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BEST POST EVER. AND IT ABOUT SUMS IT UP FOR TAN VICTIMS.
I want to begin this by saying that i was in your position. I had bad acne. I'm writing this to provide some insight to what it's been like the last 3 years after my course of accutane (some information that i would have eaten right up before i started treatment).
Let me start off by saying - this drug works. For most, if not all of middle/high school, I had very bad acne that was resistant to doxycycline, minocycline, proactiv, Murad products, benzoyl peroxide, sailicylic acid, and all the wipes i could get my hands on. You more than likely will be free from acne at least for a few years after treatment, and it's absolutely wonderful! Being able to walk around without having to check mirrors for a new red/white bump on your face is as great as you think it would be. Looking back it seems like i was a completely different person.
You're probably thinking: if it works so well, why the lackluster rating then?!
This drug works wonders but there is absolutely a reason as to why they're so serious about prescribing it. They are very cautious because this stuff is freaking legit - it alters your body in a permanent way. Once you've finished your course there is no going back. In fact, at the time of writing they still do not understand exactly how it works - but it affects acne. This was originally made to be a drug for cancer patients (yeah, people that had nothing left to lose and were willing to try something that could potentially debilitate them if it meant surviving! crazy right?)
So I went on the medication and throughout the course felt nothing but the normal side effects of dry lips, skin, nosebleeds, dry eyes and easily scarring (just a scratch on accutane can turn into a permanent scar hah, i have a few reminders). Things went through without a hitch and i was acne free! I would notice people staring at me, and if i could guess what they were thinking it would be "How in the hell did that pizza face get porcelain clear skin?!"
Strangely, the side effects of this medication slowly ease their way into your life after treatment (the effects are permanent after all). Expect something along the lines of joint pain, gastrointestinal issues, and mental health dips. These tend to be the most serious. When people get these issues they disregard it as natural, how in the world could they be associated with something they took 3, 5, even 10 years ago? Long story short in convincing you this are legit, the original manufacturers of accutane (Roche) went out of business due to lawsuits and had huge payouts of millions upon millions of dollars to peoples lives they had negatively changed (mostly focusing on permanent gastrointestinal issues).
I could talk about this for hours but to avoid making it THAT lengthy, here's the summary:
I can't stress enough how EXTREMELY important it is for you to consider these potentially permanent side effects. When i took it i couldn't care less about side effects, all i wanted was my acne to be gone! But there are people who used to play sports, ran, and workout - now experience severe pain by simply walking due to joint issues (and it's seemingly permanent unfortunately). If your acne isn't really that bad, or could go away within a couple of years normally, it is up to YOU to consider taking this drug. There are dermatologists out there who will prescribe this to people with just a few pimples, which is unecessary given how serious the side effects could be. Read up on peoples experiences years after their treatment and make an informed decision!!! God bless 
One guy said Im not going to complain it kept my acne in check for 20 years , and I say at what cost to the human body that is the question.
Expect side effects to slowly ease their way into your life sounds about right.
And so you have to ask yourself punk do you feel lucky well do you punk ?
Never forget chronic cellular dehydration painfully and prematurely KILLS. FACT
5 hours ago, guitarman01 said:I think previous cardiovascular risk factor (perhaps unknown) might be the greatest determinant of possible serious side effects from Accutane exposure.Cerebral Ischemia Probably Related to Isotretinoin - CiteSeerX
citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.869.890&rep=rep1...pdfby ML Laroche - 2007 - Cited by 13- Related articlesMay 1, 2007 -sis of extracranial arteries (cerebral andcarotid),arterialdissection, polycythemia, or drugs. Risk factors for is- chemic infarction are also risk factors for vascular diseases. (eg, age, sex, heredity, previous vascular event, hyperten- sion, atrial fibrillation, diabetes, hyperlipidemia, smoking). In young patients...
Isotretinoin increased carotid intima-media thickness in acne patients
by A Saklamaz - 2016 - Related articlesWith the patients in the supine posture the commoncarotid artery(CCA), carotid bifurcation, and proximal portion of internalcarotid arterywere evaluated. The CIMT was identified at the far wall of the CCA using the semi-automated edge detection software. The region of interest (about two centimeters in length and one...
