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FYI, Gemstone (the startup that is funding the DEX/AE HG trials) just announced that one of Gerecht Lab's alumni has joined their Technical Team. His name is Matt Davenport and he is a chemical and biomolecular engineer. In April, Gemstone announced that they would be hiring engineers this summer and it seems that they are accomplishing that goal.
The fact that they are hiring is a good sing. It's CEO, George Davis, has noted that their current research is based on the DEX/AE HG (as their foundation technology) and they would not be hiring staff if the trials were flopping.
Good news for sure. Probably looking to do a lot of hiring to get ready to scale up production for the veterinary market (at least).
Still looking forward to hearing about how the trials have progressed in pigs.
Gerecht Lab's latest paper was published today: http://m.dev.biologists.org/content/141/14/2760.abstract
The abstract discusses biomaterials, angiogenesis and tissue regeneration: "The formation of vasculature is essential for tissue maintenance and regeneration. During development, the vasculature forms via the dual processes of vasculogenesis and angiogenesis, and is regulated at multiple levels: from transcriptional hierarchies and protein interactions to inputs from the extracellular environment. Understanding how vascular formation is coordinated in vivo can offer valuable insights into engineering approaches for therapeutic vascularization and angiogenesis, whether by creating new vasculature in vitro or by stimulating neovascularization in vivo.
In this Review, we will discuss how the process of vascular development can be used to guide approaches to engineering vasculature. Specifically, we will focus on some of the recently reported approaches to stimulate therapeutic angiogenesis by recreating the embryonic vascular microenvironment using biomaterials for vascular engineering and regeneration."
Based on that, it seems relevant to the DEX/AE HG and likely discusses it. Unfortunately, the article costs $25 and the PayPal link does not appear to be working properly, so I can't give more details.
@golfpanther : sorry man, i thought you were being rude..
Cmon DH, be success on pigs so that we can use it immediately
Do you guys know that back when we were babies, we can regenerate our skin scarless?
Do you guys know that we humans were capable of fully regenerate even limbs, but evolution chose for scars ?
Do you guys know that gene called p21 is currently hindering us from full regenaration?
Do you guys know that we still have dormant abilities to fully regenerate?
Damn skin, why dont u fully regenerate after all?
why nobody try to contact with this people, Gerecht, Harmon, the investors etc.
English is not my first language, I live in Spain, but for some people in this forum can contact them and try to know something.
I don`t know why all this excessive secrecy. If the hydrogel Works it Works, if not the people will know the true before or later.
Gerecht says: It could be approved for clinical use after just a few years of testing.
I hope it comes out soon ffs. -_-
why nobody try to contact with this people, Gerecht, Harmon, the investors etc.
English is not my first language, I live in Spain, but for some people in this forum can contact them and try to know something.
I don`t know why all this excessive secrecy. If the hydrogel Works it Works, if not the people will know the true before or later.
Repola, people on this board have contacted Gerecht, Harmon and the investors. I have actually talked to Dr. Sun, the original lead author of the paper concerning the Dextran Hydrorgel in 2011. He wasn't secretive and in fact was extremely forthcoming with information.
A previous poster on the boards (look back in the early 200 pages) was in frequent contact with Harmon before the investors came on board. As far as the investors are concerned, a former poster set up a Facebook page for the dex-hydrogel and has contacted them. Here's the link:
Only Gerecht (to my knowledge anyway) has been unreachable. I tried contacting her twice and heard nothing back, but keep in mind this is her baby and she wants to line this thing up for sale and profit. It's entirely possible that she was advised by JHU and the investors to not to talk about it and may have even signed a standard confidentiality or non-disclosure agreement.
Remember, this is an incredibly competitive field (wound healing) with billions being spent world wide to find the answer. The prudent course of action is to keep your cards pretty close to your vest and only release info through official channels (e.g. news releases, published papers etc.).
If you're interested, Dr. Sun basically said that while he'd moved on from Johns Hopkins due to funding not being available for his position, he was still very much of the belief that the dextran hydrogel was a strong candidate for scar free healing in humans. He's at Columbia now and still researching scar free healing and scaffolds like the hydrogel.
Hope this helps!
@repola, i have to say that this guy here called JT1986 is the most trustable, resourceful person as he knows about JH inner infos at least
About the secrecy, i agree, why didnt they publish anything up until now.. Im dying for this scar cure, hoping by the time i reach my thirties, i can regain my life back which is 10 years to the future..
I just hope in 10 years, scars cure already exist..
I am sorry for not replying to the messages in FB, I have been on vacation and had to deal with a small tropical storm last week. Here are a few quick comments:
1- The reason that the original admin of the FB page has been inactive is due to being busy with real life. AFAIK, no new contact with the investor (George Davis) has been attempted (knowing that this is a long process, I have not tried to do so yet). I try to keep up the pace and have successfully contacted some people within JHU, but they don't spill the beans easily.
2- Gemstone rarely updates their Facebook or Twitter pages, and contacting them there is somewhat difficult. However, they are certainly active and money is not an issue. On a side note, they are sponsoring the Association for the Advancement of Wound Care.
3- Gemstones' telephone line is automated and asks for specific answers (extension numbers, et al.) that few of you would have.
4- I was told around a month ago that the staff of Gerecht Lab's was likely going to be on vacation until the last week of August. It was not a source within the Lab, but an employee of the Whiting Engineering School that told me so.
5- Penn U's vet school is expected to conduct post-trials after the original JHU trials.
6- As golfpanther mentioned, do not expect random details to be leaked before the studies are published in a peer reviewed source. This is no longer just "research", it is business.
7- I was directly told that contacting Dr. Gerecht was going to be extremely hard, since she basically oversees a multitude of people and is directly involved in most of the research.
8- I have not tried contacting Dr. Harmon.
9- Apparently, there is a fierce competition between several Labs to have their work published in one of the two WSE magazine issues.