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Currently available skin grafts and skin substitute for healing following third-degree burn injuries is fraught with complications, often resulting in long-term physical and psychological sequelae. Synthetic treatment that can promote wound healing in a regenerative fashion would provide an off-the-shelf, non-immunogenic strategy to improve clinical care of severe burn wounds. Here, we demonstrate vulnerary efficacy and accelerated healing mechanism of dextran-based hydrogel in third-degree porcine burn model. The model was optimized to allow examination of the hydrogel treatment for clinical translation and its regenerative response mechanisms. Hydrogel treatment accelerated third-degree burn wound healing by rapid wound closure, improved reepithelialization, enhanced extracellular matrix remodeling, and greater nerve reinnervation, compared to the dressing treated group. These effects appear to be mediated through the ability of the hydrogel to facilitate a rapid but brief initial inflammatory response that coherently stimulates neovascularization within the granulation tissue during the first week of treatment, followed by an efficient vascular regression to promote a regenerative healing process. Our results suggest that the dextran-based hydrogels may substantially improve healing quality and reduce skin grafting incidents and thus pave the way for clinical studies to improve the care of severe burn injury patients.
Thats what the abstract said
as expected, its the same results as you see in the greco thesis
Timing is important to wound healing. Critically, the timing of wound reepithelialization can decide the outcome of the healing.[12] If the epithelization of tissue over a denuded area is slow, a scar will form over many weeks, or months;[13][14] If the epithelization of a wounded area is fast, the healing will result in regeneration.
It can be understandable if they aim for faster wound healing after all..
When they saw the significnce of wound healing rate in porcine, they jumped into "regenerative" conclusion..
With this in hand, they just directly go into human trials
this is nonsense. I once had a small injury. 3 days later there was skin over it already, but its scar
haha we become paranoid of every small wounds
Bloodwar, it would not become scar if its still healing within 21 days
Hydrogel works on the concept to faster wound healing so that it is regenerating
Fibroblast proliferation would take longer than 3 days to produce scar
From the abstract did you see anywhere they state complete regeneration roach?
No, but I saw it in the mouse study. And again, what does it mean? It means it's possible. And also, as already said, the acne scarring ain't so huge and deep, so it will heal faster and better. Another thing, they still can add growth factors and stem cells.
You guys have contacts with researchers. Just ask them.
this hasnt been discussed, this is just a recent abstract..
they emphasize regenerative mechanism. Thats what i am curious about
its the same content if you compare it with the thesis
Can i please check the content (not the thesis)
Btw like i said, it might be at the end of our generation
From the abstract did you see anywhere they state complete regeneration roach?
No, but I saw it in the mouse study. And again, what does it mean? It means it's possible. And also, as already said, the acne scarring ain't so huge and deep, so it will heal faster and better. Another thing, they still can add growth factors and stem cells.
You guys have contacts with researchers. Just ask them.
I know roach , but regardinh acne scar,
Although the acne scar is less shalow, they still have to excise full thickness skin just to be sure that the scar is also removed
I need all of your opinion on the abstract of porcine model guys...
What do you guys think??
The abstract said that hydrogel on pigs got regenerative healinh mechanism by enhancing healing speed
Inflammation is rapid but bried in 1 week only
The way I read that abstract is that it is promising in the sense that it improves the healing process. I read nothing about scarless results in it.
this is nonsense. I once had a small injury. 3 days later there was skin over it already, but its scar
haha we become paranoid of every small wounds
Bloodwar, it would not become scar if its still healing within 21 days
Hydrogel works on the concept to faster wound healing so that it is regenerating
Fibroblast proliferation would take longer than 3 days to produce scar
no. anytime a wound is too deep. a scar is formed. the dermis never regenerates in any case
maybe i didnt get you right, but once it healed wounds with scar free tissue and i see no reason why it wont work for me. it is possible and im gonna find a biochemist and a surgeon in my country and try to get my complete regeneration.
then go do it and tell us what happens, what are you waiting for?
Currently available skin grafts and skin substitute for healing following third-degree burn injuries is fraught with complications, often resulting in long-term physical and psychological sequelae. Synthetic treatment that can promote wound healing in a regenerative fashion would provide an off-the-shelf, non-immunogenic strategy to improve clinical care of severe burn wounds. Here, we demonstrate vulnerary efficacy and accelerated healing mechanism of dextran-based hydrogel in third-degree porcine burn model. The model was optimized to allow examination of the hydrogel treatment for clinical translation and its regenerative response mechanisms. Hydrogel treatment accelerated third-degree burn wound healing by rapid wound closure, improved reepithelialization, enhanced extracellular matrix remodeling, and greater nerve reinnervation, compared to the dressing treated group. These effects appear to be mediated through the ability of the hydrogel to facilitate a rapid but brief initial inflammatory response that coherently stimulates neovascularization within the granulation tissue during the first week of treatment, followed by an efficient vascular regression to promote a regenerative healing process. Our results suggest that the dextran-based hydrogels may substantially improve healing quality and reduce skin grafting incidents and thus pave the way for clinical studies to improve the care of severe burn injury patients.
Thats what the abstract said
unfortunately, the extract means scar-free healing did not happen. only improved healing- "improved reepithelization"
sorry guys, looks like dextran hydrogel is not the scar-free solution
then go do it and tell us what happens, what are you waiting for?
I'm looking for a doc who can do it. It's not as easy as it might seem.
WHY DON'T ANY OF YOU NUMBNUT MORONS JUST GO AHEAD AND TRY MY PROTOCOL. I GUARANTEE 60 percent IMPROVEMENT ON YOUR SCARS.
HERE IT IS AGAIN:
1) Aggressive surgical loosening of scars with that pin prick technique
2) Aggressive derma-sanding (not dermabrasion) followed by RECELL
3) 4 months alter Aggressive laser full ablation CO2 followed by recell again
4) Hylauronic acid and fillers to any remaining depressions.
you might even have full removal of acne scars. if you're so desperate why the fuck don't you try it. in the end it will still be cheaper than whenever some new therapy comes out!!! And all these treatments are available NOW!!
I partly agree with you. We should do all we can while we're waiting for miraculous healing. I keep my home treatments.
WHY DON'T ANY OF YOU NUMBNUT MORONS JUST GO AHEAD AND TRY MY PROTOCOL. I GUARANTEE 60 percent IMPROVEMENT ON YOUR SCARS.
HERE IT IS AGAIN:
1) Aggressive surgical loosening of scars with that pin prick technique
2) Aggressive derma-sanding (not dermabrasion) followed by RECELL
3) 4 months alter Aggressive laser full ablation CO2 followed by recell again
4) Hylauronic acid and fillers to any remaining depressions.
you might even have full removal of acne scars. if you're so desperate why the fuck don't you try it. in the end it will still be cheaper than whenever some new therapy comes out!!! And all these treatments are available NOW!!
No, no way it can improve scar.. i tried needling before. Scar tissue cant be improved by cheap trick