20 minutes ago, TrueJustice said:

What do you mean by advocate for anti-depressant safety??

pls elaborate.....

Just look at his profile: https://www.quora.com/profile/Mark-Dunn-64

Quote

15 hours ago, Devolution said:

A person also said he saw his night vision and visual snow go back to normal while water fasting but once he ate again it reverted so Im eager to try this myself as it would indicate a reversible change

Can you provide the research please? I'm interested in this as well.

Hi all,

Is there a document someone can send link that I can print off for:

Post Accutane Syndrome? PAS

I thought I saw a document but I cant find what page its on?

I want to share it with a kinesiologist Im about to see this week.

4 hours ago, Biggest Brother said:

Hi Guys,

Lots of great material i've been reading from this thread I appreciate the findings. I'd like to know your thoughts on my brother who is experiencing this issue. He is 26 years old, nurse working in the ER.

Context: It's been about 2 months so far, he took 1 dose at 20 mg and stopped. Within two hours of taking the one dose he started to feel his body change. He explains that he feels, brain fog, dry eyes, dry skin, joint pain, anxiety, depression, and suicide. When I asked him to describe the pain he says the biggest issue ishis eyes always feel like there is sand in it. That when he wakes up his eyes feel like they were never asleep.

Action Plan: So far we found a natural path who has got him on a bunch of supplements such as, multi-vitamin, zetox, berberine, and about 6 other natural supplements (sorry I'm not at his house at the moment so i can't see the rest) He's been getting massages, runs daily, acupuncture. So far it's been two weeks on this detox program he's mentioned that his bowel movements have become much more regular than when he took accutane(1st month). And sorry it's not accutane but the generic version of accutane in the states.

While coming up with our own action plan initially our firsttheory we was that the accutane was every where in his body and it needed to find a type of food while digesting to bind to while excreting it from his body. This seemed logical because he started to have more regular bowel movements, but he started to notice that his body doesn't seem to be absorbing the tremendous amounts of water hes been drinking.

Results so far: There were two days out of the 2 month period where he said his eyes were burning, but recently he says that his eyes have felt like they're getting better. As mentioned, his bowel movements have become much more regular. However, we do continue to go through these mood phases "confident it will leave", to the initial mood type of "depressive anxiety, and the biggest is anger". I almost feel like he cannot get past a mental block.

So far i've reached out to everyone locally, a handful of derms all of which said that accutane side effects only have a two week half life and should leave the body soon(yikes they have no idea about how many patients are going through this) I'm considering speaking to oncology department to see if they can provide me with more insight (perhaps suggestions about what onocology patients do to recover from cancer treatment). I've reached out to a doctor that claims fasting will work but very dangerous(we're against this). Lastly, I found someone named Lewis Rowlands in the UK who has experienced the same symptoms my brother has gone through and claims to be fully recovered and reverted his symptoms. So we've gone forward with his strategy of providing a hair analysis and will circle back with an action plan.

Lastly, after seeing videos and doing research, I did suggest to the natural path if zinc would be good for him and 4 days after taking the multi vitamin with zinc he mentioned that his eyes felt better. Not sure if that's a directcorrelation, but im playing with a theory that his mineral levels are all off and the slightest vitamin % adjustments could be that much more effective. Some how acupuncture seems to be effective I just can't figure out how. One of the pain management providers I spoke with told me that he had a patient that had permanent nerve damage, sought out a acupuncturist in china that was able to heal him 100% whole.

My goal is to document as much of this process as I can and to share my brothers experience and story with as many people considering this drug because the numbers published are simply skewed when it comes to side effects. I browse reddit to see all these people with success before/after photos but internally i hope theyknow they might be paying for it years later. Is that really worth it? Quality of life will suffer dramatically.

Looking forward to the feedback and support!

Update: We've found another natural path that has a different approach to the previous natural path. We will still treat this holistically as a systemic problem however, we will first focus on complete detox of the liver and then address individual issues(eyes) after the liver has been completely detoxed. She has also got him using Taurine. He will also be getting his Zinc, Copper, T3, Cortisol, DHE and testosterone levels checked with blood work.