Functional Brain Imaging Alterations in Acne Patients Treated With ...
May 1, 2005 -In order forisotretinointo cause depression, it must have an effect on thebrain; however, the effects ofisotretinoinonbrainfunctioning in acne patients ... Other PET and SPECT studies of patients with unipolar depression showed low metabolism and/orblood flowin the caudate (3641, 51, 52), thalamus...
Retinoic Acid and Affective Disorders: The Evidence for an Association
by JD Bremner - 2012 - Cited by 99- Related articlesAug 23, 2011 -Retinoic acid (RA), the active form of vitamin A, regulates gene expression in thebrain, andisotretinoinis its 13-cis isomer. Retinoids represent a group of compounds ...... Alteredbrainfunction was seen in all cases involving altered orreducedfrontal lobeblood flow. Ten of these patients were evaluated to...
reports of thrombotic accidents, as well as some cases of hemorrhage in patients receiving isotretinoin, have been published. This drug seems to act on the coagulation process by a still unexplained mechanism.
Fair enough, but we still don't know whether these changes in blood flow persisted after stopping treatment. All studies have been conducted during accutane treatment. Are there any that show changes persisting beyond stopping treatment.
Again though, we may be arguing the same point. What is causing this change in blood flow, physical damage or changes in neuronal activity? Note dopamine appears to play a pivotal role not just as a neurotransmitter but also as a vasopressor. Changes to dopaminergic signalling/activity could and very likely will affect blood flow in certain brain regions - https://www.nature.com/scitable/blog/labcoat-life/dopamine_the_link_between_neuronal
My take is that blood flow is simply a symptom of dysfunctional neural activity primarily caused by changes to dopaminergic signalling. As such, if we can fix the problem relating to dopamine signalling, then I suspect changes to blood flow will be reversed. From my view, most lines of evidence all seem to point to dopamine here. Now I highly doubt this relates to dopamine deficiency, I've seen many people report using dopamine agonists without much change to symptoms. Also anecdotal reports have stated changes in the effect of drugs affecting dopamine such as ritalin or adderall to have changed after taking accutane. Thus I strongly feel, this either relates to dopamine receptor up/downregulation or another hormonal system is out of balance which has an effect of blunting dopaminergic signalling. Additionally a component which is required for dopaminergic neurotransmission is also affected by retinoic acid may deficient after topping accutane. I'm actually developing an article which points to a legitimate mechanism and hormonal culprit which research has shown is affected by accutane.
51 minutes ago, flynn said:Fair enough, but we still don't know whether these changes in blood flow persisted after stopping treatment. All studies have been conducted during accutane treatment. Are there any that show changes persisting beyond stopping treatment.
In addition to the paper that documented altered brain bloodflow in the orbitfrontal cortex, another paper did show the drug caused brain damage in patients.
" In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow.173 Ten of these patients were evaluated to have organic brain damage. "
I run a Facebook group of approximately 400 post-Accutane sufferers, and I have now talked to 4-5 individuals first-hand who have proof of persistent brain abnormalities post-Accutane (brain scan confirmed). In all cases I've seen, the abnormalities are in the frontal lobes, which has parallels to Dr. Bremner's findings and the Norwegian Medicines Agency's findings. The frontal lobes play a role in reward processing. Reward does not occur in just one part of the brain. If you read papers about anhedonia, you will see there are several dimensions to reward. For example, there is the ability to learn about reward (internalize reward), the ability to anticipate reward, and the ability to actually experience reward. All of those "feelings" involve different parts of the brain, which also obviously interact with other parts of the brain. Different things can be wrong to lead to the same problem of perceived anhedonia. This paper offers a little light on the issue (although isn't the exact paper I was referencing).
I have always been struck by how similar post-Accutane psychiatric symptoms are to the negative symptoms of schizophrenia. It's essentially a 1-1 overlap. Both conditions involve all of the following: Difficulty making decisions, lowered sex drive, cognitive deficits, anhedonia, social withdrawal, emotional blunting, etc. You may also be interested to read this piece on the connection between vitamin A receptors to schizophrenia. The long-short is that retinoid dysfunction plays a role in schizophrenia. And yes, frontal lobe issue are absolutely a big part of schizophrenia. It all adds up nicely. It is no surprise to me that much of the research and medical findings by post-Accutane patients points to the frontal lobes. It is not easy to address the negative symptoms of schizophrenia but there are options (e.g., Sarcosine, N-Acetyl-l-cysteine).
