Acne.org Products
https://www.c-span.org/video/standalone/?174192-3/safety-accutane
Just found this again so though i would post it for anyone who has not seen it before.
Truejustice and anyone looking at brain - you all know that accutane is well know for raising homocysteine right?
Obviously low B12 = high homocysteine. I am not sure if it is possible to have in range B12 but still have high homocysteine.
I know homocysteine can be checked independently of B12,
Glutathione should also be checked. NAC is a glutathione booster which may be why some people claim to have benefits from it.
There is a relationship between glutathione, L-Arginnine and citrulline
http://www.smart-publications.com/articles/l-citrulline-and-l-arginine-this-one-two-amino-acid-punch-can-improve
L-Citrulline helps gut injury.
Autistic kids have been found to be glutathione deficient and make massive improvements with gaps diet, chelation, B12/6,
glutathione and hyperbaric chamber sessions. (+ other supplements). So this protocol is addressing gut, brain and inflammation.
So for those pro-active enough to be testing - glutathione and homocysteinewould be a good idea.
This study is from 2016.
This might be one of the most fucked up studies on accutane I have read, with the most serious consequences.
This is showing it could play a role in cardiovascular disease.
I would recommend getting a full lipid profile if you haven't.
It might not be blood flow in the head, it could be blood flow in the neck.This supplies blood flow to the brain and face. This could be something that would gradually worsen with time.
Isotretinoin increased carotid intima-media thickness in acne patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074391/
its effect on lipid and glucose metabolism may induce atherosclerotic complications.
Dyslipidemia and increase in liver enzymes are the most frequently seen side effects of Iso treatment
alterations in lipid profile were reminiscent of the metabolic syndrome
Long-term use of Iso may be a risk factor for atherosclerosis
1 hour ago, radio3 said:Does anyone here know whether or not Accutane use has been associated with kidney damage? My blood tests consistently show elevated creatinine levels, indicating some damage to my kidneys, and I wonder what may have caused it.
Perhaps you could do the following tests to rule out (not entirely) Liver Disease? :
Blood : Ceruloplasmin, Serum Copper, Serum Zinc, Liver Panel, Urea.
thenLiver/Gallbladder/Pancreas Ultrasound and Fibroscan
10 hours ago, radio3 said:Does anyone here know whether or not Accutane use has been associated with kidney damage? My blood tests consistently show elevated creatinine levels, indicating some damage to my kidneys, and I wonder what may have caused it.
It is listed in the rx information that it can cause Kidney issues and diabetes. You should probably have some more testing. Are you taking anything else along with Accutane or if your course is over????
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879014/
On 6/9/2017 at 2:55 PM, Anna.F said:
Hello.
have you discoverd anything that helps a little in dry eyes? I have already tried a lot of things.
I cant stand this situation anymore.
Have you seen an eye doctor? What things have you tried??? Accutane can cause many eye issues in relation to dry eyes. Inflamation, bleperhitits and the list goes on....I personally had the glads that people with sjrogren's effected.
5 hours ago, hatetane said:Just wanted to post this again to make sure anyone visiting see this
What's your story if you don't mind sharing briefly? You kind of talk like you're Speaking for someone else sometimes. You seem a little older, did you yourself take accutane or was it someone you know? Was just curious about this. Thanks.
11 minutes ago, guitarman01 said:5 hours ago, hatetane said:Just wanted to post this again to make sure anyone visiting see this
What's your story if you don't mind sharing briefly? You kind of talk like you're Speaking for someone else sometimes. You seem a little older, did you yourself take accutane or was it someone you know? Was just curious about this. Thanks.
Regardless it's clear that she's here to fight so that future people don't become affected by this drug Ike we have. But in all honesty, I'm here to get myself better. Call me selfish, but I'm not letting this stupid drug win. I feel like we get closer every day.
35 minutes ago, guitarman01 said:What's your story if you don't mind sharing briefly? You kind of talk like you're Speaking for someone else sometimes. You seem a little older, did you yourself take accutane or was it someone you know? Was just curious about this. Thanks.
Sorry never mind. Forgot you pm'd me this awhile back.
22 minutes ago, Colinboko said:Regardless it's clear that she's here to fight so that future people don't become affected by this drug Ike we have. But in all honesty, I'm here to get myself better. Call me selfish, but I'm not letting this stupid drug win. I feel like we get closer every day.
I think the best we can do, at least with minimal help from doctors is eliminate what we dont have and move on. There have been alot of theories on here over the years, including coming from myself, but without testing to back some of these ideas up, it's all fantasy. So we test what we can, eliminate it and move on. I dont believe all these similar symptoms are chronically happening in people without a trace.
1 hour ago, guitarman01 said:1 hour ago, Colinboko said:Regardless it's clear that she's here to fight so that future people don't become affected by this drug Ike we have. But in all honesty, I'm here to get myself better. Call me selfish, but I'm not letting this stupid drug win. I feel like we get closer every day.
