
(@rudy1986)
MemberMember
3
(@roboricky)

Posted : 07/03/2015 2:44 am

I think I posted this a while back, but here's a reminder: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996784/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937506/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937507/ Long story short, there's a new combination of treatment methods that's been going around and is very promising. It's readily available because it's just a combination of established methods, and it's cheap. Read up on these links, talk to your dermatologist of choice, and enjoy. Figured you guys would jump at this rather than wait God knows how long for new science to break way.

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JackDoe, hydrogel, JackDoe and 3 people reacted