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Repairing the long-term damage from Accutane

 
MemberMember
1753
(@truejustice)

Posted : 09/08/2019 3:59 am

Surprised she hasnt commented on this forum at some point : )

 

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MemberMember
23
(@perene)

Posted : 09/08/2019 6:21 pm

About the sexual side effects: depression happened forme, too, and for years I struggled with it. I estimate that 3, 4 years after my 2011treatment I was still affected, I remember 1 year after the way I behaved was totally out of character (and I never felt that bad out of suddenEVER).

The problem with that theory is that once youget over this (I mean: once the damage that caused the depression in the first place) is completely gone (and for me I am 99.9% sureit is)then there's no reason why your body should remainthe same way. And in my case I have NO OTHER permanent disease or health problem caused by Accutane.

I mean, if depression/stress killed your libido (also lowering your testosterone) then why mine is still low (and it has decreased over time) after the depression waslong gone? I can think of many reasons as to why my T is low, and one of them are my viewsaboutwomen. But I can't disguise the fact I had a much higher libido before the treatment. What Accutane does is more pervasive than a long-lasting depression:

https://inews.co.uk/news/health/roaccutane-acne-drug-poisoned-fitness-fan/
https://www.madinamerica.com/2018/06/citizens-petition-calls-sexual-side-effect-warnings-antidepressants/

https://www.drugs.com/answers/cure-sexual-dysfunction-long-term-suicidal-3480346.html (this link says there is no known cure for the sexual dysfunction)

https://www.theyworkforyou.com/whall/?id=2018-03-07a.181.1

In the book "The Science of Sex" written byKevin Pezzi it is said the following:

************************************************
The mechanism by which Accutane causes sexual dysfunction is not known, but I suspect that it has multiple modes of action.

I think it interferes with the proper functioning of some sensory peripheral nerves, or their receptors, or the brains response to the nerve data, thus greatly distorting tactile fidelity (a subject I will discuss in detail later in this chapter). This disturbance of fidelity is not necessarily confined to the genitals; Accutane has been associated with a dysesthetic ** tingling on nongenital skin, the course and intensity of which seems to parallel the unpleasant sexual hit your funny bone tingling. These dysesthesias may persist for a few seconds after the inciting stimulus is removed. If you lightly touch your skin, for example, the sensation usually ends when the contact ceases. In contrast, Accutane- induced dysesthesias may take seconds to fade away.

I think that Accutane decreases responsiveness to testosterone, at least in those areas of the brain that control libido. (Perene's note: it has been reported and I have posted test results showing that my prolactin is high and T levels are very low; and like I said my libido is the lowest EVER).

** A dysesthesia (dis-es-THEE-zee-uh) is an unpleasant abnormal sensation, whether spontaneous or evoked. Many authors and physicians use dysesthesia interchangeably with paresthesia, which is an abnormal sensation that is not unpleasant. Dictionaries often muddy the issue by defining paresthesia as a burning, prickling, itching, or tingling skin sensation most of which are unpleasant.

>>>>> What is the treatment?

- Discontinue Accutane now. I understand that it can be a difficult decision to choose between clear skin or a satisfying sex life. I cannot make this decision for you, but I can tell you what I would do: stop the Accutane. Physicians have many other ways to treat acne besides Accutane. I would rather use a less powerful therapy and spare my sex life. Every year, I hear from many patients who wish theyd done the same thing.

- Try relatively high-dose supplemental vitamin B 6 (but avoid excessive doses that may induce a peripheral neuropathy; see the vitamin B 6 section for more information).

- Try other supplements, herbs, and drugs, as discussed elsewhere in this book.

- Stringently avoid other things that may decrease the testosterone level or effect (such as phytoestrogens and antiandrogens).

