Acne.org Products
Hey guys,
something new from the skin printer and a dermal matrix solution:
http://www.ncbi.nlm.nih.gov/pubmed/21351374
http://freshnewsdaily.com/tag/skin-regeneration/
http://www.science20.com/news_articles/vit...in_regeneration
The lotion is applied daily with a chicken feather onto the lacerated flank of a horse.
Omg, I hadn't read that sentance when I copied the text. That sounds so unusual. lol...
haha, that would explain a lot. I tried it with a pigeon feather.. my horse is now dead 
Funny thing also, to use the flank of a horse as the test site 
Here's the latest lengthy Hitzig audio interview regarding hair restoration which ties into scar prevention in a way.
http://www.baldtruthtalk.com/showpost.php?...p;postcount=120
There's one caller coming in at one point saying he's fed up with the fact there's no cure for hair loss. Hitzig replied and said he expects there to be a cure in two years which I thought was a pretty
baldbold statement.
Hey guys,
something new from the skin printer and a dermal matrix solution:
http://www.ncbi.nlm.nih.gov/pubmed/21351374
http://freshnewsdaily.com/tag/skin-regeneration/
http://www.science20.com/news_articles/vit...in_regeneration
Great links mate! Regeneration using a pre-built scaffold seems to be the new black. Hitzig's autocloning procedure kinda builds on the same principle, where the plucked hair povides the scaffold in which the new follicle can form. The fact that just some ECM can provide enough of a 'base' around the follicle for the mesenchymal cells to act gives some hope for the possibility of scarless healing using scaffold techniques imo.
LOL, wonder which star trek nerd came up with a skin printer. interesting concept though 
A scarfree future for kids, for adults too ?
http://scopeblog.stanford.edu/archives/201...r-free-fut.html
What about these dot cells?
A scarfree future for kids, for adults too ?
http://scopeblog.stanford.edu/archives/201...r-free-fut.html
What about these dot cells?
Interesting stuff! I'm going to read that.
Came across an interview with someone from Histogen (see here) saying that something they are working on which can be "hugely beneficial" to people who have scarring for whatever reason is going to come out, if it's up to them, in 2015 in the USA and prior to that in other countries. They said this in 2009 so I don't know if things have changed nor do I know if this has been discussed earlier in this thread but I thought I'd mention it here.
Here's the interview I mentioned, to avoid confusion:
http://www.baldtruthtalk.com/showthread.php?t=1560
Not much talk about scars in it, it's mostly about hair loss. But the Histogen person mentions what I said he did at some point in passing.
Interesting stuff. Maybe hair regeneration will lead to scar regeneration. Remember the iodine treatment from Dr Derry. He mentioned hair follicle as power houses of regeneration. And keep in mind that the mother of all skin stem cells can be found near hair follicles.
Interesting times. Hm. Maybe we will really receive one day the treatment we deserve.
Interesting stuff. Maybe hair regeneration will lead to scar regeneration. Remember the iodine treatment from Dr Derry. He mentioned hair follicle as power houses of regeneration. And keep in mind that the mother of all skin stem cells can be found near hair follicles.
Interesting times. Hm. Maybe we will really receive one day the treatment we deserve.
I hadn't really heard of Histogen up till now (at least not that I can remember) and I have to say that their approach using human fibroblasts if I understood correctly instead of any embryonic cells or animal products is way more appealling to me than e.g. ACell's approach where you get a pulverized pig bladder implanted into your face.
Also, here are a few interesting things I saw on Histogen's website:
Histogen is also considering additional future studies for its ReGenica skincare products, as well as the potential for product line expansion in other areas of the aesthetics and dermatology market, such as nail care, lip care, acne applications, and sun protection.
Histogen scientists have demonstrated that, in both monolayer and suspension cultures under hypoxic conditions, normal human newborn fibroblasts become multipotent cells and express key pluripotent stem cell markers including Oct4, Sox2 and Nanog as well as a number of tissue and germ layer-specific stem cell markers, such as Brachyury, Gata4, alpha-fetoprotein, and Pax6. The stem-like cells induced in monolayer are seeded onto dextran beads and grown in a hypoxic suspension where they secrete a variety of soluble and insoluble molecules associated with stem cell niches in the body, as well as rapid tissue growth with scarless healing.
scarless healingScarless healing has been here since time began. A caveman once found that if you put dirt in a wound you get a bigger scar.
Scarless healing is a weasel term.
Hey it seems they've at least got something that may improve things... Even if it isn't literally scarless it might me worthwhile nevertheless.
Came across an interview with someone from Histogen (see here) saying that something they are working on which can be "hugely beneficial" to people who have scarring for whatever reason is going to come out, if it's up to them, in 2015 in the USA and prior to that in other countries. They said this in 2009 so I don't know if things have changed nor do I know if this has been discussed earlier in this thread but I thought I'd mention it here.
Correction: he didn't say "hugely beneficial" but "extremely beneficial". lol
heh, heh, like I said the term scarless healing is a weasel term...
