Acne.org Products
More good news to contribute to our ultimate goal:
http://online.wsj.com/article/SB1195049496...=googlenews_wsj
article preview but I'm sure a full article is around here somewhere...
Ah here we go: http://www.timesonline.co.uk/tol/news/uk/s...icle2870675.ece
did you get temporary improvement from the fillers......???
I agree with you that it wouldn't be a magic bullet for scars as i don't there is such a thing. I'm under the impression juvista doesn't claim to prevent the formation of a surgical scar, rather greatly improve its potential appearance and pigment. I think if your skin was going to depress it would do so regardless of whether you used this product or not.
Exactly what I was going to post!! People on here need to understand that depressed acne scars are there for life, you go to your grave with them. They are now just as much a part of you as your eye color. I have spent thousand and thousand - silicone injections dermabrasions, excisions- anything and everything. And not ONE ounce of visible improvement!!
I have the same fear Kirk!
I thought this was the most interesting part of an overall VERY interesting article:
Creating a working organ hinges on keeping those first few cells alive, which has proven to be the biggest challenge for Atala's team. Each cell aa whether from the bladder, skin, cartilage, or heart aa prefers a different environment to grow, made up of unique cocktails of growth factors, enzymes, proteins and other nutrients. Once the incubated cells have multiplied to a sufficient number, Atala puts them through a series of rigorous tests to ensure that they look, act and function just like their normally grown siblings in the body.
And that's when the fun starts. In order to mold human organs from a clump of cells, Atala came up with creatively constructed scaffolds that would guide the newly grown cells into shape. In most cases aa for the bladder, blood vessels and valves, for example aa he uses a biodegradable material made of collagen, the structural component in skin. But in order to create more complex structures, such as the heart, he needed something far more sophisticated as a matrix. That's where the inkjet printer came in. One of Atala's colleagues had the bright idea that if a printer can spray tiny bits of ink in a pre-set pattern, why couldn't that same technique be used to scatter cells into pre-designed templates? So, instead of printing in one dimension, Atala's expert re-tooled the printer to "print" its cells in successive layers; the end result is a three-dimensional mold of cells that looks suspiciously like, for example, a rudimentary heart.
What makes the article exciting to me is, I was under the impression that these scientists had the agreed school of thought, the paradigm, that this type of regeneration had to come after research leading on from scar free healing. I had the feeling that scarless healing would come first and lead onto great insights and advancement into regeneration of skin, organs, and then limbs. It is like he has went into the future come back and helped us skip a stepping stone of research. Giving us knowledge and a greater insight. Being he already knows what completely regenerates skin and organs.
I was under the impression that organ regeneration was years away.
Interesting article:
Squid up nose excites doctors:
http://www.stuff.co.nz/4275942a11.html
tgan3,
Will this Juvista drug remove depressed scarring? Cause i have alot of depressed scars on my cheeks and i definetly dont feel like living my life with them...
Juvista has a 70%success rate in comparison to the control groups.
And the scar improvement varies amongst the successes if I remember correctly.
It hasn't been tested on acne scars revisions, only surgical cuts.
What makes the article exciting to me is, I was under the impression that these scientists had the agreed school of thought, the paradigm, that this type of regeneration had to come after research leading on from scar free healing. I had the feeling that scarless healing would come first and lead onto great insights and advancement into regeneration of skin, organs, and then limbs. It is like he has went into the future come back and helped us skip a stepping stone of research. Giving us knowledge and a greater insight. Being he already knows what completely regenerates skin and organs.
I was under the impression that organ regeneration was years away.
I don't really think what Atala is doing should be considered regeneration. I would call it re-creation and transplantation. He is creating scaffolds to create general equivalents of the patient's original organs. This will be fine functionally, but from a medical perspective most doctors still think that scarred skin functions...aside from lost sweat glands, hair, pigment, mass, etc. For the skin we have functional requirement as well as a much higher aesthetic standard to meet. We need cells that pick up the bodies signals and then follow the directions to go where we are missing tissue.
Another article on alternate sources for stem cells:
http://news.yahoo.com/s/ap/20071120/ap_on_sc/stem_cells
What makes the article exciting to me is, I was under the impression that these scientists had the agreed school of thought, the paradigm, that this type of regeneration had to come after research leading on from scar free healing. I had the feeling that scarless healing would come first and lead onto great insights and advancement into regeneration of skin, organs, and then limbs. It is like he has went into the future come back and helped us skip a stepping stone of research. Giving us knowledge and a greater insight. Being he already knows what completely regenerates skin and organs.
I was under the impression that organ regeneration was years away.
