Acne.org Products
http://www.huffingtonpost.ca/entry/emma-stone-reveals-acne-s_n_2258951
she says since then ( 2 months of Accutane ) my skin , my mouth , my lips , my eyes are all so dry , I would throw in joint pain and mental dips as the REAL LONG TERM SIDE EFFECTS , Accutane putting your personality at risk is a good read...
38 minutes ago, tanedout said:Really, and quote your source for these stats?!.... It's simply what you want to believe.
At my dermatologist office they prescribe it 20 times each day. Mind you, this is only one office out of thousands worldwide. You can do the math yourself... Accutane is not really that big of a deal at low doses. I asked around my uni campus (on yikyak) if anyone took accutane and it was astonishing how many people took it. Most of the people turn out just fine. Every drug has its (severe) side effects. I saw the studies you guys mentioned here. 'DNA alteration from isotretinoin', 'permanent toxification'..... My honest opinion: you guys are stressing yourselves way too much over this. I mean look at milk for example: it is shown to alter hormone balance in humans.. Still everyone drinks it. Look at the side effects of smoking tobacco. etc etc.. Focus on something else in your life. In the end you will die anyway, make the best out of every second you have. Don't be so bitter about stuff you have no control over. Sure you can try to live as healthy as possible to minimize the (permanent) side effects from accutane but it shouldn't be the center of your life.. I wish you all the very best. Hope you guys will find your inner peace one day
@fingaszyou really are clueless! Won't waste anymore time replying to you as you're totally ignorant to the situation people are in here and the dangers of this drug, but maybe you'll get to 'join the club' one day then you can see what it's all about.
@mariovitali Assuming a fibroscan shows evidence of NASH is there a recommended supplement regime? I understand you had success with TUDCA and choline (amongst other sups), but have people who have had these scans been able to improve their situation based on confirmation of there being a varying degree of liver damage and then taking specific actions?
4 minutes ago, tanedout said:@fingaszyou really are clueless! Won't waste anymore time replying to you as you're totally ignorant to the situation people are in here and the dangers of this drug, but maybe you'll get to 'join the club' one day then you can see what it's all about.@mariovitali Assuming a fibroscan shows evidence of NASH is there a recommended supplement regime? I understand you had success with TUDCA and choline (amongst other sups), but have people who have had these scans been able to improve their situation based on confirmation of there being a varying degree of liver damage and then taking specific actions?
Oh trust me. I will never 'join the club'. this place is very sad and depressing and I recommend everyone to stay away from this forum.
7 minutes ago, fingasz said:17 minutes ago, tanedout said:@fingaszyou really are clueless! Won't waste anymore time replying to you as you're totally ignorant to the situation people are in here and the dangers of this drug, but maybe you'll get to 'join the club' one day then you can see what it's all about.@mariovitali Assuming a fibroscan shows evidence of NASH is there a recommended supplement regime? I understand you had success with TUDCA and choline (amongst other sups), but have people who have had these scans been able to improve their situation based on confirmation of there being a varying degree of liver damage and then taking specific actions?
Oh trust me. I will never 'join the club'. this place is very sad and depressing and I recommend everyone to stay away from this forum.
Its a forum that finds the truth on Isotretinoin and its effects on the human body. Good or bad the truth must ALWAYS be found.
Future generations WILL thank us as I have often said we are living in the dark ages of medicine allopathic medicines future lies in bone mending and trauma care , its what they are really good at thats about it.
13 minutes ago, Gladiatoro said:Its a forum that finds the truth on Isotretinoin and its effects on the human body. Good or bad the truth must ALWAYS be found.Future generations WILL thank us as I have often said we are living in the dark ages of medicine allopathic medicines future lies in bone mending and trauma care , its what they are really good at thats about it.
Isotretinoin is a milestone in acne therapy. Most people turn out just fine. The majority just takes the drug, waits til the acne is gone and then never talk about the drug again.majority of the ones who are talking about it are those who had negative experiences with it because it is still affecting them. Isotretinoin will still be prescribed for many many years but of course at low doses which minimizes the side effects immensely (in europe its already happening, patients here are treated with 20mg/day maximum).
