3 hours ago, TrueJustice said:

Also dont bother seeing a vascular surgeon to get answers, theyll only say decreased blood flow and vein issues are hereditary-

I just posted recent news that cardiovascular disease might only be 15 percent hereditary. The rest is based on environmental factors.

Autonomic Neuropathy: Causes, Diagnosis, & Prevention - Healthline

1 hour ago, guitarman01 said:

I just posted recent news that cardiovascular disease might only be 15 percent hereditary. The rest is based on environmental factors.

Autonomic Neuropathy: Causes, Diagnosis, & Prevention - Healthline

https://www.healthline.com/health/autonomic-neuropathy

Nov 12, 2015 -Damage to the nerves that help your organs to function can cause a condition calledautonomic neuropathy(AN) and is associated with other conditions. ... Sweat glands. The symptoms of AN that affect your sweat glands can include dry skin on your feet andexcessive sweatingor lack of sweating.

Ok, so which specialist do we see for this??

I actually told my GP that the Vascular surgeon was a waste time!!

2 hours ago, guitarman01 said:

That doesn't seem to be the case, as dysfunction seems unrelated to testosterone levels in some. This link requires a log in. A long time ago, I used to be a honor student and was second in my class. I felt what was probably nervous system affects and what literally felt like lack of good blood flow to the brain back in high school after I took Accutane, and That was a long time ago.

Fast forward and
I have mild cerebral atrophy and thinning of the corpus callosum shown from a MRI.
When did this happen? When did this start? Did this coincide with Accutane? Was this a lack of growth into adulthood or a degenerative process?
Is this reversible? Will this progress?
I have a lot of drive because there is alot to lose or has been lost.

BTW if you want to quickly check your testosterone or estrogen, its fairly cheap at https://www.walkinlab.com/
its 15 percent off right now as well. You can go through Quest or Labcorp.

I see they can modulate neuropathic pain. Hypersensitivity.
Whats therationale ?
Serotonin generally inhibits sexual activity. Sexual behavior is impaired by many 5-HT agonists and agents that increase 5-HT [3]. Serotonin (5-HT) is primarily inhibitory, although stimulation of 5- HT2C receptors increases erections and inhibits ejaculation, whereas stimulation of 5-HT1A receptors has the opposite effects like facilitation of ejaculation and, in some circumstances, inhibition of erection.

With these labs it doesnt interfere with insurance does it? Like I have HMO which is relatively pretty dang good if I stay in network. So if I pay for it, it should be all good right ?

9 hours ago, guitarman01 said:

That doesn't seem to be the case, as dysfunction seems unrelated to testosterone levels in some. This link requires a log in. A long time ago, I used to be a honor student and was second in my class. I felt what was probably nervous system affects and what literally felt like lack of good blood flow to the brain back in high school after I took Accutane, and That was a long time ago.

Fast forward and
I have mild cerebral atrophy and thinning of the corpus callosum shown from a MRI.
When did this happen? When did this start? Did this coincide with Accutane? Was this a lack of growth into adulthood or a degenerative process?
Is this reversible? Will this progress?
I have a lot of drive because there is alot to lose or has been lost.

BTW if you want to quickly check your testosterone or estrogen, its fairly cheap at https://www.walkinlab.com/
its 15 percent off right now as well. You can go through Quest or Labcorp.

I see they can modulate neuropathic pain. Hypersensitivity.
Whats therationale ?
Serotonin generally inhibits sexual activity. Sexual behavior is impaired by many 5-HT agonists and agents that increase 5-HT [3]. Serotonin (5-HT) is primarily inhibitory, although stimulation of 5- HT2C receptors increases erections and inhibits ejaculation, whereas stimulation of 5-HT1A receptors has the opposite effects like facilitation of ejaculation and, in some circumstances, inhibition of erection.

The only study I could find on accutane and serotonin, found that it increase 5HT1A receptor expression and affected serotonin production and SERT expression - https://www.ncbi.nlm.nih.gov/pubmed/17895527

Note also that if accutane can affect 5HT1A expression, there is no reason to think it couldn't affect the expression of other serotonin receptors.

Many of the mental side effects people with PAS report, are similar/identical to people with PSSD. Emotional blunting, anhedonia, loss of personality, loss of sex drive/libido, feel disconnected from reality. Much of this, is indicative of reduced/dampened dopaminergic signalling. A very plausible explanation of this, would be that accutane has altered our serotonergic signalling in a way that has persisted. It may have left us with hypersensitive serotonin signalling. One explanation is that accutane use may lead to increased 5HT1A receptor expression, post-synaptically.