- Consider using supplemental testosterone. It is useless to use your blood testosterone level to gauge whether or not this is necessary. Judging from tests conducted on people with Accutane-induced sexual dysfunction, Accutane does not seem to appreciably lower the blood testosterone level. What it apparently does is partially block some of the effects of testosterone. This decreased responsiveness is analogous to someone who is hard of hearing. To some extent, you can compensate for their disability by speaking louder. A partially deaf ear needs more sound, and someone who is less responsive to testosterone needs more testosterone. Of course, there are drawbacks to the use of supplemental testosterone. Because the testosterone susceptibility of most areas of the body is not affected, increasing the testosterone level enough to restore libido and sexual sensation may trigger unwanted changes elsewhere, such as alopecia and acne.

- If you are a man, avoid things that increase your estrogen level.

- Avoid things that increase sex hormone binding globulin.

- Experiment with other ways to achieve orgasm. You probably will not want to forgo coitus even if your sensation is affected, because intercourse can be emotionally very satisfying. However, if you arent in a relationship and having intercourse, by trying various ways of masturbation, you will likely find that some ways provide less noxious sensations and more pleasant ones. Everyone who has masturbated knows that different techniques produce different sensations. As you will realize once you read the section on sensory fidelity, different techniques of masturbation produce different neural data streams. Accutane effectively distorts this data, which reduces sexual pleasure. However, since neural data streams differ depending on the method of masturbation, some of these will be closer to the ideal that gives optimum pleasure. Your goal is to find one that, once layered on the Accutane-induced distortion, gives a reasonably satisfying experience.

- See a knowledgeable physician to exclude other causes of dysesthesias and reduced sensation. There are numerous possible causes, such as vitamin B 12 deficiency, multiple sclerosis, brain tumors, strokes, transient ischemic attacks (TIAs), arteriovenous malformations, transverse myelitis, encephalitis, trauma, and peripheral neuropathies secondary to diabetes, alcoholism, hypothyroidism, hereditary conditions (Charcot- Marie-Tooth disease, Denny-Brown's syndrome, familial amyloidotic polyneuropathy), malignancy, uremia, connective tissue disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus, polyarteritis nodosa, autoimmune vasculitis, systemic sclerosis, and Sjogren's syndrome), inflammation (acute idiopathic polyneuritis and chronic relapsing polyneuropathy), chronic overdosage of vitamin B 6 , some chemotherapy, heavy metal toxicity (e.g., lead, arsenic, or mercury), some industrial exposures (e.g., solvents), certain medications, sarcoidosis, porphyria, Lyme disease, and leprosy. Believe it or not, but this is just the tip of the iceberg.

Physicians should keep in mind that it is possible to have symptoms of dysesthesias or paresthesias without measurable neurologic deficits of pain, touch, vibration, joint position, or thermal sensation.

- As a last resort, consider trying one of the drugs used to treat dysesthesias and paresthesias, such as carbamazepine (Tegretol ), mexiletine (Mexitil ), gabapentin (Neurontin ), and tricyclic antidepressants (e.g., imipramine [Tofranil ] and amitriptyline [Elavil ]).

Neurologists believe that paresthesias and dysesthesias represent abnormal showers of neural impulses generated from abnormalities anywhere along the sensory pathway, from the peripheral nerves to the sensory cortex of the brain. The aforementioned drugs may reduce the excitability of neurons and therefore mitigate Accutane-induced dysesthesias, especially the unpleasant tingling that persists after skin contact. However, these drugs will not restore sexual sensitivity.

- Be patient. The dysesthesias tend to diminish in time, although it may take years. Your perception of sexual pleasure will likely increase, too, although it may not return to your pre-Accutane zenith. The elimination half-life (that is, the time it takes for half of an administered drug to be excreted) suggests that Accutane does not persist in the body for a long time. The drug may not stick around for long, but its effects do. It is as if Accutane flips some switches in the body. This is true for its intended effect (the long-term suppression of acne), and its sexual side effects.

Once flipped, those effects are permanent, or at least very long lasting. Hence, you should think twice before using Accutane. There is no way to know in advance if your use of Accutane will trigger dysesthesias and reduced sensation. You may take it for a while without any problems, and then wake up with enough sensory abnormalities to make you wonder if your spinal cord was mashed in a vice while you slept. Being cheated out of lifes greatest pleasure is a terrible fate. Are you willing to take that risk?
************************************************

My personal opinion:

It is permanent (at least from what I have seen until now) and all these tips are not going to help much, if AT ALL.

