Acne.org Products
1 hour ago, guitarman01 said:just got my amino acid blood test back. Normal.
Your Value Standard Range Taurine, Pl 49nmol/mL nmol/mL Reference range: 42 to 156 Threonine, Pl 84nmol/mL nmol/mL Reference range: 85 to 231 Serine, Pl 88nmol/mL nmol/mL Reference range: 63 to 187 Asparagine, Pl 34nmol/mL nmol/mL Reference range: 37 to 92 Glutamic Acid, Pl 49nmol/mL nmol/mL Reference range: 13 to 113 Glutamine, Pl 443nmol/mL nmol/mL Reference range: 371 to 957 Proline, Pl 148nmol/mL nmol/mL Reference range: 97 to 368 Glycine, Pl 238nmol/mL nmol/mL Reference range: 126 to 490 Alanine, Pl 260nmol/mL nmol/mL Reference range: 200 to 579 Citrulline, Pl 23nmol/mL nmol/mL Reference range: 17 to 46 Alpha-amino-n-butyric Acid, Pl 22nmol/mL nmol/mL Reference range: 9 to 37 Valine, Pl 275nmol/mL nmol/mL Reference range: 136 to 309 Cystine, Pl 30nmol/mL nmol/mL Reference range: 3 to 95 Methionine, Pl 20nmol/mL nmol/mL Reference range: 4 to 44 Isoleucine, Pl 62nmol/mL nmol/mL Reference range: 36 to 107 Leucine, Pl 111nmol/mL nmol/mL Reference range: 68 to 183 Tyrosine, Pl 47nmol/mL nmol/mL Reference range: 31 to 90 Phenylalanine, Pl 50nmol/mL nmol/mL Reference range: 35 to 80 b-Alanine, Pl 21nmol/mL nmol/mL Reference range: <29 Ornithine,Pl 36nmol/mL nmol/mL Reference range: 38 to 130 Lysine, Pl 149nmol/mL nmol/mL Reference range: 103 to 255 Histidine, Pl 70nmol/mL nmol/mL Reference range: 39 to 123 Arginine, Pl 46nmol/mL nmol/mL Reference range: 32 to 120 Allo-isoleucine, Pl 0nmol/mL nmol/mL Reference range: <5 Alpha-aminoadipic acid, Pl 1nmol/mL nmol/mL Reference range: <3 Phosphoserine, Pl 0nmol/mL nmol/mL Reference range: <18 Phosphoethanolamine, Pl <2nmol/mL nmol/mL Reference range: <12 Hydroxyproline, Pl 13nmol/mL nmol/mL Reference range: 4 to 29 Ethanolamine, Pl <7nmol/mL nmol/mL Reference range: <67 Sarcosine, Pl 3nmol/mL nmol/mL Reference range: <5 1-Methylhistidine, Pl 1nmol/mL nmol/mL Reference range: <28 3-Methylhistidine, Pl 4nmol/mL nmol/mL Reference range: 2 to 9 Argininosuccinic acid, Pl 0nmol/mL nmol/mL Reference range: <2 Carnosine, Pl 0nmol/mL nmol/mL Reference range: <1 Anserine, Pl 0nmol/mL nmol/mL Reference range: <1 Homocitrulline, Pl 0nmol/mL nmol/mL Reference range: <2 Gamma-amino-n-butyric acid, Pl 0nmol/mL nmol/mL Reference range: <2 Beta-aminoisobutyric acid, Pl 4nmol/mL nmol/mL Reference range: <5 Hydroxylysine, Pl 0nmol/mL nmol/mL Reference range: <2 Cystathionine, Pl <1nmol/mL nmol/mL Reference range: <5 Tryptophan, Pl 49nmol/mL nmol/mL Reference range: 29 to 77 Aspartic acid, Pl 4nmol/mL nmol/mL Reference range: <7 AAQ RESULT In this sample, the amino acid profile was essentially
normal.
-------------------ADDITIONAL INFORMATION-------------------
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
This test was developed and its performance characteristics
determined by Mayo Clinic in a manner consistent with CLIA
requirements. This test has not been cleared or approved by
the U.S. Food and Drug Administration.