Look, what you are saying isn't wrong. It's your approach. Not all of us side effect sufferers feel the drug should be banned outright. And low dose is better than high dose from what I've read over the years. All fair points.
But you shouldn't come to an adverse event thread with what little knowledge you have on chemistry and tell people how a drug works and how life is.
90% are fine you say. ok, good estimate. so if they are handing the drug out like candy and 30 million were prescribed the drug with 10% adverse effects. That's 3 million people you are taking a piss on.
the thing about collateral damage is that it can happen in life through countless avenues such as: business, banking, auto accident, natural disaster, war, famine, medicine, etc.
When you shun those unfortunate few, you set yourself and society up for failure.
I'm not gonna walk around south central LA, tell people how bitter and miserable they seem, how most smart people (including lucky me fingasz) plan to go to college, get a job, to become successful.What do you think would happen if you did that? You don't understand the particular circumstances.
The drug needs to be controlled for severe acne. People with adverse events should have dedicated support from the manufacturers.
6 minutes ago, macleod said:Oh snap another Accutane expert. i've been coming here for 10 years. Can anyone guess how many dopey 'fingasz' i've met over the years?
I have talked with Professor B. Melnik (he has many publications on isotretinoin) and he signs what I just wrote up here. Its not that bad after all. be happy you guys are stillalive. There are millions of people out there that would switch lives with you in a single second. Good luck to you all. Be safe
On 1/5/2018 at 9:33 AM, guitarman01 said:When you think of skin thinning effects of accutane, this could be systemic as well, and not just on the outside but also internally. Example, erosion of the lining of the stomach. Someone that goes on oral steroids, It can thin the skin.It could also worsen the symptoms of hemorrhoids because of its skin thinning ability. Same could maybe apply to the throat, esophagus, they become more susceptible or sensitive.
OK, I did a little more digging and it seems Accutane isn't the only thing responsible: the main ingredients from products I was using were/are. So I am trying now a specific soap, as explained here in this research (Dove Baby); liquid soap for the genitals; a specific toothpaste, and also another foot moisturizer.
Among the ingredients that all these had was "Sodium Laureth Sulfate", which was what irritated the skin of my penis, and parabens in the other cosmetics. Also saw a podcast explaining that mouthwashes aren't that good or necessary, and this may also be the reason why the skin of my mouth peels sometimes. I am sticking with the toothpaste and dental floss, then.
Sunscreens: also in another podcast episode I was given good reasons to look into what they have, and since I only walk half a mile everyday to my gym and use long sleeves (I cover my whole body except for my face) I will probably not use it, or find a good one (with less harmful ingredients), plus the glove I bought to protect my hands from Sun exposure, and when I get home I'll sit for a few minutes in the shade (as explained here [Edited link out]) everyday between 9 am and 12 pm (the only moment the Sun is above 50 degrees from the horizon, when we are able to receive enough UVB to allow for vitamin D production in the skin).
I'll do it 5, 10 minutes a day to see if things improve and I don't need to take the D3 supplement for the rest of my life. Taking it for 3 months (two 7000 UI pills a week) increased my D levels from 26 to 40 (at least 50 is needed), and also the total testosterone.
Then there's the BPA issue, I already looked into it and will replace a few objetcs.
Besides the 14 tests I reported here: Uric Acid, Creatinine, Glucose, Complete Blood Count, Lipid profile, Total and free testosterone, Aspartate transaminase, Alanine Aminotransferase, Urea, Free T4, 25-Hydroxyvitamin D3, Thyroid-Stimulating Hormone (TSH) and Prolactin (and other 2, Abdominal Ultrasound and MRI scan - sella turcica)
I'll do it in the next days all of these: Spermogram; Luteinizing hormone (LH), Follicle-Stimulating Hormone (FSH), Vitamin B-12, Zinc, SHBG and Gamma-Glutamyl Transferase (GGT).