I mean, perhaps some will (however be careful - never try anything without some serious medical advice), but this is all just to mitigate, not to fix the issue for good.

We need to focuse on everything that can increase testosterone levels and decrease prolactin, because if prolactin is high then the libido is low (mine always measures 19-20, and for men the max range should be 13. So it's not very high, but it is high).

What isfunny is that we need to be morehealthy than SUPERMAN, we need to improve our lifestyle more than before we started the Accutane treatment, just to reduce the damage caused by this poison that should have been banned everywhere.

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Dubya_B, Dubya_B and Dubya_B reacted
MemberMember
1753
(@truejustice)

Posted : 09/08/2019 8:33 pm

How do you know the damage is gone??

Id suggest its still there in someof us and is responsible for sexual sides, depression or both.

Great that you feel better but underlying brain damage to some degree could still be present yeah... why would it have just disappeared is the question Im asking if not properly addressed?

Not that I know much about addressing it.....

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MemberMember
23
(@perene)

Posted : 09/09/2019 6:01 am

9 hours ago, TrueJustice said:

How do you know the damage is gone??

Id suggest its still there in someof us and is responsible for sexual sides, depression or both.

Great that you feel better but underlying brain damage to some degree could still be present yeah... why would it have just disappeared is the question Im asking if not properly addressed?

Not that I know much about addressing it.....

You would know if you had any of these symptoms that affect those that have low T:
https://www.medicalnewstoday.com/articles/322647.php

Since Accutane reduces testosterone and at at the same timedecreases libido, then it must be something else going on besides mere depression, which I don't have anymore.

I don't have hypogonadism too, since my testosterone levels were higher years ago, and no doctor says you have it if you can go beyond the 300 ng/DL which I think it's very likely to happen for me (still very low in my opinion, since the max is 800's - I hoped mine were at least 500 ng/DL, which is twice the current levels). One thing caught my attention in this link:
https://inews.co.uk/news/health/roaccutane-acne-drug-poisoned-fitness-fan/

Among all the symptoms this guy has, he says his vitamin-D levels were incredibly low. Mine were too, and once I started taking D-3 pills my vit-D and testosterone levels increased (these are both related).Idon't need to be measured right now(however I will soon) to find out they have been reduced again, since I stopped taking vitamin D-3 pills more than a year ago. He said that spent some time outside/exposed to the Sun, something I never do, and I am starting to do now.

Still, it makes me think: since we are always told to never expose our skin to the Sun during all themonths of the Accutanetreatment, could this mean the testosterone levels are reduced due to depletion of vitamin D in our bodies? So the answer would be to increase our D-3 levels?

Look at this bit from the guy's report:

***********
I realised fairly recently that one of the main causes of my problems was impaired liver function, due to damage caused, in my opinion, by the Roaccutane, Tom said. I was left with very low bile production, resulting in chronic toxicity. The lack of bile also meant I wasnt able to digest fats properly, hence the vitamin D deficiency, as it is a fat soluble vitamin.
***********

He claims to have had other health issues that my previous tests already proved are not my case.My health is 100% OK except for the low T, high prolactin and low vitamin D.

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MemberMember
1753
(@truejustice)

Posted : 09/09/2019 6:43 am

They are all valid points and yes Im also low in Vit D on last test. Im currently supplementing. Low testosterone is definitely worth addressing

But, what of the potential brain damage associated with Accutane?

This area has yet to be fully understood but absolutely has been documented by several people.

Frontal lobe brain issues post tane

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MemberMember
23
(@perene)

Posted : 09/09/2019 12:05 pm

4 hours ago, TrueJustice said:

They are all valid points and yes Im also low in Vit D on last test. Im currently supplementing. Low testosterone is definitely worth addressing

But, what of the potential brain damage associated with Accutane?