And all of that being said, it helps to address the secondary medical problems that often come with the brain issues. Many of us are also hit with IBS, dry eyes, pain, ect. That's where diet and anti-inflammatory supplements may help. If actual brain damage is present, controlling neuroinflammation is essential. That may explain why many at least partially respond to Acetyl-l-Carnitine.
Don't get me wrong though. At the end of the day, this is all guesswork.
On 1/6/2018 at 8:40 PM, TrueJustice said:What are your thoughts on supplementing Vit K and Vit A??
I'm definitely interested in trying vitamin K, especially because I am tempted to trying megadosing vitamin D at some point. It seems some people are able to put chronic illnesses into remission by mega-dosing vitamin D for a time. Sure, it's a long shot.
@flynn
I could smoke a cigarette and raise my dopamine levels within a couple puffs. (I dont smoke anymore)
Im looking at a regulating process, not a stimulating one, stimulation is always followed by a crash.
You should check my more recent posts when you have the time.
Looking at some tests that might start to paint a picture,
The acetylcholine ganglionic neuronal antibody is something I tested positive for, so did someone else who took Accutane.
This is evidence of something affecting the nervous system that leads to varying levels of autonomic nervous system dysfunction.
This is part of the cholinergicsystem
This is what I have been looking at more recently,
Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla proteingene
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20069/
The vitamin K-dependent matrix Gla protein (MGP) is synthesized in a wide variety of tissues such as lung, heart, kidney, cartilage, and bone. Expression of the MGP gene is regulated by various growth factors, steroid hormones, and the vitamin A metabolite retinoic acid (RA).
In this report, we present evidence that RA down-regulates MGP gene expression
Looking at possible long-term alterations in MGP expression (epigenetic)the consequences as you can see above could be quite systemic, not to mention serious (with everything they are discovering about vitamin k dependant processes), especially for a young adult.
Here's one of many examples,
Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor ...
Gas6-Axl system to regulate cell survival, proliferation, migration, adhesion and phagocytosis. Consequently, altered activity/expression of its components has been detected in a variety of pathologies such as cancer and vascular, autoimmune and kidney disorders
In the end this sick drug needs to be pulled of the market its dangerous and causes unnecessary suffering to vulnerable kids and young adults for WHAT a few red spots I have often said if you look like a beast it might be a viable option for the rest of the public 99.99999 percent its a sick and evil drug.
Most people only notice dryness , I think I noticed a little bit more then that , this drug had given me more heart aches vs any women could ever do.
Ha, well at least my instinct still works. I had a feeling a mod was gonna step in this past week. Have to totally agree, and i'm super guilty of the venting too, if not one of the topic toxic posters here. Yo, gladiatoro you make some great quotes, but kinda veer off the road a bit. The mod is specifically talking to us.
Um, some good news. I'm maintaining digestive function with a plant/fruit based diet throughout the day while utilizing digestive enzymes when eating the big protein dinners. I've addressed hormone issues with endo, so that's all green. No Autoimmune dysfunction results in any tests, so that's taken care of. My current stack is Vitamin C, D, K, B (alternate every other day) Last big hurdle is the neurology which I believe I'm making progress. I take Lions Mane daily. Running and cardio helps. CBD oil is a super effective natural medicinal that treats your whole body as your body has CBD receptors throughout regulating bodily/neuro processes. Obviously, the depression and brain fog is the main over bearing side effect for me, but it feels like it's clearing up with the help of all those things above. My anxiety is half, if not mostly, gone from the first several years post tane, and without pharmacological treatment. I've built a hyperbaric chamber and it should be up and running soon once I find a place for it. I will definitely post pictures and preliminary results as soon as I use it. Microdosing psilocybe cubensis is definitely in the picture this year for trialing.
I think we're in for some big things this year, I definitely feel we've come a long way and will rise to the occasion and climb this mountain eventually.
9 hours ago, Gladiatoro said:Can you believe people micro dose isotretinoin, might as well micro dose heroin ...