I'll get to the bottom of this, in this year I'll do it whatever is necessary to increase my testosterone naturally and see if the loss of libido as a side effect of this Accutane treatment can be mitigated. Even though I don't care about having a libido, I don't want to have the slightest signs of low testosterone (which is more than that).
Note: all I said about ingredients in cosmetics (addressed in books such as this one) and some lifestyle changes may not impact muchwhat Accutane did 6-7 years ago, however it's a start.
I am seeing that a few people that were depressed committed suicide:
And one of them said "Anything to do with the opposite sex isnt psychologically appealing. I used to have to try and stop myself from thinking about girls all of the time; now, I could hardly care less".
I remember it took me at least 2-3 years to get over of this symptom. All of sudden I was feeling depressed more than ever before.
And considering my views on women (which were even before 2011 the same as they are now) I still wonder if the lack of libido isn't just a side effect mostly from my mind.
It's a combination of many things, with Accutane in the top of reasons. Since then I changed (evolved) a lot emotionally (for the better) and a lot of things I once valued I don't hold in high regard anymore.
Even so it's not fair to have something like this removed from you. In other words, just because I don't want relationships it doesn't mean a drug can impair my sex life permanently without my consent.
That's why I think anyone that prescribes this drug for non-serious cases should go to jail, considering how much damage can cause.
This is a scary possibility.
Microcirculatory dysfunction in organs such as lungs, heart, liver, brain, kidney, pancreas, testis, rectum, spinal cord, muscles, sympathetic and parasympathetic ganglia and nerves.
15 hours ago, hatetane said:Not sure if you are male of femaleAny males had fertility tests?
I am a male with no kids. It wouldn't bother me either way. My only side effects are dry lips. My dermatologist actually did say the old method of getting 120-150mg x your body weight is actually going out of style and the low dose regime is the way to go, because they still give the same success rate.
I actually have suffered depression in the past, but so far the Accutane has had no effect on mood. The low dose regime is a lot safer. May I ask to the people who have suffered long term ill effects....
What was your daily dose?
How long were you on Accutane?
Did you immediately contact your prescribing dermatologist when you realised you were suffering severe side effects? Was any change made to the dose?
On 2017-12-14 at 5:22 PM, ailaeshiz said:On 2017-12-14 at 5:09 PM, guitarman01 said:You could take this a step further and include all steroid receptors. This includes estrogen, corticosteroids and progestogens. Maybe their metabolism as well.Which of course raises another question: why the hell can't our receptors remember how to function properly?
Its called chemotherapy.
11 hours ago, ScarRight said:I am a male with no kids. It wouldn't bother me either way. My only side effects are dry lips. My dermatologist actually did say the old method of getting 120-150mg x your body weight is actually going out of style and the low dose regime is the way to go, because they still give the same success rate.I actually have suffered depression in the past, but so far the Accutane has had no effect on mood. The low dose regime is a lot safer. May I ask to the people who have suffered long term ill effects....
What was your daily dose?
How long were you on Accutane?
Did you immediately contact your prescribing dermatologist when you realised you were suffering severe side effects? Was any change made to the dose?
I took 40 mg for 2 weeks then 80 mg for 1 month most of my hair fell out and I was severely dizzy so I quit . Took 2 months for the dizziness to go away.
Total dosage around 2500 mg. Long term side effectsinclude major hair lossdry eyes mouth skin severe lower back pain under control now mental dips . This drug will continue to treat you with side effects YEARS later I didnt believe it at first but after years of research accutane is after all the culprit to my problems.
Try 22 years and counting since CHEMO exposure.
6 hours ago, Gladiatoro said:I took 40 mg for 2 weeks then 80 mg for 1 month most of my hair fell out and I was severely dizzy so I quit . Took 2 months for the dizziness to go away.