This area has yet to be fully understood but absolutely has been documented by several people.

Frontal lobe brain issues post tane

Have you all read reports such as these? I think they are clear enough in how they demonstrate what isotretinoin does to the brain:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637283/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473493/

https://drive.google.com/open?id=1GXj82g6QuDO4swu0B8jM1v84N0A8iCDq

https://drive.google.com/open?id=12wWvskpzXjSUfyKCJl2Lm4R0NC5dUVE6

What Accutane does to cause depression may not be fully understood, yet we have a pretty good idea.

What I don't think is that my brain still suffers from the same depression I had in the first years. And of course that can't be the only reasonmy libido/testosterone are low.

In my case I noticed a 35% increase in testosterone levels once I took vitamin D-3 pills, 7000 UI, two of them, once a week, for 3 months. I took two blood tests. The first showed for D-3 26 ng/mL (that is very low). Once I started taking, then it raised to 40 ng/mL (this is still low - it'sjust higher than what your normal levels should be).

Even after I reduced to 1 pill as instructed by the doctor (so 7000 UI in eachentire week) it was still in the 40's (ng/mL) in another blood test. Without a doubt if I started exposing myself to the Sun, too, the levels would have been raised even higher.

But... even if my current testosterone levels increased 35% now they would still be very low, from 240 to 325. I said before the range for male adults is 241 to 827 ng/dL.

That suggests a lot more things need to be taken into account, from my diet to workout routine, sleep, and of course possiblyother supplements, such as vitamin B-6, vitamin E, omega-3 (fish oil), zinc, magnesium... nothing can be left out. I don't want a mere 35, what I need is a 100-150% increase.

And of course a decrease in prolactin, I believe I measured this 4 or 5 times and it has never been reduced from 20 ng/ML. That is the ultimate confirmation you have low libido/impotence.For men the normal range is between 2.6 to 13.1.

If it's irrealistic to increase my testosterone 100% then I can thank my old Accutane treatment to this. Look at what this link says (a little late for that, uh?):
https://www.gov.uk/drug-safety-update/isotretinoin-roaccutane-rare-reports-of-erectile-dysfunction-and-decreased-libido

Sexual dysfunction

A routine EU review showed that some patients taking isotretinoin had reported sexual dysfunction adverse effects, including erectile dysfunction and decreased libido. One possible mechanism for this effect may be through a reduction in plasma testosterone levels.

The review recommended that sexual dysfunction including erectile dysfunction and decreased libido should be added to the list of side effects in the product information. The package leaflet for patients will include Problems getting or maintaining an erection and lower libido as possible side effects.

In the UK, we have received 14 Yellow Card reports of sexual dysfunction associated isotretinoin between the beginning of 1985 and 7 September 2017. In the same time period, there have been 49 reports of erectile or ejaculation dysfunction, and 23 reports of decreased or loss of libido associated with isotretinoin. We estimate that over the past few years, around 30,000 patients (male and female) per year have been treated with isotretinoin (see 2014Public Assessment Report).1

 

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MemberMember
397
(@calcified)

Posted : 09/09/2019 12:07 pm

A guy on YouTube said he took dosages upto 240 mg for over a year. How is that even possible without massive long-term side effects?

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MemberMember
23
(@perene)

Posted : 09/09/2019 8:14 pm

As for dosages,this link suggests
http://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolerableuil.pdf

- 25 mg/day for vitamin B-6, which is said to decrease prolactin and boost libido. Read this thread and you'll see some members had good results with it:
https://www.nofap.com/forum/index.php?threads/vitamin-b6-to-support-your-recovery-long-post-but-tl-dr-at-bottom.135163/

- The same 25 mg/day for zinc;
- 50 ug or 2000 UI/day for vitamin D-3. That is the exact dose I took for the first time, when my testosterone increased35%.
- 300 mg/dayfor vitamin-E.