Thank you FCHAWK for writing a detailed summary i've been eager to hear your feedback.

Can you provide the research please? I'm interested in this as well.

Hes having a Major Depressive Episode by the sound of it (if hes suicidal).

Get him help which is aimed at treating this. CBT or MBCT are supposed to be good.

Hes a nurse - tell him to treat himself to the same standard as he would treat his patients, with Evidence Based Medicine.

I would not obsess over 20mg of Accutane.

4 hours ago, Benjamin94 said:

Hes having a Major Depressive Episode by the sound of it (if hes suicidal).

Get him help which is aimed at treating this. CBT or MBCT are supposed to be good.

Hes a nurse - tell him to treat himself to the same standard as he would treat his patients, with Evidence Based Medicine.

I would not obsess over 20mg of Accutane.

We're trying to get him the help he needs. I've gone with several approaches so far and the self treating patient is one of them. Doesn't seem to stick.

As far as the 20 mg dosage goes, almost 99% of people we've spoken to has said the same thing. However, I can't understand what he's feeling so maybe it is worse than we think it is or could be. Thankfully we're catching it soon but him reading into the internet doesn't help and also being a nurse doesn't help. I'm sorry what is CBT and MBCT short for?

2 hours ago, Devolution said:

It was just anecdotal evidence some guy posted, I can't remember what forum it was on, I think maybe propeciahelp. So it might or might not work, only way is to try it i suppose.

I heard that this could work. I found a Dr. Loren Lockman I think his name was. That claims he has a program that has helped many accutane patients via fasting program of his, however I think there was a major reason why he moved his clinic to costa rica instead of being in the states...I think almost a good majority of practitioners I spoke to claim that fasting does work but you're almost doing it to the point of death to trick your cells in to regenerating at a faster rate. I'm not for this at all.

@Biggest BrotherI think the panic of taking Accutane probably triggered it, rather than a single small dose of accutane.

CBT = Cognitive Behavioural Therapy
MBCT = Mindfullness Based Cognitive Therapy

They are both talking therapies for Depression.

As for fasting. It doesnt work. It makes you ill - not healthy. Water Fasting is an amazing way of losing weight, but is horrible to endure. Dry Fasting is a fantastic way of putting yourself into self-induced Renal Failure.

On 6/30/2018 at 8:11 PM, TrueJustice said:

Ive done a lot over the years - shit loads of time/money and effort.

I studied yoga full on for 10 years and applied myself but continued to get worse with sore joints etc so Ive minimised yoga these days - mainly just do restorative postures to ease back and help relax. Im grateful for what I learnt in yoga.

As much as I suffer fatigue I do about 4 X 40 minute exercise bike activity and Im back into jogging lightly and do light weights. Regardless of issues Ill always recommend exercise as it improves sleep and helps with depression- for me anyway

I dont smoke, do very little alcohol.
Diet isnt perfect and I do watch what I eat more so these days. Havent done any extensive water fasting, maybe a few days of fasting as part of liver detox but not over a week.

Ive done the Moritz liver/gallbladder cleanse by the book about 5 times. Got results and then started to see none of the stones on the last 2 so figured my liver was clean.

Ive done kinesiology plenty of times which has provided relief for my brain fog issues but nothing has brought back my health - its all a bandaid up till now I hate to say. Having said that Im going back for some more this week after having not done it for 3-4 years. My brain fog and irritability are just too acute at the moment to do nothing.

Ive given the body every chance possible including letting time heal it but its not happening Im afraid to say. You just learn to cope.

oh yeah - Ive also seen world leading gastroenterologist that didnt find anything nasty going on in gut or bowel. Although he did find herniated esophagus for which I take patriot to control stomach acid - it works and Ill probably be on it for life.

Didnt you say at one time you had fatty liver?

1 hour ago, Chris16 said:

Didnt you say at one time you had fatty liver?

Yes, ultrasound did conclude a fatty liver about a year ago. No stones found though.

