Acne.org Products
What is the difference between hydrogel and this
http://www.eurekalert.org/pub_releases/2012-07/foas-nyu070612.php
Wentworth I know there is no right or wrong way to do this page, but here is my two cents. Also I know I'll have some blind spots. First of all I believe the image of the salamander should be removed. This has nothing to do with a salamander. Perhaps you could put an image of a gel? IMO this is also something which has a factual basis regarding a hydrogel and digestion, and it stands on its own, it needs no associations. I also believe it also needs nothing peripheral in the detail. It should just stick in the main, here at the beginning to the cited facts. It is my opinion the info you should put up on this specific page should be a kind of a public interest creative commons, that is brief and concise and not to hard of a read.
Anyway here is a rough draft of what I think it should be like. Dont be afraid to disagree with this.
Here I go with what I propose in a draft.
>>>Title<<< (Someone choose a title, or keep the current title etc.)
>>>very brief intro here<<<< (I havent wrote any introduction here, perhaps one of you could amend the draft here with a few lines?)
>>>>Facts to be included (any more?) here<<<<<<After the very brief introduction (or not very brief intro???), the message body revolving around the main facts, should also be readable, backed with citations, no distractions, nothing peripheral. You should be able to read it, note the facts, and go away with it. I believe the page should have key facts highlighted and easy to see.
-After digestion of the soft gel, the wound was completely restored to normal skin structure and function by the body, the wound achieved complete skin regeneration. The state of the art control did not.
-What was involved was a digestion process; a digestion of a material whereby tissue was created upon digestion.
-The optimized 8020 hydrogel degraded in about 7days and was faster than the 6040 hydrogel and way faster than the state of the art control. Which highlights the important role of the white blood cell and neutrophils being able to digest the material. (Or is that too peripheral???)
>>>>a thank you message below<<<<
Thank you for reading this. We think this is hydrogel is of significant public interest to those with scarring and disfigurements.
seabs135 I will take some of that into account as soon as i get a chance! Just quickly though i think some people get weighed down by the details, which they then have a choice to delve into by visiting the links to the actual research. I think first up we need numbers, so that we can keep them up to date with status updates and get them interested and even wanting to contribute/help. I agree that the salamander is irrelevant but i was strapped for ideas and wanted to get the page up quick! I still think it sparks some interest though, but i will look at some other images.
chuckston chew, let me know anything worth mentioning that you hear from Harmon. As i think we should start sharing as much as possible on the page.
Any ideas on getting more numbers? i Have joined burn survivor groups, keloid groups, on facebook and yahoo. Ive contacted JR Martinez, but whether or not he monitors that page himself is another story. And even if it is im sure he doesnt read all posts, especially not ones that look like advertising! Hmmmmm..........
I also joined Katie Piper support groups.. Ideas???
seabs135 I will take some of that into account as soon as i get a chance! Just quickly though i think some people get weighed down by the details, which they then have a choice to delve into by visiting the links to the actual research. I think first up we need numbers, so that we can keep them up to date with status updates and get them interested and even wanting to contribute/help. I agree that the salamander is irrelevant but i was strapped for ideas and wanted to get the page up quick! I still think it sparks some interest though, but i will look at some other images.
chuckston chew, let me know anything worth mentioning that you hear from Harmon. As i think we should start sharing as much as possible on the page.
Any ideas on getting more numbers? i Have joined burn survivor groups, keloid groups, on facebook and yahoo. Ive contacted JR Martinez, but whether or not he monitors that page himself is another story. And even if it is im sure he doesnt read all posts, especially not ones that look like advertising! Hmmmmm..........
I also joined Katie Piper support groups.. Ideas???
Wentworth, ok I may have blind spots.
by the way chuckstonchew, speaking on the phone!? awesome
seabs135 I will take some of that into account as soon as i get a chance! Just quickly though i think some people get weighed down by the details, which they then have a choice to delve into by visiting the links to the actual research. I think first up we need numbers, so that we can keep them up to date with status updates and get them interested and even wanting to contribute/help. I agree that the salamander is irrelevant but i was strapped for ideas and wanted to get the page up quick! I still think it sparks some interest though, but i will look at some other images.
chuckston chew, let me know anything worth mentioning that you hear from Harmon. As i think we should start sharing as much as possible on the page.