I think it would be wise to start taking at least D-3 and B-6 for a couple of months and then get tested again. I promised to do that years ago and ended up not doing it, because I always disliked the idea of taking suplements forever. The issue is not just how much they cost, it's the need to remember taking them, being forced toincorporate this into your lifestyle. I thought taking a vitamin was like taking a medicine, something you remember that needs to, yet you can't wait until it's over and you are fine again.

Of course we would all love to be 100% healthy without any new drug/workaround/supplement, but if that isNEVER going to happen, so be it... treat it as a some food you need to keep ingesting to stay in a good shape. Of course lots of things are important, including diet (and perhaps my low T is also a result of recent indulgences I made, by eating some junk food, which is also known to be detrimental - my current diet was devisedby a sports nutritionist, and doesn't include among other things sugar).

However all of the good lifestyle changescombinedare not going to be enough to restore how we felt before the treatment. The vitamins, I hope, will do the trick.I think I should be thankful for not suffering fromthe other side effects from low testosterone, onlylow libido, or my tests showing avery high prolactin that would need a drug like Cabergoline. It could have been a lot worse.

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MemberMember
1753
(@truejustice)

Posted : 09/09/2019 9:53 pm

Is prolactin only ever high when testosterone is low in males?

Can one have normal healthy testosterone levels but also have high prolactin?

what Im getting at is, its pointless surelyto try lowering prolactin whilst ever theres low testosterone. Youd be better just trying to improve testosterone levelsyeah?

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MemberMember
23
(@perene)

Posted : 09/10/2019 6:27 am

8 hours ago, TrueJustice said:

Is prolactin only ever high when testosterone is low in males?

Can one have normal healthy testosterone levels but also have high prolactin?

what Im getting at is, its pointless surelyto try lowering prolactin whilst ever theres low testosterone. Youd be better just trying to improve testosterone levelsyeah?

If the prolactin is too low then you have the same sexual dysfunction.

Heres what a study said:

Men who had higher body mass indexes and higher glucose levels tended to have lower levels of prolactin. In addition, men who engaged in less physical activity and reported feeling unhealthier also had lower prolactin levels.

Lower prolactin, even within the normal range, was associated with more sexual issues, especially the ability to enjoy orgasm. Depression was also associated with low prolactin.

The results contrast with previous studies, which showed that high prolactin levels interfered with sexual function.

If you are just above the 300 ng/DL you are not in need of testosterone therapy (which should be the last resort anyway, due tobad side effects) and in the absence of other symptoms andtests showing something wrong (not just blood, CT scan test as well) then you dont have hypogonadism or some other debilitating condition. Asperm analysis also showed I am OK.

The problem is that most doctors will tell that having 300s is normal and you are totally fine, but the truth is that if were not for the Accutane treatment then I am sure my results would be in the 500s and what these doctors consider fine seems to me beinga mollycoddle, a soy-boy, instead of a masculine man in all its potential. Low testosterone not only affects libido, cognitive impairment is among the side effects, too.

Thatswhy I am going to take a few of these vitaminsregardless of what these doctors tell me, most of them are idiots thatcan only read numbers and dont interpret whatsbehind them. Oh, and of course they dont believe or know more about the deleterious effects of the isotretinoin treatment.

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MemberMember
1753
(@truejustice)

Posted : 09/10/2019 6:58 am

Thx Perene - appreciate the info.

I know youre taking Vit D, what else you taking?

What are your thoughts on supplementing Vit E? What do you notice in particular with this?

Also, how dry is your skin?mine is fucked.....so bloody dry....

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MemberMember
23
(@perene)

Posted : 09/10/2019 9:13 am

On 9/10/2019 at 8:58 AM, TrueJustice said:

Thx Perene - appreciate the info.

I know youre taking Vit D, what else you taking?

What are your thoughts on supplementing Vit E? What do you notice in particular with this?

Also, how dry is your skin?mine is fucked.....so bloody dry....

I am going to take 25 mg of B6 (daily - and, the Pyridoxal 5 Phosphate (P5P)). Plus 2000 UI of D-3 + 200 UI of vitamin E combined. After at least 60 days of this I'll do another testosterone and vitamin D test.Andthis time i'll also hire someone to help with my workout routine.

