Thomas, do you know the similarities between Ashwagandha and Mifepristone?

If youre having a positive outcome and those who took mifepristone also had a positive outcome, Im thinking they might be addressing the same issue

I know which Id prefer to take though.

Your thoughts?

Similarities? I believe both address cortisol excess. Differences? Ashwaganda is pro androgen. Mifeprisrone is anti androgen, which is what accutane is.

Other than noticable energy increase, I can tell my liver function is somewhat improved. Bloating has slightly decreased, and my biofeedback scan today indicated significantly improved liver function.

It's not just ashwagandha though. Mucuna is playing an important role as well. Without the Mucuna I get extreme rls. Mucuna does a better job of knocking out rls than anything I've ever used. I believe accutane is still in the body, and when ashwaganda downregulates 5ht1a back to normal, it increases cytochrome p450, which has been suppressed from accutane, which pulls accutane out of the brain and into the toilet, which creates the rls that Mucuna addresses.

Vitamin A regulates the dopaminergic system. Daily retinol or beta carotene intake is important. I get my retinol from lactose free skim milk and cheese. Others might choose carrots, sweet potatoes, or carrot juice for beta carotene. Whole beef liver I believe is too much retinol to intake while trying to detox accutane.

The main problem with ashwagandha is a lot of companies screw around with it in a lab and create something that does more harm than good. Anytime you see a percent sign on the backside of the label, you know the product is not natural and is garbage. Adding black pepper or piperine is also problematic because black pepper and piperine are anti androgenic and impairs cytochrome p450.

I'm using pure organics brand ashwaganda and earthborn elements Mucuna, both from Amazon. Search for no fillers in Amazon search engine and those brands should come up. I believe the ancestral living bone product is helping my joints and back issues. Mcha is similar to the ancestral product and might be cheaper.

My medicomat biofeedback machine has always done a great job of pinpointing and naming specific issues all over my body, but the engineers failed to include ashwagandha and mucuna in the supplements database. I think if they had included these two herbs, my issues would've been over with years ago. Fingers crossed.

Cytochrome p450 is an iron based enzyme, and the machine has been calling for iron, so I added it today. I'm finding it's best for sleep to take supplements in the morning.

With what I'm feeling right now, I think the drug is still in the body and I think we've been pushing it around the body like a pinball. We take something for our brain, it travels to our liver and heart. We take something for the liver, it goes to the brain. It goes to tissues that aren't being treated at the time.

I think I recall tj experiencing this with his kinesiologist. The kinesiologist would treat one part of tj's body, and that body part would improve, but another part of his body got worse. Is that accurate tj?

Starting Sunday I'm trying every Himalaya herbals organ support product they've got. I'm sick and tired of this war and I want it over with.

Im not sure Id describe it as pushing it around as such, Im not even entirely sure its still in the body

My kinesiologist thinks my body, mainly my brain triggers off an autoimmune inflammatory response. He is using a kinesiology program by Wally Schmitt called putting out the brain on fire

Its early days but well see where this leads. Gallbladder issues continue to come up, cleared a virus last session that was in the pancreas. Ultimately though the goal is to get rid of that brain inflammation!!

19 hours ago, Thomas76 said:

Cytochrome p450 is an iron based enzyme, and the machine has been calling for iron, so I added it today. I'm finding it's best for sleep to take supplements in the morning.

Hi, does st John's wort do the same thing in terms of inducing cytochrome p450? Is at John's wort pro or anti androgen? Which is bad for us accutane sufferers? Pro or anti androgen?

I'm not sure about St John's worts exact mechanisms. Google probably does though. I had a bad reaction to St John's wort years ago and won't touch the stuff again. Anti androgens are bad for accutane ppl, pro androgens are good for us, but only minimally.

I agree with TJ about brain inflammation being a central issue in all of this. My gallbladder is problematic as well. Stress can lead to gallbladder issues. I've always felt that accutane syndrome feels like ptsd. I've changed my mind on going crazy with a ton of different products from Himalaya herbals, and instead chose just one of their products called Stresscare, which is a combination of a very wide variety of herbs, not just one or two. It arrives tomorrow. East Indian herbal medicine has been around for thousands of years. Obviously it's a far better approach than pharmaceuticals.

It seems like I start to get some benefit from an adaptogenic type herb here, another adaptogen herb there, but then the positive effect goes away and I'm back to square one. My machine has always indicated systemic hypertension, and it's listed solutions have always been pharmaceutical antihypertensive drugs, which my body doesn't like. Another term for tension is stress, right? So will see how the Himalaya stresscare does starting tomorrow. Lots of good reviews for it on Amazon.