Interestingly, people with PSSD don't always respond to dopamine agonists and testosterone levels don't seem to matter as in PAS (correct me if I'm wrong).

Ultimately most mental side effects involve some kind of dopamine neurotransmission problem. However dopaminergic agonists or dopamine enhancing drugs such as steroids seem to do very little? So either something fundamental to dopamine neurotransmission has been damaged/dysregulated (seems unlikely as dopamine neurotransmission in other regions such as motor cortex works fine) or something is exerting a strong inhibitory effect on dopaminergic activity. As far as a I can tell. The serotonergic system seems like the only plausible candidate capable of doing this (please correct me if I'm wrong here).

I just got my last results and there's nothing specific about them worth mentioning.

[Edited link out]

And:
[Edited link out]

[Edited link out]

DHT (Dihydrotestosterone): 360 pg/mL. Lab ranges for men (31-40 years old): 17,7 - 775,0 pg/mL

*****
I also did complete blood count, Beta-2 microglobulin, Cholesterol and Lactate dehydrogenase (the latter was added by mistake). All within normal lab ranges.

DHEA-S result was 262 mcg/dL. Lab ranges are 106 - 464 mcg/dL for men (31-40 years old).

This is it, then. I am not going to do further tests for a long time, and I'll see a second nutritionist after APRIL for him to prescribe a good diet to increase testosterone and gain lean mass (I think that's what's called). Also a personal trainer to help with a workout routine suited for that goal.

As for all the rest the 1st nutritionist prescribed (omega 3, vitamin D+E, probiotics, whey protein + creatine), I am not going to buy any of them, since I am disregarding everything from him. It's very important to see multiple doctors about these issues, NEVER (I mean it!) consult one or two about anything. I am going to do all these proposed lifestyle changes to see how things are going to improve.

But even though I am disregarding all prescriptions, I can tell that I am not going to dismiss taking vitamin D-3, E and B-6 (the latter no more than 20, 25 mg/day). I predict this 2nd nutritionist will be more helpful than the first and I expect good results this year, to help increasing my libido and testosterone levels.

Note: I don't know about probiotics, yet there's a very good chance whey + creatine will be recommended by this other doctor, and in my case I see this is really needed. I'll discuss with him the best strategies to follow.

16 hours ago, Colinboko said:

With these labs it doesnt interfere with insurance does it? Like I have HMO which is relatively pretty dang good if I stay in network. So if I pay for it, it should be all good right ?

Yes, with no doctors order, all of the test from that website are 100 percent out of pocket.
you also have access to all the tests from labcorps test catalog, not just what's on walkinlabs website.
If its the same for quest diagnostics, a person might be able to get that
acetylcholine ganglionic neuronal antibodytest without a doctors order.
I'm going to see if I can check the book price, there is a chance it would cost too much (but, its only one antibody as opposed to a full panel)

^well, just checked, that test is 500 dollars out of pocket, so nevermind about getting that without going through insurance.

8 hours ago, Perene said:

I don't know about probiotics

This is something im staying aware of. There is nothing else quite like it on the market atm. I'm not sure of the availability in other countries.
I can't personally comment or review it atm the moment, because I don't like taking multiple products at once when looking into things.
Currently all i'm taking is k2mk7 at 270 mcg from Jarrow.

This is what im talking about, a spore based probiotic.
https://www.amazon.com/Just-Thrive-Probiotic-Antioxidant-Survivability/dp/B00IO9PMDO/ref=sr_1_3_a_it?ie=UTF8&qid=1518738125&sr=8-3&keywords=just+thrive+probiotic+and+antioxidant

It is derived from this product, Megasporebiotic
https://microbiomelabs.com/products/megasporebiotic/

One of the founders of this company is a microbiologist. He has done many conferences, webinars, and podcast and seems very intelligent.
You look at what they sell and its basically 3 products,
The spore based probiotic
A fungus based probiotic
and Vitamin K2 MK-7.

These videos are long. Because of this, these videos arent necessarily something you watch, but something you listen to. I've listened to a few of these just while driving.