Here's an excerpt from a report of some gathering from last year regarding the RGTA ECM:
MATRIX THERAPY RGTA.
BASED REGENERATIVE MEDICINE:
CLINICAL STUDIES IN CHRONIC WOUNDS
AND DIABETIC FOOT ULCERS AND
DEVELOPMENTS IN PLASTIC SURGERY
Denis Barritault
Francia
Extra cellular matrix (ECM) is the natural reservoir of peptide signals identified as
local regulators of tissue homeostasis (growth factors, cytokines, chemokines etc.).
Heparan sulfates (HS) are key elements of the ECM architecture bridging and
protecting matrix proteins and forming a scaffold on which these signals are
positioned in a spatial organization. Tissue lesions destabilize this microenvironment,
inducing destruction of HS and then of HS protected factors.
We have engineered biodegradable nano-polymers to replace HS in the scaffold and
to protect the newly synthesized signals when introduced in the wounded tissue. By
restoring a microenvironment resembling the initial ECM architecture, the natural
process of tissue homeostasis can resume and tissues regenerate. This concept of
regenerating agent (RGTA)A and matrix therapy was validated in preclinical studies
in over 20 animal models by a network of academic laboratories worldwide in 70
publications. A specific product issued from RGTA technology was developed and
EC marked as a medical device under the trade mark CACIPLIQ20 adapted to treat
chronic skin ulcers. Several clinical trials and studies performed in France, US, Italy,
Holland, Tunisia, Saudi Arabia, have now demonstrated unique efficacy of
CACIPLIQ20 to induce wound closure and saved many patients from amputation
when no other treatment showed efficacy.
This ability to induce a regenerative process, strongly supported by preclinical
studies is now under evaluation in plastic surgery for scar reduction, resurfacing and
other esthetic and aging uses with adapted RGTA polymers and formulation.
Denis BARRITAULT
It's pretty cool that they're looking into this at the moment apparently as up until now they really only used this RGTA technology for closing chronic wounds.
Btw, I also might shoot an e-mail Histogen's way, asking politely about how what's in the pipeline may be of benefit to us. No stalker. haha As they said anyone can contact them anytime.
http://www.otr3.com/index.php?lang=en
So if I've understood correctly they've got the orange cacipliq20 the blue cacicol20 and eventually they'll have a third product for scar reduction. I'm guessing it's going to be green.
One thing I've heard is that these products are seen as things that aid rather than cure. So that means that all that has to be proven is that they are safe before they can be used to treat people. Which means that they become commercially available way faster. We'll see.
unrelated story:img8.imageshack.us/g/picture001ig.jpg/
small wound on my thumb healed without a scar. process took 2 weeks. guess nature decided the functionality of the fingers are more important than, say, face...
lol I once had a paper cut in my index finger which took FOREVER to heal but there's no visible scarring either! 
They say that EVERY wound no matter which size or place ALWAYS has a BIT of scarring, though. Even though you might not see it. 
Btw, what's with Imageshack attacking people's computers man? I checked out those photos and Norton had to block an attack. Norton wins. Flawless victory!
Well scarless healing is bound to happen just hope it would be sometime soon and easily accessible. And if someone really does have the winning formula or something close the first thing after fda approves is the hit the plastic surgery area, they'd get a hell lot more money to fund the research then what govt or investors can offer.
I just want to see something effective on the market even if it's not full scar free healing, say like a solid 70-85% healing without scars.
Well scarless healing is bound to happen just hope it would be sometime soon and easily accessible. And if someone really does have the winning formula or something close the first thing after fda approves is the hit the plastic surgery area, they'd get a hell lot more money to fund the research then what govt or investors can offer.
I just want to see something effective on the market even if it's not full scar free healing, say like a solid 70-85% healing without scars.
People have been researching scar less healing since time began bud. If you look there is even a citation that shows scarless healing has been researched since before 1906.
The term scarless healing is also an absolute weaselling term bud. It has get out written all over it.
Scar'less' healing can mean anything.
And I can promise you scar'less' healing right now?
I could get you to put two cuts on you. BTW these cuts would be bigger than 2mm, to ensure myofibroblast proliferation (the cause of the scar). Also we at acne.org could make our own interpreted scar scale, which we could call the acne scale. In one of these two cuts we would constantly apply horse shit, on the other we would makes sure it was clean and moist.
We would then assess the wound using our special acne scale, with our confirmation bias, we would expect to see one wound scarred alessa; the moist one would be the one scarred alessa guessing on expectations. We'd see scarred less.
However the term ascar freea, is a completely different term, has no get out.
IMO someone should lock this thread. Or change its name to scar free healing.
Hey guys, something new for the treatment of scars concerning tge physical stress which leads to nearly scarless healing. One of the factors of scarring is solved.
http://www.medicalnewstoday.com/releases/226245.php
And the paper for this study:
http://www.ncbi.nlm.nih.gov/pubmed/21606834
I hope it will have a huge impact on wound dressing and scar managment. I think that with this work one major problem of scars has been adressed, the tension.
Neo