Works well for me. Taking a low dose of 10mg daily has significantly cleared up my acne and my only side effect is dry lips. Hopefully in a few months I will stop taking Accutane. Permanent side effects are rare. That quote above is simply astonishing. How is Accutane like heroin? it is not addictive, that's for sure.
My condolences if you are suffering from long term side effects. I hope you feel better soon.
48 minutes ago, ScarRight said:Works well for me. Taking a low dose of 10mg daily has significantly cleared up my acne and my only side effect is dry lips. Hopefully in a few months I will stop taking Accutane. Permanent side effects are rare.
Yep exactly what it was like for me, 10mg/day for 30 days. Dry lips was the only issue while I was on it. I was kidding myself with stuff like 'permanent side effects are rare' too.
1 hour ago, tanedout said:Yep exactly what it was like for me, 10mg/day for 30 days. Dry lips was the only issue while I was on it. I was kidding myself with stuff like 'permanent side effects are rare' too.
This is my second time on it. The first occasion was a decade earlier. I know how my body reacts. And the literature does state permanent side effects can happen, but are rare.
11 hours ago, ACCUiTy_drANE said:In addition to the paper that documented altered brain bloodflow in the orbitfrontal cortex, another paper did show the drug caused brain damage in patients." In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow.173 Ten of these patients were evaluated to have organic brain damage. "
I run a Facebook group of approximately 400 post-Accutane sufferers, and I have now talked to 4-5 individuals first-hand who have proof of persistent brain abnormalities post-Accutane (brain scan confirmed). In all cases I've seen, the abnormalities are in the frontal lobes, which has parallels to Dr. Bremner's findings and the Norwegian Medicines Agency's findings. The frontal lobes play a role in reward processing. Reward does not occur in just one part of the brain. If you read papers about anhedonia, you will see there are several dimensions to reward. For example, there is the ability to learn about reward (internalize reward), the ability to anticipate reward, and the ability to actually experience reward. All of those "feelings" involve different parts of the brain, which also obviously interact with other parts of the brain. Different things can be wrong to lead to the same problem of perceived anhedonia. This paper offers a little light on the issue (although isn't the exact paper I was referencing).
I have always been struck by how similar post-Accutane psychiatric symptoms are to the negative symptoms of schizophrenia. It's essentially a 1-1 overlap. Both conditions involve all of the following: Difficulty making decisions, lowered sex drive, cognitive deficits, anhedonia, social withdrawal, emotional blunting, etc. You may also be interested to read this piece on the connection between vitamin A receptors to schizophrenia. The long-short is that retinoid dysfunction plays a role in schizophrenia. And yes, frontal lobe issue are absolutely a big part of schizophrenia. It all adds up nicely. It is no surprise to me that much of the research and medical findings by post-Accutane patients points to the frontal lobes. It is not easy to address the negative symptoms of schizophrenia but there are options (e.g., Sarcosine, N-Acetyl-l-cysteine).
And all of that being said, it helps to address the secondary medical problems that often come with the brain issues. Many of us are also hit with IBS, dry eyes, pain, ect. That's where diet and anti-inflammatory supplements may help. If actual brain damage is present, controlling neuroinflammation is essential. That may explain why many at least partially respond to Acetyl-l-Carnitine.
Don't get me wrong though. At the end of the day, this is all guesswork.
I'm definitely interested in trying vitamin K, especially because I am tempted to trying megadosing vitamin D at some point. It seems some people are able to put chronic illnesses into remission by mega-dosing vitamin D for a time. Sure, it's a long shot.
Yes I've looked at this research before, need to look at role of retinoids in schizophrenia in depth. I don't discount it and you're right the parallels between PAS and negative symptoms are significant. I'm still looking into this. As far as I can find (please show me if I'm wrong), its thought that the negative symptoms of schizophrenia are caused by a reduction in dopaminergic activity (hypoactivity) in the mesocortical tract, where as the positive symptoms (hallucinations etc.) are caused by an increase in dopaminergic activity (hyperactivity) in the mesolimbic areas. Note that this is fairly significant as post accutane sufferers don't seem to report any of the positive symptoms of schizophrenia, just the negative symptoms. Nobody knows for sure yet, but there is good reason to believe that the negative symptoms of schizophrenia relate to dopamine. If so, the hypoactivity of dopaminergic signaling in the mesocortical tract could help explain changes in blood flow etc. in these regions, given the correlation between dopamine and blood flow. Note the frontal lobe contains most of the dopamine sensitive neurons in the cerebral cortex.