Test Performed by:
Mayo Clinic Laboratories - Rochester Main Campus
200 First Street SW, Rochester, MN 55905
I'm kind of new to all this science stuff lol... what does this rule out?
Where have I been?
I've been busy having sex cause I don't suffer these types of sides.
I just looked into pfs- I'd forgotten some of you are into researching this, it's a rotten side effect I am sorry some you have to deal with this shit, I really am.
I guess for me it is chronic depression and fatigue that I drew.
my girlfriend also took tane - couldn't believe that when she first told me - she has no side effects, she's also astounded at the amount of supplements I have in the house....
but try try telling someone/anyone who doesn't suffer and they just don't comprehend it.
2 hours ago, Colinboko said:I'm kind of new to all this science stuff lol... what does this rule out?
I was more so trying to find something to rule in. thought this might be a good test no one has looked at. Also includes looking into some possible methylation issues. Mainly was looking at anything abnormal going on with protein absorption that could result in some kind of muscle wasting .
This is the description for this test:
May aid in evaluation of endocrine disorders, liver diseases, muscle diseases, neoplastic diseases, neurological disorders, nutritional disturbances, renal failure, and burns
actually this result just got updated. My doctor must have just looked at it. I didnt look to closely but I guess a few proteins were slightly below normal. she wrote this.
Okay to inform pt he has low threonine, asparagine, and ornithine. Pt may obtain ammino acid supplementation at natural health food store. Take one tablet daily for four weeks. Pt may recheck amino acid levels in 4 weeks.
This overall seems like a non-issue though.
6 hours ago, guitarman01 said:http://apps.weber.edu/wsuimages/DCHPResearch/mls_2015_16_projects/Posters/Research_poster_Intrinsic_factor_Isotertinoin_16.pdf&ved=0ahUKEwji_8OH8fTTAhUBKiwKHRPgALEQFggcMAA&usg=AFQjCNFbthov91T2SNL6VQWtEQENELU7ng&sig2=TNnzqMwoc8GHqVd2iK566 Q" rel="external nofollow" style="text-decoration:none;font-weight:inherit;font-family:'Roboto-Regular', HelveticaNeue, Arial, sans-serif;padding:13px 16px 33px;line-height:20px">INTRINSIC FACTOR INHIBITION DUE TO USE OF ISOTRETINOIN
Weber State University apps PostersIsotretinoin (Accutane) is a therapeutic drug used for the treatment and prevention of severe acne. A previous study done on the effects of isotretinoin concluded that patients taking isotretinoin showed a significantly prolonged activated partial thromboplastin time (aPTT). aPTT is a timed, clinical test to detect abnormalities in the intrinsic pathway of the coagulation cascade. An irregular or prolonged aPTT indicates at least one factor deficiency or inhibition in the intrinsic pathway
Well hell, here's this test right here for only 29 bucks. im getting this tomorrow. So many people have complained of bleeding gums post tane.
ProthrombinTime (PT) w/INR and Partial Thromboplastin Time (PTT) Blood Tests
The prothrombin time (PT) w/INR test measures the length of time it takes for a blood clot to form in a sample of blood. Partial Thromboplastin Time (PTT) test is ordered when someone has unexplained bleeding or clotting. The PTT test is usually used as a starting place when investigating the cause of a bleeding or thrombotic episode.
https://www.walkinlab.com/blood-disorder-tests/prothrombintime-pt-winrandpartialthrombopla.html
The PT and PTT Blood Tests are useful in the diagnosis of excessive, unexplained bleeding in patients who are not taking blood-thinning medications. These bleeding disorders include conditions such as nosebleeds, bruising, heavy menstrual periods, blood in the stool and/or urine, and bleeding gums, among others. The tests are also sometimes ordered for patients prior to surgery to ensure normal clotting ability.
On 5/11/2017 at 6:53 PM, guitarman01 said:
(1)-page-001.jpg.44c9f5852f8f966ea0377eb4fe0a0174.jpg)
actually going back and looking at this again the presence of TPO antibodies could mean something, and it might not even be exclusive to the thyroid.
