I have experienced this issue about 2 weeks ago or so. I was told by my specialist to use it a week to see results, such as dryness, redness etc..However, on my third day using epiduo daily, my skin was extremely dried, I couldn't even smile without feeling the pain. I decided to stop using epiduo and purchase a daily moisturizer which is against dryness. 3-4 days of using moisturizer my skin went back to normal, no dryness, no painful stuff, no redness.

But it could also be depending on your skin, in case you are sensitive, you shouldn't be going for products such as epiduo.

I'm saying that I only used Epiduo ONCE and it has done so much damage to my skin.