6 minutes ago, Thomas76 said:

I'm not sure about St John's worts exact mechanisms. Google probably does though. I had a bad reaction to St John's wort years ago and won't touch the stuff again. Anti androgens are bad for accutane ppl, pro androgens are good for us, but only minimally.

I agree with TJ about brain inflammation being a central issue in all of this. My gallbladder is problematic as well. Stress can lead to gallbladder issues. I've always felt that accutane syndrome feels like ptsd. I've changed my mind on going crazy with a ton of different products from Himalaya herbals, and instead chose just one of their products called Stresscare, which is a combination of a very wide variety of herbs, not just one or two. It arrives tomorrow. East Indian herbal medicine has been around for thousands of years. Obviously it's a far better approach than pharmaceuticals.

It seems like I start to get some benefit from an adaptogenic type herb here, another adaptogen herb there, but then the positive effect goes away and I'm back to square one. My machine has always indicated systemic hypertension, and it's listed solutions have always been pharmaceutical antihypertensive drugs, which my body doesn't like. Another term for tension is stress, right? So will see how the Himalaya stresscare does starting tomorrow. Lots of good reviews for it on Amazon.

Thank you for your reply.

2 minutes ago, Sweetcapricorn1234 said:

Thank you for your reply.

As a female sufferer I'm not sure which way to go. My symptoms are hair shedding, dry eyes, bloating, constipation, can't seem to lose weight easily. Boobs are bigger after accutane. But no sexual problems. Had every blood test under the earth and everything normal. Had a full thyroid panel every few months for years now and that's all normal. Tash, T3, t4 normal. What am I suffering? High estrogen or high testosterone, who knows. All hormone levels normal as well

17 minutes ago, Sweetcapricorn1234 said:

Thank you for your reply.

As a female sufferer I'm not sure which way to go. My symptoms are hair shedding, dry eyes, bloating, constipation, can't seem to lose weight easily. Boobs are bigger after accutane. But no sexual problems. Had every blood test under the earth and everything normal. Had a full thyroid panel every few months for years now and that's all normal. Tash, T3, t4 normal. What am I suffering? High estrogen or high testosterone, who knows. All hormone levels normal as well

Just want to add, I tried st John's wort. It did nothing to help with depression, but it did make me more sexual.

SC you have high estrogen and likely low T. might want to try Oregon's wild chaste tree from Amazon. Lots of women swear by it for female hormonal balance.

I read some pubmed studies today that stress increases aromatase activity. Resolve the stress, resolve the aromatase excess.

2 hours ago, Thomas76 said:

SC you have high estrogen and likely low T. might want to try Oregon's wild chaste tree from Amazon. Lots of women swear by it for female hormonal balance.

Thanks Thomas, so would I need anti or pro androgens?

If I were a female accutane victim I'd try vitex agnus castus, aka chaste tree. It does an excellent job of balancing out female hormones, regardless of which direction they need to go, because its amphoteric. If a woman's libido is too low, it brings it up. If her libido is too high, it brings it down a notch. If her breasts are too small it slightly increases size. If the breasts are too large and sore, it reduces size.

As for me, I realized the ashwaganda was doing me more harm than good because it is a nightshade, and nightshades are just no good for gut health. Also cancelled the Himalaya stresscare order. Trying a combo of Mucuna and magnolia bark tonight. Mucuna boosts dopamine, and magnolia bark is anti adrenergic and calming to mind and gut. Will see how it goes.

SC, vitex can be pro or anti androgen, depending on what the woman's body needs to happen. That's the beauty of an amphoteric herb like vitex.

5 minutes ago, Thomas76 said:

If I were a female accutane victim I'd try vitex agnus castus, aka chaste tree. It does an excellent job of balancing out female hormones, regardless of which direction they need to go, because its amphoteric. If a woman's libido is too low, it brings it up. If her libido is too high, it brings it down a notch. If her breasts are too small it slightly increases size. If the breasts are too large and sore, it reduces size.

As for me, I realized the ashwaganda was doing me more harm than good because it is a nightshade, and nightshades are just no good for gut health. Also cancelled the Himalaya stresscare order. Trying a combo of Mucuna and magnolia bark tonight. Mucuna boosts dopamine, and magnolia bark is anti adrenergic and calming to mind and gut. Will see how it goes.

SC, vitex can be pro or anti androgen, depending on what the woman's body needs to happen. That's the beauty of an amphoteric herb like vitex.

