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Hi NeoMike. Nice to see you around! I hope it all works with your treatment. 
I'll check out the link you posted in a minute as I gotta run in a second. 
Here's more interesting stuff; people have actually created CAR-decorin which seems to be more effective than decorin itself in the prevention of scars when wounds are flooded with it. They say the reason it hasn't been seen so far in clinics may be that decorin seems to be hard to make in large quantities. Read all about it here in this article from November 2010:
http://beaker.sanfordburnham.org/?p=2764
Excerpts: The healing power of even the most promising drug is diminished if it can‚„t reach the right spot. The peptide portion of this new therapeutic molecule, called CAR-decorin, is made up of just nine amino acids (see Proteins 101) that selectively target new blood vessels in a healing wound, squeezes out of the bloodstream and penetrates the injured site. Once carried there by the peptide, the decorin portion blocks an inflammatory molecule called transforming growth factor-Ž² (TGF-Ž²). Fortuitously, as it turned out, the CAR peptide component not only carries decorin to the site of injury, but also enhances its ability to block TGF-Ž² activity. With this CAR-decorin damper, TGF-Ž² cannot generate the fibrotic tissue that makes up a scar.
Our original results showing that decorin blocks scarring have been repeated in numerous animal studies and drugs like this are badly needed. However, decorin has never reached the clinic, most likely because decorin is difficult to manufacture in large quantities,‚ says Dr. Ruoslahti. ‚Å“Here we demonstrate that CAR-decorin is far more active than decorin itself, which may make this compound attractive for clinical development.
Hey Lapis, thanks for the kind words. Indeed, if my therapy works well, than it will work well for most of the people here, because their scars are relatively mild in comparison to my burn scars.
Here are some websites regarding the printing of skin. Nothing new, but it shows the progress in this field.
http://www.bbc.co.uk/news/science-environment-12507034
http://edition.cnn.com/2011/TECH/innovatio...unded.soldiers/
If somebody here needs original papers, please ask me, I can get nearly everything because I am a scientist, a biologist.
Through google, there is only a little bit of information available.
Has anyone here large scars and treated them with something successfull?
NEO
Hi NeoMike. Nice to see you around! I hope it all works with your treatment.
Here's more interesting stuff; people have actually created CAR-decorin which seems to be more effective than decorin itself in the prevention of scars when wounds are flooded with it. They say the reason it hasn't been seen so far in clinics may be that decorin seems to be hard to make in large quantities. Read all about it here in this article from November 2010:
http://beaker.sanfordburnham.org/?p=2764
Excerpts: The healing power of even the most promising drug is diminished if it can‚„t reach the right spot. The peptide portion of this new therapeutic molecule, called CAR-decorin, is made up of just nine amino acids (see Proteins 101) that selectively target new blood vessels in a healing wound, squeezes out of the bloodstream and penetrates the injured site. Once carried there by the peptide, the decorin portion blocks an inflammatory molecule called transforming growth factor-Ž² (TGF-Ž²). Fortuitously, as it turned out, the CAR peptide component not only carries decorin to the site of injury, but also enhances its ability to block TGF-Ž² activity. With this CAR-decorin damper, TGF-Ž² cannot generate the fibrotic tissue that makes up a scar.
Our original results showing that decorin blocks scarring have been repeated in numerous animal studies and drugs like this are badly needed. However, decorin has never reached the clinic, most likely because decorin is difficult to manufacture in large quantities,‚ says Dr. Ruoslahti. ‚Å“Here we demonstrate that CAR-decorin is far more active than decorin itself, which may make this compound attractive for clinical development.
It will not be better than decorin at blocking scarring, it can only equal it. Decorin inhibits fibroblast proliferation completely, this means no scar can be made.
Finally, I found some info on the 3rd scar club meeting that took place at the end of last year.
http://www.pshlibya.org/pshlibya_converted...ting%200210.pdf
I'm also looking for the report of this but no such luck yet. It'd be interesting to see what they had to say about clinical results regarding new therapies.
Finally, I found some info on the 3rd scar club meeting that took place at the end of last year.
http://www.pshlibya.org/pshlibya_converted...ting%200210.pdf
I'm also looking for the report of this but no such luck yet. It'd be interesting to see what they had to say about clinical results regarding new therapies.
inside that pdf i see some interesting...'''Seeing is believing. Amazing results with a herbal preparation for
hypertrophic scars.