I don't really think what Atala is doing should be considered regeneration. I would call it re-creation and transplantation. He is creating scaffolds to create general equivalents of the patient's original organs. This will be fine functionally, but from a medical perspective most doctors still think that scarred skin functions...aside from lost sweat glands, hair, pigment, mass, etc. For the skin we have functional requirement as well as a much higher aesthetic standard to meet. We need cells that pick up the bodies signals and then follow the directions to go where we are missing tissue.
It is all regeneration, it is just his is in vitro, whilst others are trying technologies that are in vivo. They will all learn off each other. But it must be noted that human skin can now be grown in vitro which is a massive advancement.
In my arguementative tone, with you 
, I regard scarring as 100% a functional problem. Be it I reckon if you look at it objectively, people who are scarred, through their poor quality lives, statistically, would live shorter lives than those who are not scarred. Just like someone who has another malfunctioning organ. 
Also I'm suprised no one linked this article:
http://www.guardian.co.uk/science/2007/nov...medicalresearch
cheers
What makes the article exciting to me is, I was under the impression that these scientists had the agreed school of thought, the paradigm, that this type of regeneration had to come after research leading on from scar free healing. I had the feeling that scarless healing would come first and lead onto great insights and advancement into regeneration of skin, organs, and then limbs. It is like he has went into the future come back and helped us skip a stepping stone of research. Giving us knowledge and a greater insight. Being he already knows what completely regenerates skin and organs.
I was under the impression that organ regeneration was years away.
I don't really think what Atala is doing should be considered regeneration. I would call it re-creation and transplantation. He is creating scaffolds to create general equivalents of the patient's original organs. This will be fine functionally, but from a medical perspective most doctors still think that scarred skin functions...aside from lost sweat glands, hair, pigment, mass, etc. For the skin we have functional requirement as well as a much higher aesthetic standard to meet. We need cells that pick up the bodies signals and then follow the directions to go where we are missing tissue.
It is all regeneration, it is just his is in vitro, whilst others are trying technologies that are in vivo. They will all learn off each other. But it must be noted that human skin can now be grown in vitro which is a massive advancement.
In my arguementative tone, with you
Also I'm suprised no one linked this article:
http://www.guardian.co.uk/science/2007/nov...medicalresearch
cheers
Indeed we live in exciting times. If we can reprogram skin cells back into stem cells then why can't we reprogram scar skin cells back into normal skins cells. It's only a step back and not even back to start!
Here is another interesting article that may prove useful in the future for scarring. Not really strange bedfellows: http://www.guardian.co.uk/science/2007/may...genetics.health
Gee, I really don't know what to say...after reading all this outstanding research presented in the news recently regarding the reprogramming of normal cells back into stem cells. The possibilities are virtually endless when it comes to curing diseases including acne/scarring etc.
But I think this is also worrying...can you guys honestly see this technology being adopted by Big Pharma et. al. These companies don't want complete cures, they only want to provide money making 'medicines' that temporarily mask symptoms.
I don't know, I think I need more time to think about this but at the moment I am not going to get my hopes up, we have been disappointed so many times in the past.
Gee, I really don't know what to say...after reading all this outstanding research presented in the news recently regarding the reprogramming of normal cells back into stem cells. The possibilities are virtually endless when it comes to curing diseases including acne/scarring etc.
But I think this is also worrying...can you guys honestly see this technology being adopted by Big Pharma et. al. These companies don't want complete cures, they only want to provide money making 'medicines' that temporarily mask symptoms.
I don't know, I think I need more time to think about this but at the moment I am not going to get my hopes up, we have been disappointed so many times in the past.
Rest easy. If there is a cure it will be developed. Company A has a way to continue to mask acne scaring. I am however in Company B and we are losing out against Company A (our biggest competitor). We need to one up them some how. If it's possible, WE WILL ONE UP THEM if they don't one up themselves.
It is all regeneration, it is just his is in vitro, whilst others are trying technologies that are in vivo. They will all learn off each other. But it must be noted that human skin can now be grown in vitro which is a massive advancement.
In my arguementative tone, with you
Also I'm suprised no one linked this article:
http://www.guardian.co.uk/science/2007/nov...medicalresearch
cheers
Oh Kirk, I didn't mean to be negative, I DO think this is regenerative, but it's not regeneration. They can already propagate human skin cells in vitro, but that is not the same as your body perfectly recreating the skin cells it lost in the exact correct way according to your genetic code. They will still have problems of transplantation like a punch graft does.
And, I would agree with you, I personally think that scarred skin IS a functional problem...especially if you need insurance to pay for the treatment!!!
