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I got my senior citizen life line screening tests scheduled for next week to check for calcification.
Arthritis precipitated by isotretinoin treatment for acne vulgaris. - NCBI
Arthritis precipitated byisotretinointreatment for acne vulgaris. ... with reported arthritis, arthralgia, myalgia, vasculitis and skeletal andsoft tissue calcification.
[PDF]Isotretinoin - European Medicines Agency
Softcapsules. Oral use. B lister. 20, 28, 30, 50 .... In adults,isotretinointherapy should be started at a dose of 0.5 mg/kg daily. The therapeutic response .....tissueand organcalcificationsobserved with vitamin A in the rat. The liver cell changes...
[PDF]ACCUTANE - FDA
Birth defects which have been documented followingAccutaneexposure include ... is available asAccutanein 10-mg, 20-mg and 40-mgsoftgelatin capsules .....calcificationof the gastric mucosa were greater than in control rats of similar age. ...... exuberant granulationtissuewith crusting; see PRECAUTIONS: Information...
[PDF]Accutane (isotretinoin) Capsules Label - FDA
Jun 20, 2002 -CONTRAINDICATIONS AND WARNINGS:Accutanemust not be used by ....softgelatin capsules for oral administration. .... myocardium,calcificationof coronary, pulmonary and mesenteric arteries, and ..... abnormal wound healing (delayed healing or exuberant granulationtissuewith crusting; see.
Isotretinoin - Wikipedia
Isotretinoin(INN), also known as 13-cis-retinoic acid, is an oral pharmaceutical drug primarily ..... Other problems include premature epiphyseal closure andcalcificationof ... in the action of TIMP1 and TIMP2 (thetissueinhibitors of metalloproteases). .... Jump up to: "Roaccutane20mgSoftCapsules - Summary of Product...
38 minutes ago, guitarman01 said:I got my senior citizen life line screening tests scheduled for next week to check for calcification.
Arthritis precipitated by isotretinoin treatment for acne vulgaris. - NCBI
by RA Hughes - 1993 - Cited by 21- Related articlesArthritis precipitated byisotretinointreatment for acne vulgaris. ... with reported arthritis, arthralgia, myalgia, vasculitis and skeletal andsoft tissue calcification.
[PDF]Isotretinoin - European Medicines Agency
www.ema.europa.eu/docs/en_GB/document.../Isotretinoin_29/WC500010881.pdfSoftcapsules. Oral use. B lister. 20, 28, 30, 50 .... In adults,isotretinointherapy should be started at a dose of 0.5 mg/kg daily. The therapeutic response .....tissueand organcalcificationsobserved with vitamin A in the rat. The liver cell changes...
[PDF]ACCUTANE - FDA
Birth defects which have been documented followingAccutaneexposure include ... is available asAccutanein 10-mg, 20-mg and 40-mgsoftgelatin capsules .....calcificationof the gastric mucosa were greater than in control rats of similar age. ...... exuberant granulationtissuewith crusting; see PRECAUTIONS: Information...
[PDF]Accutane (isotretinoin) Capsules Label - FDA
Jun 20, 2002 -CONTRAINDICATIONS AND WARNINGS:Accutanemust not be used by ....softgelatin capsules for oral administration. .... myocardium,calcificationof coronary, pulmonary and mesenteric arteries, and ..... abnormal wound healing (delayed healing or exuberant granulationtissuewith crusting; see.
Isotretinoin - Wikipedia
Isotretinoin(INN), also known as 13-cis-retinoic acid, is an oral pharmaceutical drug primarily ..... Other problems include premature epiphyseal closure andcalcificationof ... in the action of TIMP1 and TIMP2 (thetissueinhibitors of metalloproteases). .... Jump up to: "Roaccutane20mgSoftCapsules - Summary of Product...
Are you going to ever try and get a CRP test?
31 minutes ago, Colinboko said:Are you going to ever try and get a CRP test?
