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15 And Starting Accutane

MemberMember
0
(@cleanjunebug)

Posted : 07/21/2013 2:13 am

Hello everyone,

Ok so I have just recently started talking Clarus (accutane) at 40mg/day, I am 60kilos and I am excited because already after 2 weeks I am seeing improvement, and the other day I stumbled onto this website and have seen some of these posts about people getting really screwed up by this drug. So far in terms of side effects I have had chapped lips, dry skin around my face and some minor joint pain and back pain here and there.

So I just wanted to know what are the chances of me being affected by these long term effects?

I'm really just concerned and worried about permanently or even just damaging my body in a negative way.

And also if anyone could recommend a good moisturiser and lip chap I could find at like a walmart

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MemberMember
13
(@biggs881)

Posted : 07/21/2013 2:24 am

 

There are 2 studies to my knowledge on the long-term safety of Accutane:

 

http://www.ncbi.nlm..../pubmed/7918010 (720 people)

 

We assessed possible long-term side-effects of isotretinoin therapy in 720 patients who had received one or more courses of treatment, and had a mean follow-up period of 4.9 years (range 2-12 years). Most patients (442) had received a total cumulative dose of 120-200 mg/kg body weight. One hundred and sixty-two patients received a cumulative dose of < 120 mg/kg body weight, and 116 received a cumulative dose > 200 mg/kg. Fifty-two patients (7.2%) reported persistent symptoms during the follow-up period. No correlation was found between age, sex, cumulative dose, or number of courses of isotretinoin and occurrence of reported possible side-effects. The reported symptoms were predominantly musculoskeletal (2%) or mucocutaneous (4.8%), and were mild in all cases. Xeroderma, dry eye syndrome, arthralgia, and possible exacerbation of
were considered to be infrequent but probable long-term side-effects. The findings of this study indicate that isotretinoin in the treatment of acne is a safe drug, with no serious long-term side-effects.

 

http://www.ncbi.nlm..../pubmed/8286227 (88 people)

 

The purpose of this study was to assess the long-term benefit of isotretinoin in otherwise therapy-resistant
We also assessed risk factors which might influence the long-term outcome. We studied 88 patients (mean age 20.8 years), most of whom had suffered from acne for many years (mean 7.4 years). They received isotretinoin in an initial dose of 0.5 or 1.0 mg/kg/day. The dose was subsequently adjusted according to response and side-effects. Most patients only required 4 months' therapy to produce at least 85% clinical improvement. The patients were seen up to 10 years post-therapy (mean 9 years). Sixty-one patients were still virtually clear of disease. Of the others, 16% required further treatment with conventional antibiotics and 23% required a second course of isotretinoin. Of those who relapsed, 96% did so within 3 years of stopping therapy. The patients' age, sex, and duration of acne did not influence outcome. However, in patients with predominantly truncal acne, especially when severe, there was an increased incidence of relapse. Sebum excretion is known to correlate with acne severity, but the long-term degree of sebum suppression was found not to be related to relapse. The dose schedule, in particular cumulative dose, was an important factor in determining relapse rate. Those patients who received 0.5 mg/kg daily, or a cumulative dose of < 120 mg/kg, had a significantly higher relapse rate than patients receiving a larger dose. We did not elicit any long-term systemic or biochemical side-effects. We conclude that isotretinoin is a safe and effective therapy.

 

j.1365_2133.1994.tb08524.x.pdf

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