Published on May 29, 2017
Much of the probiotic market was built on assumptions and hypotheses of how the gut functions. With the $157 million NIH Human Microbiome Project dramatically changing our understanding of the gut in the last 5 years, we have come to discover that the assumptions and hypotheses under which the vast majority of probiotic products are formulated are simply false. We have a paradigm shift in our understanding of probiotic therapy. This talk will discuss details of the new understanding of the human microbiome and how it specifically relates tohealth , including spectrum disorders. We ARE 10x more bacteria than we are human; bacteria that live in and on us play a significant role in how our body responds to stress, food, andour environment. Our microbes control many of our behaviors and can even influence what we eat.

Here are more topics with videos he covers. Im not going to paste the links because it will fill this page up with videos, just copy the topics in a search and they should pull up.

Understanding the Gut-Brain Connection with Kiran Krishnan
Mitochondria-Microbiome Axis
Everything You Need To Know About Vitamin K2
MegaSporeBiotic Webinar: September 12, 2013

Their megasporebiotic product also appears in a recent study in the World Journal of Gastrointestinal Pathophysiology.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561432/
Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

Was just listening to the video, he comments that just a seven day course of Amoxicillin can take the body up to 2 years to recover from.

Kind of starting to get worried with this whole water retention/kidney thing..

Really want to get an MRI done after some blood tests to rule out any type of pituitary tumor. Ive seen lots of correlation between Accutane and adenomas. A pituitary tumor would be a blessing actually. That way something could at least be fucking treated. Would also explain a lot of the balance issues/dizziness/pressure behind eyes/light sensitivity

I must be releasing a SHIT ton of ADH because Im holding onto every sip of water I take but when I drink things that inhibit ADH, I pee it right out. Such as coffee, alcohol...

My urineis rarely clear also.. Like I said it seems like every ounce of water is being stored somewhere

2 hours ago, Colinboko said:

Kind of starting to get worried with this whole water retention/kidney thing..

Really want to get an MRI done after some blood tests to rule out any type of pituitary tumor. Ive seen lots of correlation between Accutane and adenomas. A pituitary tumor would be a blessing actually. That way something could at least be fucking treated. Would also explain a lot of the balance issues/dizziness/pressure behind eyes/light sensitivity

I must be releasing a SHIT ton of ADH because Im holding onto every sip of water I take but when I drink things that inhibit ADH, I pee it right out. Such as coffee, alcohol...

My urineis rarely clear also.. Like I said it seems like every ounce of water is being stored somewhere

Be sure to let us know if you get an MRI done.

My white coat syndrome is bad these days, cant even go to the dentist without being a bundle of nerves. Its not helped by my extreme fatigue though.

A good kidney cleanse is the Dr Schulzes detox. Good in the sense that the herbs I found to be very pure.

Its not a cure but I felt it did actually cleanse my kidneys.

8 hours ago, Colinboko said:

Kind of starting to get worried with this whole water retention/kidney thing..

Really want to get an MRI done after some blood tests to rule out any type of pituitary tumor. Ive seen lots of correlation between Accutane and adenomas. A pituitary tumor would be a blessing actually. That way something could at least be fucking treated. Would also explain a lot of the balance issues/dizziness/pressure behind eyes/light sensitivity

I must be releasing a SHIT ton of ADH because Im holding onto every sip of water I take but when I drink things that inhibit ADH, I pee it right out. Such as coffee, alcohol...

My urineis rarely clear also.. Like I said it seems like every ounce of water is being stored somewhere

I second this. Ive experienced many of these symptoms. Ive had a very notable pressure behind my right eye for some time now. Its so distinctive my right eye feels as though its watering. Often when its quite bad I notice at night I loose vision, not much but a noticeable amount in my right eye.
Ill try and get an MRI soon and post results. test not guess etc

A recent serum/plasma glucose test I have had (27-1) came back as being elevated above the accepted range. Doctor said it was an indication of Diabetes, could this be more a result of a pituitary tumour caused by accutane? stay tuned i guess.

Edit: Ive now realised from another test i had at the same time showed abnormally high levels of urea..

