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so, when hydrogel is on sale?
Maybe 2013.
We haven't even hit large animal trials, let alone human trials. IF it works on humans the same way it does on mice, then we may see it in a few years.
I thought someone said that it could be approved in a year or less. Remember now, if it does work it's going to come to fruition faster than other things would as it's classified as a device and not as a drug, if I remember correctly.
Really? My bad. Well in either case, I should suspect large animal trials and human trials to take a couple years at least. Usually there are three phases of human trials, each separated by some number of months... they'd also need funding for human trials as well. It's a long ways away imo. Or did one of the researchers explicitly state that it would take only 1 year with all research, funding, FDA applications and processes considered?
Dr. Sun said if it worked it could get approved in only a few months.
Look up the 501k process for devices.
It really shouldn't take long at all. 'Shouldn't' being the key word. But who knows.
Really? My bad. Well in either case, I should suspect large animal trials and human trials to take a couple years at least. Usually there are three phases of human trials, each separated by some number of months... they'd also need funding for human trials as well. It's a long ways away imo. Or did one of the researchers explicitly state that it would take only 1 year with all research, funding, FDA applications and processes considered?
Yeah, I think someone stated that one of the researchers said it could take a year or less.
But time will tell. Your skepticism is quite understandable.
This is wonderful news. I just have one question though, will the hydrogel work on stretch marks?
In theory - you would be able to get a doctor to cut out any skin imperfection and regrow new "clean" skin.
I DONT THINK SO, sounds to good to be true.
In the paper it cites that non degradable hydrogels scar, whilst degradable hydrogels create new tissue.
It was demonstrated that the soft 8020 hydrogel degraded in 7 days, It was also stated in under 14 days the wound had reepithilized. (Scars take over 21 days to form, cited fact.). In the paper the 8020 hydrogel degraded rapidly, the hydrogel was degraded rapidly by the neutrophils in the 7days, after 10 days the neutrophils couldn't infiltrate the control scaffold and had only degraded the edges of the control scaffold. In the study the appendages regenerated whilst the control, a standard used by hospitals, scarred (the control behaved like it exactly does in mammals). With regards to appendages, appendages do not grow in scar, the hydrogel treated wound regenerated appendages. In the study you had complete regeneration of a 3rd degree burn, hence no scar. The facts are clearly there.
This is wonderful news. I just have one question though, will the hydrogel work on stretch marks?
In theory - you would be able to get a doctor to cut out any skin imperfection and regrow new "clean" skin.
I DONT THINK SO, sounds to good to be true.
In the paper it cites that non degradable hydrogels scar, whilst degradable hydrogels create new tissue.
It was demonstrated that the soft 8020 hydrogel degraded in 7 days, It was also stated in under 14 days the wound had reepithilized. (Scars take over 21 days to form, cited fact.). In the paper the 8020 hydrogel degraded rapidly, the hydrogel was degraded rapidly by the neutrophils in the 7days, after 10 days the neutrophils couldn't infiltrate the control scaffold and had only degraded the edges of the control scaffold. In the study the appendages regenerated whilst the control, a standard used by hospitals, scarred (the control behaved like it exactly does in mammals). With regards to appendages, appendages do not grow in scar, the hydrogel treated wound regenerated appendages. In the study you had complete regeneration of a 3rd degree burn, hence no scar. The facts are clearly there.
It's not fact that wounds that heal in 14 days will not produce a scar. I haven't done much research, but the first result I pulled off of google stated that wounds that heal withint 10-14 days still have a risk of scarring, and wounds that heal after 21 days are almost guaranteed to scar.
Link (second paragraph): https://docs.google....XhPg0tT5BO1j3AA
@trendycat I keep getting a post to short error and cant post your quotes.
Any way it is a fact if a wound reepithilizes in under 14 days there will be no scar. Scars loop take a long time to form and loop. When a wound reepithilizes this means the wound has closed. The faster your wound reepithilizes the less chance of a scar blocking of regeneration pathways. The less chance of a scar loop taking over the healing. As when regeneration pathways are blocked your body goes into a scar turnover and you produce hypertrophic scarring. E.g. Your non scarred skin turnovers, sheds and reepithilizes. If it did not reepithilize you'd have a wound and the chances are to fill in the void your body would go into a scar loop.
Here is a cite I posted a while ago on this thread. Which states
Healing in 2 weeks minimal to no scar
Healing in 3 weeks minimal to no scar except in high risk scar formers
Healing in 4 weeks or more hypertrophic in more than 50% of patients
http://www.burnsurgery.com/Modules/BurnWound%201/sect_IX.ht m" rel="external nofollow"> http://web.archive.o...d 1/sect_IX.htm
Your cite is basically what I've posted before.
Also here is another cite I've posted, with regards to a deep second degree burns and appendages. Then check 3rd degree burns.
1st degree burn
Painful, red, non-blistering (i.e. sunburn)
What is sunburn
Superficial layer of skin (epidermis) only.
Unless entire body is affected, can be managed in doctor's office
They may heal within 3-4 days, scarring is rare.
2nd degree burn
Deeper than 1st degree and extends into dermis of skin
Superficial
Moist, blistering, pink, painful
Turns white (blanches) with pressure
Heals within 3 weeks with little scarring.
Deep
Pale, indurated or boggy
Non-blanching with pressure
Deeper, so scarring more likely
Formation of a thick eschar, slow healing (>1month),
Obvious scarring, hair loss.
