Lapis, why is George Davis of gemstone willing to invest 15 yers of testing? Isnt he old enough?

 

I don't understand the question.

 

Hey team,

 

It seems there is a great deal of potential with Gemstone's biosynthetic scaffold to initiate scarless healing in both acute and chronically scarred dermal tissue. Additionally, Gemstone is getting a great deal of attention from investors: http://www.baltimoresun.com/business/bs-bz-gemstone-biotherapeutics-20150605-story.html - hopefully the additional funding will speed up trials. A real viable solution could be around the corner. My only concern at the moment is that Gemstone may not be considering or interested in the potential "cosmetic" applications of the hydrogel. Similar to Avita Recell, the focus seems to be on urgent and chronic wound care.

 

1. Is there any information or evidence suggesting Gemstone's hydrogel COULD be used for the cosmetic treatment of dermatological problems such as acne scarring?

 

2. Has any member of the Acne.org community reached out to Gemstone Biotherapeutics to inquire about the hydrogel's potential use for cosmetic use? If not, this may be a good idea. I would recommend a group of us draft a document expressing our questions and concerns, then find a way to advance that document to a reputable member of Gemstone Biotherapeutics. Thus, we may be able to get the answers we need instead of simply speculating. Again, this is unless someone here can produce a tangible document released by Gemstone alluding to the hydrogel's use for cosmetic purposes.

 

Thanks!

 

I don't get what you mean seeing that the end result of being treated with something that enables the skin to regenerate is regenerated skin. So you wouldn't need cosmetic surgery after treatment.

I think he means that Gemstone may not have considered using Hydrogel for cosmetic purposes. Gemstone only mentioned how the Hydrogel is able to heal 3rd degree burns, but they have not mentioned using it for other purposes like cosmetic (acne scars). This whole thread might be for nothing unless we know if the Hydrogel can be catered for people with acne scarring, and other scars. Honestly, this speculating on the potential of the Hydrogel is just getting us nowhere. I would like the hard facts from a reptuable person from Gemstone as well.

They have mentioned using it for scarring caused by other traumas. For instance here:

Our primary development studies are centered on our novel dextran-based hydrogel for scar-free wound healing. Our hydrogels are produced from original protocols and are highly tunable, meaning they can easily be tailored for specific wound healing applications.

I think he means that Gemstone may not have considered using Hydrogel for cosmetic purposes. Gemstone only mentioned how the Hydrogel is able to heal 3rd degree burns, but they have not mentioned using it for other purposes like cosmetic (acne scars). This whole thread might be for nothing unless we know if the Hydrogel can be catered for people with acne scarring, and other scars. Honestly, this speculating on the potential of the Hydrogel is just getting us nowhere. I would like the hard facts from a reptuable person from Gemstone as well.

Also, achieving regenerated skin after a burn wound isn't just done for functional reasons. It's also for cosmetic reasons. The cosmetic side might not be the first priority but it's without a doubt part of it all.

The basic principle of wound healing is always the same. So why would something enable the body to regenerate skin only when the damage is caused by one specific thing? It only matters so much what caused the damage. The point is, there is no skin where at one point there was and from that point the body starts fixing things. That's always the same with every wound, isn't it? Whether the loss of skin was caused by an incision or fire or whatever you can think of.

What sooner matters is the location of the wound. Depending on where the wound is, it's a greater or smaller challenge for the surgeon to go in and do what needs to be done. That's sooner a "worry", I'd say. But the hydrogel (should it work) basically just does what it does regardless of the cause of injury.

Also, for those of you who actually think the hydrogel (should it work) can "only" fix a third degree burn wound but not acne scarring (just listen to how that sounds) they mention on their website that they are currently designing a trial for the gel's ability to achieve the same results when it comes to "acute wounds". These are defined as follows:

http://www.woundcarecenters.org/article/wound-types/acute-wounds

Ok?

