8 minutes ago, guitarman01 said:

im sure there are many types of chronic inflammation.
my ana, sed rate, and crp have always been negative.
we'll see about this protein electrophoresis test. I should have the results in a few days.
when you get a chance maybe you can find out what was abnormal.

That's the thing! I wasn't told what was abnormal! I would like to know. I'll try calling tomorrow

On 9/15/2017 at 4:58 AM, Jorcruz24 said:

Im getting a bilateral hip x-Ray tonight because my digestion has been increasingly worse this past month. Will post results.

if you dont figure anything out, you could always try a colonoscopy prep minus the colonoscopy. That is if youve never tried this. This will completely clean out the pipes, so you can kind of reset and see where your at. if you still notice bloating(if you already had this) then you know you got some inflammation going on. Its very safe cheap and all otc. just make sure you dont make any plans for a while of course.
[Edited image out]
Gatorade / Miralax Prep for Colonoscopy

theres also a version of this where it was just 64 oz of gatorade, 14 serv full bottle of miralax and two overnight dulcolax tablets at the start, you drink 8 oz of the picture every 10 mins. I tried it once.

If you guys haven't read this book yet you must , Virus Mania , it has never been possible to create a disease with the relevant microbe EVER.

And NO medical Virus has EVER been properly isolated now think about that for a minute the germ theory is a complete fraud. It's not the germ it's the terrain .

This is one of the reasons i'm still looking at vitamin k2. Forget the website and this guy's opinions for the moment, im looking at the source material. The study.
https://chrismasterjohnphd.com/2009/04/07/tufts-university-confirms-that-vitamin/

Vitamin A Curbs the production of vitamin k dependant proteins.

The authors made another interesting observation that I had not hypothesized: vitamins A and D appear to increase the turnover of vitamin K and the conversion of vitamin K1 to vitamin K2. In the D group, liver stores of K1 were reduced and kidney levels of MK-4, the form of vitamin K2 that animals synthesize, were increased. All A groups, whether the A was given alone or in combination with D, had reductions in both K1 and MK-4 levels. The authors referred to this as antagonism between vitamins A and K, but since vitamin A improved vitamin K-dependent activation of MGP, could it not be that the reduction in K1 was due to conversion of K1 to MK-4 and that the reduction in MK-4 was due to increased utilization and turnover of MK-4? The authors never suggested that vitamin D antagonizes vitamin K1, for example, even though its levels were reduced.

This is the actual full study.

9-Cis retinoic acid reduces 1alpha,25-dihydroxycholecalciferol-induced renal calcification by altering vitamin K-dependent gamma-carboxylation of matrix gamma-carboxyglutamic acid protein in A/J male mice.

https://www.researchgate.net/publication/242387859_9Cis_Retinoic_Acid_Reduces_1a25-Dihydroxycholecalciferol-Induced_Renal_Calcification_by_Altering_Vitamin_K-Dependent_g-Carboxylation_of_Matrix_g-Carboxyglutamic_Acid_Protein_in_AJ_Male_Mice12

The mechanisms by which 9-cis RA and 1,25(OH)(2)D3 alter vitamin K concentrations warrant further investigation.

Remember1,25(OH)(2)D3 blood levels being high in some persons with CFS.

[Edited link out]

I've heard the similarities of permanent damage being caused by Finasteride.

I I wish an article like this had existed for Accutane before I took it.

https://tonic.vice.com/en_us/article/ypkpe5/your-doctor-is-probably-being-paid-off

also just goes to show pharmaceutical companies are truly evil and doctors sell their souls for a few extra bucks to poison us.

After my 2nd dose this morning I feel a little bit weird now can't really describe. I think something is going on now but not sure maybe placebo.

You guys should watch the documentary VAXXED. Millions of lives destroyed by the greedy pHARMa $luts.

And remember don't rub yours skin unless you want to have a heart attack trust me I found this out the hard way.

i think I know more about this drug than anyone on theplanet. Remember our skin cell receptors are permanently fucked up.

Pardon myFrench.

heres another one. They already had some idea of this in 1989.

Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K.