3rd degree burn
No sensation, numbing, all layers of skin destroyed
Leathery
Skin grafting is almost always necessary.
http://www.skincareg...care_art_3.html
The cites above can be found on Wikipedia, and Ive used them before to use in this thread. What you have cited has been cited before in this thread. Remember the hydrogel reepithhilized a 3rd degree burn and full thickness wound with no scarring. The control scarred. Also established was the fact that non degradeable hydrogels scar, degradable hydrogels create tissue. This was cited in the article. And was proven in the article with regards to the control. By day 7 the hydrogel was almost digested. By day 14 the wound was reepithilized. By day 21 appendages were regenerating. It is also a fact if a wound regenerates appendages there will be no scar appendages do not regenerate in scar. This regenenerated appendages.
Seabs, it's all nice what you've just said but I wouldn't like to put all my hopes into a single bet.
This is not my opinion, this is not a bet, a bet implies a chance, e.g. 60% for this or that to happen. There is no bets here. This is just stating facts. Just like water freezes at 0. Appendages do not grow in scar, this degraded in 7days and regenerated a 3rd degree burn 100%, yet the control scarred and continued to scar after 30days. This is not an opinion or a bet.
Any updates from Dr. Harmon chuckstonchew? Eagerly awaiting the news that they got their funding.
Lol, check the post above yours - Just posted an update earlier today!
Unfortunately, the update is that there is no update. 
They still haven't gotten any word about funding... Blows my mind.
I don't understand, by now dr Harmon should have a positive or negative response from the DoD? Is he supposed to get a positive or negative response by now but he didn't get any response or what? For how long we will wait for their response?
Yep, he still hasn't gotten any response. He doesn't know when he'll receive one. In September he told me he expected a yes or no response by November. But as of yesterday, I spoke to him and he said he still had not gotten one. Who knows how long it will be before they respond... As we know, taking excessively/unnecessarily long seems to be their strong suit.
I wish they would just bring their research overseas or something. This is absurd. They discovered it in 2011 and here were are approaching 2013 and still absolutely nothing.
I don't understand, by now dr Harmon should have a positive or negative response from the DoD? Is he supposed to get a positive or negative response by now but he didn't get any response or what? For how long we will wait for their response?
Yep, he still hasn't gotten any response. He doesn't know when he'll receive one. In September he told me he expected a yes or no response by November. But as of yesterday, I spoke to him and he said he still had not gotten one. Who knows how long it will be before they respond... As we know, taking excessively/unnecessarily long seems to be their strong suit.
I wish they would just bring their research overseas or something. This is absurd. They discovered it in 2011 and here were are approaching 2013 and still absolutely nothing.
IMO when we heard November, after waiting all those months previously, I feared procrastination in November.
Hi again everyone -
just to be clear - did the army say they would defiantly make a decision sometime in November - and just haven't yet, it's still only the 10th - or did the doctor say that he would know by November as a vague guesstimate.
Personally I think that the army would have given some sort date they would respond by - or even time frame with a final date - it's not like these are two people who met in a bar and one said I'll call you up some time about that thing - I imagine both these organizations have set time tables for most things, including decision-making.
In any event - it's great that the uni have gone to the army anyway - it shows (that despite the john hopkins in the past focusing exclusively on academic research - ie. research for it's own sake) that they are going to lengths to take this product to market...
I'm not thrilled about the [glacial] speed that things are moving at either but I guess all these things have their own time frames - and the fact is John Hopkins ARE trying to develop it - and have gone outside their comfort zone to do so - so there is hope.
I just hope there's a positive army response by Christmas - that would be a great end to the year - but even if they turn it down I can't believe that the next stage testing wont happen somewhere, somehow
And just another thought - I imagine there is a lot of legal work and negotiation in these things - even if everything is going to plan - could tat also hold things up?
Since I have a family member that previously worked for the DoD I can tell you guys that there are never really any set dates that things are decided by. Part of this is by design since the very nature of their undertakings (security being the chief concern) require quick reactions to changing conditions. The other part of it though, and the shitty part, is that it's filled with tons of bureaucracy like most government departments and things rarely get where they need to go on time. As an example, my relative was told they would be relocated to another office but didn't find out which location until a week before they had to move because someone didn't push the paperwork down the line properly.
However, a huge part of me is afraid that some of the feet dragging could be stemming from the huge investment the DoD has made already regenerative medicine by setting up AFIRM. Tons of studies and researchers working across disciplines to solve this very problem and then someone at a private university comes up with the solution? As Vladislav mentioned above, the DoD pumped money into trails for ReCell just this year so it doesn't really make them look good even if they come late to the party and help Johns Hopkins get over the hump. Still, I'm fairly confident that a yes from the DoD for funding the project is forthcoming and will see this through to its conclusion.
And guys, November isn't close to being over yet. 
Hopefully we'll hear back before the end of the month.
Thanks for the inside info golfpanther! so basically the army when it comes to timetables acts the complete opposite way to what I assumed! Glad you know someone in the know.
I guess we'll all just have to hope something is said before November - yeah, I can see how the army might not want to negate other funding they've given - BUT I think/hope this might be too good for them to pass up!
I'm hoping they'll focus on the same things we do, ie: the fact it is device and not a drug - the fact it leads to NO scarring, not 68% or something like that - the fact itt would be cheap and easy for anyone to manufacture - and that it would be relatively cheap to carry out the next stage experiments.
How could anyone NOT want to take this further 