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22 hours ago, Dubya_B said:There is a study showing measured conversion rates of Isotretinoin to 4-oxo-Isotretinoin, All-trans retinoic acid, 9-cis retinoic acid, and some other metabolites. So there's not a true 1:1 conversion of 13-cis to All-trans retinoic acid, but almost certainly still what would be considered a toxic level of All-trans while on the drug, ( going by the retinol equivalent of a toxic dose.)
Another study showed there was a small percentage of individuals who had a very high (think it was around 5x greater than mean average)
level of all-trans retinoic acid detected in their blood after taking the same dose of isotretinoin as the rest of the group.
Maybe most of us who were severely affected were among that small percentage?
When I posted that conversion I mainly had dietary or supplemental vitamin A in mind. For example retinolpalmitate (orretinyl palmitate)
Then I see supplemental retinol might go through a conversion process,
Retinyl palmitate must be broken down into retinol, then retinaldehyde and finally retinoic acid.
Retinyl palmitate is about 20 percent less potent than retinol? according to futurederm.com
^and your not even at retinoic acid yet.
So with Accutane your avoiding these extra conversion steps (and possibly regulating factors) and just skipping to the last one? (most potent form)
Example, retinaldehyde very slowly gets converted to retinoic acid in the skin.
When I see all trans retinoic acid (drug name Tretinoin, which can be oral) is this the most potent form? its in the title.
The two seem to have different uses, Tretinoin and isotretinoin. Tretinoin is preferred for a type of Leukemia for example.
Regarding metabolism, I think it comes down to genetics and maybe gut microbiome. Examples. There's gut bacteria that clear things like estrogen and metals like zinc. Again you can look at responders to Warfarin, they can test their SNPs (on Vitamin K metabolism) to see how they respond for most accurate dosage, which is very important for a blood thinner.
The universal dosage applied for Accutane could be greatly adjusted per individual response im sure. They are just not there yet and were nowhere near this kind of thinking or testing in the 70s,80s,90s.
Correct me if i'm wrong, but no form of retinoic acid comes from dietary sources, only its precursors.
2 hours ago, idontknow1993 said:Hey guys I want to give you an update on my situation. I got bad news..
My recovery was 100% real and I was feeling absolutely awesome for the last couple of months but I have to say the last weeks and espaciallly the last couple of days I feel that I am loosing my sexdrive slowly. Not that bad so far and I'm still 10 times better than before the use of fin but honestly at the moment I can't say that I am still fully recovered. One interesting fact is that my situation was getting worse again when I took cocaine about 1 month ago and I couldnt have sex because my dick wasn't working.
So I it scarred me a little bit and since that moment it goes down the road.
Thanks for keeping us updated. Its good to let people know the good and the bad news. If you continue to get worse or better, please keep us updated. I still can't figure out why Finasteride would help somebody with PAS??? Could anyone else shed any light on this?
It's either:
1. Placebo
2. Accutane treatment results in elevated levels of progesterone. Which alters progesterone receptor expression and function in the brain. Note that progesterone is known to lower/affect male sex drive in the presence of normal/elevated testosterone levels. Some think that Finasteride is a progestin, and as such it alters progesterone receptor expression in brain etc. bringing the body back to healthier balance.
3. Accutane causes from type of lasting HPA dysfunciton which is rescued by FIN
4. (least plausible in my view) - through altering 5 alpha reductase activity, FIN alters androgen receptor expression in a favourable way, resulting in enhanced androgen sensitivity.
In my eyes the androgen receptor has always represented the most promise or been the most likely culprit of our problems. As we suffer symptoms very similar to hypogonadism. Studies have shown that accutane metabolites alter androgen receptor expression. However my problem with theories of the androgen receptor are: 1. androgen receptors in muscles seem to work fine for me but I still have sides. 2. Also dopamine agonists which bypass the level of androgen receptor don't seem to be very effective (indicates a dopamine problem to me).
5. Another theory I haven't thought of.
8 hours ago, Dubya_B said:That's new.... I'm not familiar with how sex works for guys on other planets though.Pleasuring someone else without being able to feel sensations of pleasure yourself isn't my idea of "perfectly fine". Most women I know aren't fond of the idea of a non-mutual arrangement either.
Thanks Accutane!