Yea ive had this.
| C-Reactive Protein | <0.3mg/L | 0.0 - 4.9 mg/L |
On 6/15/2017 at 6:55 PM, hatetane said:So for those pro-active enough to be testing - glutathione and homocysteinewould be a good idea.
Also had this.
| Homocysteine | 9umol/L | 0 - 15 umol/L |
and this
| Biotinidase Plasma | 10.9U/L | 3.5 - 13.8 U/L |
this
| Alpha-Tocopherol | 12.9mg/L | 5.5 - 17.0 mg/L |
this
| Sed Rate | 4MM/HR | 0 - 15 MM/HR |
this
| IgM | 162mg/dL | 40 - 230 mg/dL |
| IgG | 1118mg/dL | 700 - 1600 mg/dL |
| IgA | 310mg/dL | 70 - 400 mg/dL |
This is immune.
| ANA Screen | 0.2 | 0.0 - 0.6 |
and countless others. Its more what havent I tested.
Ive almost had my entire a to zinc tested as well.
| Magnesium | 1.8MG/DL | 1.6 - 2.6 MG/DL |
was wondering if this test had any significance. prob not.
Retinol-binding Protein (RBP)
https://www.labcorp.com/test-menu/34381/retinol-binding-protein-rbp
18 minutes ago, guitarman01 said:Yea ive had this.
C-Reactive Protein <0.3mg/L 0.0 - 4.9 mg/L Also had this.
Homocysteine 9umol/L 0 - 15 umol/L and this
Biotinidase Plasma 10.9U/L 3.5 - 13.8 U/L this
Alpha-Tocopherol 12.9mg/L 5.5 - 17.0 mg/L this
Sed Rate 4MM/HR 0 - 15 MM/HR this
IgM 162mg/dL 40 - 230 mg/dL IgG 1118mg/dL 700 - 1600 mg/dL IgA 310mg/dL 70 - 400 mg/dL This is immune.
ANA Screen 0.2 0.0 - 0.6 and countless others. Its more what havent I tested.
Ive almost had my entire a to zinc tested as well.
Magnesium 1.8MG/DL 1.6 - 2.6 MG/DL was wondering if this test had any significance. prob not.
Retinol-binding Protein (RBP)
https://www.labcorp.com/test-menu/34381/retinol-binding-protein-rbp
Good for you for getting all of these done! I thought for sure some type of systemic inflammation would come up somewhere. To be completely honest though, I'm still convinced we could all very well be suffering from different triggers. Like truejustice, ehohel and I have almost EXACT symptoms while some people don't have any of the things we have. Just so weird.
like ehohel has been the only other person I've seen on this thread that has posted about not catching any type of common colds since accutane which is super indicative of inflammation (him doing well on prednisone could also vouch for this).
I don't remember you ever talking about getting colds/flus/bugs. Do you still catch them? Runny noses? Coughing up mucus? Stomach bugs? Anything?
I just think we're all so set on following one person's journey and hoping that one person may have something that we have, when actually we could all very well be suffering from different things..
histone antibody might be another test when looking at absolutely everything. Its a antibody for drug induced lupus.
People with lupus who have a negative ANA test may have anti-Ro/SSA or antiphospholipid antibodies.
lupus anticoagulantcould be another test as well.
Fibrinogenis another test looking at thrombosis/cardiac risk, coagulation.
On 6/19/2017 at 9:45 PM, Colinboko said:hoping that one person may have something that we have, when actually we could all very well be suffering from different things..
There is always a chance we already had something in common before taking accutane.
This is what my chest angiography said
reconstructed images demonstrate a coarsely notched appearance of the anterior ascending aorta which is likely a manifestation of pulsation artifact during scan acquisition. significantly lesser but similar findings are seen within the mid descending thoracic aorta.
everything else: normal
impression: no ct angiographic findings to suggest aortitis or arteritis involving the proximal aortic branch vessels.
