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2 hours ago, Calcified said:How your drops going? I looked into them sounds good, seems too favour vitamin D. Would probably make me too oily.
Nothing noticeable to be honest
im looking forward nowto my upcoming hormone test with endocrinologist.Its time to go down this path, get on to a drug that actually has some impact. My fatigue and brain fog is worse than ever right now - Ive thrown everything possible at it going down the natural path, its just not having a big enough impact, I wish this approach did workthough
Besides, if this natural approach did work than surely I can expect my hormone panel to show nothing wrong, I bet my bottom dollar that wont be the case.
Adding to my last post, pretty lengthy paper here.
The molecular mechanisms mediating dendritic cell responses to anti-inflammatory microbes
There is a whole lot of discussion and hypothesis on bifido 35624 (Align) probiotic and its interactions and possible synergy with vitamin a.
"RALDH2 expression and retinoic acid production link nutrition (vitamin A), commensal microbiota and tolerance induction. These results suggest that supplementation with specific tolerogenic microbes may provide benefits to patients suffering from wide range of mucosal inflammatory disorders."
"One such strategy is the deliberate manipulation of CD103+RALDH+ dendritic cells by microbes or microbial components in combination with dietary supplementation with vitamin A. The murine data presented in this report strongly support the further evaluation of these strategies in human clinical studies."
"Moreover, induction of vitamin A metabolism in the gut may result in higher retinoic acid concentration in the plasma and subsequent anti-inflammatory effects in other tissues."
B. infatis administration together with vitamin A may be beneficial for patients suffering from diverse intestinal inflammatory disorders. Moreover, recent reports about the positive impact on non-gut related diseases, such as psoriasis, opens the possibility for specific supplementation in other inflammatory conditions. Interestingly, the development of immunoregulatory bacterial compounds may broaden the spectrum of applications and could lead to new medicaments.
Guitarmans gut research is interesting. I think the gut is the source of our problems. Excessive serotonin, inadequate melatonin. Accutane seems to impair the conversion of serotonin into melatonin, which leads to ibs-d, hypertension and poor sleep. I recall testing extremely high in 5hiaa several years ago. Maybe there is a gut bug that increases serotonins conversion to melatonin.
My machine has several different therapy sections, including pharmaceutical, nutraceutical, foods, and homeopathic. I never really paid much attention to the homeopathic section because I don't believe in homeopathy. But one thing always showed up high in that section. Chamomilia. I just ordered chamomile capsules and they should arrive today. Will post results later.
Remeron is a drug that blocks serotonin, increases sleep and decreases ibs-d. If nothing natural exists to reverse the damage that may be the only option.
Took my first dose of chamomile and so far I'm ranking it ahead of all other herbs, including ginkgo, cordyceps, ginseng, ginger, garlic and passionflower. 2nd dose coming in a few hours. Doing two capsules twice daily. Definitely not healed by any means but I am definitely feeling the anti stress effects on my brain.
With the medicomat biofeedback machine, what I'm finding is the homeopathic section seems to be the most revealing about what the body needs. For example, today I woke up, scanned the body, and the machine wasn't recommending much of anything from the drugs or nutraceutical sections, but there were plenty of things listed in the homeopathic section. The most glaring thing that stood out this morning was dandelion. Just took some. If anyone has a medicomat device or buys one in the future I'd pay close attention to the homeopathic section recommendations.So right now it's chamomile dandelion and fish eggs. Will keep the board posted.
On 3/21/2022 at 5:47 PM, guitarman01 said:Adding to my last post, pretty lengthy paper here.
The molecular mechanisms mediating dendritic cell responses to anti-inflammatory microbes
There is a whole lot of discussion and hypothesis on bifido 35624 (Align) probiotic and its interactions and possible synergy with vitamin a.
"RALDH2 expression and retinoic acid production link nutrition (vitamin A), commensal microbiota and tolerance induction. These results suggest that supplementation with specific tolerogenic microbes may provide benefits to patients suffering from wide range of mucosal inflammatory disorders."
"One such strategy is the deliberate manipulation of CD103+RALDH+ dendritic cells by microbes or microbial components in combination with dietary supplementation with vitamin A. The murine data presented in this report strongly support the further evaluation of these strategies in human clinical studies."
"Moreover, induction of vitamin A metabolism in the gut may result in higher retinoic acid concentration in the plasma and subsequent anti-inflammatory effects in other tissues."
B. infatis administration together with vitamin A may be beneficial for patients suffering from diverse intestinal inflammatory disorders. Moreover, recent reports about the positive impact on non-gut related diseases, such as psoriasis, opens the possibility for specific supplementation in other inflammatory conditions. Interestingly, the development of immunoregulatory bacterial compounds may broaden the spectrum of applications and could lead to new medicaments.