Also cholesterol has been high at times.
This can be controlled with diet - to a point.

9 hours ago, Benjamin94 said:

CBT = Cognitive Behavioural Therapy
MBCT = Mindfullness Based Cognitive Therapy

They are both talking therapies for Depression.

As for fasting. It doesnt work. It makes you ill - not healthy. Water Fasting is an amazing way of losing weight, but is horrible to endure. Dry Fasting is a fantastic way of putting yourself into self-induced Renal Failure.

@Benjamin94Thanks, I think i'll look into fasting a bit more, but i'd prefer not to have my brother try it.

Right now he's going to start neurofeedback to help with depression and coping skills.

7 hours ago, Devolution said:

Fasting can get rid of scars and promote healing, it works for some people, I should be doing a 10 day fast soon enough. Everyone to their own.

@DevolutionCurious to hear how the fasting goes, Im sure it varies from person to person, but what program are you going to follow?

9 hours ago, Devolution said:

Fasting can get rid of scars and promote healing, it works for some people, I should be doing a 10 day fast soon enough. Everyone to their own.

Im a fan of fasting, particularly intermittent fasting, something like 16 and 8. It's definitely helped me through some hard times. Any one that's interested should check out the process of autophagy, some guy won the nobel prize for his work on autophagy.
I would recommend Dr Jason Fung's books and YouTube videos to learn about fasting. There is a film that came out last year too which is good. I do wonder why fasting has helped me so much much and now im starting to think it helped me deplete my retinoic acid stores.

Thanks,
Lee

2 hours ago, marshl1 said:

I do wonder why fasting has helped me so much much and now im starting to think it helped me deplete my retinoic acid stores.

What kind of symptoms did you have that you noticed went away after fasting? What fasting program did you follow?

1 minute ago, Biggest Brother said:

What kind of symptoms did you have that you noticed went away after fasting? What fasting program did you follow?

Its called 16/8. 16 hour fast mostly overnight. 8 hour window for eating through the day. I still do it now most days.
I've had too many symptoms to mention after accutane but most of the common ones. Fatigue, brain fog and headaches lasting for weeks which I now believe were most probably intracranial hypertension.
https://www.ncbi.nlm.nih.gov/pubmed/28017254

Just now, marshl1 said:

Its called 16/8. 16 hour fast mostly overnight. 8 hour window for eating through the day. I still do it now most days.
I've had too many symptoms to mention after accutane but most of the common ones. Fatigue, brain fog and headaches lasting for weeks which I now believe were most probably intracranial hypertension.
https://www.ncbi.nlm.nih.gov/pubmed/28017254

I'd get flares of inflammation throughout my body lasting for weeks and best described as a Fibromyalgia type condition. Fasting is a very powerful anti inflammatory and it helped me massively during these flare up. I would fast for 24 hours and feel much better the next day.

19 hours ago, marshl1 said:

Its called 16/8. 16 hour fast mostly overnight. 8 hour window for eating through the day. I still do it now most days.
I've had too many symptoms to mention after accutane but most of the common ones. Fatigue, brain fog and headaches lasting for weeks which I now believe were most probably intracranial hypertension.
https://www.ncbi.nlm.nih.gov/pubmed/28017254

Thanks!

On 7/3/2018 at 10:48 AM, Devolution said:

Apologies I know some of you have seen this already as someone made it a post over at Propeciahelp but i would like to link the study anyhow for the people who haven't seen it, it show's how we can fix gene expression without causing unwanted mutations, if that is our issue, I'd recommend following the Propeciahelp forum too as I only joined the other day and it's quite a positive forum.

@Benjamin94
https://www.ncbi.nlm.nih.gov/pubmed/29224783

Thanks for sharing this here.

Here are links to the full text of that study, and another one describing use of CAS9 with deactivated nuclease activity to change methylation status without cutting the DNA:

H.-K. Liao et al., In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation, Cell, vol. 171, no. 7, p. 14951507.e15, Dec. 2017.