P.S. I'll also add omega 3 fish oil, 1000 mg (180/120, 3 pills a day), which was recommended to me along with the D-3+E in the first appointment with a nutritionist I had, andfollowing what this guy said about how he doubled his T levels: https://www.artofmanliness.com/articles/how-to-increase-testosterone-naturally/

As for the skin being too dry I haven't noticed anything unusual, I also don't use anythingfor the lips. I think after years there's no unusual dryness.

This is worse depending on the weather and if you take hot baths (I don't do the latter anymore). Also be careful of what kind of soap and shampoo you are using. I believe my penis had this problem for a while, perhaps it had something to do with what I applied to it everyday. This is something most people don't consider important, but it really is and a dermatologist will tell you, for example, that a liquid soap instead of bar is better for your face.That's because they are less harsh on your skin and their pH is closer to your skin's normal pH level.

If you prefer a bar soap to liquid, at least look for one that's really gentle. If your skin is sensitive or easily gets red and itchy, try to avoid sodium lauryl sulfate, a common skin irritant. I purchased a natural soapwithout this ingredient and I believe that was the reason over time the skin of my penis improved and stopped being irritated easily.

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MemberMember
223
(@gladiatoro)

Posted : 09/10/2019 11:01 am

22 hours ago, Calcified said:

A guy on YouTube said he took dosages upto 240 mg for over a year. How is that even possible without massive long-term side effects?

Its not.

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MemberMember
397
(@calcified)

Posted : 09/10/2019 12:33 pm

1 hour ago, Gladiatoro said:

Its not.

Yeah it's a time game isn't it.

I don't get how people on YouTube don't have much peeling skin. My dose was high 26 years ago, but im starting to think it's a little more watered down these days. My skin was peeling off almost in sheets. Moisturisers were useless.

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MemberMember
359
(@dubya_b)

Posted : 09/10/2019 11:11 pm

On 9/9/2019 at 1:07 PM, Calcified said:

A guy on YouTube said he took dosages upto 240 mg for over a year. How is that even possible without massive long-term side effects?

Because some people can take high doses for a long time without much trouble and some of us react very very badly, even to low doses. There is some genetic susceptibility or other confounding factor involved in Accutane causing severe and permanent side effects in only a small percentage.

For example, two of the members here, @Crank92 and @mes6890 had very low cumulative dosages and were left with persistent sexual side effects. Crank took a trial dose of 20mg daily for a few weeks, and mes took it for less than a week. Mes also has skin thinning and neurological symptoms.

 

 

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macleod, macleod and macleod reacted
MemberMember
397
(@calcified)

Posted : 09/12/2019 1:52 am

Stomach issues or ibs seems common with accutaners has it ever progressed to colon cancer or are we now tuned to never get colon cancer?

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MemberMember
299
(@macleod)

Posted : 09/17/2019 6:53 pm

Yes, as I've posted a while ago on this very thread, those that are able to tolerate high doses of retinoidin their diet's are those of Scandinavian descent. Something to do with the cold weathe, diet, and vitamin Agoing back thousands of years. It's a fairly reasonable probability that Roche used Swiss nationals to carry out their clinical trials. Some can handle it, others not so much.

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MemberMember
1753
(@truejustice)

Posted : 09/17/2019 7:31 pm

Ive tested very favourably to both Vit D/K - I take this in a pump spray. It definitely helps libido for anyone interested.

I took in Vit E supplement today and I test really well also, all over the body actually practitioner said - especially with muscles!!

Im thinking of buying Vit A and taking it in to test next.

Unfortunately systemic dryness still remains no matter what I do......

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MemberMember
397
(@calcified)

Posted : 09/19/2019 12:42 am

On 9/18/2019 at 10:01 AM, TrueJustice said:

Ive tested very favourably to both Vit D/K - I take this in a pump spray. It definitely helps libido for anyone interested.