LOL.
I literally have two lacking bacterias on my gut mucus. Provetella and Akkermensia. I think that is it. I found my root issue.
Be 16 years old- take Accutane for 3 days- experience retrogade ejaculation on the third day and quit the drug- 7 years of nightmare begins- my symptoms go worse each year- still have libido though.
Accutane f*cks up my gut microbiome- that creates gut permability and infammation-that creates pelvic floor issues because why not- pelvic floor issues disables the healthy ejaculation of semen- the semen gets stuck inside and creates edemas in the prostate- prostate gets f*cked up- nerves get f*cked up- vessels get f*cked up- my scortum slowly loses fullness- varicoceles form- erections get soften- my whole lower body gets numb.
F*ck me for years of wasted time thinking the problem was on my androgen receptors due to that devil forum called Propecia''help''. That forum destroyed my mind. I was looking to the wrong direction all the time. That's why TRT or HCG didn't work for me but Progesterone did for a month,now everything makes sense.
https://www.linkpicture.com/view.php?img=LPic6218f7fd51e6e1187981798 = My gut microbiome test.
And by the way, i have no idea if you did a gut microbiome test or not too, if not, you are wastedyour life researching countless studies on the web and sitting on your PC screen all day. Sorry for everyone who went through this utterless crap.
18 hours ago, SaffronAide said:LOL.
I literally have two lacking bacterias on my gut mucus. Provetella and Akkermensia. I think that is it. I found my root issue.
Be 16 years old- take Accutane for 3 days- experience retrogade ejaculation on the third day and quit the drug- 7 years of nightmare begins- my symptoms go worse each year- still have libido though.
Accutane f*cks up my gut microbiome- that creates gut permability and infammation-that creates pelvic floor issues because why not- pelvic floor issues disables the healthy ejaculation of semen- the semen gets stuck inside and creates edemas in the prostate- prostate gets f*cked up- nerves get f*cked up- vessels get f*cked up- my scortum slowly loses fullness- varicoceles form- erections get soften- my whole lower body gets numb.
F*ck me for years of wasted time thinking the problem was on my androgen receptors due to that devil forum called Propecia''help''. That forum destroyed my mind. I was looking to the wrong direction all the time. That's why TRT or HCG didn't work for me but Progesterone did for a month,now everything makes sense.
https://www.linkpicture.com/view.php?img=LPic6218f7fd51e6e1187981798 = My gut microbiome test.
And by the way, i have no idea if you did a gut microbiome test or not too, if not, you are wastedyour life researching countless studies on the web and sitting on your PC screen all day. Sorry for everyone who went through this utterless crap.
what are you going to take to fix it though??
what product specifically?
not to be alarmist but gut dysbiosiscan be permanent in some cases Ive read.
great result for you though, a good find andglad you identified what is wrong at least with gut
15 hours ago, TrueJustice said:what are you going to take to fix it though??
what product specifically?
not to be alarmist but gut dysbiosis can be permanent in some cases I™ve read¦.
great result for you though, a good find and glad you identified what is wrong at least with gut
There are some substances that can increase those bacterias. Mainly fiber. My Dr. gave me some good probiotics and prebiotics which contain pre-cursor bacterias and fiber that feed my lacking bacterias. But i am sure that won't be enough to heal so im going to start a 30 day waterfast next week. Which, heals cancer even and i have read few other stories about PFS cases recovering with waterfast.
So, waterfast with enemas and liver cleanse is my plan to heal.
Yeah i don't think there is an issue with my hormones or something anymore. If i had that, TRT and HCG would help me out or would alter my androgen receptor expressions like other PFS cases. All i know is i have prostate edemas confirmed by Urologist.
Gut and pelvic floor issues can cause that. So hopefully, i finally know what is wrong with me, it makes sense.
I even remember having excessive gas and cramps after taking Accutane, it lasted for few months. A guy on Reddit who fixed his PSSD with gut treatment said that that was the sign of ''Bad bacteria taking over,'' Wish i had visible gut symptoms so that i wouldn't waste 7 years of my life. But yeah, the grass is always greener on the other side.
My message to anyone who is reading this thread, to the old school sufferers: PAS is fixable, you just have to find your own spesific issue.
1- Get a gut microbiome test with additional inflammation markers. (Zonuline)
2- Get organic acid test
3- Get a full hormonal panel
4- Test your gut to see if you have leaky gut: Progesterone injections Subq 50mg everyday for 1.5 months.