 

Hey team,

 

It seems there is a great deal of potential with Gemstone's biosynthetic scaffold to initiate scarless healing in both acute and chronically scarred dermal tissue. Additionally, Gemstone is getting a great deal of attention from investors: http://www.baltimoresun.com/business/bs-bz-gemstone-biotherapeutics-20150605-story.html - hopefully the additional funding will speed up trials. A real viable solution could be around the corner. My only concern at the moment is that Gemstone may not be considering or interested in the potential "cosmetic" applications of the hydrogel. Similar to Avita Recell, the focus seems to be on urgent and chronic wound care.

 

1. Is there any information or evidence suggesting Gemstone's hydrogel COULD be used for the cosmetic treatment of dermatological problems such as acne scarring?

 

2. Has any member of the Acne.org community reached out to Gemstone Biotherapeutics to inquire about the hydrogel's potential use for cosmetic use? If not, this may be a good idea. I would recommend a group of us draft a document expressing our questions and concerns, then find a way to advance that document to a reputable member of Gemstone Biotherapeutics. Thus, we may be able to get the answers we need instead of simply speculating. Again, this is unless someone here can produce a tangible document released by Gemstone alluding to the hydrogel's use for cosmetic purposes.

 

Thanks!

 

I don't get what you mean seeing that the end result of being treated with something that enables the skin to regenerate is regenerated skin. So you wouldn't need cosmetic surgery after treatment.

I think he means that Gemstone may not have considered using Hydrogel for cosmetic purposes. Gemstone only mentioned how the Hydrogel is able to heal 3rd degree burns, but they have not mentioned using it for other purposes like cosmetic (acne scars). This whole thread might be for nothing unless we know if the Hydrogel can be catered for people with acne scarring, and other scars. Honestly, this speculating on the potential of the Hydrogel is just getting us nowhere. I would like the hard facts from a reptuable person from Gemstone as well.

Thank you, Keenfruit. That was exactly what I was getting at with my questions. Now, based upon the research we've seen thus far, I'd say that it is HIGHLY probable that such a product could be used for cosmetic applications. Granted, if this were actually the case, the reach of such a product would be far beyond that of treating 3rd degree burns and chronic wounds per se; even beyond acne scarring for that matter. We're talking about total, scar-free skin resurfacing that could treat an array of dermatological conditions that current ablative procedures and resurfacing techniques cannot (at least alone). Under that presumption, in combination with a resurfacing procedure, the hydrogel scaffold COULD treat acne scars, large pores, wrinkles, bad texture, baldness, severe dermatitis, sun damage; the list goes on and on. It would radically and exponentially change the cosmetic and plastic surgery industry BUT the catch is we cannot be certain that this is or will be the intent of Gemstone now or at anytime in the future. What we're inferring here is that we purposely damage tissue to regenerate using a hydrogel scaffold that seems to be intended strictly for wounds. Again, this is not to say that cannot or will not be used for cosmetic purposes but I would certainly like some more straight forward answers that offer more than hope. I want a definitive yes or no answer from someone on the inside.

Not to get off topic here but I think Aubrey de Grey put it perfectly. Grey is a biomedical gerontologist and Chief Science Officer of the SENS Research Foundation, which does pioneering anti-aging and age reversal regenerative research. Grey stated that many of the techniques in various medical disciplines are phenomenally good at producing complex proverbial band-aids for medical issues. From dermatology to oncology, medicine can treat and suppress symptoms associated with maladies and disease but seldom do they actually address the underlying issue at a biological level. Cosmetic dermatology is great at producing band-aids for issues but most of these treatment are a shot in the dark because everyone's skin is different, thus will react differently to whatever procedure - sometime positively but more often than not unfortunately negatively. My opinion but I'd go as far saying some procedures are akin to dangerous, experimentation rather than actual solutions. What good will ever come of slathering chemicals and ablating or resurfacing already distressed skin in hopes that it'll "help"? It doesn't, it won't, it never will.

I'm proud to see medicine is finally jumping on the regenerative medicine bandwagon because most medical practices as is over this past century have been great band-aids for issues, but seldom viable solutions (a.k.a cures). From a economic standpoint, people suffering from medical ailments cost the economy more per capita annually then those that are happy and healthy. Sure, there will be money invested in "treatments" and visits to the doctor but what happens when a once productive individual can't continue to produce? They have no money to spend, they become a drain on the medical industry and insurance companies, and their employer is losing valuable labor resources which produces a deficit somewhere else in the market. This is my opinion but I truly believe regenerative medicine is the answer to such economic issues caused by biologically addressable diseases and ailments.