Actually im also looking at this test. They didnt really mention this much. I just recall them saying I had a slight sag in my heart. Damn, going to have to get some more info on this tomorrow. Thats why it always pays to look at your reports. They dont tell you everything or might miss something.
Stress EKG
Abnormal ECG response to stress. 2 mm flat depressed ST segment in leads
III occuring in Stage 2 using Bruce protocol.
CONCLUSION: The conclusion of the Stress EKG is.
Positive stress EKG for ischemia.
On 6/19/2017 at 7:00 AM, mariovitali said:Just so that you know the ignorance of some doctors out there. I have attached a Fibroscan of a 31 year old female with CFS symptoms for more than 20 years.
The doctor said that she is fine and that she should forget anything about Liver Fibrosis. Upon further inspection take note of the 123% IQR. This should had been less than 30% and yet this doctor dismissed her, telling her to forget fibrosis.
So this is coming from the doctor that actually gave her this test and is familiar with Fibroscan?
On 6/21/2017 at 10:43 AM, guitarman01 said:So this is coming from the doctor that actually gave her this test and is familiar with Fibroscan?
No this doctor said nothing about it. This requirement exists in numerous papers and also to a paper from Samsung (the same device used for the test)
[Edited link out]
We do expect a second opinion from a Hepatologist and i will report back
On 6/19/2017 at 7:00 AM, mariovitali said:The doctor said that she is fine and that she should forget anything about Liver Fibrosis. Upon further inspection take note of the 123% IQR. This should had been less than 30% and yet this doctor dismissed her, telling her to forget fibrosis.
looking into this quickly, her kpa score was still below 7 which is normal, even with the spread of 123%.
The IQR is the spread of the 10 readings. so the high percentage is saying its not very accurate but still below normal. correct?
Obviously based on my recent posts I have more concerns then the liver atm.
But cardiovascular and liver disease can go hand and hand I know.
You might still be right about k2 if any type of abnormal calcification was going on, induced by accutane.
but then again if there is no abnormal calcification or artery stiffness, which im about to find out next week, then im not sure about k2. or at least it playing an integral role, and like I said before it could even be antagonistic.
5 hours ago, guitarman01 said:looking into this quickly, her kpa score was still below 7 which is normal, even with the spread of 123%.
The IQR is the spread of the 10 readings. so the high percentage is saying its not very accurate but still below normal. correct?
Obviously based on my recent posts I have more concerns then the liver atm.
But cardiovascular and liver disease can go hand and hand I know.
You might still be right about k2 if any type of abnormal calcification was going on, induced by accutane.
but then again if there is no abnormal calcification or artery stiffness, which im about to find out next week, then im not sure about k2. or at least it playing an integral role, and like I said before it could even be antagonistic.
My current understanding is that if we have >30% IQR then the test should be repeated as the results are not considered that reliable. I will wait for the answer from a hepatologist who is a specialist for Liver elastography, hopefully very soon.
Regarding K2 : i believe it is not just a case of calcification. K is used for proper protein folding in the endoplasmic reticulum which -in our case- is very important i believe.
On 2017-6-17 at 9:20 PM, guitarman01 said:I wanted to go back to what I posted about atherosclerosis.
This could cause muscle spasms.
This could cause ed.
this could cause cerebral atrophy.
this could cause neurologic degeneration
tinnitus
muscle weakness, pain
gum inflammation
eye damage
digestive and kidney disorders due to lack of blood flow or slowed blood flow to vital organs
The HDL level is more important in young people as opposed to ldl (bad cholesterol)I feel as important as this is, this needs to be fully explored to rule this out.
Ive read mixed reviews and controversy surrounding these screenings, but for me this feels too important to not have these tests.
So im going to schedule this as soon as possible. its cheap at 150 I want to say, for the middle test.http://www.lifelinescreening.com/What-We-Do/Screening-Packages
Screening Packages
PACKAGE OPTIONS Complete Wellness Package Stroke, Vascular, Heart Rhythm with Osteoporosis Stroke, Vascular, Heart Rhythm with Osteoporosis and 6 for Life TESTS Carotid Artery Disease (Plaque) Peripheral Arterial Disease Osteoporosis Abdominal Aortic Aneurysm Atrial Fibrillation 6 for Life Health Assessment Complete Lipid Panel Glucose (blood sugar)
^ this also sort of reminds me of cystic fibrosis. Same low iga marker in stool.
