I have been on Spiro for three months now, initially taking 25mg for 1.5 months before increasing my dosage to 50mg. On both occasions I experienced IB (initial breakout) from the medication. Everyone's experiences will vary with some finding their skin clearing quickly, but from what I've read online from other people's experiences with spiro, it can take as long as 6 months to really see drastic change. Even at the third month, I still have minor issues (blackheads, closed comedones) but my inflamed pimples and cysts have tremedously gone down. Two months is not that long so keep taking the spiro, the doxy should help in reducing inflamation from the purging.

When I started I realize I stop breaking out on my chin and broke out more on my cheeks. Now into the 3rd month (doctor said no it would take 3 months to work) my acne significantally subside. I have little white ones here and there but its nothing Marios drying lotion cant cure.