Additional Information
Antibodies to thyroid microsomes (thyroid peroxidase) are present in 70% to 90% of patients with chronic thyroiditis. They are also present in smaller percentages of patients of other thyroid diseases. Antibody production may be confined to lymphocytes within the thyroid, and serum may be negative. Small numbers (3%) of people with no evidence of disease may have antibody.
Values >9.0 IU/mL generally are associated with autoimmune thyroiditis, but elevations are also seen in other autoimmune diseases.
Moderately increased levels of thyroperoxidase (TPO) antibodies may be found in patients with nonthyroid autoimmune disease such as pernicious anemia, type I diabetes, or other disorders that activate the immune system.
20 hours ago, tanedout said:Yeah did ask about tests for bile acid related stuff, but there aren't any available on the NHS. Interestingly I mentioned about my 23andme results showing some defective genes regards to bile acid synthesis and my doctor didn't even know what 23andme was which surprised me a little! I'm getting an ultrasound on liver/gallbladder and a shed load of bloods, thyroid panel, liver enzymes etc. Expect all these to come back within range, as per usual!@mariovitaliyou mentioned my 23andme had a number of SNP's regards problems metabolising bile acids - I know one isATP8B1rs10503019, any chance you would be able to let me know the others which are common as I want to be ready with this when I see the doctor again.
Regarding cortisol that someone was mentioning could be low - mine has always come back within range, but at the high end of the range.
@tanedout
The worse one i believe is CYP7A1 - rs8192877, Risk is G . Do you have high Cholesterol by the way?
All these Isotretinoin test/results various peple are posting currently were conducted by Roche right??
I mean with all the adverse reactions people have with Accutane, they really want to help us get to the bottom of what's wrong correct!!?
They're working around the clock to resolve this mess right....
8 hours ago, mariovitali said:@tanedout
The worse one i believe is CYP7A1 - rs8192877, Risk is G . Do you have high Cholesterol by the way?
What is G?
32 minutes ago, Chris16 said:8 hours ago, mariovitali said:@tanedout
The worse one i believe is CYP7A1 - rs8192877, Risk is G . Do you have high Cholesterol by the way?What is G?
It is the Minor Allele letter
12 hours ago, guitarman01 said:actually going back and looking at this again the presence of TPO antibodies could mean something, and it might not even be exclusive to the thyroid.Additional Information
Antibodies to thyroid microsomes (thyroid peroxidase) are present in 70% to 90% of patients with chronic thyroiditis. They are also present in smaller percentages of patients of other thyroid diseases. Antibody production may be confined to lymphocytes within the thyroid, and serum may be negative. Small numbers (3%) of people with no evidence of disease may have antibody.
Values >9.0 IU/mL generally are associated with autoimmune thyroiditis, but elevations are also seen in other autoimmune diseases.
Moderately increased levels of thyroperoxidase (TPO) antibodies may be found in patients with nonthyroid autoimmune disease such as pernicious anemia, type I diabetes, or other disorders that activate the immune system.
I really think we're onto something as far autoimmune diseases are concerned. SEVERAL people have ended up with Lupus from isotretinoin. Even if it's not lupus for every individual on here, I believe systemic inflammation is the biggest cause of our problems...
i was out in the sun for literally 20 minutes the other day and started to get really red. Photosensitivity is definitely an immune system reaction. And not to mention me not catching a common cold/stomach bug. There's just way too much evidence for me at least. I really need to get a hold of some prednisone, even for experimental purposes because if I feel better on it, then I know there's an inflammation problem.
I truly don't think accutane is in our systems anymore because bloody noses, incredibly dry lips and dry skin definitely stopped for me weeks after cessation of the drug. I think it has altered the immune system in some way to always be switched "on" and to stay "on". Call me crazy but at least for my personal symptoms, that's the only answer I can seem to give myself. My biggest clue should've been when I realized I stopped catching common colds that I would most DEFINITELY catch before tane.
Also for those of us who have weird/random hair growth... instead of this being hormonal, it could VERY well be our immune systems... Hair is one of the first lines of defense.. so although our body is attacking our hair follicles (head and body wide) causing it to fall out, we still get little random hair growth because our response is always turned on.