Total dosage around 2500 mg. Long term side effectsinclude major hair lossdry eyes mouth skin severe lower back pain under control now mental dips . This drug will continue to treat you with side effects YEARS later I didnt believe it at first but after years of research accutane is after all the culprit to my problems.
Try 22 years and counting since CHEMO exposure.
Why do others whove been through Chemo get on with their lives with no lingering side effects for the most part??
What is it about Accutane that it hangs around for so long?
I know cancer patients who go through hell while on chemo but after that all back to normal health. To be fighting cancer youd say yep its worth it, this is what I have to do....
To be given a cancer drug for pimples is fucking pathetic, absolutely fucking pathetic!!!!
1 hour ago, TrueJustice said:Why do others whove been through Chemo get on with their lives with no lingering side effects for the most part??What is it about Accutane that it hangs around for so long?
I know cancer patients who go through hell while on chemo but after that all back to normal health. To be fighting cancer youd say yep its worth it, this is what I have to do....
To be given a cancer drug for pimples is fucking pathetic, absolutely fucking pathetic!!!!
Looking at old pictures in my youth I had very mild acne and I'm not kidding , I was just a dumb young man who trusted allopathic medicine . My knowledge is now vast on many topic but back then a few pimples was my only health problem .
And honest derms WILL tell you joint pain and depression I call them mental dips which is really what they are ARE real long term side effects , CRAZY DRUG , no wonder I never took anything after that ever again , any kind of prescription drug , I really was traumatized by that experience , especially the hair loss at a young age from super thick hair to 50 % loss now I don't care but back then it was hard on me .
Trust me side effects WILL eventually work there way into your life.
This is pretty cut and dry right here.
This is showing a antagonistic relationship with Retinoic Acid and Vitamin K2.
Transcriptional regulation of matrix gla protein.
Abstract
Matrix Gla Protein (MGP) is a small protein which is thought to be an inhibitor of tissue calcification and a regulator of cell differentiation. In this study we have examined the transcriptional regulation of MGP within rat vascular smooth muscle cells (VSMCs). We found that MGP transcription is downregulated by retinoic acid and transforming growth factor beta (TGF beta) whereas it is upregulated by vitamin D3 and cyclic AMP.
Then Looking at the potentialconsequences...
Matrix Gla protein regulates calcification of the aortic valve.
Matrix Gla protein regulates calcification of the aortic valve.
CONCLUSIONS:
An important anti-calcification defense mechanism is deficient in calcified aortic valves. MGP expression is significantly lower in diseased relative to normal AVICs. Lack of this important "anti-calcification" protein may contribute to calcification of the aortic valve.
ACCUTANE (isotretinoin capsules) - FDA
calcification of the coronary arteries
were observed in two dogs after approximately 6 to 7 months of treatment with isotretinoin
Looking at this, there could be vascular signs/symptoms long before the ultimate consequence.
This might be where "atrophy" comes from. Tissues are literally being choked out of blood supply/oxygen.
Vascular remodeling.
Retinoic acid is a negative regulator of matrix Gla protein gene expression
13 hours ago, guitarman01 said:This is pretty cut and dry right here.
This is showing a antagonistic relationship with Retinoic Acid and Vitamin K2.Z Kardiol.2001;90 Suppl 3:38-42.Transcriptional regulation of matrix gla protein.
Abstract
Matrix Gla Protein (MGP) is a small protein which is thought to be an inhibitor of tissue calcification and a regulator of cell differentiation. In this study we have examined the transcriptional regulation of MGP within rat vascular smooth muscle cells (VSMCs). We found that MGP transcription is downregulated by retinoic acid and transforming growth factor beta (TGF beta) whereas it is upregulated by vitamin D3 and cyclic AMP.
Then Looking at the potentialconsequences...
Matrix Gla protein regulates calcification of the aortic valve.
Matrix Gla protein regulates calcification of the aortic valve.
CONCLUSIONS:
An important anti-calcification defense mechanism is deficient in calcified aortic valves. MGP expression is significantly lower in diseased relative to normal AVICs. Lack of this important "anti-calcification" protein may contribute to calcification of the aortic valve.