Any ideas on getting more numbers? i Have joined burn survivor groups, keloid groups, on facebook and yahoo. Ive contacted JR Martinez, but whether or not he monitors that page himself is another story. And even if it is im sure he doesnt read all posts, especially not ones that look like advertising! Hmmmmm..........
I also joined Katie Piper support groups.. Ideas???
Wentworth, ok I may have blind spots.
or i !!
so i gave the patent study to a person on forum that is really into biology and here is his reply!
Here is the nugget of gold in the entire patent, at paragraph 89.
See when I was reading it I was wondering how VEGF encapsulated in this hydrogel scaffold could have any effect. I mean it didn't appear to be released. but this paragraph seems to explain.
[0089] In exemplary embodiments, the delivery of VEGF promotes tissue ingrowth and functional vascularization. In the examples that follow, five- week-long study first revealed significantly more tissue ingrowth, primarily by macrophages, into the VEGF-encapsulated hydrogel than into blank hydrogel. This result may suggest that VEGF attracts circulating cells into the hydrogel, thus promoting tissue penetration. Phelps et al. also found that matrices lacking VEGF showed less tissue invasion than VEGF-incorporating matrices (Phelps et al., Proc Natl Acad Sci U S A, vol. 107, no. 8, pp. 3323-8, 2010). The tissue ingrowth might further expedite scaffold biodegradation, which in return could facilitate further ingrowth. This result was further confirmed by a three-week-long multiple GF delivery study; without the VEGF encapsulation, in which neither the blank hydrogel nor the hydrogel loaded with SDF-1 and IGF showed any significant tissue ingrowth. Although Cohen et al. (Dvir et al., Proc Natl Acad Sci U S A vol. 106, no. 35, pp. 14990-5, 2009) demonstrated that a scaffold encapsulated with SDF-1 and IGF promoted prevascularization when implanted onto a rat omentum, these hydrogels revealed neither significant tissue ingrowth nor vascular structures with the encapsulation of SDF-1 and IGF. Overall, these results suggest that VEGF delivery is required to initiate sufficient tissue ingrowth, which eventually leads to functional vascular development within the hydrogel implants.
Thanks for digging this up.
i dont study medicine or biology( i study law unfortunately:/) but from what i understand ..vegf is a key growth factor to be encapsulated
in the hydrogel...cause it manages to attracts the nearby cells promoting more tissue growth...and more tissue growth helps the biodegration of the hydrogel...
without the vegf in the hydrogel the researchers couldnt achieve such results.i dont know about the page ...i have deactivate my fb but i will try by referring it.
Hey the grpup stated that 'we are not selling anything we just want to raise awareness of this amazing research from John Hopkins University and make it a reality' but I can see some 'Kelo-kote Advanced Formula Scar Treatment', 'turn your scars into stas' I mean it's most probably a scam, remove that crap please and do not allow advertising in our group.
Kelo kote: scam
Give the password of the facebook account to some user english speaker , so watch share account details...
I went here for months that started the idea of facebook account (so now opened), but did not account for the issue of the english language is not my native language, I think either of vladislav but what handles well.
The thing is, do not let the scammers from taking over the facebook profile, careful.
panos i wish i understood any of that!
just a suggestion and not sure if its a good idea or not....but should we move the discussions to facebook, and get more people involved and joining? what you think?
went,
first of all: great initiative with the fb page. I think it would be best if you kept it as professional as possible though; just news about the hydrogel from official sources, without any speculative discussions as on here.
I could set up a forum that we can link to from the fb page though, if you guys feel like that would be a better place to keep the discussion (more "branded" toward scarfree healing) than in an anonymous thread thread on an acne board? Would perhaps attract more people.
Hey the grpup stated that 'we are not selling anything we just want to raise awareness of this amazing research from John Hopkins University and make it a reality' but I can see some 'Kelo-kote Advanced Formula Scar Treatment', 'turn your scars into stas' I mean it's most probably a scam, remove that crap please and do not allow advertising in our group.
vladislav ill have a look and delete any advertising tomorrow. What i did do though was post on kelocotes page and advertisr ours. I wanted to get to their likers. I do know of someone who's son had open heart surgery at birth and has started using kelocote with good results, which is why i tracked it down. I wasnt aware it was showing up on our page though. Will fix that.
panos i wish i understood any of that!
went,
first of all: great initiative with the fb page. I think it would be best if you kept it as professional as possible though; just news about the hydrogel from official sources, without any speculative discussions as on here.