X. S. Liu et al., Editing DNA Methylation in the Mammalian Genome, Cell, vol. 167, no. 1, p. 233247.e17, Sep. 2016.

On 7/1/2018 at 1:29 PM, marshl1 said:

Yes they could see the floaters after dilating my pupils and performing a simple slit lamp test. They were floating around inside the vitreous

I have floaters. I am going to get this test when I get a chance to confirm the floaters are of the same nature. (you would think this could be a lawsuit if provable and not mentioned in the pamphlet.)
Something like this is also what sparks further studies.
there are still plenty of ongoing studies on isotretinoin and similar.

Speaking of floaters and various eye problems
who has vision problems? dryness, irritation, light sensitivity, problems with night vision, eye floaters
BUT still has 20/20 vision?
anyone?
Do you haveastigmatism?
Do you wear contacts?

A side note if you wear contacts.
Clean & Clear might help.
Its a unique lens solutions that contains hydrogen peroxide.
This will help kill unwanted pathogens that could easily build up on your contacts.

On 7/6/2018 at 10:31 AM, Devolution said:

i have those issues yes and my good eye showed no issues in a general eye test, still awaiting the optamolgist appointment but my best guess would be to get anelectroretinogram to check for cell dysfunction as a few of these issues are more than likely linked to epigenetic changes that will show no issues with the eye itself in a standard test.

"Persistent, scotopic electroretinographic changes and significant reduction of dark adaptation have been associated with isotretinoin use,^4,5but it is unclear if these are clinically significant.^4,7Animal studies have demonstrated persistent delays in rhodopsin regeneration and a slow recovery of rod sensitivity after light exposure after administration of isotretinoin."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857209/

I do think this stuff is reversible, just a matter of working out how to fix it by returning the dysfunction back to its previous state. As a fair few people are starting to think Crispr is our best bet if these issues don't eventually return back to their original function with time. Hopefully there are many treatment options in the future.

Here is the place im currently awaiting to go to and its interesting that they do research there too so maybe they will be willing to listen, i think im going to send them an email about the potential long term complication of oral isotretinoin on the eyes in case they aren't aware, im not great with all this stuff so if anyone has any studies or anything that may help me show them the dangers of this medicine on the eyes, feel free to message me. If i can try get them to take an interest, it could help others in a similar situation as I'll be posting the results.

[Edited link out]

Yes I definitely have these issues. Particular floaters, dry eyes, photophobia and loss of night vision. I've had these issues for at least 4 years since taking Accutane. My vision is 20/20.
I can't see floaters getting better. They are lumps of collagen floating around in the vitreous with no place to go. Posterior vitreous detachment is a natural deterioration of the eyes which happens in the natural process of ageing and this often leads to floaters. Maybe Accutane speeds up this process?
The only way to get rid of floaters would be to have an FOV or Floaters Only Vitrectomy.

I don't know if it's apparent to anyone else that these eye conditions are the same as those caused by Vitamin A toxicity. Accutane is a form of retinoic acid as is Vitmain A therefore in my opinion it's not enough to stop Accutane and expect these eye conditions to heal why you are still consuming the same poison in the form of Vitamin A. Yes it's not the same mega doses we consume in the form of Accutane pills but dietary Vitamin A can still be very high and therefore significant. This idea just doesn't seem to be getting the attention it deserves here.
Im getting on with trying to restore my eye health anyway and i'll report back if I have success but like I said im pretty much sure the floaters are here to stay.

