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[Sticky] Scarless Healing

 
MemberMember
68
(@rudy1986)

Posted : 05/22/2015 8:45 am

Scar free myth

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MemberMember
24
(@jackdoe)

Posted : 05/22/2015 12:09 pm

Nice before and after pic of recell. Costs 2500 pounds in UK I think..

 

http://www.ukcosmeticclinic.co.uk/Recell-spray-on-skin-in-Kings-Lynn-and-Peterborough

 

The lighting is different.

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MemberMember
24
(@jackdoe)

Posted : 05/22/2015 12:29 pm

http://www.sciencedirect.com/science/article/pii/S0142961212013348

 

Abstract

 

Scar inhibition of dermal equivalent is one of the key issues for treatment of full thickness skin defects. To yield a bioactive RNAi functionalized matrix for skin regeneration with inhibited scarring, collagen-chitosan/silicone membrane bilayer dermal equivalent (BDE) was combined with trimetylchitosan (TMC)/siRNA complexes which could induce suppression of transforming growth factor-1 (TGF-1) pathway. The RNAi-BDE functioned as a reservoir for the incorporated TMC/siRNA complexes, enabling a prolonged siRNA release. The seeded fibroblasts in the RNAi-BDE showed good viability, internalized the TMC/siRNA complexes effectively and suppressed TGF-1 expression constantly until 14 d. Application of the RNAi-BDE on the full-thickness skin defects of pig backs confirmed the in vivo inhibition of TGF-1 expression by immunohistochemistry, real-time quantitative PCR and western blotting during 30 d post surgery. The levels of other scar-related factors such as collagen type I, collagen type III and -smooth muscle actin (-SMA) were also down-regulated. In combination with the ultra-thin skin graft transplantation for 73 d, the regenerated skin by RNAi-BDE had an extremely similar structure to that of the normal one. Our study reflects the latest paradigm of tissue engineering by incorporating the emerging biomolecule siRNA. The 3-D scaffolding materials for siRNA delivery may have general implications in generation of bioactive matrix as well.

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MemberMember
68
(@rudy1986)
MemberMember
24
(@jackdoe)

Posted : 05/23/2015 2:26 am

Can I get the PDF?

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MemberMember
68
(@rudy1986)

Posted : 05/23/2015 3:55 am

Theres no pdf

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MemberMember
24
(@jackdoe)

Posted : 05/23/2015 4:22 am

I can't even translate the text... Dammit.

 

Tell me please in a nutshell. Hope you are not too busy))

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MemberMember
101
(@lapis-lazuli)

Posted : 05/23/2015 1:01 pm

 

At the end of page 58 they seem to say that the results they achieved was a dermis that had a normal architecture after treatment with "gelatin spheres". That's interesting. I'll read the whole thing later on. Thanks for posting.

 

Dermalregeneration_zps6kt2o2ds.png

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MemberMember
24
(@jackdoe)

Posted : 05/23/2015 1:06 pm

Damn, guys, how can I print this book? I gotta show it to the doc.

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MemberMember
68
(@rudy1986)

Posted : 05/23/2015 8:12 pm

Yeah, its recently posted at 2015 to prove that HUMAN can REGENERATE DERMIS. Its the best article i find thprughout may

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MemberMember
68
(@rudy1986)

Posted : 05/23/2015 8:48 pm

Damn, guys, how can I print this book? I gotta show it to the doc.

You cant show it to the doc just yet Roach, although it is in human, it is experimental

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MemberMember
68
(@rudy1986)
MemberMember
24
(@jackdoe)

Posted : 05/25/2015 12:58 am

You cant show it to the doc just yet Roach, although it is in human, it is experimental

 

I'm a goddamn brave guy.

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MemberMember
24
(@jackdoe)

Posted : 05/25/2015 12:06 pm

Okay, dextran hydrogel doesn't work. What we're talking about now?

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MemberMember
68
(@rudy1986)

Posted : 05/25/2015 10:20 pm

ghost stories perhaps?

Okay, dextran hydrogel doesn't work. What we're talking about now?

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MemberMember
68
(@rudy1986)

Posted : 05/26/2015 7:12 am

I dont get it why people here said hydrogel failed. Fail = not scar free healing in human.

 

seeing regenerative response, they could've just accelerate it to human Like what they are doing right now.

 

Rete ridges are rarely regenerates in scar, if any.

 

thats sign of regeneration

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MemberMember
24
(@jackdoe)

Posted : 05/26/2015 12:21 pm

Porcine wound healing is considered to be most similar to that of humans and as a translational model, pigs display the greatest concordance with human trials. First, porcine skin most closely resembles human skin both anatomically and physiologically. Both have similar dermal-epidermal thickness ratio and dermal vascularization pattern. Biochemically, porcine and human skins have similar collagen matrix and keratinous proteins. Studies have also shown an excellent agreement between pig and human with respect to wound healing responses from growth factors.

 

Just because of that.

 

Anyhow, I believe that it can regenerate dermal wounds. Scar by scar. The most noticeable in the first place, next time another ones. It's impossible to cut your whole cheek out and regenerate it.

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MemberMember
73
(@seabs135)

Posted : 05/26/2015 12:34 pm

There has been an announcement on the gemstone Facebook page.

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MemberMember
5
(@skinregenerator)

Posted : 05/26/2015 1:19 pm

There has been an announcement on the gemstone Facebook page.

about what?

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MemberMember
24
(@jackdoe)
MemberMember
101
(@lapis-lazuli)

Posted : 05/26/2015 6:24 pm

"Positive results from recently completed study of our Biosynthetic Wound Therapeutic approved for a pending publication in the Journal of Investigative Dermatology."

 

That sounds promising. I will keep track of it.

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MemberMember
5
(@skinregenerator)

Posted : 05/26/2015 9:18 pm

"Positive results from recently completed study of our Biosynthetic Wound Therapeutic approved for a pending publication in the Journal of Investigative Dermatology."

 

That sounds promising. I will keep track of it.

they call that positive?

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MemberMember
68
(@rudy1986)

Posted : 05/26/2015 11:28 pm

What do you guys think about the recent post from facebook?

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MemberMember
24
(@jackdoe)

Posted : 05/26/2015 11:58 pm

It's positive results, but not scar-free.

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MemberMember
101
(@lapis-lazuli)

Posted : 05/27/2015 6:06 am

 

"Positive results from recently completed study of our Biosynthetic Wound Therapeutic approved for a pending publication in the Journal of Investigative Dermatology."

 

That sounds promising. I will keep track of it.

they call that positive?

 

What exactly are they referring to according to you? Which results are they referring to which you wouldn't describe as positive?

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