Jain Pradeep (Varanasi, India) & Nikolaos Kostopoulos (Athens, Greece)'''
I found something about the herbal preparation
http://www.wuwhs.com/congress2008/abstract...ract_PW278.html
PW278 - Topical Herbal Preparation for Hypertrophic Scars : Our Experience
PRADEEP JAIN (DEPT. OF PLASTIC SURGERY,INSTITUTE OF MEDICAL SCIENCES, BANARAS HINDU UNIVERSITY,VARANASI-) SHEIKH ADIL BASHIR (DEPT. OF PLASTIC SURGERY,INSTITUTE OF MEDICAL SCIENCES, BANARAS HINDU UNIVERSITY,VARANASI-) ANIMESH DAMANI (DEPT. OF PLASTIC SURGERY,INSTITUTE OF MEDICAL SCIENCES, BANARAS HINDU UNIVERSITY,VARANASI-) V K Shukla (DEPT. OF SURGERY)
Goals and Objective
To find out the efficacy of a herbal preparation in management of hypertrophic scars as regards to color, texture and thickness.
Purpose
To find a single most effective modality for treating hypertrophic scars.
Method
Following informed consent and ethical approval, a new topical herbal preparation was used as the sole agent for treating hypertrophic scars in 15 patients, 10 with post-burn and 5 with post-traumatic scars, 6-12 months after the accident. The preparation was applied twice a day, no water/saline applied to remove the residue. No pressure garment was used. Color, texture and thickness of the scar were assessed periodically.
Results
Smoothened and shining skin was the first change noticed after 3 weeks of application but itching persisted. After 6 weeks, the thickness was reduced and the color changed from hyperemic to normal. The scars softened, and thickness further decreased at 12 weeks. At 16 weeks, the scar was confined to 10% of the previous extent in 10, and 15% in 5 patients with tolerable itching.
Discussion / Conclusion
Different therapeutic modalities have been tried for treating hypertrophic scars with mixed results. While silicon gel sheets are costly, intralesional triamcinalone is not free of systemic effects and the pressure garments are not user friendly in tropical climate.
The herbal preparation used as monotherapy had tremendous success in improving the hypertrophic scars with scar disappearing or flattening to great extent. There was slow and steady decrease in itching but it persisted within tolerable limit. There were no side effects and the patients' compliance was good. One lady had secondary infection due to scratching and responded to antibiotic.
The preparation has a promising potential for being used as a single agent therapy in management of hypertrophic scars and perhaps keloids as well. It is highly cost-effective too.
--------------------------------------------------------------------------------
Data current as of May 23, 2008
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Click here to see the latest version of this abstract on the server.
Maldition, its not terribly impressive.
I've attached a link to the poster they used back in 2008 for their herbal cream. It clearly shows the before and after shots and god, it looks less effective than silicone sheets or even enalapril.
What a disaster and to think they call it amazing. I think the doctors must be on cocaine or perhaps anything these days can be classified as amazing, or perhaps stupid or desperate.
I see... 
Thanks for the link
The only hope i have in this days are this:
http://www.scientificamerican.com/article....-a-common-sugar
http://machineslikeus.com/news/common-suga...-wound-scarring
Blocking a Common Sugar Molecule May Be Key to Preventing Scar Formation
Small sugar fragments can set off a signal cascade that increases inflammation and scar formation. A small peptide can block this process and allow scar-free healing
Unfortunately this is for sale in the year 2500
The only hope i have in this days are this:
http://www.scientificamerican.com/article....-a-common-sugar
http://machineslikeus.com/news/common-suga...-wound-scarring
Blocking a Common Sugar Molecule May Be Key to Preventing Scar Formation
Small sugar fragments can set off a signal cascade that increases inflammation and scar formation. A small peptide can block this process and allow scar-free healing
Unfortunately this is for sale in the year 2500
This is the only bit of hope I have as well.
Unfortunately, like you say, it will probably be a long time before we can actually try it out. It seems so simple as well. It's just a peptide.
The only hope i have in this days are this:
http://www.scientificamerican.com/article....-a-common-sugar
http://machineslikeus.com/news/common-suga...-wound-scarring
Blocking a Common Sugar Molecule May Be Key to Preventing Scar Formation
Small sugar fragments can set off a signal cascade that increases inflammation and scar formation. A small peptide can block this process and allow scar-free healing
Unfortunately this is for sale in the year 2500
That sugar was put forward as a carrier for decorin
I'm back.. i'm sorry if this is old news but i stumbled across this interesting short article i'd like to share :
February 7, 2011
"Insulin to Prevent or Reduce Scar Tissue?"