Cosmetic dermatological maladies should be treated as serious diseases as they produce a host of secondary issues, often psychological in nature. When you don't look your best, you don't feel your best. That's understandable in a society that places a great deal of emphasis on appearance. And when you don't feel your best, thus begins the endless cycle of despair that causes the aforementioned issues that not only impact you but the people around you. Lastly, the treatments we have available today, as politely as I can put it, suck! The shear number of issues caused by resurfacing procedures alone is horrifying. Not to mention, even though a clear risk exists using such procedures, these treatments are pushed to already desperate and hurting people as solutions. Some plastic surgeons and dermatologists should really do some soul searching if you ask me. As Grey would put, it's a band-aid. And a really crappy one at that which rips off the scab leaving and open wound afterwards.

Acne is hell, along with a host of other cosmetic conditions, that can and should be addressed. It affects 40-50 million people in America alone on an annual basis (that's nearly 1 in every 6 Americans). So, I really do think it's time we sought out answers, evidence that work is being done to address these issues. The proverbial band-aid just is cutting it anymore. Hydrogel has an immense amount of potential and it COULD be the answer. But we'll never no for certain unless we seek out answers. So, with that being said, I purpose we make a concentrated effort to reach out to Gemstone and raise out questions to them. I think they'd be more than blown away that the Acne.org community has been following this development so closely over the past few years. I believe the least they could do is provide us some more guided insight into their research, and perhaps a bit more than just a glimmer of hope.

• Address:810 Wyman Park Drive,

  Suite 400A

  Baltimore, Maryland 21211

• Phone:(443) 873-7010
• Fax:(443) 873-7010
• Email:[email protected]
• Office Hours:Monday“Friday, 8:00“19:00

It's time to get some answers.

 

They have mentioned using it for scarring caused by other traumas. For instance here:

 

Our primary development studies are centered on our novel dextran-based hydrogel for scar-free wound healing. Our hydrogels are produced from original protocols and are highly tunable, meaning they can easily be tailored for specific wound healing applications.

 

 

I think he means that Gemstone may not have considered using Hydrogel for cosmetic purposes. Gemstone only mentioned how the Hydrogel is able to heal 3rd degree burns, but they have not mentioned using it for other purposes like cosmetic (acne scars). This whole thread might be for nothing unless we know if the Hydrogel can be catered for people with acne scarring, and other scars. Honestly, this speculating on the potential of the Hydrogel is just getting us nowhere. I would like the hard facts from a reptuable person from Gemstone as well.

 

 

Also, achieving regenerated skin after a burn wound isn't just done for functional reasons. It's also for cosmetic reasons. The cosmetic side might not be the first priority but it's without a doubt part of it all.

 

 

The basic principle of wound healing is always the same. So why would something enable the body to regenerate skin only when the damage is caused by one specific thing? It only matters so much what caused the damage. The point is, there is no skin where at one point there was and from that point the body starts fixing things. That's always the same with every wound, isn't it? Whether the loss of skin was caused by an incision or fire or whatever you can think of.

 

What sooner matters is the location of the wound. Depending on where the wound is, it's a greater or smaller challenge for the surgeon to go in and do what needs to be done. That's sooner a "worry", I'd say. But the hydrogel (should it work) basically just does what it does regardless of the cause of injury.

 

 

Also, for those of you who actually think the hydrogel (should it work) can "only" fix a third degree burn wound but not acne scarring (just listen to how that sounds) they mention on their website that they are currently designing a trial for the gel's ability to achieve the same results when it comes to "acute wounds". These are defined as follows:

 

http://www.woundcarecenters.org/article/wound-types/acute-wounds

 

Ok?

Interesting. Thank you for the information.