I could set up a forum that we can link to from the fb page though, if you guys feel like that would be a better place to keep the discussion (more "branded" toward scarfree healing) than in an anonymous thread thread on an acne board? Would perhaps attract more people.
scarminator that could be a good idea 
my only reason for wanting to take discussions there is to make the most out of facebook. It generates interest by status updates and new posts popping up on peoples news feeds. There really isnt much official news that we have access to. In which case it will just be a dudd amongst the other hundred pages someone has liked.
As for keeping it branded, i dont want to deter the billionaire who is going to make a duplicate for us in china...hahaha!
oh well! i dunno, i just wanted to get a buzz happening, but no ones buzzing!!
scarminator that could be a good idea
my only reason for wanting to take discussions there is to make the most out of facebook. It generates interest by status updates and new posts popping up on peoples news feeds. There really isnt much official news that we have access to. In which case it will just be a dudd amongst the other hundred pages someone has liked.
As for keeping it branded, i dont want to deter the billionaire who is going to make a duplicate for us in china...hahaha!
oh well! i dunno, i just wanted to get a buzz happening, but no ones buzzing!!
Yeah, I see your intention. I think there's a risk that people would be annoyed if they get flooded with unsourced claims. For me personally, also, I'd not like to associate my personal fb with scar treatments, but then I'm not as "open" with myself as some (most?) ppl are on facebook.
The idea with the discussion board would not be to make a brand for the hydrogel per se, just to have a more appropriate place to discuss it on than here. I think it would be easier to attract more followers and create a buzz if we placed the discussions on a more independent platform than merely in a thread on an acne board. Just an idea though.
My conversation with Dr. Harmon went absolutely perfect today. The fire has been lit.
The main thing we discussed was crowd funding. He really likes the idea.
He said he was frustrated with everything prior to our conversation, but he is now very excited again.
He's discussing this option with his colleagues. He said he's not going to take no for an answer easily and will go all the way to the dean if he has to. He seems like a great guy that really wants to help people. I have confidence in him and I know he will do all he can.
The ball is in their court again, but Harmon will try to do something with it as soon as possible. At this point, we must just be patient and wait for them to okay our full blown movement. Everyone continue to formulate ideas of how we will make this as big as possible if/when he gives us the go ahead. Don't worry about sending anyone anymore emails or anything like that - I now have Harmon's cell phone number so if we ever need to know anything, he said not to hesitate to call him.
Not to be overly optimistic, but I might see a silver lining...
Imo this does not need to say 'your not selling something'; it is just a page trying to raise public interest.
Also more importantly, I agree with vlad that the Kelo product completely lowers the tone, it does not need any associations.. Get it removed asap..
agreed, i only added that part about 'not selling' after i got a few messages from people asking what i wanted.
after making it clear we just wanted help to spread the word 1 person still wasnt clear what the page was all about. Not exactly sure how to make it black and white.
Anyhoo the kelacote links will be gone asap.
My conversation with Dr. Harmon went absolutely perfect today. The fire has been lit.
The main thing we discussed was crowd funding. He really likes the idea.
He said he was frustrated with everything prior to our conversation, but he is now very excited again.
He's discussing this option with his colleagues. He said he's not going to take no for an answer easily and will go all the way to the dean if he has to. He seems like a great guy that really wants to help people. I have confidence in him and I know he will do all he can.
The ball is in their court again, but Harmon will try to do something with it as soon as possible. At this point, we must just be patient and wait for them to okay our full blown movement. Everyone continue to formulate ideas of how we will make this as big as possible if/when he gives us the go ahead. Don't worry about sending anyone anymore emails or anything like that - I now have Harmon's cell phone number so if we ever need to know anything, he said not to hesitate to call him.
Not to be overly optimistic, but I might see a silver lining...
chuckstonchew, im amazed! good work! So its definately the funding holding up them up, and no further testing has been done right?
What do you want to do as far as facebook page? is that an update or tmi for a public page? did Harmon have anything to say on
that?
scarminator that could be a good idea
my only reason for wanting to take discussions there is to make the most out of facebook. It generates interest by status updates and new posts popping up on peoples news feeds. There really isnt much official news that we have access to. In which case it will just be a dudd amongst the other hundred pages someone has liked.
As for keeping it branded, i dont want to deter the billionaire who is going to make a duplicate for us in china...hahaha!
oh well! i dunno, i just wanted to get a buzz happening, but no ones buzzing!!