I took in Vit E supplement today and I test really well also, all over the body actually practitioner said - especially with muscles!!

Im thinking of buying Vit A and taking it in to test next.

Unfortunately systemic dryness still remains no matter what I do......

I'm still on the fence about vitamin A.

Don't know how safe it is either.

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MemberMember
1753
(@truejustice)

Posted : 09/19/2019 1:09 am

Vit A....take it, dont take it.....I dont think itll make much difference either way in combating systemic dryness imo

It mightimprove say wound healing but no more so than taking eitherZinc or Vit E

Right now I think the biggest breakthrough would be to workout this systemic dryness, its all well and good that Ive cleaned up gut and wiped out a heap of nasty stuff but were fucked as long as the dryness remains. Other than offering Hyaluronic Acid which was discussed years ago on this forum, there is no other option that I know of??

Theres drops for dry eyes etc but nothing else....

Heres where the dermatology sector could redeem itself somewhatby offering ussome solutions/ideas yeah

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MemberMember
19
(@anna-nim)

Posted : 09/19/2019 8:10 pm

Hello Repairers,

I am not happy to find myself here. My not-even-out of high school son just tossed his Accutane away about 5 days ago. He has reported to me an issue with ED (overly tight testicles, loss of strength of erection). He was 2.5 months intohis second round (after a break of a year or so), they upped his dose to 3 pills a day 8-ishdays prior and then he noticed this issue. Now I know all the horrors. I am hysterical. Utterly hysterical. I know the damn Dr's won't be able to do a damn thing ("We've never seen a issue with Isotretinoin") , although he is going to the GP tomorrow for a referralto a Uro & I guess a Endo? (insert bitter laugh). Today, 4+ days without he is exceptionally thirsty, like WAY more than the other few days, but at least his depression has lifted almost 100% (we didn't even realize how bad it was).

Is there anything he can do to help get this shit out of his system faster? Anything to heal the damage to his Pituitary/Hormone system at this early stage? I've read (some) of the past 695 pages & am overwhelmed, almost suicidal and broken hearted. Reduce foods with Vitamin A. (My dumb ass was letting him eat multivitimans, more than normal with damn Athis week). Keep it simple, natural. Maybe fasting? Milk Thistle for liver? (We are in the USA).

So, also, for the "rare" side effect of ED related issues, of those who have it, is there any sort of consensus of how many recover vs stay the same or get worse?Is it that once that the sexual side effect hits, you have passed the point of return OR is itthat men get better, simply never land here, and go on their way. WDYT?

Hoping Against Hope for my only child and reason for life.

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Dubya_B, Dubya_B and Dubya_B reacted
MemberMember
397
(@calcified)

Posted : 09/20/2019 11:46 am

Truejustice - Vitamin A supplements made me a little dryer, lips and face. Was hoping it would reduce/dry up my scalp folliculitis, but seemed to mostly dry face, so I gave up on it. Anyway I think you might be right about the dryness, as celebrities seem to have to work with that issue as well. I found it ok on the stomach in low supplementation doses.

Not taking it at the moment but I probably will make sure I get atleast the minimum daily recommended dose from food or supplements going forward.

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MemberMember
223
(@gladiatoro)

Posted : 09/20/2019 4:51 pm

Whoever masterminded this chemo torture deserves deserves a monument in hell quoted from Dr Hamer father of.... German New Medicine.

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MemberMember
23
(@perene)

Posted : 09/20/2019 5:13 pm

I am going to do 37 or 38 new blood tests to evaluate my condition that I reported before to be low testosterone and slightly high prolactin. I don't trust the last measure of 240 ng/DL and PRL seems to be always at 20 or more for me in ALL tests, howeverI don't expect more than 300 this time.

The interesting thing to discover now is how much vitamin D I have, since I stopped taking more than a year ago, and when I did 2000 UI a day it increase my total T 35%. I'll check stuff like IGF-1, DHT, SDHEA, zinc, magnesium, vitamin B-12, SHBG, LH and FSH.