5- Test your Androgen Receptors: Try TRT+ HCG (200mg Test a week divided into thirds, with 300iu HCG every other day.) for at least 8 weeks and do a 5 week PCT with Enclomiphene or Clomid (50mg every 3 days) afterwards.
If you respond good to Progesterone and don't respond to androgenic hormones, you probably have the gut issue that i have.
Waterfast for 30 days with correct probiotic enemas to fix it.
That's all there is to it. I wish good luck to everyone. 
30 days water fast is quite ambitious. I know I wouldn't be able to do it. 7 days was the longest I've been able to water fast.
I've switched back to wild yam and dropped the chamomile. Wild yam contains the hormonal precursor diosgenin that chamomile doesn't have. When it comes to bile, it's not just a matter of getting the bile to flow properly, it's also a matter of producing it in the first place. Wild yam is likely superior to all other bitters in this regard due to its hormone producing diosgenin content.
Craving green tea right now so including that. Peas and carrots also. I think when your bile flow is improved you stop craving fat and start craving veggies. Seems to be what's happening with me thanks to the wild yam.
One side note, i met with a guy from Reddit, called ''Jire'', he is a fully recovered PAS case with daily TRT and HCG. Very high doses but he tells me that if he quits using them, his symptoms will appear again.
Because he thinks that Accutane decreased Androgen Receptor sensitivity, only high amounts of androgens in blood can compensate what is missing. But as we also know taking external androgens actually downregulates the ARs even more. So his fix is a life- time fix and injecting Testosterone everyday until you die seems like a nightmare to be honest.
Just wanted to add this because on my above comment i gave the advice of trying 200mg a week of T for 8 weeks to see if you have receptor issues, after talking with Jire, now i would say trying for at least a 3 monthsof TRT with 500mg a week is also an option for severe cases like him, sometimes you need more time to see any changes. So he experienced benefits which led to full recovery after 3 months in and 1000iu of HCG+ 500mg Test E. a week. And he also took rectal and oral Progesterone 200mg totally which then he experienced full blown libido recovery.
Just an addition and tip to my actual comment above.
It was wrong of me to condemn all pharmaceuticals earlier. some pharmaceuticals are good and some are bad. My main issue with pharmaceuticals are the anti androgenic drugs. I'm finding the natural herbs like wild yam and chamomile just aren't strong enough.
I'm trying ibuprofen today and tomorrow, and have a Dr appt for Monday. If the ibuprofen doesn't give me the results i want then will try to get lorazepam Monday.
The post accutane issue for me atleast is autonomic imbalance. It's always felt like ptsd. Too much sympathetic activity, not enough parasympathetic activity. Fight or flight mode 24/7/365. Www.Drugs.com lists otc nsaids as being used to treat dysautonomia, with ibuprofen showing up at the top of the list. I've found some research that says ibuprofen isnt as hard on the gut as other nsaids like aspirin, which rips my gut to shreds. Drugs.com also lists lorazepam as the top rated pharmaceutical to treat dysautonomia. Hopefully ibuprofen will get the job done, but if not then lorazepam should be able to handle it. Will keep the board posted.
The thing I've found with exogenous hormone replacement therapy, regardless of gender or hormone, is how extremely hard it is to maintain proper hormonal balance. When you let the body regulate it's own hormones, the job is a lot easier.
I believe autonomic imbalance throws off a lot of hormones, particularly cortisol, adrenaline, and testosterone. If you can achieve optimal autonomic balance, the hormones automatically fall back into proper alignment, and you don't have to worry about manually augmenting any particular hormone.
Think of driving a stick shift vs an automatic transmission vehicle. Which would you rather drive? It's the same way with hormones. I'd rather achieve optimal autonomic balance and let my body autoregulate it's hormones.
7 hours ago, Thomas76 said:The thing I've found with exogenous hormone replacement therapy, regardless of gender or hormone, is how extremely hard it is to maintain proper hormonal balance. When you let the body regulate it's own hormones, the job is a lot easier.
I believe autonomic imbalance throws off a lot of hormones, particularly cortisol, adrenaline, and testosterone. If you can achieve optimal autonomic balance, the hormones automatically fall back into proper alignment, and you don't have to worry about manually augmenting any particular hormone.
Think of driving a stick shift vs an automatic transmission vehicle. Which would you rather drive? It's the same way with hormones. I'd rather achieve optimal autonomic balance and let my body autoregulate it's hormones.
Yes but how much longer are you going to give this situation a chance to balance naturally???
Another 5 years, another 10 years?
If the HPA is damaged lets say, how can we hope to achieve hormonal balance naturally?