PharmEcosse, a Scottish company, is starting clinical trials to explore the use of insulin (PE001) for the reduction or prevention of surgical scars in patients undergoing non-cancer bilateral breast surgery. The trial will commence in January 2011 and is expected to report in the first quarter of 2013.
Insulin was found to control the activity of the key cells involved in wound closure and subsequent scar formation which apparently slows down or stops the build up of scar tissue.
For more information about taking part in clinical trials, please go to pharmecosse.com
It appears as though things have become stale.
All i can come up with in searches is Fraxel laser and the reviews are mixed indicating that this is simply another risk that could make matters work.
Yet i have this sense that there is something out there.
much of it has been discussed here.. Decorin and the recent study posted involving a peptide..
right now all we have is some information,
faith and hope (we need both)
has anyone found anything new?
I'm constantly reading articles about new discoveries and things but they seem to just disappear and we never hear about them again.
It's so frustrating. I recently read an article on osteopontin and a protein that blocks the creation of RSK. Both have been hailed as huge discoveries that could banish scarring, the only problem is that one article is over 3 years old and the other nearly 4 years old. I'm sure both these stories have been posted here in the past.
So what happened to these discoveries???? Where's a decorin treatment available? What about peptide 15-1? I suppose the peptide treatment is fairly new so I can understand why nothing has come of that yet but what about all the other discoveries we hear about?
Sorry for rambling on guys I'm just so frustrated at the moment. I've been on the enalapril for god knows how long now and still absolutely nothing. There really doesn't seem to be anything else in the near by future that could work, lots of new discoveries, but they appear to be quite a way off (and that's if we ever hear about them again). What frustrates me more than anything is that we seem to have the answers already (potentially) but when we get a viable treatment that's available to the public is anyone's guess.
http://www.timesonline.co.uk/tol/news/uk/article559955.ece
We created a mouse that could regrow limbs and organs. This was 6 years ago. In 2011 we don't even have an available treatment that works for the most basic scar.
We created a mouse that could regrow limbs and organs. This was 6 years ago. In 2011 we don't even have an available treatment that works for the most basic scar.
Regeneration and greater longevity... I WANT THOSE GENES! ;p
Would be interesting to know how long they lived for, should be known by now. I'd otherwise imagine that a higher rate of cell division would imply a shorter lifespan.
On a side note, Ellen Heber-Kratz is one cruel ...
‚Å“We have experimented with amputating or damaging several different organs, such as the heart, toes, tail and ears, and just watched them regrow,‚ she said. ‚Å“It is quite remarkable. The only organ that did not grow back was the brain.
Pepo I feel exactly the way you do about all of this.
So many potential studies to build on : Insulin shots, Peptide 15-1 etc.. and still nothing?
No they will continue to push lasers even as reviews are mixed. I came close to doing Fraxel ..for what? 20 % improvement? My scars are mild but enough to piss me off. I read the reviews and after reading negative comments decided, It's not worth it. We want to banish scars and if limbs can be regrown in these studies then humans deserve new skin.
It is all very disappointing, i am as when started my research, in zero.
My years of research on growth factors b1.b2.b3, are in the trash, even i do not understand that they do not operate juvista if was the explanation of the modulation of these factors.
start all over again, is very hard.
Pepo I feel exactly the way you do about all of this.So many potential studies to build on : Insulin shots, Peptide 15-1 etc.. and still nothing?
No they will continue to push lasers even as reviews are mixed. I came close to doing Fraxel ..for what? 20 % improvement? My scars are mild but enough to piss me off. I read the reviews and after reading negative comments decided, It's not worth it. We want to banish scars and if limbs can be regrown in these studies then humans deserve new skin.
Personally I don't think Fraxel is worth the money at all. Even if it offered complete resolution (which of course it doesn't) it is still a hell of a lot of money. The results really don't seem that good either.
why dont more of you look into bee venom therapy.
It's simply too hard to do. It just doesn't seem very accessible at all. I read the thread posted about it a while ago and looked into it briefly but I couldn't find anyone who sold the venom, even then I wouldn't know how to apply it. Also it seems virtually impossible to get a bunch of bees and then to get them to sting you exactly where you want. All the cases out there appear to be anecdotal and all I read were entirely accidental, highlighting the nature of the treatment.