.
I personally had trouble with getting an erection my first 10 times. And from that i got to know that you can get pleasured in many other ways than just getting you willy stroked. And the joy of seeing someone you love having a klimax is something really enjoyable by itself.
Because retinoic acid is a metabolite and not retinol or not a precursor, maybe that is a reason it might not get stored in tissue.
I will post more info when I find it but here is a start. If your going to look for more clues from possibly its most potent form, you could probably start to research tretinoin as well.
Retinoids - LiverTox
Tretinoinis used topically and several other retinoids have been developed for therapy of uncommon forms of cancer (alitretinoin, bexarotene). The commonly used retinoids have many of the side effects of vitamin A including dry skin, cheilosis and nosebleeds and hair loss, but are not stored in theliverand do not causethe typical form of chronic liver disease associated with excessive vitamin A intake.
You need to click this second link. cant paste info from the book.
Retinoids in Oncology - Page 133 - Google Books Result
Unlike other retinoids, 4HPRaccumulatesextensively in the adipose tissue but not in theliver(33,34). ... Data reported from Stuttgen et al. on the use oftretinoinsuggest that oral retinoic acid has a toxicity profile similar to that of vitamin A, with a high incidence of headache (80%), central nervous system effects [lethargy and...
^it states isotretinoin does not accumulate in tissue, but another synthetic does in fat tissue, and its the most potent of all the retinoids. They also state it might interfere with retinol.
Page 133 states isotretinoin does not accumulate.
Lot of info in this book. 1st chapter.
It also mentions central nervous system side effects.
Neuropathy comes to mind and this can be very wide ranging.
On 2/10/2018 at 5:36 PM, flynn said:I'm from the UK. I have already reported it.
The problem here is how people are measuring sexual sides. Sexual sides don't necessarily mean altered sperm and testicular function or erectile function.
Sexual sides can also mean loss of libido, interest in sex, loss of nocturnal and morning erections etc. The problem here is that its very difficult to test these things in a model such as a rat. Also given the embarrassing nature of these side effects, I would be they are significantly under-reported. Either because
1. People don't want to report them
2. People haven't made the connection between their sexual side effects as accutane (note it's taken me 10 years to make the connection).
3. People who have these side effects are almost in denial about them and try as hard as they can to ignore that they even exist.I agree these side effects needs to reported far more frequently.
Hi Flynn, thanks for reporting your side effects.
I appreciate all that you are saying and trust me, the nature of these problem and the fact that many of the sufferers are so young
is not lost on me. That is why we need the vets and the stronger guys out there to lead the way and encourage all the newbies to report their sides.
Dubya for instance has all the links available for anyone to report their sides and I know he wrote a long email to PRAC. This helped in getting the PIL updated to include erectile dysfunction and diminished libido. That's a step in the right direction but we have to get the regulators to recognise how enduring these side effects can be so that they can warn patients. Surely we can all recognise that this is important.
Can you please write an email to PRAC and MHRA asking for a review of the sexual sides and to explain how your side effects are playing out.
They need to get a better understanding of PAS so that everyone will be informed and doctors will have a greater understanding of the syndrome and at least be more understanding when victims present themselves.
Quite frankly i don't believe there is a safe way to prescribe accutane and it needs to be banned but we are years away from that happening.
What we can all do is is raise awareness and hope and pray we have less victims in the future.
Based on postings over the years, alot have mentioned symptoms that could indicate signs of Neuropathy.
https://my.clevelandclinic.org/health/diseases/14737-neuropathy
The peripheral nervous system is made up of 3 types of nerves, each with an important role to play in keeping your body healthy and functioning properly.
- Sensory nervescarry messages from your senses through your spinal cord to your brain. For example, they tell your brain you are touching something hot.
- Motor nervestravel in the opposite direction. They carry messages from the brain to your muscles. They tell your muscles to move you away from the hot surface.
- Autonomic nervesare responsible for controlling body functions that occur outside our control, such as breathing, digestion, heart rate, and blood pressure.
Common symptoms of sensory neuropathy include:
- Tingling.
- Numbness, especially in the hands and feet.
- Changes in sensation Some people feel severe pain, especially at night, and some are unable to feel pain, pressure, temperature, or touch.
- Loss of coordination.