Thanks,
Lee

Hi, i've been lurking for a while now but just signed up to comment here. About a year ago i noticed i had a lower libido, my frequency and quality of erections had decreased, ejaculate volume had decreased and over time the size of my testicles has drastically decreased. After going to numerous doctors it was found that my hormone levels were essentially normal. My total T, SHBG and LH were high but everything else was normal as far as I recall. Not sure of free T. The only thing my symptoms could've been explained by in any way was a severe left sided varicocele (a testicular varicose vein), which I had unsuccessful surgery for. Still hoping to have it treated just to rule it out. Basically, as time has gone on I've realised that literally no one suffers from symptoms to this extent if they just have a varicocele. So, trying to work out why this is happening to me, I remembered that I had the same ejaculatory and erectile issues whilst on accutane. I was on accutane for just over a week about two years ago, on the lowest dose, 20mg a day or something I think. I stopped because of the sexual side effects, which started literally straight away. Weirdly, I had the strangest and most disturbing dreams too. After stopping, the side effects went away. Did nothing for my acne in that time of course, but I had slightly dry skin. Forgot about accutane in the intervening year, and then a year ago suddenly all these sexual problems started out of the blue. After a load of research to find out what is happening to me, I keep coming back to accutane. Even the fact that an endocrinologist I saw suggested I might have some kind of androgen insensitivity adds up. It's the only cause I can think of that explains the extent of testicular atrophy. To be honest just typing this out seems mad, taking accutane at a low dose for a week surely couldn't cause these effects? But I'm at a point where I have no other explanation. I also suffer from very severe depression and anxiety which were nowhere near as bad pre-accutane. I've always been extremely sensitive to drugs and supplements but surely such a low dose of accutane for just over one week couldn't be the reason for these symptoms?

I was wondering whether or not anyone here has heard of anything like this or what your thoughts were?

On 7/5/2018 at 9:56 PM, guitarman01 said:

NIH study shows microbe living on the surface of the eye protects cornea
Eye microbiometrains immune cells to fend off pathogens in mice. NIH study shows microbe living on the surface of theeyeprotects cornea from infection. C. mast is a commensal bacterium living on the surface of theeye. Bugs in youreyesmay be a good thing.Jul 11, 2017

Eye microbiome trains immune cells to fend off pathogens in mice - NIH

https://www.nih.gov/news.../eye-microbiome-trains-immune-cells-fend-pathogens-mice

Perhaps altered lipid profile of tear film creates an unfavorable environment for these commensal bacteria, and leads to conjunctivitis and blepharitis?

S. F. Egger et al., Ocular side effects associated with 13cisretinoic acid therapy for acne vulgaris: clinical features, alterations of tearfilm and conjunctival flora, Acta Ophthalmologica Scandinavica, vol. 73, no. 4, pp. 355357, May 2009.

Quote

 

ABSTRACT Isotretinoin (13cisretinoic acid) is commonly used for the treatment of acne vulgaris. We included 55 patients in this prospective study, and inspected them before, while and after therapy with isotretinoin regarding ocular side effects. Careful slitlamp inspection, measurement of breakuptime and Schirmertest and microbiological investigations of the conjunctival flora were performed. While staphylococcus aureus was cultured from the conjunctival sac before application of isotretinoin in 7.3%, this percentage increased to 61.8% during therapy. A pathological decrease of breakuptime was realized in 69.1% of the cases, the development of blepharitis in 40%. But in spite of the alteration of conjunctival flora, bacterial conjunctivitis developed in just 7.3% of the cases. However, only 34.5% of the patients showed symptoms of a conjunctivitis sicca, in spite of the impressive diminution of breakuptime in so many cases. All ocular side effects of isotretinoin were treatable and disappeared completely within 1 month after stopping therapy.

 

H. Norouzi, H. M. Rabei, K. Sheibani, R. Malekmohammadi, and S. Salehirad, Evaluation of Tear Function among Acne Vulgaris Patients Undergoing Treatment with Isotretinoin, Journal of Ophthalmic and Optometric Sciences, vol. 1, no. 1, pp. 16, Sep. 2016.

Quote

 

Findings: Thirty nine patients entered the study. There were 5 patients complaining of eye strain before treatment, which rose to 19 patients after Isotretinoin therapy (p<0.001). The tear break up time was 131 seconds which decreased to 91 (p<0.001) after therapy and the Schirmers test mean reading was 222mm, which was reduced to 185 (p<0.001) after treatment. There were 4 patients with blepharitis before the treatment which rose to 19 patients after the end of Isotretinoin treatment (p<0.001).