Yeah, I see your intention. I think there's a risk that people would be annoyed if they get flooded with unsourced claims. For me personally, also, I'd not like to associate my personal fb with scar treatments, but then I'm not as "open" with myself as some (most?) ppl are on facebook.
The idea with the discussion board would not be to make a brand for the hydrogel per se, just to have a more appropriate place to discuss it on than here. I think it would be easier to attract more followers and create a buzz if we placed the discussions on a more independent platform than merely in a thread on an acne board. Just an idea though.
scarminator i feel the same about my personal facebook page and having everyone i know reafing my posts about scar treatments. But i guess the people on the burn survivor pages dont have a problem with it and they are some of the people we want to get to. You could always have a seperate login. I guess its no different to having a login
for these boards, or another. But starting another board could be good too, definately more general and not just acne. And we could link it
Maldition, You have been showing a lot of interest towards making this hydrogel. I thought I will share whatever I have read so far -
They said "We dissolved Dex-AE/PEGDA at the ratio of 60/40 and 80/20 (means Dex-AE80% and PEGDA20%)
into phosphate-buffered saline (PBS) containing 0.1% (wtˆ•wt)
2-methyl-1-[4-(hydroxyethoxy)phenyl]-2-methyl-1-propanone
(Irgacure 2959, Ciba). The mixture was pipetted into a sterile
mold (70-¼L volume per well) to obtain discs measuring 8 mm
in diameter by 2 mm in thickness and photopolymerized (approximately 10 mWˆ•cm2
of UV light for 10 min; Black-Ray, UVP).
We removed the resulting hydrogels from the mold and immersed
them in sterile PBS solution before application onto wounds."
The above steps has two ratios - one is 60/40 and other is 80/20. 80/20 ratio is shown to be more effective in skin re-generation in mice.
The wounds, after applying the hydrogel on them were covered with dressings which are easily available in market.
From what I read and what I imagine, we would need the following to give any realistic shot at preparing the hydrogel -
1) Dex-AE (Dextan Allyl Iso cynatae Ethylamine) (needs dextran, other chemicals and lab setup to be synthesized) - This is not available in market and needs to be synthesized in a lab. Looks to be a possible but little complicated and time consuming procedure. The following paper by Dr.Sun discusses the procedure. There are many variables in this preparation procedure depending on which, some properties of final Dex-AE synthesized may vary. I don't know which variant of the Dex-AE was used in the experiment with Mice. If anybody does, I would be glad to know.
Synthesis, characterization of biodegradable dextran“allyl isocyanate“ethylamine/polyethylene glycol“diacrylate hydrogels and their in vitro release of albumin
http://www.sciencedirect.com/science/article/pii/S0144861706000221
2) PEGDA/Poly ethylene glycol diacrylate - The good news is PEGDA is available in the market (available in sigmaaldrich.com and it looks like anyone can order this), but the bad news is Sigma provides three variants of it, based on molecular weight I guess (Mn250, Mn575 and Mn700). Again, i don't know which one of these, if one of these was used in the experiment with Mice. Another alternative is what they did at JHU lab - they synthesized their own PEGDA. The above paper discusses the synthesis of PEGDA too and it looks like there are not many variants in the procedure, so it should be fairly less complicated.
3) Phosphate buffered Saline.
4)Photoinitiator - 2-methyl-1-[4-(hydroxyethoxy)phenyl]-2-methyl-1-propanone (Irgacure 2959, Ciba) - Looks like available in Ciba
5) UV light source ( I don't know what wavelength was the light source, if the wavelength mattered at all - Again, i would be glad to know if someone already knows this)
6) A bio tech student/scientist who has access to a state of the art bio tech lab facility and who would be ready to do this.
And last, even if we somehow manage to get this hydrogel synthesized in the lab, i would definitely give it a very hard look before even considering testing it on my boss 
And lets not forget that testing this on humans might be illegal and we don't exactly know if it will make the scar disappear or the man disappear
im looking for the kelocote posts on the page and i cant see them....i 'liked' the page and then posted on their page about ours. I have since unliked it to remove any association. But i cannot see any other link to them at all on the pages timeline. If someone else can see it and tell me specifically what to remove i will do!
Kelo kote: scam
Give the password of the facebook account to some user english speaker , so watch share account details...
I went here for months that started the idea of facebook account (so now opened), but did not account for the issue of the english language is not my native language, I think either of vladislav but what handles well.