- Loss of reflexes.
- Burning sensation.
- Feeling that you are wearing socks or gloves when you are not.
Common symptoms of motor neuropathy include:
- Muscle weakness.
- Difficulty walking or moving your arms or legs.
- Muscle twitching.
- Cramps.
- Spasms.
- Loss of muscle control.
- Loss of muscle tone.
- Loss of dexterity.
- Falling.
- Inability to move a part of the body.
Common symptoms of autonomic neuropathy include:
- Abnormal blood pressure or heart rate.
- Decreased sweating.
- Problems with urination.
- Sexual dysfunction.
- Diarrhea.
- Weight loss (unintentional).
- Dizziness when standing up or fainting.
- Nausea or vomiting.
- Problems with digestion.
This is a possible cause that I've been looking at.
Acquired neuropathy
Vascular disorders: Neuropathy can occur when blood flow to the arms and legs is hindered by inflammation, blood clots, or other blood vessel disorders. Decreased blood flow deprives the nerve cells of oxygen, causing nerve damage or nerve cell death.
And not just the arms and legs, we've already seen studies of reduced cerebral blood flow from Accutane.
Im looking at Micro and macro circulatory disorders.
Possibly similar to what happens in Diabetes.
Diabetic neuropathiesare nerve damaging disorders associated withdiabetesmellitus. These conditions are thought to result from adiabeticmicrovascular injury involving small blood vessels that supply nerves (vasa nervorum) in addition to macrovascular conditions that can accumulate indiabetic neuropathy.
Here's a test that i've mentioned that might show real evidence of autonomic dysfunction.
The immune system isnt necessarily involved and this can still test positive. Meaning it might not be autoimmune in nature.
What this is, is blood proof of some level of neuropathy. (autonomic)
ACETYLCHOLINE RECEPTOR GANGLIONIC (ALPHA 3) AB (93881)
serves your office? Call us 1-866-MYQUEST (1-866-697-8378) ACETYLCHOLINE RECEPTOR GANGLIONIC (ALPHA 3) AB Test Code 93881 CPT Code(s) 83519 Preferred Specimen(s) 1 mL...More
Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients.
2017
the first objective evidence of a neuropathy involving peripheral neurogenic control of erection.
https://www.ncbi.nlm.nih.gov/pubmed/28408350
It's the PNS or CNS in my opinion. I probably smoked a few times while on the medication, which exacerbated toxicity, in my case. It completely rewired everything and not in a good way. In a TBI way. Now when I smoke (and I can only tolerate small amounts) my nerves go haywire (loss of sensation in limbs, body, up to the neck, tachycardia, scary shit) However, if I do just the right amount, my depression is temporarily relieved, my sex drive skyrockets. It took me years to get to this semi functional level. Rebuilding my nervous system with quite a lot of cardio (i've ran a minimum of 10 miles a week for the past 4 years) and of course a healthy whole foods diet. Now, if you look at the picture of the CNS/PNS, what does it look like?
[Edited image out]
It looks a bitlike mycelium.Our best shot at getting better are things that will stimulate neurogenesis (mushrooms, ssri's, hyperbaric o2, exercise, games, etc.) You need to get your serotonin back up and running, you have to rebuild your nervous system and receptors. I'm seeing progress but it's not easy.
But, you know everyone is different, and this drug affects everyone differently. For some people their problems may just be hormonal, whether the receptors are the issue, is the big question. Afterresearching some of these bodybuilding drugs,there seems to be purported ways of increasing your LH and FSH (Which we know Accutane, Finasteride, Dutasteride affectsnegatively). Such drugs to stimulate are HCG or HMG. Maybe even HGH. All of which is available for purchase online (if you find the right people).. For those who are hesitant of trialing Clomid or other drugs, just know from browsing thebodybuilding forums, it seems to beused A LOT.
Interesting video: might help in managing symptoms. I wonder how it works, but I'm too brain dead today to look into it much further. Haven't been able to really sleep in days. Fuck this disease
Edit: I guess theres just something alluring to me about injecting a solution of pig brain peptides into my deltoid? Ha!