Fresh out of the world of anti-aging, I found these studies particularly interesting to our predicament because of the epigenetic nature that we could be in. Heres an article: [removed]
The study the article refers: [Edited link out]
The mouse study: [Edited link out]
Basically, some researchers were able to "modulate epigenetic topography" by inducing yamanaka factors, genes associated with inducing pluripotency, in specific ways and times. Food for thought, but maybe lacking practical relevance. They used genetically modified mice that would express these yamanaka factors when exposed to doxycycline. One day though

On 2017-11-26 at 9:39 PM, Neezar said:

Hi

do you have to take vitamin b1 thiamine? How many mg per day? Accutane (in my country - Roaccutane) i take start 7 years ago and take it 3 years, no i do not use roaccutane 4 years, but the side effect I feel so far.

Hi,

blood test results :
Progesterone 0,49 nmol/l (normal level 0,7 4,3 nmol/l);
Sex hormone binding globulin (SHBG) 21,33 nmol/l (normal level 18,3-54,1 nmol/l);
Estradiol (e2) <5 pg/ml (normal level 25,00-60,70);
Follicle-stimulating hormone (FSH) 4,44 IU/l (normal level 1,5-12,4);
Luteinizing Hormone (LH) 3,51 IU/l (normal level 1,7 - 8,6);
Prolactin 162,3 mIU/l (normal level 86,00 - 324,00);
Testosterone 8,95 nmol/l (normal level 6,68-27,0)

i'm 27 years old, blood tests taken 8:00 AM

11 hours ago, Frage said:

some researchers were able to "modulate epigenetic topography" by inducing yamanaka factors, genes associated with inducing pluripotency, in specific ways and times. Food for thought, but maybe lacking practical relevance. They used genetically modified mice that would express these yamanaka factors when exposed to doxycycline.

So they cycled doxycycline to induce these yamanaka factors that influenced these anti-aging markers? Meaning the antibiotic had anti aging effects? But then they didnt really explain how or why the doxycycline had this effect.
I see they mentioned cycling because prolonged induction of yamanaka factors can lead to tumor growth or possibly cancer.

You look hard enough you can probably find some studies on Accutane having anti aging properties as well.
People say Accutane speeds up the aging process, sometimes I feel the opposite.
Accutane halted the aging process or development, In more ways than one.
A Lot have mentioned they have retained a "young look" post Accutane.
at a certain age you "peak" on numerous levels and then processes start to gradually decline from there.
Accutane in a sense might have frozen this "peak" that never reached its full growth potential or plateaued prematurely. Especially based on the fact that a lot that take Accutane are still at a growing age.
Growth Arrest.

Chemotherapy often induces bone growth arrest and osteoporosis or ...

Influence of isotretinoin on hippocampal-based learning in human subjects

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360864/
Isotretinoin does not reduce learning and memory and our study suggests that it may instead lead to a dose-related improvement in specific aspects of hippocampal learning and memory. Retinoic acid functions in the hippocampus as the active metabolite of vitamin A, suggesting that this may be a limiting factor in the human hippocampus and addition of exogenous retinoic acid brings levels closer to an optimal state.

Oral isotretinoin as part of the treatment of cutaneous aging.

https://www.ncbi.nlm.nih.gov/pubmed/10886272

Vitamin A regulates hypothalamic-pituitary-adrenal axis status in LOU/C rats.

https://www.ncbi.nlm.nih.gov/pubmed/23847298
The high vitamin A status of LOU/C rats could contribute to their low HPA axis activity/reactivity and to a protective effect against 11-HSD1-mediated deleterious action on cognitive performances during ageing

4 hours ago, guitarman01 said:

You look hard enough you can probably find some studies on Accutane having anti aging properties as well.
People say Accutane speeds up the aging process, sometimes I feel the opposite.
Accutane halted the aging process or development, In more ways than one.
A Lot have mentioned they have retained a "young look" post Accutane.

I have never heard of this one before. If this was true, I would be happy to keep taking Accutane to get that young look.

On 2/15/2018 at 8:09 PM, Colinboko said:

Kind of starting to get worried with this whole water retention/kidney thing..

I've had what I always thought was abnormal urine retention for a very long time since Accutane.
I've also had darker urine at times, had protein in my urine once that was right on the border of being too high and also ketones from the same urine test. I had a follow up urine test and the ketones were gone so was the protein in the urine. These tests were fairly recent. This is something to keep an eye on for me.

Obviously you know what I've been looking at recently, since I already knew about this I might as well post it.

Vitamin K Deficiency in Chronic Kidney Disease: Evidence Is Building Up

https://www.karger.com/article/fulltext/451070

Now look what else they are finding, these are mostly vitamin k antagonist.