I mean excessive nose hairs... I'm 21.... I wouldn't be getting those yet. Nose hair is one of the first lines of defense for pathogens in the nasopharynx region... overactive immune system = overactive nose hair growth...
idk maybe not. But I just find it really interesting.
20 hours ago, TrueJustice said:Where have I been?
I've been busy having sex cause I don't suffer these types of sides.I just looked into pfs- I'd forgotten some of you are into researching this, it's a rotten side effect I am sorry some you have to deal with this shit, I really am.
I guess for me it is chronic depression and fatigue that I drew.
my girlfriend also took tane - couldn't believe that when she first told me - she has no side effects, she's also astounded at the amount of supplements I have in the house....but try try telling someone/anyone who doesn't suffer and they just don't comprehend it.
Totally inappropriate comment!
2 minutes ago, hatetane said:20 hours ago, TrueJustice said:Where have I been?
I've been busy having sex cause I don't suffer these types of sides.I just looked into pfs- I'd forgotten some of you are into researching this, it's a rotten side effect I am sorry some you have to deal with this shit, I really am.
I guess for me it is chronic depression and fatigue that I drew.
my girlfriend also took tane - couldn't believe that when she first told me - she has no side effects, she's also astounded at the amount of supplements I have in the house....but try try telling someone/anyone who doesn't suffer and they just don't comprehend it.
Totally inappropriate comment!
TrueJustice hasn't helped this thread out in any way. Should be banned in my opinion.
2 hours ago, hatetane said:23 hours ago, TrueJustice said:Where have I been?
I've been busy having sex cause I don't suffer these types of sides.I just looked into pfs- I'd forgotten some of you are into researching this, it's a rotten side effect I am sorry some you have to deal with this shit, I really am.
I guess for me it is chronic depression and fatigue that I drew.
my girlfriend also took tane - couldn't believe that when she first told me - she has no side effects, she's also astounded at the amount of supplements I have in the house....but try try telling someone/anyone who doesn't suffer and they just don't comprehend it.
Totally inappropriate comment!
Sorry but I was kinda offended by being asked "where have I been?"
like its so easy keeping up to date with the 5000 possibilities currently circulating on curing side effects, to say it's a mine field is an understatement.
Id forgotten about clomid.
I apologise Hatetane, it was a bad comment.
Hi,
Wanted to sign up for this site to post about my accutane experience. I wrote a big long thing about it and came to register but then realized I already had an account that I'd totally forgot about and apparently posted a somewhat similar account of my drug experience 5 years ago. Damnit! Well, new things have cropped up in the past five years and I spent a while on this and want to post it anyway. I'd be very thankful if anyone actually reads through it and has any advice. Thanks. 
As an 18 year old in the year 2000 who suffered from moderate acne I was excited about getting on the drug and finally ending my horrible acne affliction. Things were fine at the beginning but I soon lowered my dose on my own because the skin and lip dryness was insane. I think my doctor had prescribed something along the lines of alternating between 80mg and 40mg each day. I think I ended up taking 40mg every other day to give myself some breathing room from the drug. I still wonder what would have happened if I'd stuck to the original dosage my doctor had prescribed. I'd probably be worse off. I think he's dead now.
I was about a month or so into my course when my heart sank at the sight of some hairloss at the corners of my hairline. That's also when I first noticed a thick, whiteish sludge of sebum on my scalp that I'd never had before. As my hairline receded, something else happened: all the hair on my head began to slowly miniaturize. I used to have very, very thick hair but now it was see-through. My head looked like a mountain in winter, when all the leaves have fallen off the trees and you can see right through to the ground. This drove me kinda nuts and I angrily shaved my head bald. That's when I realized the extent of the sebum on my scalp - it was insane. I would drag my nails across my scalp every day and scrape up huge amounts of the stuff.
Shaving my head may have not been the best idea though, because it triggered one more horrible situation: folliculitis. Not only was my hair now see-through, but I was starting to develop a severe case of folliculitis that was now easily visible! Hats became my friend and unfortunately have been my friend for 17 years. I'm the weird hat guy at all the parties.