Happy Thanksgiving All!!!
Gee, I really don't know what to say...after reading all this outstanding research presented in the news recently regarding the reprogramming of normal cells back into stem cells. The possibilities are virtually endless when it comes to curing diseases including acne/scarring etc.
But I think this is also worrying...can you guys honestly see this technology being adopted by Big Pharma et. al. These companies don't want complete cures, they only want to provide money making 'medicines' that temporarily mask symptoms.
I don't know, I think I need more time to think about this but at the moment I am not going to get my hopes up, we have been disappointed so many times in the past.
I agree Neca. I share your dark assessment of the pharmaceutical companies' not so hidden agenda of keeping the cash cows fat and milky. My main hope was when I saw the military was involved in tissue regeneration...that is one entity that shares our agenda of complete cures in that they want to get the disabiled veterans off the benefit rolls.
Rest easy. If there is a cure it will be developed. Company A has a way to continue to mask acne scaring. I am however in Company B and we are losing out against Company A (our biggest competitor). We need to one up them some how. If it's possible, WE WILL ONE UP THEM if they don't one up themselves.
Thank you hopeseed! We need some positive energy!
this isnt scarring but i think i have the reason we breakout in the first place.one we are all diabetic prone.sugar is the culprit.....it converts to testosterone and if we have sensative sebasious glands.look at people in lands that have no sugar in their diet.i was drinking regular pepsi and coke for years...switched to diet and my skin is no longer breaking out.testosterone comes from the adrenal gland and from the male testes.thats why stress might break out skin.sugar stimulates the adrenal gland which produces testosterone...and acne.
this isnt scarring but i think i have the reason we breakout in the first place.one we are all diabetic prone.sugar is the culprit.....it converts to testosterone and if we have sensative sebasious glands.look at people in lands that have no sugar in their diet.i was drinking regular pepsi and coke for years...switched to diet and my skin is no longer breaking out.testosterone comes from the adrenal gland and from the male testes.thats why stress might break out skin.sugar stimulates the adrenal gland which produces testosterone...and acne.
I think there is a lot to this nikkigirl. Over the last couple of weeks I have converted to essentially a Vegan diet after reading a book called, 'Eat to Live' by Dr. Joel Fuhrman. My skin is actually pretty darn good now, with only a few bumps here and there throughout the month, but after just a week on the diet which is largely greens and more greens my skin is very calm. Part of the book talks about diabetes. Dr. Fuhrman writes, "Diabetics, regardless of type, have higher levels of triglycerides and increased levels of LDL cholesterol than the general population."
With the diet many of his patients are able to cut their insulin levels in half or even eliminate them over a couple of weeks.
Relatedly, but not from the book, I have a friend who has Poly Cystic Ovarian Disease which makes her prone to hormonal acne on her chin. One of the first lines of treatment doctors use when treating PCOD is to put patients on Glucophage which is an oral diabetic drug.
In the book, Dr. Fuhrman lists out guidelines for diabetic patients:
1. Refined starches such as white bread and pasta are particularly harmful; avoid them completely.
2. Do not consume any fruit juice or dried fruits. Avoid all sweets, except for fresh fruit in reasonable quantities. Two or three fruits for breakfast is fine, and one fruit after lunch and dinner is ideal. the best fruits are those with less sugar - grapefruit, oranges, kiwis, strawberries and other berries, melons, green apples.
3. Avoid all oil, Raw nuts are permitted, but only one ounce or less.
4. The name of your diet is the "greens and beans" diet; green vegetables and beans should make up most of your diet.
5. Limit animal food intake to no more than two servings of fish weekly.
6. Try to exercise regularly and consistently, like dispensing your medication. Do it on a regimented schedule, preferably twice daily. Walking stairs is one of the greatest exercises for weight loss.
Incidentally, on page 144 he lists those diseases which he refers to as, "Dietary-Caused Illneses with High Prevalence" and Acne is the first disease listed.
I absolutely LOVE to cook so this has been an adventure for me. I bought about six different Vegan cookbooks and have been using Tofu and Seitan as meat substitutes in recipes so I don't really miss meat. I have been cooking a bit of brown rice because I tend to lose weight really easily - especially when I'm dancing a lot. All in all I have to say that this conversion has been pretty painless for me and I would recommend it.
My favorite recipe is for a smoothie that I found somewhere here. It is a really easy way to eat your greens:
Green Smoothie
4 Ounces Baby Spinach
1/2 Cup Soy Milk
1 Medium Banana
1/2 Cup Unsweetened Pomegranate Juice
1 Cup Blueberries
1 Tablespoon Ground Flax Seed
Throw everthing in a blender (make sure its a powerful one) and whip everthing into a slimey green froth. Looks like swamp water but it tastes WONDERFUL!