Conclusion: Isotretinoin usage (0.5-1mg/kg for two months) impairs the tear secretion and causes dry eye and blepharitis among patients. Considering the young age of patients using this drug, some of them candidates for keratorefractive surgery, a history of Isotretinoin usage should be considered before commencing the surgery. We recommend postponing the refractive surgery among these patients until the signs of dry eye are subsided.

@Biggest Brother

https://www.mayoclinic.org/diseases-conditions/blepharitis/symptoms-causes/syc-20370141

Blepharitis symptoms and signs include:

• Watery eyes
• Red eyes
• A gritty, burning or stinging sensation in the eyes
• Eyelids that appear greasy
• Itchy eyelids
• Red, swollen eyelids
• Flaking of the skin around the eyes
• Crusted eyelashes upon awakening
• Eyelid sticking
• More frequent blinking
• Sensitivity to light
• Eyelashes that grow abnormally (misdirected eyelashes)
• Loss of eyelashes

Im more concerned with what its done to the brain??

As much as I have some of these eye issues, what about brain impairment?

On 7/5/2018 at 3:56 PM, guitarman01 said:

Speaking of floaters and various eye problems
who has vision problems? dryness, irritation, light sensitivity, problems with night vision, eye floaters
BUT still has 20/20 vision?
anyone?

We took my brother to a ophthalmologist and he had everything you are mentioning, but also 20/20 vision. We noticed that the doc could not collect tears from the left eye but could from the right. We did this meiobian gland therapy which massaged the glands with heat to help push the blocked oil out.

This seemed to work at first he claimed he felt great but there would also need to be some daily maintenance of rubbing his glands and i don't think he's been keeping up with it.

As an update, to my brother's condition, he's seeing another natural path that believes the first step is to rid the body of Vitamin A and then address the other symptoms.

We received the hair analysis back that was very in depth. Overall report suggest the following:
1. Slow Oxidation rate
2. body is in the exhaustion stage of stress.
3. pattern of diminished cellular adrenal glandular activity
4. cellular thyroid effect that is outside an optimal range.
5. low sodium potassium ratio.
6. copper imbalance
7. impaired protein synthesis
8. High phosphorous level/low sodium potassium ratio.

and more. ......basically this is a 42 page pdf that shows his mineral levels and what his body is going through. Thankfully they say his results are one of the healthiest they've seen in a while of people who have opted for this hair analysis.

we are waiting further instruction from lewis rowlands and dr. wilson on what his supplements should be to balance out his levels. In the mean time he's adopted a suggested diet that is heavy on vegetables. There was one night this week where he got up in the middle of the night and claimed his mouth was moist and his eyes were oily. Very promising so far it's been almost 3 months since he took the one pill and about 3 weeks total of detox.

The depression is still brutal though.

13 hours ago, Dubya_B said:

https://www.mayoclinic.org/diseases-conditions/blepharitis/symptoms-causes/syc-20370141

Blepharitis symptoms and signs include:

• Watery eyes
• Red eyes
• A gritty, burning or stinging sensation in the eyes
• Eyelids that appear greasy
• Itchy eyelids
• Red, swollen eyelids
• Flaking of the skin around the eyes
• Crusted eyelashes upon awakening
• Eyelid sticking
• More frequent blinking
• Sensitivity to light
• Eyelashes that grow abnormally (misdirected eyelashes)
• Loss of eyelashes

@Dubya_B Thanks!

13 hours ago, childofsungod said:

I've always been extremely sensitive to drugs and supplements but surely such a low dose of accutane for just over one week couldn't be the reason for these symptoms?

I was wondering whether or not anyone here has heard of anything like this or what your thoughts were?

@childofsungodMy brother took 1 dose at 20 mg and in hours he felt his body change. Thankfully it's only been 3 months so we're seeing signs of improvement. We've taken the right steps to try and detox his body of the Vitamin A. If it's still relatively new in your system i'd say try and detox it out , take natural supplements, exercise and do acupuncture. Drink plenty of liquids. Ultimately, help your body eat foods that will make the vitamin A bind to it while you're trying to detox it out. Theres plenty of great research people here on this forum have been supplying i'd suggest reading through most of it as I have. The one thing I do believe in is the mental state of mind being a huge factor of finding success in reverting symptoms.