Edit2: And then again, a few users who tried cerebrolysin in this longecity forum, had some very severe reactions to this drug. Reactions that actually kind of share some similarities to PAS interestingly. (Disassociation, 0 libido, brain fog, anhedonia, insomnia). One guy in the thread claims to have got the same sides from ssri use, which brings pssd into my mind. Oh boy. Well, thought I'd at least add that addendum before knocking myself out with benadryl.
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Nice video. I actually have a couple boxes of cerebrolysin in my fridge. I just haven't gotten around to using it because the needle gauge is reallly big and intimidating. I also want to use it in conjunction with my o2 chamber that i haven't finished setting up yet (ETA March 2018). The horror stories are scary (it's just that one thread from 2013 what i've seen) but if you trust your source you shouldn't worry too much. It's made from a pharma in Austria, and as long as it's not expired you should be fine. Like everything, weigh the odds and decide if you truly have nothing to lose.
Heres a paradox. I haven't seen this exact description until just now. I have tried supplementing vitamin a on numerous occasions, and for me something wasnt right about it, or came with side effects, messed with my mood too much. Maybe there is another metabolite to be looking at or something in the Retinoid Cycle.
Inhibition of the visual cyclein vivoby 13-cisretinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy
The retinoid cycle inhibitor13cisRA is also called isotretinoin and is used as a treatment for severe acne. Due to its inhibition of the RPE retinoid cycle, isotretinoin causes poor night vision in some patients (Weleber et al., 1986;Sieving et al., 2001). Our data suggest that it could also attenuate melanopsin-based photoreception and thus compromise ipRGC-driven photoresponses, such as circadian entrainment, mood enhancement, and sleep regulation, a hypothesis first proposed bySzabo (2007). This action on ipRGCs could contribute to some of the psychiatric side effects of this drug (Kontaxakis et al., 2009).
Im seeing 11-cis retinol mentioned a lot
Dark adaptation and the retinoid cycle of vision.
We review a large body of evidence showing that the time-course of human dark adaptation and pigment regeneration is determined by the local concentration of 11-cis retinal
Why 11-cis-retinal? Why not 7-cis-, 9-cis-, or 13-cis-retinal in the eye?
Abstract
One of the basic and unresolved puzzles in the chemistry of vision concerns the natural selection of 11-cis-retinal as the light-sensing chromophore in visual pigments. A detailed computational examination of the structure, stability, energetics, and spectroscopy of 7-cis-, 9-cis-, 11-cis-, and 13-cis-retinal isomers in vertebrate (bovine, monkey) and invertebrate (squid) visual pigments was carried out using a hybrid quantum mechanics/molecular mechanics (QM/MM) method. The results show that the electrostatic interaction between retinal and opsin dominates the natural selection of 11-cis-retinal over other cis isomers in the dark state. In all of the pigments, 9-cis-retinal was found to be only slightly higher in energy than 11-cis-retinal, which provides strong evidence for the presence of 9-cis-rhodopsin in nature. 7-cis-Retinal is suggested to be an "upside-down" version of the all-trans isomer because the structural rearrangements observed for 7-cis-rhodopsin from squid were found to be very similar to those for squid bathorhodopsin. The progressive red shift in the calculated absorption wavelength ((max)) (431, 456, 490, and 508 nm for the 7-cis-, 9-cis-, 11-cis-, and 13-cis-retinal isomers) is due to the decrease in bond length alternation of the retinal.
Mechanism of Action.
Isotretinoin slowed rhodopsin regeneration and chromophore recycling within 1 hour after systemic administration by inhibition of the retinoid isomerase and 11-cisretinol dehydrogenase enzymes that are necessary for the synthesis of 11-cisretinal in the RPE
11-cisretinol dehydrogenase (RDH5) is a candidate for inhibition by isotretinoin
Important?
Vitamin A deprived rats can be kept in good general health with supplementation ofretinoic acid. This reverses the growth-stunting effects of vitamin A deficiency, as well as early stages ofxerophthalmia. However, such rats show infertility (in both male and females) and continued degeneration of the retina, showing that these functions require retinal or retinol, which are interconvertible but which cannot be recovered from the oxidized retinoic acid. The requirement of retinol to rescue reproduction in vitamin A deficient rats is now known to be due to a requirement for local synthesis of retinoic acid from retinol in testis and embryos.[60][61]
For those of you suffering from post-tane depression and erictile dysfuntion, have any of you tried micro-dosing on mushrooms or LSD. If you havent, that should be the first thing you do.