I think the best we can do, at least with minimal help from doctors is eliminate what we dont have and move on. There have been alot of theories on here over the years, including coming from myself, but without testing to back some of these ideas up, it's all fantasy. So we test what we can, eliminate it and move on. I dont believe all these similar symptoms are chronically happening in people without a trace.
Exactly. I've moved on from anything hormonally related at this point. Now whether or not my hormones are being affected by a bigger picture is a totally different thing. I'll stand by systemic inflammation for as long as I can. Like I've said so so many times, this whole "never getting sick aside from being chronically sick" thing is just way too weird for me to disregard inflammation.
On 6/15/2017 at 6:37 AM, tryingtohelp2014 said:Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis
http://dmm.biologists.org/content/5/4/457vs.
Phosphatidylcholine (lecithin) and the mucus layer: Evidence of therapeutic efficacy in ulcerative colitis?
Results from a stool test that I took showed low IgA. Secreted IgA: 205 low g/ml (norm range: 510-2040)
'The secretory IgA is produced by all mucous membranes and can be found in the secretions like saliva, tears, nose mucus and gastrointestinal secretions. It provides our first line of defence against bacteria, food residues, fungus, parasites and viruses. The concentration of sIgA in this test gives us information not only about the immune status of your intestinal immune defence but also all your mucous tissues.
Low levels indicate a general low mucosa immune system.' Quoted from the people who carried out the test.
'The intestinal mucosa contains several immune antibodies known as immunoglobulins: sIgA, IgA, IgG and IgM. IgA is the most abundant immunoglobulin in the gut mucosa.' Quoted from [removed] - interesting section on vitamin A relation on this page too, have not copied to save creating a wall of text.
The test did not check for levels of the other immunoglobulins.
Makes sense for me as since taking accutane I have had to spend a lot of time fighting off various fungal/bacterial infections and trying to re-balance levels in my gut.
What is the best way to temporarily recover your libido? I'm honestly hopeless at this point and realize that NO aspect is ever going to permaneantly improve, but i'm sick of not having a libido. I don't care anymore how destructive it will be in the long term, honestly it feels like everything I do is destructive. I'm just looking for a temporary thing. An ED pill, or something similar.
Also, I should add that I'm looking into possibly an alternative medicine expert at a local grocery store. Do you guys have any advice? What should I mention. Are there any key things I should ask?
like I said this needs to be fully looked into, just in case. This could be why nothing helps in some people. not sure if anyone has looked into this possible aspect of ed yet.
Arteriosclerosis of penile arteries: histological findings and their significance in the treatment of erectile dysfunction.
Abstract
OBJECTIVES:
In this pathomorphological study, location, distribution, and degree of arteriosclerotic stenoses in penile arteries from unselected cadavers are investigated. The findings are discussed in the context of penile revascularization and may explain the poor results of this form of surgery in older patients with general arteriosclerosis.
MATERIALS AND METHODS:
120 penile specimens from 120 cadavers were examined histologically after van Gieson staining. Transverse sections were performed at the level of the pubic bone, in the middle of the penis, and at the sulcus coronarius. At these levels the dorsal and deep penile arteries were examined.
RESULTS:
We found arteriosclerotic stenoses of the penile arteries in 65% of the specimens. Of these stenotic lesions, 20.4% were situated proximally, 37.1% centrally, and 42.5% distally.
CONCLUSIONS:
In patients with arteriosclerotic stenoses of the penile arteries, microsurgical penile revascularization to the proximal part of the dorsal arteries at the base of the penis seems to be without any relevant long-lasting hemodynamic effect, because the blood flow will be impeded by the peripheral stenoses. This can explain the poor results of revascularization in this group of patients.
Erectile Dysfunction & Atherosclerosis: Symptoms, Causes, Treatments
Oct 19, 2015 -But if you have ED, it could be a sign that yourarteriesare clogged. It's all about blood flow. To get and keep an erection, blood needs to have no problem getting to yourpenis. ... Doctors call it atherosclerosis, which means the hardening of thearteriesdue to plaque buildup.
Atherosclerosis and Erectile Dysfunction: Causes, Warning Signs and ...
Erectile dysfunction is recognized as an early warning sign foratherosclerosis. Learn about otheratherosclerosisrisk factors and impotence treatments.
Is Penile Atherosclerosis the Link Between ED and CV Risk?
Abstract. Erectile dysfunction (ED) is increasingly linked to coronary heart disease risk. ...Atherosclerosisat the following localizations were histologically classified: right coronaryartery, left coronaryartery, left circumflexartery, internal iliacartery, dorsalpenile arteryand deeppenile artery(bilateral).
Arteriosclerosis of penile arteries: histological findings and their ... - NCBI
Urol Int. 2002;68(4):261-4.Arteriosclerosis of penile arteries: histological findings and their significance in the treatment of erectile dysfunction. Grein U(1)...