The thing is, do not let the scammers from taking over the facebook profile, careful.
i can add admins if anyone interested. ive actually tried adding vladislav but facebook requires adding via email so feel free to send it to me if you want. Im not sure who else on this forum has liked the page. we only have 10 likers!
I've just send you my e-mail, but my English is not very good, it's not my native language, I have a problem that I still don't know with a 100% certainty when to use a/an/the and present simple/contiuous/perfect, past simple/continuous/perfect, I have to learn that one day so I wouldn't like to make any rewriting of the text because it would be full of grammatical mistakes, seabs135 or chuckstonchew should do that instead of me, seabs135 or chuckstonchew if you have no FB profile just open a blank profile so you can make rewriting of the text in the group if it is necessary.
I also think it would be useful to briefly explain in 2 or 3 sentences in the text that the dextran hydrogel is structurally similar to the natural ECM, that it is non toxic material and that it is easily degraded by white blood cells and that if you want scar free healing it is necessary to surgically remove a scar, then apply the hydrogel in a wound and get a completely scar free regenerated skin instead of a new scar, we know that very well, but someone who heard about the hydrogel for the first time doesn't know that, of course.
Kelo kote: scam
Give the password of the facebook account to some user english speaker , so watch share account details...
I went here for months that started the idea of facebook account (so now opened), but did not account for the issue of the english language is not my native language, I think either of vladislav but what handles well.
The thing is, do not let the scammers from taking over the facebook profile, careful.
i can add admins if anyone interested. ive actually tried adding vladislav but facebook requires adding via email so feel free to send it to me if you want. Im not sure who else on this forum has liked the page. we only have 10 likers!
I've just send you my e-mail, but my English is not very good, it's not my native language, I have a problem that I still don't know with a 100% certainty when to use a/an/the and present simple/contiuous/perfect, past simple/continuous/perfect, I have to learn that one day so I wouldn't like to make any rewriting of the text because it would be full of grammatical mistakes, seabs135 or chuckstonchew should do that instead of me, seabs135 or chuckstonchew if you have no FB profile just open a blank profile so you can make rewriting of the text in the group if it is necessary.
I also think it would be useful to briefly explain in 2 or 3 sentences in the text that the dextran hydrogel is structurally similar to the natural ECM, that it is non toxic material and that it is easily degraded by white blood cells and that if you want scar free healing it is necessary to surgically remove a scar, then apply the hydrogel in a wound and get a completely scar free regenerated skin instead of a new scar, we know that very well, but someone who heard about the hydrogel for the first time doesn't know that, of course.
IMO, with its blindspots, this does not need an explaination that it is similar to anything? Doing so could be periphery and and maybe an association and this needs no associations as it can stand on its own feet. Though I do think the fact that it is degraded by the white blood cells rapidly is a key point about this.
Hello
I'm new to this forum and hopefully I can be a contribution to this forum.
Firstly, I'm not sure if this is the place to post (if not, please remove my post or tell me where to post this so I can edit it out) but I went to my dermatologists and did something called Genesis Laser Treatment to get rid of acne scars and redness in my face skin (previously, I've done something called V-Beam and Photodynamic therapy and MTS for acnes which was helpful)
Anyway, I did this Genesis Laser Treatment and the treatment was done mainly focusing on my nose which had minor acne scar. After the treatment, my face was bit red here and there as usual after every acne treatment, but my nose.. was especially red. I thought this would go away but later at home, I had water blisters on my nose which I accidentally popped when I was washing my face.
This is first time a blister came up after a laser treatment so I'm pretty sure it's not normal. I called the my dermatologist about this issue and he told me to visit his centre which I did 2 days later (it was weekends) and he put on antibiotic cream (I assume) and told me to stick something called duoderm on the scar for a week!
I didn't like the idea of putting a sticky bandage for a week but I had no choice as I didn't want to leave any scars...
It's been 3 days and from the first day, the bandage kept on falling off so I had to replace it with new one everyday. But whenever I examine the this scar, it looks to me as if it's still bleeding and the skin(?) still hasn't filled up etc. I feel like it's going to leave me with quite a big scar right in the tip of the nose.
So my question is, how long would it normally take for these type of wounds to heal? Would it heal or leave a bigger scar? Has anyone had any similar experiences? And Is there a better way to fasten the healing process? It's hard enough to wash my face properly without this thing falling off everytime...
Thanks in advance