About the changes I made to my current situation, these are: 1) I'll add againraisins, almond, hazelnuts, dried apricots, Brazil nuts, walnuts, prunes, cashew nuts, since these are rich in BORON and I am sure the removal of them from my diet impacted my levels. Since boron helps with testosterone.

I'll also bring back oats which were excluded once I stopped with milk and cheese (or chia seeds, 1 tablespoon a day), and add coconut oil for more satured fats, I am also positive my diet doesn't have enough FAT, it's mostly proteins, and the lack of good FATs and carbs sure reduce testosterone.

Then there's AVOCADOS which I don't eat often (instead ALL other kinds of fruits), yetseem to be really important for this goal.

FISH was also removed from my diet (used to include them at least 3 times a week) and meat replaced every single day of the week. I opted this time formackerel and mussel for being rich in iodine (google for iodine + testosterone).

Supplements: alread decided to add (all of them are new to my lifestyle)1) Ashwagandha KSM-66, for now 1 every day, 300 mg.Got the Vitacost bottle (with milk), in the future I'll get a better one. 2) Vitamin B-6, P5P, 25 mg, also 1 every day, Both at breakfast.

3) Vitamins D-3 (2000 UI) + E (200 UI), combined, 1 every day, at lunch. 4) Dinner: Omega 3 Fish Oil 1000 MG - 180/120 - 3 pills. 5) ZMA, 2 pills 30-60 minutes after last meal and 30-60 minutes before going to sleep. In 2 pills this supplement I got has256 mg of magnesium, 7 mG of ZINC and 1.3 mG of vitamin B-6. I know many say ZMA is not necessary, yet I haveincluded anyway.

I'll also hire a professional to help me with a new exercise plan that should includelifting and lifting heavy, something I never did seriously all these years I spent in the gym. Then there are all other tips such as "get more and better sleep, avoid xenoestrogens and other T-lowering chemicals, stop using devices a few hours before going to sleep"...

Once I start all of this I'll visit a nutritionist again for a more proper diet, I plan to gain more weight and muscles.

Now... the point I will makeis this...

If after a 1000changes my testosterone levels don't improve and the prolactin continues to be high (still low libido, still the same sexual dysfunction)then I'll know once and for all this can't be fixed (or at least it will take a long time or to consider more things).

Testosterone replacement therapy is not something I look forward to. I think we owe to ourselves at least try for a few months.

Reasons why TRT is not an option for me: I am sure it would cost more than all the things I mentioned combined and 2) these links say a few things interesting:

https://www.healthline.com/health/trt

"When considering the cost, keep in mind that TRT simply boosts your T levels. It wont treat the underlying cause of your low T, so you may need life-long treatment."

https://www.webmd.com/men/replacement-therapy#2

How long do I have to take testosterone replacement therapy?
A: Indefinitely. TRT does not cure low testosterone, so your symptoms may return if you stop taking it.

I always said we need to do a lot of blood tests and investigate thoroughly what kind of damage Accutane did to our bodies. Unfortunately it's not everyday a doctor agrees to do that and if myhealth insurance plan is not covering then I can't afford paying for each test.

Next monday I'll do these 37 or 38 blood tests (one of them I suspect it's not covered, which is vitamin B-6 - however homocysteine is among the rest, and this is used to determine a deficiency in vitamins B6, B9 (folate) or B12))and 60 days after I implement all these changes I'll do more, at least total/free T,vitamin D and prolactin. I promise to return to this forum and divulge all my results. For now there is no indication I have anyhidden disease/conditionthat accounts for these symptoms.

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MemberMember
1753
(@truejustice)

Posted : 09/20/2019 5:13 pm

18 minutes ago, Gladiatoro said:

Whoever masterminded this chemo torture deserves deserves a monument in hell quoted from Dr Hamer father of.... German New Medicine.

I wonder what led a Dr to say this?

Im assuming he didnt take it himself so he can only partially know the hellinvolved. Then again hes probably speaking on behalf of patients hes seen who suffer the effects over the years....

Its a good fitting quote

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