Note also that its possible that symptoms such as loss of libido could also have strong knock on effects for things such as drive, motivation, social interest, excitability etc.
I'm just interested in how accutane could have caused this, with the hope that there is someway to reverse it. There are a few possibilities here:
1. Accutane has damaged/irreversibly destroyed dopaminergic neurons in the brain associated with functions such as pleasure, reward/goal seeking, motivation etc. in areas such as the frontal lobe, mesocortical pathway and mesolimbic pathway. Essentially we need to look at regions of brain with the highest density of retinoid receptors to guess areas most likely damaged. Though possible, I find this scenario hard to believe. Note that when taken for chemotherapy purposes, a far stronger dose is used for a longer period of time. Now even at doses used for acne, I agree that the drug could/can still destroy/kill cells. But we have to note that brain regions such as the mesocortical and mesolimbic pathways are highly complex and well established neural pathways in the brain, especially by the time youre in your twenties, which I assume are fairly resilient to damage. I find it highly unlikely that in the time and dose used, it could wipe out neural circuits as significant as these especially in older people. Note that PAS sufferers have used Accutane in their early 20s etc. and gotten these persisting side effects. If this were true, I think our side effects would be far more severe. I also feel like these effects would be far more widespread than they are. Additionally, if this scenario is true, it would be the worse case as it would mean, relatively little could be done.
2. Accutane has altered normal dopaminergic signaling. We know that retinoids affect dopamine signaling. Retinoids regulate dopamine receptor expression. Thus whilst on Accutane, we would have a marked increase in dopamine receptors. Upon stopping, does this lead to a continued increase or a significant reduction of Dopamine receptors. One theory I postulate is that due to the over activation of retinoid receptors during Accutane treatment the body responds to excess of Accutane by downregulating retinoid receptors. When we stop Accutane, the retinoid receptors remain downregulated. Which could result in a continued downregulation of dopamine receptors (in this case a retinoid receptor antagonist may work to increase retinoid receptor expression and bring system back to equilibrium). Or dopamine receptors remain up-regulated leading to a blunted or less sensitive dopamine response.
3.Another hormonal system is out of balance due to accutane which affects dopamine signaling. I am currently researching this now. Accutane has been shown to cause a degree of HPA hyperactivity and glucocorticoid receptor dysfunction. Note that if these effects persist they can also help to explain blunted dopamine signaling/reward processing in the brain -- https://www.nature.com/articles/tp201398
I dont discount the idea that Accutane has caused irreversible brain damage as some say. But the bottom line is this. Though possible, the brain damage line of thought is not helpful as there is little that can be done. We still havent exhausted all possible causes and possible treatments for this yet. We still know relatively little about it. Once we exhaust all those avenues fully, then we can resort to accepting that there is little that can be done.
Though these side effects are severe. We must remember a few things.
1. Many people have taken Accutane. If the mechanism of damage was caused by direct destruction of brain regions. I think a far greater number of users would be affected and the side effects would be far more severe than they are. We see reductions of function not complete removal of them. People report poorer memory after Accutane not complete loss of memory. This to me, points to a reduced/blunted neural activity rather than no neural activity at all.
2. There have been many people with PSSD and PFS who have gone on to make full recoveries. Im sure in the midst of their condition, they were convinced their brains had been permanently damaged/destroyed/altered when in reality they were out of balance or normal homeostasis.
Could people post any blood tests they have for hormones such as DHEA-S, cortisol and progesterone.
20 hours ago, Gladiatoro said:Altered brain function was seen in ALL cases hmmm.
No wonder some derms dont even use it in their practice, this one derm I Skyped bluntly said we dont use it in our practice, we dont know the long term outcome of these patients.
Now remember thats coming from a DERMATOLOGIST, hmmm. That would explain the deformed frontal head I have after tan exposure.
Now it finally ALL makes sense.
Do you have an email address for this Derm? I don't understand why all doctors and dermatologist are not more circumspect.
They are ultimately responsible for patient care and they have to be responsible regardless of what the regulators are telling them.