Thats like trying to fix a broken leg by taking supplements.
For uslong term sufferers, the more natural approach just isnt having the desired effect, ifit was we wouldnt be still here posting updates and contemplating our next moves.
Im doing my full hormonal blood test later this week and back to see endocrinologist in coming weeks. I anticipate Im going down the path of some type of therapy, just hope it doesnt involve daily injections- that sounds like hell and too much to manage.well have to see what they suggest.
With a bit of luck I might do well starting on progesterone or something, have to see how my panel looks and go from there
If you would reread my post, you'd see that I gave up on the natural approach in favor of drugs such as ibuprofen and/or lorazepam, which are known to balance the HpA and restore autonomic balance. I tried trt years ago and learned the hard way what a complete mistake it was, constantly having to balance aromatase and dosing to prevent side effects. Not to mention the testicular shrinkage as long as I was on it. No thanks, I'll pass.
Not healed obviously but so far I would say the ibuprofen is superior to any herb ive ever used, mentally and physically.
I'd be willing to bet tjs hormonal profile will show low t, low cortisol, low dopamine, and high 5hiaa...all hallmarks of autonomic imbalance, which I believe we all have, and which I believe can be corrected pharmaceutically.
The problem with exogenous progesterone is it can act against dht, which for me would not be a good thing.
Well the ibuprofen is definitely balancing out my brain in less than one day of use better than any herb ever has. Ginkgo, cordyceps, ginseng, chamomile, wild yam...none of them can touch ibuprofen. Stress and anxiety are completely gone. Doing 800mg every 4 hours for no more than 3200mg per day.
I scanned my brain and gut before bed and both show improvement. Sleep pattern adjustment would be the hardest thing for me. I will hopefully get the lorazepam Rx Monday but won't fill it right away. I'd like to give the ibuprofen more time before i go with the lorazepam.
It's possible that a gaba supplement would eliminate any issues that some people seem to have with benzodiazepines. I think what benzos do is they stimulate gaba release, which relaxes the mind and body. But over time, this constant stimulation of gaba release depletes the brain of gaba, which is where a gaba supplement would come into play to ensure the benzo always has plenty of gaba to work with.
So accutane depletes B12 and folate (see link below). Now I'm starting to wonder if maybe the garden of life raw iron product would be all that's needed. It's loaded with B12 and folate, as well as c and iron. I think I'll drop the ibuprofen and just do the gol raw iron daily and see how it goes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248518/
https://www.innate-nutrition.com/blog/accutane
The machine has been recommending iron quite a bit. That second link provides some very interesting info on accutane and key nutrient depletions.
https://www.livestrong.com/article/512072-accutane-zinc/
After taking the gol raw iron supplement, it feels like my liver is in overdrive with metabolism, which is def a good thing. Can hear tons of gurgling inside from it.
@SaffronAideYou're just crazy. You have HPA Hyperactivity and want to fast for 30 days, which puts so much more stress on the body. Also proclaiming it to be the cure, when you're not even cured yourself is inappropriate.
HPA Axis is indeed linked to the sympathetic nervous system and could cause this 24/7 fight or flight mode. I already took lorazepam for some time and it makes you careless, but doesnt alleviate the symptoms.
I will ask my doctor to prescribe me mifepristone on Tuesday. It restores Glucocorticoidreceptordensity and repairs the negative feedback loop of the HPA axis.
All this time I've been looking for a supplement or drug to add to my regimen, when maybe all this time I should've been looking for something to subtract from my diet. That something I believe is milk. Research seems to indicate that cow milk should be reserved for babies only.
I've drank multiple glasses of milk daily for years. Last glass was I believe Thursday or Friday and it feels like I'm going through opiate withdrawal. Milk has naturally occuring morphine in it that overtime can wipe out your body's supply of histamine, which causes all kinds of problems including vasoconstriction. Instead of milk I'm drinking V8 original, Arizona green tea, unsweetened vanilla almond milk, and kevita lemon ginger probiotic drink. Cheese is something I'll eat occasionally but not daily.
I've dropped the ibuprofen and any and all supplements. Not going to fill the Ativan rx if I receive it. Will see how the milk free diet goes and report results later.
Google search big 8 food allergens. I think accutane makes ppl sensitive to one or more foods from this list. For me, I have issues with soy, eggs, shellfish, and now i realize dairy milk as well. Supplementing with copper potassium natural beta carotene and organic ginkgo.
It was frustrating when guys would come here and say "change your diet" but never get into specifics. I think the list of big 8 food allergens helps ppl here determine what they need to cut out of their life for good.