AND, most importantly, how this all ties into this thread is that on the same day I started this diet I cut my leg shaving. This cut is healing differently than cuts have in the past. Usually cuts get a little red halo around them which means inflammation, this cut did very little of that. This diet is strongly anti-inflammatory if anyone ever any of Perricone's books you'll know that is good for acne and good for minimizing aging...hopefully it's good for minimizing scarring too!
http://phx.corporate-ir.net/phoenix.zhtml?...&highlight=
http://www.isolageninc.com/isolagen/default.htm
Isolagen is in phase III clinical trials for acne scars. The poor volunteers are only getting half their face treated. The other half is injected with a placebo (I wonder what the hell they will use).
Is suppression of TGFB1 the way to go for scar free healing?
New Step Towards Regenerating An Amputated Limb, Canada
http://www.medicalnewsblog.info/2007/11/30...imb-canada.html
Perhaps there are numerous manipulations?
Eg. Manipulation x could suit A because of this.
Manipulation y could suit r because of that. etc.
Interesting Kirk. I don't believe I have ever seen an article where TGF B1 was favorably credited in the regeneration process. Everything I have previously read detailed it as the bad guy causing fibrin deposits and blocking regeneration. Again they do a lot of generic referencing to TGF, which drives me crazy. Maybe TGF B1 is important in the initial sealing but then immediately afterwards it's expression is negated and TGF B3 takes over. It would be interesting in seeing a sequential chart -hour by hour- of the expression of all TGF factors during the entire regeneration process of the axolotl. That way we could see what is up and down regulated up to the point of complete regeneration and scar free healing.
Thanks for posting this!
Anna
Nothing really new. Damn that 2011 at the earliest statement.
An interesting study -turns out this article is a direct comparison between fetal and adult tissue (they say to their knowledge it has not been done)
Turns out Dr. Linge that was mentioned in the above links also does research in dermal replacement.
and finally this article that got me a little excited
"These developmentally related differences in fibroblast response to TGF-beta1 may influence wound-healing outcome, i.e., perfect regeneration or fibrosis."
P.S - does anyone have access to this article? There is a 12 month lag time with this journal through my library so I can't access it online.
P.P.S one more review that I want to get my hands on (Says it comes out Jan 08 but I think an electronic version is available online)
Renovo back in the news
Nothing really new. Damn that 2011 at the earliest statement.
An interesting study -turns out this article is a direct comparison between fetal and adult tissue (they say to their knowledge it has not been done)
Turns out Dr. Linge that was mentioned in the above links also does research in dermal replacement.
and finally this article that got me a little excited
"These developmentally related differences in fibroblast response to TGF-beta1 may influence wound-healing outcome, i.e., perfect regeneration or fibrosis."
P.S - does anyone have access to this article? There is a 12 month lag time with this journal through my library so I can't access it online.
P.P.S one more review that I want to get my hands on (Says it comes out Jan 08 but I think an electronic version is available online)
Yes, they keep dangling the carrot and we keep following like asses (no offense and I am one of the biggest asses (figuratively)!)
Let me see if I can get into these on Monday. We might have a corporate account, although I have purchased these articles in the past.
Renovo back in the news
Nothing really new. Damn that 2011 at the earliest statement.
An interesting study -turns out this article is a direct comparison between fetal and adult tissue (they say to their knowledge it has not been done)
Turns out Dr. Linge that was mentioned in the above links also does research in dermal replacement.
and finally this article that got me a little excited
"These developmentally related differences in fibroblast response to TGF-beta1 may influence wound-healing outcome, i.e., perfect regeneration or fibrosis."
P.S - does anyone have access to this article? There is a 12 month lag time with this journal through my library so I can't access it online.
P.P.S one more review that I want to get my hands on (Says it comes out Jan 08 but I think an electronic version is available online)
Yes, they keep dangling the carrot and we keep following like asses (no offense and I am one of the biggest asses (figuratively)!)
Let me see if I can get into these on Monday. We might have a corporate account, although I have purchased these articles in the past.
Ok, but don't purchase it ...it's at my school's library I believe so if I need to I can grab it and photocopy it and scan it. There is just a 12 month delay on the electronic versions. I'm not sure of my school carries the journal that the review is from though.
EDIT: Don't know if I posted this article earlier but its another one I'd like to get my hands on:
http://www.ncbi.nlm.nih.gov/sites/entrez?D...Pubmed_RVDocSum