For those of you suffering from pain, have you tried CBD oil, GABApentin, duloxetine or LDN. I would recommend the CBD oil over all the others, but the rest help with pain too.
Swimming, Acupuncture, sauna and steam room help a lot with managing pain and headaches, energy and viatality and mood too.
Diet is important. To what extent, Im not sure. But a plant based diet heavy in vegetables and fruits cant hurt. Try intermittent fasting and meditation.
For dry dry and itchy scalp, try olive oil, tea tree oil and peppermint on the scalp.
In my experience, all vitamins are a waste of time, so I dont know why people keep advocating this on here.
And if youre scared or worried about never getting better, dont be, beaceausyou will. The ones who recover leave this forum and move on with their lives. The ones who dont, stay here and advocate vitamins and false leads.
14 hours ago, TrueJustice said:Can you translate into lay terms??
while I appreciate the science posted, half the time I dont know how to apply to my life.
what are we suggesting with this one,
supplement Vit A??
This is information I came across that I felt was at least worth posting. I like to put information out there. It's not much more than that atm.
6 hours ago, Jorcruz24 said:In my experience, all vitamins are a waste of time, so I dont know why people keep advocating this on here.
And if youre scared or worried about never getting better, dont be, beaceausyou will. The ones who recover leave this forum and move on with their lives. The ones who dont, stay here and advocate vitamins and false leads.
If I recall your also on multiple drugs now post Accutane, and not too far removed from having taken Accutane.
This shouldn't have to be the case.
Everything I post I try to be as accurate as possible and unbiased, its based on research and testing.
So its not false, but it's a matter of finding what might apply.
5 hours ago, Jorcruz24 said:For those of you suffering from post-tane depression and erictile dysfuntion, have any of you tried micro-dosing on mushrooms or LSD. If you havent, that should be the first thing you do.
For those of you suffering from pain, have you tried CBD oil, GABApentin, duloxetine or LDN. I would recommend the CBD oil over all the others, but the rest help with pain too.
Swimming, Acupuncture, sauna and steam room help a lot with managing pain and headaches, energy and viatality and mood too.
Diet is important. To what extent, Im not sure. But a plant based diet heavy in vegetables and fruits cant hurt. Try intermittent fasting and meditation.
For dry dry and itchy scalp, try olive oil, tea tree oil and peppermint on the scalp.
In my experience, all vitamins are a waste of time, so I dont know why people keep advocating this on here.
And if youre scared or worried about never getting better, dont be, beaceausyou will. The ones who recover leave this forum and move on with their lives. The ones who dont, stay here and advocate vitamins and false leads.
Any success in improving sexual side effects?
I am interested in hearing what anyone has to say about this report and also what your experience was in regards to how you were advised
and monitored before and during medication.
Scientific conclusions Taking into account the PRAC Assessment Report on the PSUR(s) for isotretinoin (oral formulations), the scientific conclusions are as follows: The totality of data presented in this review suggest there is evidence that isotretinoin can be associated with sexual dysfunction including erectile dysfunction and decreased libido and that the mechanism may be a reduction in plasma testosterone. Cumulatively total of 689 events occurring in 471 patients have been retrieved using the High Level Group Term Sexual function and fertility disorders. The majority of cases reported erection and ejaculation conditions and disorders (311 cases), followed by High Level Term Sexual function and fertility disorders NEC (165) and Spermatogenesis and semen disorders (43). The most common Preferred Terms reported in these cases were: erectile dysfunction (281), libido decreased (92), sexual dysfunction (38), oligospermia (15), and ejaculation disorder (13). A negative dechallenge is reported in 10 cases and a positive dechallenge is reported in 15 cases. Two cases include rechallenge information: one negative and the other positive. Based on the cases from spontaneous reporting and the literature review there is sufficient evidence to warrant an update to section 4.8 of the isotretinoin SmPC and the package leaflet. The CMDh agrees with the scientific conclusions made by the PRAC. Grounds for the variation to the terms of the Marketing Authorisation(s) On the basis of the scientific conclusions for isotretinoin (oral formulations) the CMDh is of the opinion that the benefit-risk balance of the medicinal product(s) containing isotretinoin (oral formulations) is unchanged subject to the proposed changes to the product information. The CMDh reaches the position that the marketing authorisation(s) of products in the scope of this single PSUR assessment should be varied. To the extent that additional medicinal products containing isotretinoin (oral formulations) are currently authorised in the EU or are subject to future authorisation procedures in the EU, the CMDh recommends that the concerned Member States and applicant/marketing authorisation holders take due consideration of this CMDh position.