Anticoagulants Tied With Stroke, Hemorrhage in CKD

https://www.renalandurologynews.com/chronic-kidney-disease-ckd/chronic-kidney-disease-afib-anticoagulants-tied-ischemic-stroke-bleeding/article/744827/

^This is interesting right here, this is both blood clotting causing stroke and its opposite, increased bleeding or hemorrhage. So coagulation and anticoagulation.

and what else,

Growth inhibitory effects of vitamin K2 on colon cancer cell ... - NCBI

So linking this and my last posting with the video, your looking at possible dysbiosis in the intestinal tract, where menaquinones are produced and absorbed to some extent.

@mariovitali
You can look at these numbers to give an idea. I assume only a fraction of this is getting absorbed though. But its there. Or should be. and no Im not still sick. I have some more to post about that later.

Vitamins In Foods: Analysis, Bioavailability, and Stability

So all of the above = continue Vit K supplements??

urine retention??

arent we all pissing like race horses after tane? I piss very frequently, more so than pre tane.

I also sweat like no ones business after tane, others have reported they dont sweat....this continues to be very confusing all these extremes....

I think you can be on one end of the spectrum or the other with sweating/ frequent urination. This might be related to autonomic function.
and we could just be different. Its going to be harder to tell as people get older.

I treat this forum as a journal or a way to save information sometimes.
Everything is your choice, i'm just providing my thoughts on the issues atm.
If I really feel I can help you at some point, I will let you know.
Some of this is thinking out loud, but someone might pick up on something that relates.

@guitarman01
No, it was not the doxycycline that had anti-aging and epigenetic effects. They genetically engineered mice using a "OSKM polycystronic cassette" process that allowed those mice to express the OSKM genetic factors, OCT4 SOX2 KLF4 MYC, when doxycycline was exposed to them. Normally, doxycycline will do no such thing. The best part about this study, and why the people at the salk institute and others in this field believe this could be in clinical trials in the next 10 years, is that this method showed that OSKM factors can modulate epigenetic topography without inducing a pluripotent state. Cause yeah, tumors and stuff. So basically, they made the epigenome of old cells appear like one year old cells without changing that cells assigned type (it did not become pluripotent). If researchers can figure out how to replicate this process for humans, without using a polycystonic cassete method of course, well thats the end goal. And if PAS is epigenetic it could be very beneficial for us.

I've heard about the growth arrest possibilities of accutane, especially to those who took it during development. That includes me. But I currently look like an aids patient post accutane. Terrible thin wrinkly skin, facial fat changes, dark circles under eyes, dry skin. Happened nearly overnight for me when I had a crash of sorts. Don't know why some people get this and others don't, but it's not all that uncommon among pfs and pas people. So in some ways PAS can make you look young, in other ways it can age you quickly. Its going to be a long time until we fully understand this disease and why these things exactly happen. I think all we need to know though is the general idea of what has happened to us, and then look for treatments that broadly correct that. What I mean is that, we don't need to know every detail if we know enough about the root cause. If we know that pfs is at the root epigenetic or apoptosis related, then we don't need to know all the details to get benefit from OSKM factors treatments. This is the benefit of a lot of SENS technology I've been looking into. At the same time, that technology may be years away. It might be that insight about the details of our disease are found that allow us to use conventional treatments before then. But I haven't found many conventional treatments that might correct the root cause of our issues (being epigenetic, apoptosis, immune related). And this is because most of conventional treatments require intimate knowledge of tons of metabolic pathways, or other feedback systems, or something other. And we can never hope to understand every singe effect accutane has had on us. So at most, I think most conventional medicines can only help correct downstream effects. And I know I haven't defined "conventional treatments" well, but hopefully my point makes it across.

On 2/17/2018 at 3:24 PM, guitarman01 said:

Some of this is thinking out loud, but someone might pick up on something that relates.

Pretty much what I'm doing above

Also , a good starter about genetics is the book, The Epigenetics Revolution - by Nessa Carey. You can find it on Library Genesis: [Edited link out]

3 hours ago, Frage said:

No, it was not the doxycycline that had anti-aging and epigenetic effects.