Thanks Thomas I'll look into that. I know when I was on st John's wort, my libido increased although I didn't have any issues with it and also my hair shedding was less. Any ideas why that would be?

SC, the St John's wort improved your liver cytochrome p450 function, which improved your libido and hair growth. The reason it failed me is it decreases 5 alpha reductase, which is the enzyme that converts testosterone to dht. Dht is far more important for men than testosterone.

14 minutes ago, Thomas76 said:

SC, the St John's wort improved your liver cytochrome p450 function, which improved your libido and hair growth. The reason it failed me is it decreases 5 alpha reductase, which is the enzyme that converts testosterone to dht. Dht is far more important for men than testosterone.

Thanks, I might go back on it, I've read that it decreases estrogen, not sure if that is true or not.

Dropped the magnolia bark, maintaining the Mucuna, and just added passionflower and noni today for pineal gland detox. Dr Christopher's glandular herbal formula arrives Wednesday.The pineal converts serotonin to melatonin.

My posts should always be taken with a grain of salt. Nobody knows the cure yet, but I like to throw lots of ideas out there for others to research.

And anyone who comes in here and says change your diet was never suffering from accutane syndrome in the first place. They were suffering from a poor diet.

7 hours ago, Thomas76 said:

And anyone who comes in here and says change your diet was never suffering from accutane syndrome in the first place. They were suffering from a poor diet.

Doubt its a low p450 issue, not aware of any reported toxicities.

On 5/19/2022 at 11:58 AM, Calcified said:

What if it's the other way around.

Cancer cells feed off of whatever normal cells use to thrive. Don't feed the tumors. I've been out of this conversation for a while, what's going on? You have benign colon tumors? Did they test them for HPV?

On 12/10/2017 at 11:06 PM, Agustha said:

1. I would take up the biotin supplement and wait for THREE months. Yes, it can take up months until you notice the result. If you're taking this, please continue.

Realized this myself. I've used Biotin on and off but am now sticking with it and I'm getting positive effects.

I'm going to try and get to the bottom of this Biotin issue. I think I've had a 20 year deficiency that was caused by Accutane. I have all the signs and symptoms and using Biotin is making me feel better. I'm going to stop using it today, wait a week, then test Biotin levels, and biotinidase enzyme levels. I already did the genetic test for biotinidase and it was negative so I wasn't born with this problem.

I wonder what were NOT deficient in??

For me this week after seeing kinesiologist it was Magnesium, such a major co factor in almost everything esp serotonin and dopamine production etc

On asking practitioner on how much I need he said keep going with it bottle after bottle, 20 drops per day.

10 minutes ago, TrueJustice said:

I wonder what were NOT deficient in??

It makes sense. Why are we getting worse years after taking tane? And developing new problems? Because what's happening is we are manifesting signs and symptoms of long term, chronic vitamin deficiencies.

Hello kasyani, we aren't suffering from adult acne. We are suffering the aftereffects of accutane. I've been pimple free for over 30 years due to accutane.

I think monster diesel has naturally high 5 alpha reductase, which is why he can tolerate a biotin supplement without negative hormonal consequences. If I were to supplement biotin it would destroy me hormonally.

My biofeedback machine says my brain magnesium is high. I never get any good effect when I supplement magnesium. Always makes me feel worse. Bovine based bone calcium on the other hand my body reacts well to.

I can understand Tommy's use of mifepristone from a cortisol perspective, since it does lower it. The problem is it's also anti androgen, which is no good for me.

Right now I believe it's a case of permanent brain damage, in a way that causes chronic insomnia and chronic cortisol release. Thst would explain why i crave skim milk, and why my machine is always recomending Biocalcium, and why I get a slightly positive result from Biocalcium. Cortisol is acidic. Adrenaline is acidic. These two hormones strip my bones of calcium, thus the constant skim milk craving.

Besides insomnia Im also prone to depression and rls. So which antidepressants are for sleep. Trazodone, remeron, and the tricyclics amytriptaline and doxepin. Remeron causes rls so it's out. The tricyclics are anticholinergic, so they're out. Which leaves trazodone. Trazodone also lowers cortisol release. im trying low dose trazodone before bed starting this coming weekend, with whole herb earthborn elements ginkgo mornings. Will see what happens.

15 minutes ago, Thomas76 said:

 

I think monster diesel has naturally high 5 alpha reductase, which is why he can tolerate a biotin supplement without negative hormonal consequences. If I were to supplement biotin it would destroy me hormonally.

In what way does it affect you? And have you measured your hormones to confirm it? My T levels have been 100-400 for the last 20 years.