Also, I would like to draw attention to Replicel:

http://replicel.com/product-pipeline/rcs-01-skin-rejuvenation/

Like I said in my previous post, Gemstone has already clearly stated they aim for the hydrogel to be used for people with acne scars. Maybe they didn't type "acne scars" on their website but it's unambiguously stated.

A scar free wound healing product is inherently something which in part has to do with producing cosmetic improvement.

Like I said in my previous post, Gemstone has already clearly stated they aim for the hydrogel to be used for people with acne scars. Maybe they didn't type "acne scars" on their website but it's unambiguously stated.

 

A scar free wound healing product is inherently something which in part has to do with producing cosmetic improvement.

Well that is reassuring but it'd feel better to know just what exactly they are doing and how they will cater to people with acne scarring. Just some detail on the hydrogel will make most of us feel relieved, I believe. I can't follow every single page of this thread so I apologize if I am ignorant of certain things Gemstone pointed out. I'm sure a lot of us would like to know specific details of this project. I know it works for 3rd degree burns so it'll and should work for all types of scarring. There are just some few details that would be most helpful as hydrogel pointed out that some people might worry about. "Acne scars, large pores, wrinkles, bad texture, baldness, severe dermatitis, sun damage; the list goes on and on." Not only that but there could be more information that we can derive from the team such as the clinical trials and when it will be available to the market. I don't see any reason why not to contact them and ask for infomation about it. Again I apologize if I don't know every single detail about Gemstone's hydrogel. Perhaps, we could use the direct information of Gemstone to set out clear and reliable information of hydrogel on another thread or somewhere. Let's stay optimistic.

 

Like I said in my previous post, Gemstone has already clearly stated they aim for the hydrogel to be used for people with acne scars. Maybe they didn't type "acne scars" on their website but it's unambiguously stated.

 

A scar free wound healing product is inherently something which in part has to do with producing cosmetic improvement.

 

Well that is reassuring but it'd feel better to know just what exactly they are doing and how they will cater to people with acne scarring. Just some detail on the hydrogel will make most of us feel relieved, I believe. I can't follow every single page of this thread so I apologize if I am ignorant of certain things Gemstone pointed out. I'm sure a lot of us would like to know specific details of this project. I know it works for 3rd degree burns so it'll and should work for all types of scarring. There are just some few details that would be most helpful as hydrogel pointed out that some people might worry about. "Acne scars, large pores, wrinkles, bad texture, baldness, severe dermatitis, sun damage; the list goes on and on." Not only that but there could be more information that we can derive from the team such as the clinical trials and when it will be available to the market. I don't see any reason why not to contact them and ask for infomation about it. Again I apologize if I don't know every single detail about Gemstone's hydrogel. Perhaps, we could use the direct information of Gemstone to set out clear and reliable information of hydrogel on another thread or somewhere. Let's stay optimistic.

Just wanted to let you guys know that I did contact them via email. I will also leave a voice message. This is the email that I wrote:

Greetings,

Also, I don't know if you guys saw my previous link but Replicel is another company to keep an eye on:

replicel.com/product-pipeline/rcs-01-skin-rejuvenation/

From the CEO of Replicel, David Hall: "RCS-01 is focused on replacing damaged or non-functioning fibroblasts in the dermis. Fibroblasts damaged by UV irradiation, smoking and other factors stop producing healthy amounts of collagen and the constituents of the skin™s extracellular matrix. As a result, the skin loses its texture. Similarly, acne and burn scars are targets for us to deliver highly expressive fibroblasts to initiate remodelling of the damaged skin. The supporting manufacturing technology is also a critical asset to the company as we believe our process is scalable."

Initial human clinical trails will start this year and are projected to end by 2018.

A fairly long time ago I e-mailed Sharon Gerecht and she never replied. She may not even have read my message. But let us know what they said if they responded to your message, hydrogel.

A fairly long time ago I e-mailed Sharon Gerecht and she never replied. She may not even have read my message. But let us know what they said if they responded to your message, hydrogel.

I'll follow up Dr. Gerecht and see if we can get a response.