I skimmed through that article pretty fast looking for the headline. I'm still not quite clear on how doxycycline is having an effect.
This seems like a more digestible summary, you summed it up pretty well though.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452046/
Reprogramming adult, fully differentiated cells to pluripotencyinvivoviaOct3/4,Sox2,Klf4andcMyc(OSKM) overexpression has proved feasible in various independent studies and could be used to induce tissue regeneration owing to the proliferative capacity and differentiation potential of the reprogrammed cells. However, a number of these reports have described the generation of teratomas caused by sustained reprogramming, which precludes the therapeutic translation of this technology. A recent study by the IzpisuaBelmonte laboratory described a cyclic regime for shorttermOSKMexpressioninvivothat prevents complete reprogramming to the pluripotent state as well as tumorigenesis. We comment here on this and other studies that provide evidence thatinvivoOSKMinduction can enhance tissue regeneration, while avoiding the feared formation of teratomas. These results could inspire more research to explore the potential ofinvivoreprogramming in regenerative medicine.

"When such animals were fed with doxycycline for extended periods of time, ubiquitous and sustained expression ofOSKM caused uncontrolled proliferation and disorganized differentiation followed by extensive tumorigenesis and death"

^just looking at that line right there, this seems a long way off from any type of commercialization. Or a person walking into a doctors office saying I need a prescription for this. 10 years will probably turn into 20 at the least. Although this is nothing i've been looking at, so Im sure you have more knowledge then me.

When I mention a "young look" and growth arrest or lack of growth, Im probably looking at the skeletal system first.
This might cause some to maintain a kiddish look. lack of fully mature bone density or peak bone mass.
you could look at the jaw, the skull, the neck, wrists, lower back, hips, shoulders, height.
Im also looking at the brain, critical parts in the brain continue to develop until age 25 or so.
looking at skin and hair, this is growth as well. constant cellular division to maintain healthy skin cells.
So I guess there could be a different interpretation of this.

On 2/15/2018 at 4:46 AM, flynn said:

Interestingly, people with PSSD don't always respond to dopamine agonists and testosterone levels don't seem to matter as in PAS (correct me if I'm wrong).

SSRI's do seem to have a negative effect on testosterone. So now you have all three groups in common. replacement therapy isnt the cure, but something is still going on here.

The effect of sertraline, paroxetine, fluoxetine and escitalopram on testicular tissue and oxidative stress parameters in rats.

https://www.ncbi.nlm.nih.gov/pubmed/24642156
the testosterone levels were lower in all groups compared with the control group

CONCLUSION:

These data suggest that SSRIs have a negative effect on testicular tissues. This negative impact is markedly greater in the paroxetine group. To determine the exact mechanism of action of these drugs on testicular tissue, well-designed randomized controlled clinical studies are needed on a larger population.

On 2/16/2018 at 8:48 AM, Neezar said:

Testosterone 8,95 nmol/l (normal level 6,68-27,0)

Right here, he just posted it. Low testosterone. Or lower then it should be.

3 hours ago, guitarman01 said:

I skimmed through that article pretty fast looking for the headline. I'm still not quite clear on how doxycycline is having an effect.
This seems like a more digestible summary, you summed it up pretty well though.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452046/
Reprogramming adult, fully differentiated cells to pluripotencyinvivoviaOct3/4,Sox2,Klf4andcMyc(OSKM) overexpression has proved feasible in various independent studies and could be used to induce tissue regeneration owing to the proliferative capacity and differentiation potential of the reprogrammed cells. However, a number of these reports have described the generation of teratomas caused by sustained reprogramming, which precludes the therapeutic translation of this technology. A recent study by the IzpisuaBelmonte laboratory described a cyclic regime for shorttermOSKMexpressioninvivothat prevents complete reprogramming to the pluripotent state as well as tumorigenesis. We comment here on this and other studies that provide evidence thatinvivoOSKMinduction can enhance tissue regeneration, while avoiding the feared formation of teratomas. These results could inspire more research to explore the potential ofinvivoreprogramming in regenerative medicine.

"When such animals were fed with doxycycline for extended periods of time, ubiquitous and sustained expression ofOSKM caused uncontrolled proliferation and disorganized differentiation followed by extensive tumorigenesis and death"

^just looking at that line right there, this seems a long way off from any type of commercialization. Or a person walking into a doctors office saying I need a prescription for this. 10 years will probably turn into 20 at the least. Although this is nothing i've been looking at, so Im sure you have more knowledge then me.