For all retinoid-dosed groups maintained on the purified diet, changes in prothrombin times occured as early as 1 week.
purified diet devoid of vitamin K.

heres another one.

Retinoic acid induces matrix Gla protein gene expression in human cells.

The present results suggest that part of the known actions of retinoic acid on skin, bone, cartilage, and other tissues in the human may be mediated by the stimulation of MGP synthesis

Matrix gla protein(MGP) is member of a family ofvitamin-K2dependent,Gla-containingproteins

Thx for report guitarman.

how are you going though with the Vit K supplementing??

Are you noticing anything from it?

some guy on this thread mentioned taking Sulforaphane

Accutane inhibits NrF2.................

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

http://www.pnas.org/content/104/49/19589.long

NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity

http://www.sciencedirect.com/science/article/pii/S0891584908005108

https://selfhacked.com/blog/about-nrf2-and-natural-ways-to-increase-it/

The UDP-glucuronosyltransferase (UGT) family catalyze the conjugation of aglucuronic acidto drugs, chemicals, and toxins, making them morewater-soluble and readily excreted. Nrf2 has been shown to induceUGT1A1andUGT1A6.

Top Ways to Increase Nrf2

• Exercise(R),
• LLLT(R)
• Fish oil/DHA(R),
• Vitamin D(R)
• Sulforaphane/Broccoli sprouts(R) -and otherIsothiocyanates from cruciferous vegetables (R),
• Lipoic Acid
• Butyrate(R),
• Garlic (R),
• Curcumin(R)
• Luteolin(R) luteolin is ideal because it inhibits Nrf2 in manycancercells (R),
• PGC-1a(R)
• Calorie Restriction (R)
• Ketosis(R),
• Molecular Hydrogen (Machine)(R),
• Thyroid hormones(R) make sure your thyroid hormones are up to par.
• Berberine(R)See this post for more on Berberine.
• PQQ(R),
• Cinnamaldehyde/Cinnamon(R),
• Anthocyanins(R,R2,R3)
• Carnitine(R),
• Interestingly, several widely used dietary components or supplements with medicinal properties have recently been shown to activate adaptive stress response pathways in cells. For example, sulforaphane (present in high amounts in the broccoli sprouts) (Juge et al., 2007), and curcumin (concentrated in the roots of the turmeric plant) each activate the transcription factor Nrf2 which binds to the antioxidant response element (ARE) of genes that encode antioxidant and phase 2 enzymes (Dinkova-Kostova and Talalay, 2008). Other adaptive stress response pathways activated by phytochemicals include the sirtuin FOXO pathway (resveratrol) and the transient receptor potential - calcium pathway (Calixto et al., 2005). The mechanism of action of such phytochemicals can therefore be considered as a form of hormesis in which exposure to a low amount of a stressor triggers an adaptive response which increases resistance to more severe stress and disease (Calabrese et al., 2007).

My serum manganese came back below the detectable range...i have no idea the significance of this... just putting this out there. Could have no link to my Tane usage at all.

Hi All,

I took Roacutane roughly 8 years ago now to help with a bad Acne issue predominantly on my face but also on my back.

On the plus side I can say the Roacutane has cured my Acne. I now only get the odd spot which i think is just normal every day when having a poor diet, lots of sugar etc.

I have for years it seems now been suffering with dry skin. I have an extremely itcy scalp, dandruff and thinning hair. I notice when styling my hair or even drying it after a show losing hairs on the bed and in my hands when using my styling products. I also periodically get patches on my upper arms of dry skin which go a bit red.

I wear contact and again notice form time to time my eyes drying out, some days are fine then some days i cant wait to get my lenses out.

Every now and again i get a weird burning sensation in my arms and legs which feels really odd.

I have only recently found this thread and wondered whether these symptoms could have been due to my Roacutane treatment. I remember at the time of taking the drug i had severe dry skin to the point i looked really ill, I also has really bad cracked lips.

Prior to taking the drug i never suffered with dry skin, hair or scalp issues.

I'm currently contemplating going to my doctors to share my thoughts on my skin issues and the link to Roacutane and see whether i can get a referral back to Dermatology which is who prescribed the Roacutane.