Guys,

I also want to emphasize how important it is for you to make your voices heard as well. I am only one individual but if we work together we can get the answers we seek. If you have not reached out to Gemstone, I implore you to do so. It only takes two minutes for you to write a short email or leave a quick voice mail. You may even copy/paste my message from above if you like. Let's get some more movement on this!

• Address:810 Wyman Park Drive,

  Suite 400A

  Baltimore, Maryland 21211

• Phone:(443) 873-7010
• Fax:(443) 873-7010
• Email:[email protected]
• Office Hours:Monday“Friday, 8:00“19:00

Blatchley contacted me once

Seabs, is your summary topical at this point?

It'd be great if someone make a new summary.

I emailed them months ago but I just emailed them again today. Hopefully a response.

Hey guys,

I just wanted to let you guys know that I did reach out to Gemstone and Dr. Gerecht via email yesterday evening but I have yet to receive a response. If I do not here anything by about this time next week, I'll send a follow up email. Hopefully that won't be perceived as pestering. Besides, I'm a potential future customer

On that note, any updates or new developments that you guys have been tracking since today or yesterday? And again, I haven't heard anything back from you guys on that new company that I found named Replicel.

Also, I don't know if you guys saw my previous link but Replicel is another company to keep an eye on:

replicel.com/product-pipeline/rcs-01-skin-rejuvenation/

From the CEO of Replicel, David Hall: "RCS-01 is focused on replacing damaged or non-functioning fibroblasts in the dermis. Fibroblasts damaged by UV irradiation, smoking and other factors stop producing healthy amounts of collagen and the constituents of the skin™s extracellular matrix. As a result, the skin loses its texture. Similarly, acne and burn scars are targets for us to deliver highly expressive fibroblasts to initiate remodelling of the damaged skin. The supporting manufacturing technology is also a critical asset to the company as we believe our process is scalable."

Initial human clinical trails will start this year and are projected to end by 2018.

Check it out and let me know what you think.

Hydrogel, doean't mean to be rude here. But i caught no interest in something that doesnt state

"Complete regeneration, scar free, hair follicle, skin ppendages"

Also the article state about injecting..

Injecting doesnt make your scars vanish

Hell i will take it anytime as long as rete ridges was similar to my healthy skin when observed with mason's trichomme.

 

even sun wouldnt able to tell if it is a scar

Okay. Show me where the "rete ridges" are. The untranslatable phrase...

Just wanna read more about that on my native language.

So, you mean if the hydrogel restore the rete ridges even with partial scarring the wound will be flat and normal skin colored, won't it?

Replicel, it seems to me only improves the appearance (perhaps). It's not interesting compared to the hydrogel which (according to Gemstone) has the potential to truly regenerate skin.

Fibroblasts damaged by UV irradiation, smoking and other factors stop producing healthy amounts of collagen and the constituents of the skins extracellular matrix.

Shit...

Think of rete ridges like this

Epidermis is north korea, while dermis is south korea

Rete ridges is a border between north and south.

When injury happen , dermis (south korea) is pushed back deeper.. the border automatically destroyed and replaced by scar tissue..

By definition if after injury the rete ridges / border comes back to wht it was (similar to helthy skin), meaning the dermis / south korea regin its original position

In your picture , between epidermis and dermis there is a small valley that looks like :

nununununu

Thats rete ridges

When injry happens it will become something like

nununu_____ nununu

Thats right, it will become underscore instead a collection of

Nunununu

If even with masson trichome the state the nununu waa similar ,

Meaning sun will also be not able to tell

Ok, I got it. The good answer. Thanks.

BTW, does it mean that epidermis regenerates completely? If I get it right, the epidermis gives the skin its color and texture. Then a wound will look like the healthy tissue.

Epidermis regenerate completely, while dermis could also regenerate, it usually doesnt

Epidermis regenerate completely, while dermis could also regenerate, it usually doesnt

So, I happy with that. It will look flat and skin colored. Only thing that may remain is sealing (I dunno how to say it on English. I mean that area will be tighter than normal tissue.) But who will touch your skin?

They need funding

They just got $2.5m in funding

http://www.baltimoresun.com/business/bs-bz-gemstone-biotherapeutics-20150605-story.html

anyone got a reply from them?