According to a few pages I've seen online atherosclerosis might be reversible.
A pill that was once used that was a combination of iodine and niacin helped lessen atherosclerosis or clear it up.
11 minutes ago, hatetane said:22 hours ago, Colinboko said:I'm thinkin we should all start getting some stool samples. Anyone else have weird colored crap? Random dark green spots? My poop has been SUPER green.. but I have constipation? How does that work?
Have you booked a test?
Headed to the ENT first week of July for a vocal cord viewing (and some ear stuff). Hoping to find some inflammation that could be responsible for my loss of middle range. Will work on the stool stuff afterwards. (Trying to afford all of these visits isn't entirely easy). Fingers crossed I can get ahold of some prednisone and see the results I get from anti-inflammatories
was just looking at these connections.
Excessive Growth of Bacteria
just the right conditions for bacteria to flourish
Helicobacter pylorihas received much attention,
but new research by scientists at the Howard Hughes Medical Institute (HHMI) at the University of Michigan shows that many other types of bacteria can cause gastritis.
The new research suggests that gastritisis triggered by bacterial overgrowth, rather than by stomach acidity.
including overgrowth of other types of bacteria, Lactobacillus, Enterobacter, StaphylococcusandProbionibacterium.
SIBO Patients Should Consider K2 Supplements, Italian Doctors Recommend
Italian researchers have proposed that vitamin K2 supplementation may be of great therapeutic value for patients diagnosed with small intestinal bacterial overgrowth (SIBO) by linking subclinical atherosclerosis to SIBO via vitamin K2-dependent mechanisms. The results of this important observational study have recently been published in theWorld Journal of Gastroenterology.1
recent studies have highlighted that patients with SIBO have low circulating levels of vitamin K2.2Several maladies of the gastrointestinal tract, wherein gut bacteria act in a pathogenic capacity, are associated with vascular dysfunction and increase the risk of atherosclerosis in the host.
I would be interested in getting a breath test. This is one test ive never had.
The most common cause of SIBO is the reduction of the normal cycle of muscular activity of the small intestine at night
After antibiotic treatment is finished and the symptoms improve, then we treat the underlying muscular disturbance with either low dose erythromycin or low dose naltrexone (LDN) each night at bedtime.
http://www.gidoctor.net/small-intestinal-bacterial-overgrowth.php
Should finally be getting the results of that autoimmune dysautonomia test from mayo in the mail in the next few days.
Curious as hell about this one, the doctor is mailing me a copy to take to a neurology dept at a major university. Still have no clue as to what it says.
On 6/22/2017 at 8:47 AM, guitarman01 said:The most common cause of SIBO is the reduction of the normal cycle of muscular activity of the small intestine at night
After antibiotic treatment is finished and the symptoms improve, then we treat the underlying muscular disturbance with either low dose erythromycin or low dose naltrexone (LDN) each night at bedtime.
http://www.gidoctor.net/small-intestinal-bacterial-overgrowth.phpShould finally be getting the results of that autoimmune dysautonomia test from mayo in the mail in the next few days.
Curious as hell about this one, the doctor is mailing me a copy to take to a neurology dept at a major university. Still have no clue as to what it says.
Have you had this test
https://www.greatplainslaboratory.com/articles-1/2015/11/13/a-new-generation-of-organic-acid-testing-pushing-the-limits-of-detection-with-new-technology
On 6/22/2017 at 5:40 AM, hatetane said:On 6/21/2017 at 7:09 AM, Colinboko said:I'm thinkin we should all start getting some stool samples. Anyone else have weird colored crap? Random dark green spots? My poop has been SUPER green.. but I have constipation? How does that work?