19 hours ago, marshl1 said:

I don't know if it's apparent to anyone else that these eye conditions are the same as those caused by Vitamin A toxicity. Accutane is a form of retinoic acid as is Vitmain A therefore in my opinion it's not enough to stop Accutane and expect these eye conditions to heal why you are still consuming the same poison in the form of Vitamin A. Yes it's not the same mega doses we consume in the form of Accutane pills but dietary Vitamin A can still be very high and therefore significant. This idea just doesn't seem to be getting the attention it deserves here.
Im getting on with trying to restore my eye health anyway and i'll report back if I have success but like I said im pretty much sure the floaters are here to stay.

@DevolutionI was reading somewhere that someone suggested taking some small % of vitamin A because it could counter act the toxicity, i can't recall where but I do believe you are right that it's just triggering your body to enable it again. Some how i want to believe acupuncture is connected to this but i don't have the research to prove that. I just wanted to be sure that you are suggesting taking a small amount of vitamin A to act as a solution. When my brother was on the multivitamin he did start to feel a bit better, not sure if it was the copper or the zinc or vitamin a that did it.

never give up.

I doubt one pill would have done any damage at all and it certainly wouldnt have caused vitamin a toxicity.
thats as stupid as drinking one pint of beer and claiming you have liver damage
this thread is going down hill

I know someone who got side effects just reading about Roaccutane - thats how dangerous this drug is

Nah...one pill though and getting side effects, that is bizarre, must of wreaked havoc on hormones over say effecting the liver....who knows....

Hello
I"m 31years old male

I"m taken the accutane 2years ago 2 month
then hairloss begun.............

The hairloss has continued now..

no male pattern baldness, i lost side, back, crown, ,front all hairloss

i lost 80% hair........

I"m take finasterid in 6 months. But don't stop the hair loss

DOES ANYONE HAVE A SOLUTIONS FOR HAIRLOSS??????

I want to commit sucide because of my hair loss..........

I often read accutane can speed up MPB but how does this work? Accutane is highly anti-androgenic and acts kinda like finasteride (5AR inhibition) so I am wondering why people say accutane can accelerate mpb? I found some old posts where people took accutane for hair loss (because of the DHT decreasing effects)... it is to mention that hundred thousands of guys took accutane and if it truly accelerated MPB it have been medically noted by now, right?
Maybe the answer for early onset of MPB in these individuals is 'shitty genetics' but this answer is highly unsatisfying so they search for other causes.. i for myself too experienced some acceleration of MPB but I could never know for sure if accutane caused this because MPBdoesactually run in my family.. my dad and granddad have a full head of hair but 2 of my uncles and one cousin (who is the same age as me) are bald so this all could also be natural... dont know

Ah man, after over a year of trying to find out what is happening to me, all the signs point towards Post Accutane Syndrome. I get joint pain too, especially in my knees and knuckles, but never connected that with the sexual problems. I have slightly dry eyes and very occasionally get floaters. Does anyone know if there is a way to get tested for it? Is there some way to actually find out if it has affected gene expression? Like gene mapping or something? Feeling pretty bleak that there is a possibility I am suffering from this as recovery looks like a hard task that can take many years if it even happens at all. The most concerning symptom for me is the testicular atrophy, which I think it is fair to say is linked to the sexual problems. I went from having a bulk that I was confident in to having two large-ish grapes. According to a recent ultrasound they are both at around the 10ml mark, whilst the average is 20ml. Does anyone know of anyone who has managed to recover from testicular shrinkage? Must say I'm feeling quite bleak. As it is I am fairly certain I won't be able to have kids or get into any kind of meaningful, long-term relationship. It has me kind of wondering what's the point? This is hardly a walk in the park at any age but at 22 it's so painful to see my friends going out and enjoying their lives whilst this is hanging over me, and I'm indoors moaning about my shrinking nuts to complete strangers on an acne forum lol.