ACCUTANE (isotretinoin capsules) - FDA
calcification of the coronary arteries
were observed in two dogs after approximately 6 to 7 months of treatment with isotretinoinLooking at this, there could be vascular signs/symptoms long before the ultimate consequence.
This might be where "atrophy" comes from. Tissues are literally being choked out of blood supply/oxygen.
Vascular remodeling.Retinoic acid is a negative regulator of matrix Gla protein gene expression
This really must be the worlds most dangerous DRUG.
1 hour ago, guitarman01 said:This is pretty cut and dry right here.
This is showing a antagonistic relationship with Retinoic Acid and Vitamin K2.Z Kardiol.2001;90 Suppl 3:38-42.Transcriptional regulation of matrix gla protein.
Abstract
Matrix Gla Protein (MGP) is a small protein which is thought to be an inhibitor of tissue calcification and a regulator of cell differentiation. In this study we have examined the transcriptional regulation of MGP within rat vascular smooth muscle cells (VSMCs). We found that MGP transcription is downregulated by retinoic acid and transforming growth factor beta (TGF beta) whereas it is upregulated by vitamin D3 and cyclic AMP.
Then Looking at the potentialconsequences...
Matrix Gla protein regulates calcification of the aortic valve.
Matrix Gla protein regulates calcification of the aortic valve.
CONCLUSIONS:
An important anti-calcification defense mechanism is deficient in calcified aortic valves. MGP expression is significantly lower in diseased relative to normal AVICs. Lack of this important "anti-calcification" protein may contribute to calcification of the aortic valve.
ACCUTANE (isotretinoin capsules) - FDA
calcification of the coronary arteries
were observed in two dogs after approximately 6 to 7 months of treatment with isotretinoinLooking at this, there could be vascular signs/symptoms long before the ultimate consequence.
This might be where "atrophy" comes from. Tissues are literally being choked out of blood supply/oxygen.
Vascular remodeling.Retinoic acid is a negative regulator of matrix Gla protein gene expression
Very important info there.
Now for me I have chronic varicose vein issue in both legs. When seeing the Vascular Specislist only a few months ago, I lead the conversation about Roaccutane and he had no knowledge about this, he basically said varicose veins are hereditary and in my case they need to be removed - hes given me another 9 months to consider options.
I went there looking for answers and a connection to Accutane, I talked about how fatigued I am and like every other GP or specialist he just said control diet and do more exercise.
When I went back to my regular GP I simply told her the specialist didnt give me any insight into what I was wanting out of this consultation, surgery isnt going to fix my fatigue or depression issues, I can live with varicose veins Im happy to just wear compression socks!!
Thanks for this info - Ill be using it!!
Also, depriving oxygen to parts of body notably the brain, you dont have to be Einstein to know why we might have fatigue, feelings of sadness etc etc.
Its like depriving someone of sleep, it wont take long to drive them mad and for themto burst into tears - this is completely different to clinical depression and thus needs to be treated differently, prob why antidepressants arent really what we need!!
eliminating or at least minimising artery calcification is critical at this point!!
Great info!!
1 hour ago, TrueJustice said:Also, depriving oxygen to parts of body notably the brain, you dont have to be Einstein to know why we might have fatigue, feelings of sadness etc etc.
Its like depriving someone of sleep, it wont take long to drive them mad and for themto burst into tears - this is completely different to clinical depression and thus needs to be treated differently, prob why antidepressants arent really what we need!!
eliminating or at least minimising artery calcification is critical at this point!!
Great info!!
I think we are finally getting some where.
On 2017-12-19 at 10:03 PM, ailaeshiz said:This is everything you need to know about whale.to https://rationalwiki.org/wiki/Whale.to
Whale.to is an excellent web site for truth finders. The vaccine damage info is especially good .
The only thing missing is accutane damage but it does talk about chemotherapy damage same thing.