Have you booked a test?
Why are you so keen to try prednisone? I would have thought glutathione would be a better choice.
[Edited link out]
[Edited link out]
This is pretty interesting.
Ultrastructural findings in the liver due to long-term retinol (isotretinoin) treatment. Significance of the perisinusoidal (Ito) cells].
Abstract
A twenty year old, foreign-born sportsman visited the Out-patient Clinic of our Hospital with complaints of progressive arthralgia, hepatomegaly and increasingly abnormal liver function tests of six months duration. Tests for virus hepatitis were negative, alcohol abuse or drug addiction could be excluded. An open needle biopsy of the liver was performed and the tissue was examined with the light and electron microscope. On routine light microscopy no abnormality was recognized. Electron microscopic examination revealed changes characteristic of vitamin A toxicity: hyperplasia of the perisinusoidal (Ito) cells with evidence of their activation and transformation, increased storage of lipids and vitamin A, perisinusoidal fibrosis, damage of the sinusoidal wall, partial necrosis in hepatocytes and an increased number of lysosomes, megalysosomes and smooth endoplasmic reticulum (SER), the signs of cholestasis as well as an increased number of Kupffer cells in the lobules etc. Histochemical examination showed a high content of vitamin A in the transitional (Ito) cells and in hepatocytes. These data led to further questioning of the patient who disclosed that he had acne conglobata which had been treated with Isotretionin, 20 mg/day, for more than half a year. After the therapy was stopped, the symptoms of polyarthralgia improved and after a few months they ceased entirely, however, the laboratory data returned to normal only after a long period of time. This case indicates that electron microscopic examination of the liver biopsy may play an important role in the recognition of vitamin A intoxication. It also illustrates that symptoms of joint disease may be caused by long-term retinoid treatment. The authors have presented the latest clinical and experimental data concerning the changes in the liver, joints and skeleton caused by retinoid intoxication.
On 6/22/2017 at 11:20 AM, hatetane said:Have you had this test
https://www.greatplainslaboratory.com/articles-1/2015/11/13/a-new-generation-of-organic-acid-testing-pushing-the-limits-of-detection-with-new-technology Why are you so keen to try prednisone? I would have thought glutathione would be a better choice.
[Edited link out][Edited link out]
Gee idk? Maybe because it's the only known drug to have actually 100% helped someone?
I'm not opposed to try other things but at this point my fatigue and brain fog and depression are so intense that I need at least some sort of relief to muster up the energy to try and experiment.
So I got a QEEG last week, and while I haven't seen detailed results yet, the doctor called up to say that something is really wrong with my brain waves pertaining to Emotions, and Executive functioning.
4 hours ago, cnb30 said:So I got a QEEG last week, and while I haven't seen detailed results yet, the doctor called up to say that something is really wrong with my brain waves pertaining to Emotions, and Executive functioning.
Okay I believe accutane can be held responsible for lots of things but this seems a tad far fetched...
i just think that anything we have that is brain related is most definitely a symptom of something else happening in the body. (I.e inflammation, hormonal (for some people)
1 hour ago, Colinboko said:Okay I believe accutane can be held responsible for lots of things but this seems a tad far fetched...i just think that anything we have that is brain related is most definitely a symptom of something else happening in the body. (I.e inflammation, hormonal (for some people)
Unfortunately, it's not far-fetched at all for someone to have brain abnormalities post-Accutane. A study titled, "Retinoic Acid and Affective Disorders: The Evidence for an Association" talks of documented brain abnormalities in patients who took Accutane. In one study, altered blood flow was found in the orbitofrontal cortex. In another report, the Norwegians Medicines Agency documented altered bloodflow in the frontal lobes and even brain damage in some former Accutane patients. The fact cnb30's doctor mentioned issues with "executive function" leads me to believe the issue is with the frontal lobes, and that seems to be the theme in these studies. Furthermore, in running a group full of 150+ post-Accutane sufferers, I have talked to multiple people with documented brain abnormalities post-Accutane. And so far, it has always involved the frontal lobes, consistent with the literature.