I have had a number of Doctors appointments over the years specifically about my scalp and have been given some anti fungal shampoo before which never helped. I have changed my shapoo to a Liz Earle one which is all natural which seems to help. I notice when i run out and use another brand such as Toni and Guy my scalp is almost instantly itchier.

Keep up the post everyone, its been an interesting read.

Cheers
Allister

http://articles.mercola.com/sites/articles/archive/2012/12/12/acne-drug-accutane.aspx

5 hours ago, Gladiatoro said:

http://articles.mercola.com/sites/articles/archive/2012/12/12/acne-drug-accutane.aspx

So if all this info brought to light in article is known in the medical industry why aren't there any follow up plans in place for those who have adverse reactions to Roaccutane??

For those who suffered inflammatory bowel disease I totally get why they sued Roche but then there's the rest of us who suffer other debilitating side effects with nowhere to really go....certainly no follow up plans that any dermatologist or doctor knows to put us on.......it's fucken completely criminal....

Yes criminal is right. Chemotherapy is well know for damaging the body permanently, if you want to learn about chemotherapy go to whale.to excellent web site you will be on there for a while . Major info on lots of stuff.

And remember this drug was only approved for severe cystic nodular acne , not mild not medium SEVERE nodular cystic acne.

How many on this board had or have this , I sure as hell didnt. Looking back I had very mild acne I found old photos the other day.

an update on some tests I got. Il look into this more when I get a chance.
The positiveantiphospholipid antibody phosphatidylserinemight correlate with this as well.

Lupus Anticoagulant Work-Up

20 minutes ago, guitarman01 said:

an update on some tests I got. Il look into this more when I get a chance.
The positiveantiphospholipid antibody phosphatidylserinemight correlate with this as well.

Lupus Anticoagulant Work-Up

Dilute Russell Viper Venom Confirmation

Positive

Lupus Interperpretation	Possible	Negative
Interpretation for Lupus Anticoagulant workup may be based on test results for ultracentrifuged APTT, Silica Clotting Time, DRVVT (Dilute Russell's Viper Venom Time), Thrombin time, APTT inhibitor screen and/or Factor VIII Assay plot pattern. Testing is invalid when patient is on Rivaroxaban, Apixaban, Fondiparinux, or low molecular weight heparin. Clinical Correlation is Advised.

Okay wait what...

ya lost me..

please explain lol

Mechanism. This in vitro diagnostic test is based on the ability of thevenomof theRussell's viperto induce thrombosis. Thevenomcontains some substances (RVV-V and RVV-X) which directly activatefactorV andfactor X, which turns prothrombin into thrombin in the presence of phospholipid and calcium.

This might be more a blood disorder then lupus. Increased blood clotting risk.
so now i have to worry about the safety of vitamin k.
but then I see this as well.

warfarin is a vitamin k antagonist. maybe il have more tests to look into specific clotting factors. I have another appointment in a couple weeks for tilt table testing. Hopefully I get in front of the right doctor. I feel like im at least building a case here.
Warfarin use often causes false-positive results in the dilute Russell viper venom time test (DRVVT)
https://link.springer.com/article/10.1007/s12185-017-2228-y

Interactions of vitamin K-dependent proteins with calcium ions and phospholipid membranes.

ObjectiveVitamin Kdependent proteins (VKDPs), which require post-translational modification to achieve biological activity, seem to contribute to thrombus formation, vascular calcification, and vessel stiffness.

higher risk of incident ischemic cardiovascular disease. The association was consistent across strata of participants with diabetes mellitus, hypertension, renal impairment, and low vitamin K nutritional intake.

What im saying here^ is this could be a false positive from certain factor deficiencies caused by vitamin k antagonist/deficiency.

Vitamin K-dependent factors: II, VII, IX, X, C, S,

Factor x deficiency, vitamin k deficiency. false positive drvvt?

Im not sure though.

Whoever masterminded this chemo torture deserves a monument in HELL.