Erectile Dysfunction: A Blessing in Disguise | HuffPost
Jun 27, 2010 -Thepenile artery, likearteriesaround the heart and leading to the brain, can become blocked with plaque fromatherosclerosis. If this happens...
im not sure how I feel about k2 or mk7 atm(Ive seem to have had extreme reactions). But maybe this could be the link between accutane and fin. Maybe it could be cardiovascular dueto displacement of calcium. Not sure. I think some testing is def in order to rule this out. I know arteriosclerosis for instance can be silent in the carotid arteries. First warning sign is usually a stroke.
Not trying to freak people out, but would like to take this off the table as soon as possible.
obviously im not a doctor, im not sure if this could affect limited parts of the body before showing up in main arteries or have to be triggered by high blood pressure/cholesterol etc.
I have had a echocardiogram, and ct angiogram that came back fine, although they did mention something on the angiogram they chalked up to "movement" so I might check this again.
This could also affect breathing, clear thinking and a whole bunch of fun stuff.
Btw im also getting a thyroid ultrasound on friday, because i guess at this point, why not. Continue to rule things out.
1 hour ago, guitarman01 said:Btw im also getting a thyroid ultrasound on friday, because i guess at this point, why not. Continue to rule things out.
You're doing well getting a ton of testing done, nice work!
I had another ultrasound last week on liver/gallbladder, but this showed no evidence of anything wrong. Another load of bloods as well, including bilirubin, AST, ALT - all within range, as per usual. In fact I've never had any bloods come back out of range, ever, although free T is always on the low side, and cortisol tends to be on the high side (DHT also borderline high).
At the moment just focusing on liver detox pathways via supplementation, based on my 23andme results, nice clear article here which is worth reading. Also hanging on for any further updates from Mario's research, obviously along the same lines, but good for suggesting areas to focus on.
https://www.modernherbalmedicine.com/articles/the-low-down-on-liver-detoxification-2.html?page=3
BTW, has anyone ever used 'Progesterone cream'?! I've read some PFS guys have recovered from using this, and in my case I have quite high DHT and cortisol, and this should in theory lower both. I've read people improving ED and libido and mental clarity with it's use. Can't find any 'tane suffers saying they've tried it before?
I have the MAO-A (rs6323) mutation. homozygousso high risk, and 'Nutrahacker' suggestsProgesterone for this defect. Anyone?
8 hours ago, cnb30 said:What is the best way to temporarily recover your libido? I'm honestly hopeless at this point and realize that NO aspect is ever going to permaneantly improve, but i'm sick of not having a libido. I don't care anymore how destructive it will be in the long term, honestly it feels like everything I do is destructive. I'm just looking for a temporary thing. An ED pill, or something similar.
Also, I should add that I'm looking into possibly an alternative medicine expert at a local grocery store. Do you guys have any advice? What should I mention. Are there any key things I should ask?
Brain inflammation = depression = anhedonia = loss of libido
Calming brain inflammation can seriously help reduce a lot of our symptoms I think.
26 minutes ago, Colinboko said:Brain inflammation = depression = anhedonia = loss of libidoCalming brain inflammation can seriously help reduce a lot of our symptoms I think.
Luckily the pain I used to have in my head that made it feel inflamed has subdued, but nothing seems to be improving.
@guitarman01@tanedout
FYI : Post on Phoenix Rising from 2014. A user called "tatt" discusses about an abnormal Fibroscan test but unfortunately does not say anything about the extent of the problem.
I am waiting for more results from other people, i will report back.
Just so that you know the ignorance of some doctors out there. I have attached a Fibroscan of a 31 year old female with CFS symptoms for more than 20 years.
The doctor said that she is fine and that she should forget anything about Liver Fibrosis. Upon further inspection take note of the 123% IQR. This should had been less than 30% and yet this doctor dismissed her, telling her to forget fibrosis.
10 hours ago, cnb30 said:11 hours ago, Colinboko said:Brain inflammation = depression = anhedonia = loss of libidoCalming brain inflammation can seriously help reduce a lot of our symptoms I think.
Luckily the pain I used to have in my head that made it feel inflamed has subdued, but nothing seems to be improving.
I don't think you necessarily have to "feel" inflamed to have inflammation. Heavy brain fog/depersonalization can be a symptom of inflammation. But for me I have had a constant pressure behind my eyes for a longggg time now. (Making me feel like I could just rip em out and feel better)
Besides inflammation I know I have blood flow issues - I haveterrible varicose veins for one!
Where to go next? Can you get tested for these two issues - don't know?
And even if you can I'm not sure it will pinpoint the cause even though I know it's from isotretinoin ingestion.
1 hour ago, TrueJustice said:Besides inflammation I know I have blood flow issues - I haveterrible varicose veins for one!
Where to go next? Can you get tested for these two issues - don't know?
And even if you can I'm not sure it will pinpoint the cause even though I know it's from isotretinoin ingestion.
Phlebitis is essentially inflammation of the veins.