It truly is an abomination!
6 hours ago, flynn said:Could people post any blood tests they have for hormones such as DHEA-S, cortisol and progesterone.
According to Mayo, DHEA results can be used interchangeably with DHEA-S
| Component | Your Value | Standard Range |
|---|---|---|
| DHEA | 5.9ng/mL | <13 ng/mL |
CORTISOL, A.M.14.4 mcg/dL Reference Range 8 a.m. (7-9 a.m.) Specimen: 4.0-22.0 | ||
I havent tested progesterone, im guessing some others have.
1 hour ago, guitarman01 said:According to Mayo, DHEA results can be used interchangeably with DHEA-S
Component Your Value Standard Range DHEA 5.9ng/mL <13 ng/mL I havent tested progesterone, im guessing some others have.
Thanks for sharing. I'm assuming you're a male? were these results all take after stopping accutane? Also if you don't mind me asking, what are your main persisting side effects?
47 minutes ago, Gladiatoro said:All tests are meaningless , chronic cellular dehydration is after all permanent , get used to it.
Consider yourself luck if you dont have joint pain or sexual disfunction. Mental dips are to be expected.
And please dont mess with your skin you will pay the price.
Yep, no change in the chronic dryness regardless of what you take and dont expect time to heal you, it wont!!!
how did you go with Baxyl did that make a difference for you at all?
1 hour ago, flynn said:Thanks for sharing. I'm assuming you're a male? were these results all take after stopping accutane? Also if you don't mind me asking, what are your main persisting side effects?
Im 20 years post Accutane. I took a course when I was around 15 for the minimum recommended duration (4 months?) im guessing the dosage was around 40mg a day that I worked up to.
Im going to show you my greatest concerns that may be related to Accutane.
When I talk about blood flow to the brain, I literally felt this when I was younger. (I felt the need to hang upside down from my bed at times to get good blood flow) I also felt heart type symptoms (abnormal skips, abnormal reaction to loud noises like fluttering)
Obviously I wasnt putting it all together as a young teenager, especially with hardly any internet.
So fast foward. These are my greatest concerns as it might relate, or have taken a toll.
MRI BRAIN WO CONTRAST
Volume loss of brain parenchyma is seen, advanced for patient's
age.
There is thinning of the body of the corpus
callosum. This finding is stable compared to prior MRI, 8/10/2013.
EKG 12-LEAD - Details
POSSIBLE LEFT ATRIAL ENLARGEMENT
Are these all my symptoms? no. But they are the most concerning and possibly induced or worsened by Accutane as some evidence might suggest.
Association of left atrial enlargement with left ventricular hypertrophy and diastolic dysfunction: a tissue Doppler study in echocardiographic practice.
Left atrial (LA) enlargement is a powerful risk factor for cardiovascular diseases
Why am I looking at Vitamin K?
There could be a strong antagonistic relationship with retinoids.
Low vitamin K intake in teens linked to early signs of left ventricular ...
12 hours ago, Gladiatoro said:Accutane is like heroin for one simple reason , its just as distructive to the human body.
Only problem is NO mental illness has ever been proven to exist , read my post on trump .
The first paragraph is nonsense. No evidence comparing Accutane to heroin. Any peer reviewed studies?
I guess Trump took Accutane then back in the day. Explains a lot.
I have continued problems of fatigue, depression, light sensitivity.
Finally got back to my GP to get red blood cell count results. Its all fine on this test!!
ANA ( anti-nuclear antibodies) is Negative. Report suggests that negative would rule out Lupus in 95% of cases.
So no signs of inflammation.
On one hand you feel relieved when tests are negative but with our condition you always walk out none the wiser.
I talked about blood flow issues post tane inc frontal lobe issues, she didnt feel I exhibited the symptoms, I asked who one would see for such issues - its a Haematologist she said, perhaps someone else can get a referral to see about blood flow issues??
If you are truly focusedon fixing the brain, please refer to my previous posts. I'm advocating a natural means of treatment utilizing mushrooms, plant/fruit based diet, moderate exercise, hyperbaric oxygen therapy to promote neurogenisis. This year we start trials and I hope you guys take the time to really listen to some of the videos I post and follow along this protocol if you want, why not, give it a shot.
[Edited video out]
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