The following adverse reactions should be added under the SOC Reproductive system and breast disorders in section 4.8 with a frequency not known: Sexual dysfunction including erectile dysfunction and decreased libido Package Leaflet 4. Possible side effects Unknown frequency: (frequency cannot be estimated from the available data) Dark or cola-coloured urine Problems getting or maintaining an erection Lower libido
This is the update that is going to be included in the PIL.
Does anyone think this goes far enough?
MHRA maintain that the sexual side are temporary.
If you don't agree - let them know!!
1 hour ago, hatetane said:Scientific conclusions Taking into account the PRAC Assessment Report on the PSUR(s) for isotretinoin (oral formulations), the scientific conclusions are as follows: The totality of data presented in this review suggest there is evidence that isotretinoin can be associated with sexual dysfunction including erectile dysfunction and decreased libido and that the mechanism may be a reduction in plasma testosterone. Cumulatively total of 689 events occurring in 471 patients have been retrieved using the High Level Group Term Sexual function and fertility disorders. The majority of cases reported erection and ejaculation conditions and disorders (311 cases), followed by High Level Term Sexual function and fertility disorders NEC (165) and Spermatogenesis and semen disorders (43). The most common Preferred Terms reported in these cases were: erectile dysfunction (281), libido decreased (92), sexual dysfunction (38), oligospermia (15), and ejaculation disorder (13). A negative dechallenge is reported in 10 cases and a positive dechallenge is reported in 15 cases. Two cases include rechallenge information: one negative and the other positive. Based on the cases from spontaneous reporting and the literature review there is sufficient evidence to warrant an update to section 4.8 of the isotretinoin SmPC and the package leaflet. The CMDh agrees with the scientific conclusions made by the PRAC. Grounds for the variation to the terms of the Marketing Authorisation(s) On the basis of the scientific conclusions for isotretinoin (oral formulations) the CMDh is of the opinion that the benefit-risk balance of the medicinal product(s) containing isotretinoin (oral formulations) is unchanged subject to the proposed changes to the product information. The CMDh reaches the position that the marketing authorisation(s) of products in the scope of this single PSUR assessment should be varied. To the extent that additional medicinal products containing isotretinoin (oral formulations) are currently authorised in the EU or are subject to future authorisation procedures in the EU, the CMDh recommends that the concerned Member States and applicant/marketing authorisation holders take due consideration of this CMDh position.
The following adverse reactions should be added under the SOC Reproductive system and breast disorders in section 4.8 with a frequency not known: Sexual dysfunction including erectile dysfunction and decreased libido Package Leaflet 4. Possible side effects Unknown frequency: (frequency cannot be estimated from the available data) Dark or cola-coloured urine Problems getting or maintaining an erection Lower libido
This is the update that is going to be included in the PIL.
Does anyone think this goes far enough?
MHRA maintain that the sexual side are temporary.
If you don't agree - let them know!!
Sexual side is definitely not temporary
On 2/12/2018 at 7:15 PM, guitarman01 said:Based on postings over the years, alot have mentioned symptoms that could indicate signs of Neuropathy.
https://my.clevelandclinic.org/health/diseases/14737-neuropathy
The peripheral nervous system is made up of 3 types of nerves, each with an important role to play in keeping your body healthy and functioning properly.
- Sensory nervescarry messages from your senses through your spinal cord to your brain. For example, they tell your brain you are touching something hot.
- Motor nervestravel in the opposite direction. They carry messages from the brain to your muscles. They tell your muscles to move you away from the hot surface.
- Autonomic nervesare responsible for controlling body functions that occur outside our control, such as breathing, digestion, heart rate, and blood pressure.
Common symptoms of sensory neuropathy include:
- Tingling.
- Numbness, especially in the hands and feet.
- Changes in sensation Some people feel severe pain, especially at night, and some are unable to feel pain, pressure, temperature, or touch.