I know you are focused on the inflammation angle, but I encourage you to keep an open mind. Inflammation is likely part of the puzzle, but perhaps not the main issue. Keep in mind we are dealing with a drug that causes telomerase downregulation and telomere shortening (i.e., pro-aging effects), which seems substantiated by other studies that confirm this drug causes cellular death in multiple regions of the body, including brain, bones, and muscles. The telomere shortening effects of Accutane have had my attention since I learned about it. This potentially has implications for every region of the adult body that contains stem cells (e.g., brain, bones, teeth, heart, gut, skin, ect.), as the telomerase enzyme is important for stem cells. Read research on chemotherapy drugs in general, and much of it applies to Accutane. Accutane causes the same pro-aging effects any other chemo drug does. And yes, this often involves hormonal disruptions as well. This puzzle is vast.
23 minutes ago, ACCUiTy_drANE said:Unfortunately, it's not far-fetched at all for someone to have brain abnormalities post-Accutane. A study titled, "Retinoic Acid and Affective Disorders: The Evidence for an Association" talks of documented brain abnormalities in patients who took Accutane. In one study, altered blood flow was found in the orbitofrontal cortex. In another report, the Norwegians Medicines Agency documented altered bloodflow in the frontal lobes and even brain damage in some former Accutane patients. The fact cnb30's doctor mentioned issues with "executive function" leads me to believe the issue is with the frontal lobes, and that seems to be the theme in these studies. Furthermore, in running a group full of 150+ post-Accutane sufferers, I have talked to multiple people with documented brain abnormalities post-Accutane. And so far, it has always involved the frontal lobes, consistent with the literature.I know you are focused on the inflammation angle, but I encourage you to keep an open mind. Inflammation is likely part of the puzzle, but perhaps not the main issue. Keep in mind we are dealing with a drug that causes telomerase downregulation and telomere shortening (i.e., pro-aging effects), which seems substantiated by other studies that confirm this drug causes cellular death in multiple regions of the body, including brain, bones, and muscles. The telomere shortening effects of Accutane have had my attention since I learned about it. This potentially has implications for every region of the adult body that contains stem cells (e.g., brain, bones, teeth, heart, gut, skin, ect.), as the telomerase enzyme is important for stem cells. Read research on chemotherapy drugs in general, and much of it applies to Accutane. Accutane causes the same pro-aging effects any other chemo drug does. And yes, this often involves hormonal disruptions as well. This puzzle is vast.
I understand this puzzle is super vast. And that's why I will always stand by saying that everyone could be fighting something different than the person next to them. I don't necessarily think this drug has affected everyone in the same way. Hence people having JUST dry eyes, or gut problems to people only having psychological problems. I for one, have the ability to still get erections and can still masturbate where some people cannot. Why is that? If I sit here and read "brain damage" my instant thought is "irreversible" and that would cause me to kind of give up my fight so to speak. Knowing that these problems can't be fixed should be everyone's biggest fear on here. If you want to believe your brain has been crushed to mush then by all means go for it! That thought just terrifies me and would probably drive me to suicide if I knew this was irreversible.
If the studies are known it can cause blood flow issues or worse brain damage why can't we find a Neurologist who'll put their hand up and say "yes, that can happen, tests have been conducted and you might have brain damage"??
Like on the previous page - the link between isotretinoin and calcification issues - if that's some sort of finding than it could only have resulted from doing tests on Accutane patients correct??
For now I'll live with the impaired brain function but for fuck sake I wish the medical community wouldsmarten up and acknowledge what's going on here.
Thank God for the internet and the ease of accessing these studies, if it weren't for the ability to do that we'd be screwed, I mean imagine if you took tane in the 1980's, what would be your chances of getting anywhere with doctors back then?
As ive said before - print these reports off and use them, when you face another ignorant doctor, you know what to do!!