On 9/11/2017 at 10:56 AM, Nemesisbrady said:

I keep telling everyone who has dryness rashes flushing

and similar issues as me

get igg4 related disease testing

go to Boston mass general they study igg4

no one ever checked this allergist did and said it can attack eye glands saliva mimic sjorgens
and can attack vital organs and lymph nodes

im seeing top rheum in Boston soon

Sjorgens symptoms is one of the issues that flares when I eat offending foods. It showed up on my blood work as high SSA Anitbodies which my doctor said is responsible for eye and mouth lubrication. I don't really notice a dry mouth, just eye pain like sand was thrown in them.

On 9/16/2017 at 10:04 PM, Pezza371887 said:

Hi All,

I took Roacutane roughly 8 years ago now to help with a bad Acne issue predominantly on my face but also on my back.

On the plus side I can say the Roacutane has cured my Acne. I now only get the odd spot which i think is just normal every day when having a poor diet, lots of sugar etc.

I have for years it seems now been suffering with dry skin. I have an extremely itcy scalp, dandruff and thinning hair. I notice when styling my hair or even drying it after a show losing hairs on the bed and in my hands when using my styling products. I also periodically get patches on my upper arms of dry skin which go a bit red.

I wear contact and again notice form time to time my eyes drying out, some days are fine then some days i cant wait to get my lenses out.

Every now and again i get a weird burning sensation in my arms and legs which feels really odd.

I have only recently found this thread and wondered whether these symptoms could have been due to my Roacutane treatment. I remember at the time of taking the drug i had severe dry skin to the point i looked really ill, I also has really bad cracked lips.

Prior to taking the drug i never suffered with dry skin, hair or scalp issues.

I'm currently contemplating going to my doctors to share my thoughts on my skin issues and the link to Roacutane and see whether i can get a referral back to Dermatology which is who prescribed the Roacutane.

I have had a number of Doctors appointments over the years specifically about my scalp and have been given some anti fungal shampoo before which never helped. I have changed my shapoo to a Liz Earle one which is all natural which seems to help. I notice when i run out and use another brand such as Toni and Guy my scalp is almost instantly itchier.

Keep up the post everyone, its been an interesting read.

Cheers
Allister

I'm really sorry to tell you this, but going to the doctor with those symptoms and the link to accutane won't help what so ever. Even if they believe you, they don't have a clue what to do about it.

I have the same issue with dry skin and hair 7 years after taking it. I got referred to a dermatologist who discharged me after 1 visit saying theres nothing they can do.

I'm currently applying borage oil to my face on an evening, taking taurine at night along with omega 3 and borage oil for omegas 6 and 9. This seems to be helping my skin a lot at the moment and i've only been doing it for just over a week. Unsure if its the topical application or the oral supplementation.

On 9/15/2017 at 8:28 PM, Gladiatoro said:

You guys should watch the documentary VAXXED. Millions of lives destroyed by the greedy pHARMa $luts.

Well - also look at vaxxed recoveries, Few and far between but they recognise inflammation which is why they suggest glutathione

On 9/14/2017 at 3:05 PM, Kynarr said:

A new project involving Post-Retinoid Sexual Dysfunction that might be of interest:

https://rxisk.org/launching-the-rxisk-prize/

So this post barely got attention.
Do you all understand that this competition is about encouraging researchers to figure out what these drugs are doing and to find a cure.
I guess the alternative is that we can all be here chasing our tails in 20 years time no further on than we are now!
Actually anyone can win this prize!
So you all need to be pro-active and spread the word about this competition.
You should all be donating and getting friends and family to donate as well.

Yet again I urge you all to report your side effects - there really is no excuses!
Don't you see that by not reporting you are PART of the problem and you should be accepting some of the blame for every kid who follows in your footsteps!

We need expert help here and this competition may just bring us that.

Report your sides to Rxisk and your own health authorities.
Share competition details wherever you can.
Donate!!
Anyone who is brave enough - do a youtube video (PM me as I know a doctor who is hoping he can find someone who might be willing to do this)
We also need concise case histories. Maybe someone would like to start this of in a new thread called case histories so that doctors can access the thread without trawling through hundreds of unnecessary posts.