When I mention a "young look" and growth arrest or lack of growth, Im probably looking at the skeletal system first.
This might cause some to maintain a kiddish look. lack of fully mature bone density or peak bone mass.
you could look at the jaw, the skull, the neck, wrists, lower back, hips, shoulders, height.
Im also looking at the brain, critical parts in the brain continue to develop until age 25 or so.
looking at skin and hair, this is growth as well. constant cellular division to maintain healthy skin cells.
So I guess there could be a different interpretation of this.

SSRI's do seem to have a negative effect on testosterone. So now you have all three groups in common. replacement therapy isnt the cure, but something is still going on here.

The effect of sertraline, paroxetine, fluoxetine and escitalopram on testicular tissue and oxidative stress parameters in rats.

https://www.ncbi.nlm.nih.gov/pubmed/24642156
the testosterone levels were lower in all groups compared with the control group

CONCLUSION:

These data suggest that SSRIs have a negative effect on testicular tissues. This negative impact is markedly greater in the paroxetine group. To determine the exact mechanism of action of these drugs on testicular tissue, well-designed randomized controlled clinical studies are needed on a larger population.

Right here, he just posted it. Low testosterone. Or lower then it should be.

The last 4 years the level ranged from 4 to 11

Just realized something....

I get intermittent dripping from my nose. Its clear, watery fluid, and when it accidentally slides down my throat its fairly salty tasting..

CSF leaking from a sinus/pituitary adenoma? Will be finding out soon. It just makes so much sense from my head pressure to my eye problems and constant dizziness.

And then maybe all of the other hormonal problems followed suit?

36 minutes ago, Colinboko said:

Just realized something....

I get intermittent dripping from my nose. Its clear, watery fluid, and when it accidentally slides down my throat its fairly salty tasting..

CSF leaking from a sinus/pituitary adenoma? Will be finding out soon. It just makes so much sense from my head pressure to my eye problems and constant dizziness.

And then maybe all of the other hormonal problems followed suit?

Will you seek out the blood test or a brain scan for this?

My concern is with all the hormone testing weve all had done, surely wed of fluked apon finding out its pituitary tumour by now.....surely wed of discovered this??

49 minutes ago, TrueJustice said:

Will you seek out the blood test or a brain scan for this?

My concern is with all the hormone testing weve all had done, surely wed of fluked apon finding out its pituitary tumour by now.....surely wed of discovered this??

Im going to do some bloods and an MRI..

Countless people on the internet have questioned a relationship between their prolactinomas/pituitary tumors and their use of isotretinoin....

We need to stop thinking of this as one big golden key.

This drug is powerful and has the power to screw a lot of different things up in a lot of different ways. If you think about it; anything to do with the brain and its signaling has the potential to cause symptoms that may bleed into other seemingly relatable illnesses; if that makes sense.

My point being... many different illnesses share the same symptoms. Yes we were all affected by isotretinoin but the real question is in what way? That opens a whole new can of worms for each and every individual on here. And Im not saying there arent smaller sectors of us that share the exact same cause because I believe thats totally possible. But because your hormones came out normal, that avenue closes for everyone else? Thats why I momentarily step off this thread here and there. (Always have my notifications on of course) but I just think sometimes its best to figure out things individually first.

This was totally not a shot at you. Just wanted to explain some things.

Thats a thoughtful response - I appreciate it.

I really hope youre on to something, nothing would please me more this year than to see all this digging we do eventuate into something!!

More cures would be a fucking awesome thing to see and would give hope to all of us.

Your post about pituitary did intrigue me, my very basic understanding is that many tumours in that part of brain dont necessarily need to be operated on.
I believe there are medications to treat these non life threatening tumours!!

@guitarman01

According to the hypothesis, Vitamin K is very important. However there are many more pathways that need to be looked at. What we are dealing with is a vicious cycle of Inflammation, Oxidative Stress, Endoplasmic Reticulum Stress and impaired Phagocytosis (list not inclusive).

FWIW : We are very close in a full Recovery of a Woman in her 40s having ME/CFS for 25 years along with severe Neurological Issues. Her DNA Data have been forwarded to a well-known ME/CFS Researcher for evaluation. This will be the second case of Full Recovery using a personalised regimen. Her Fibroscan suggests Liver Fibrosis (f2-f3). Also she presented with slightly elevated Total Bile Acids (=mild cholestasis). All of the results have been forwarded along with the Patient's full identity.