- Loss of coordination.
- Loss of reflexes.
- Burning sensation.
- Feeling that you are wearing socks or gloves when you are not.
Common symptoms of motor neuropathy include:
- Muscle weakness.
- Difficulty walking or moving your arms or legs.
- Muscle twitching.
- Cramps.
- Spasms.
- Loss of muscle control.
- Loss of muscle tone.
- Loss of dexterity.
- Falling.
- Inability to move a part of the body.
Common symptoms of autonomic neuropathy include:
- Abnormal blood pressure or heart rate.
- Decreased sweating.
- Problems with urination.
- Sexual dysfunction.
- Diarrhea.
- Weight loss (unintentional).
- Dizziness when standing up or fainting.
- Nausea or vomiting.
- Problems with digestion.
This is a possible cause that I've been looking at.
Acquired neuropathy
Vascular disorders: Neuropathy can occur when blood flow to the arms and legs is hindered by inflammation, blood clots, or other blood vessel disorders. Decreased blood flow deprives the nerve cells of oxygen, causing nerve damage or nerve cell death.And not just the arms and legs, we've already seen studies of reduced cerebral blood flow from Accutane.
Im looking at Micro and macro circulatory disorders.Possibly similar to what happens in Diabetes.
Diabetic neuropathiesare nerve damaging disorders associated withdiabetesmellitus. These conditions are thought to result from adiabeticmicrovascular injury involving small blood vessels that supply nerves (vasa nervorum) in addition to macrovascular conditions that can accumulate indiabetic neuropathy.
I appreciate all your posts but they make me wonder...
Has your cognition been affected at all? Doesnt seem like it has. When you post I cant even concentrate on reading half the information because my cognition is so poor.
Whilst it could be Neuropathy, the symptom of decreased sweating
No chance - complete opposite, I sweat brushing my teeth post tane!!
Also dont bother seeing a vascular surgeon to get answers, theyll only say decreased blood flow and vein issues are hereditary- when I asked about Accutane there was just a blank look given....wasting your time with half of these so called specialistswho are only interested in doing their surgery, collecting their massive pay check. When it comes to knowledge and insight they are bankrupt.
Has anyone here tried any of the treatments for PSSD which some PSSD users reported helped them, such as 1. St. John Wort? 2. Inostiol 3. low dose SSRI's?
Starting to think PAS sexual sides could be caused by similar thing to PSSD as accutane affect 5HT1A receptor expression
5 hours ago, hatetane said:erectile dysfunction and decreased libido and that the mechanism may be a reduction in plasma testosterone.
That doesn't seem to be the case, as dysfunction seems unrelated to testosterone levels in some.
5 hours ago, hatetane said:
This link requires a log in.
4 hours ago, Colinboko said:I appreciate all your posts but they make me wonder...Has your cognition been affected at all? Doesnt seem like it has. When you post I cant even concentrate on reading half the information because my cognition is so poor.
A long time ago, I used to be a honor student and was second in my class. I felt what was probably nervous system affects and what literally felt like lack of good blood flow to the brain back in high school after I took Accutane, and That was a long time ago.
Fast forward and
I have mild cerebral atrophy and thinning of the corpus callosum shown from a MRI.
When did this happen? When did this start? Did this coincide with Accutane? Was this a lack of growth into adulthood or a degenerative process?
Is this reversible? Will this progress?
I have a lot of drive because there is alot to lose or has been lost.
BTW if you want to quickly check your testosterone or estrogen, its fairly cheap at https://www.walkinlab.com/
its 15 percent off right now as well. You can go through Quest or Labcorp.
1 hour ago, flynn said:Starting to think PAS sexual sides could be caused by similar thing to PSSD as accutane affect 5HT1A receptor expression
I see they can modulate neuropathic pain. Hypersensitivity.
Whats therationale ?
Serotonin generally inhibits sexual activity. Sexual behavior is impaired by many 5-HT agonists and agents that increase 5-HT [3]. Serotonin (5-HT) is primarily inhibitory, although stimulation of 5- HT2C receptors increases erections and inhibits ejaculation, whereas stimulation of 5-HT1A receptors has the opposite effects like facilitation of ejaculation and, in some circumstances, inhibition of erection.