Anyway, the folliculitis got really bad and I stupidly agreed with my derm to go on minocycline. I didn't last long on the antibiotic because it gave me horrible dry eyes. Any winter wind would make me look like I was crying. While I kind of hate having dry eyes and still have them, they weren't my worst side and I only saw one optometrist about it a very long time ago. I vaguely remember him claiming I had oily eyes or something. I don't know. After quitting cold turkey the folliculitis came back worse, obviously. The answer? Stupidly agree to go on Doxycycline. Doxycycline took two weeks to give me permanent eye floaters so I dropped it cold turkey too. I still remember the day after quitting. It was about 4 in the afternoon when I could feel the first hints of the folliculitis storm coming. I actually felt feverish. The folliculitis hit me the hardest it ever has and my scalp basically turned into one giant scab. I couldn't sleep it hurt so bad. I'm pretty sure my derm is dead.
My derm then prescribed me topical clindamycin to attack it. I basically soaked my scalp in the stuff, so of course it got into my system. It didn't take too long before it gave me jaundice and I stopped. I then went on Tetracycline which I'd taken previous to Accutane but it eventually gave me jaundice, too. I resorted to giving up on antibiotics and after a while the folliculitis did calm slightly. I was also using a shampoo called Sebulex which really helped. Of course it's now discontinued because life is unfair. He's definitely dead because he was super old and this was all 17 years ago.
Anyway, I finally ended up doing a ton of research in 2006 and began to realize intestinal permeability and food allergies were the culprit behind my aggressive folliculitis. By cutting out dairy, excess sugar, and wheat, while taking supplements like L-Glutamine, I was able to really keep my scalp clear. Unfortunately I had to stop the L-Glutamine after I upped my dose one night and woke up the next morning with Multiple Sclerosis type symptoms. Terrible balance, speech stuttering and involuntary muscle spasms that lasted a year. So... I may have MS since L-Glutamine is something that would be very bad for someone with MS to take.
In 2007 I took a stool analysis test that showed bizarre fat malabsorption. The presence of fat in my stool was highly elevated and my triglycerides were literally off the chart.
Despite the knowledge of malabsorption I didn't really do anything about it. I kind of got wrapped up in work and since I'd healed my gut a little I kind of forgot about it all - though I still had the dry eyes, floaters, and hairloss. My sebulex shampoo was working quite well controlling the crazy dandruff I now had. Although I did have, and still do, an annoying amount of seborrheic dematitis around my nose and in my beard area.
Fast forward to the past couple of years where I started experiencing GERD and IBS. My stomach would make the most insane gurgling sounds when I'd drink a can of coke. My stool changed. It started to become looser and looser until one day I saw a bit of blood and freaked out a little. Despite my concern I really procrastined in getting it checked out. I'd also moved to a new province (I'm in Canada) and didn't have a health card so it took a long time to see a doctor and by then my stool was mostly blood and mucus. I had to start wearing extra pairs of underwear to bed in case of accidents. 😡
I got a colonoscopy done last month and was diagnosed with Colitis. Doctors aren't sure if it's Ulcerative Colitis or Crohn's. I was prescribed Mesalamine but stopped due to fear of side effects. I'm prone to permanent sides and at this point rarely risk adding to my collection. I've managed to normalize my bowel movements relatively well without the drug via diet and supplements. No more blood and my bowel movements are sort of formed. Just not quite what they used to be. Although I still often get stool that is pale and floats on the surface.
This whole colon thing was a real nuisance, but something else has cropped up in the past month: acne. 
I mean, I still had some acne over the years since Accutane but it was never that hard to control. But something happened about a month and a half ago that made it much worse. I don't really get regular pimples but mostly whiteheads around my nose and at the edges of my lips. I'll wake up with 8 new tiny whiteheads each morning. I also recently had an instance of deep cystic acne all around my chin and jawline. The only thing I can think of that happened a month and a half ago is I very stupidly drank vodka like 5 days in a row. I've never done that before and it's a long story. Actually the past couple years where my bowels have gone down hill correlate with when I started drinking more. Most of the past 17 years I drank about 3 times a year but in the past 2 years or so I started drinking at least once a week. Hmmm.
So now I'm wondering if my recent drinking impaired my liver more than it already was. While on accutane I never got my liver enzymes tested. Then there's all that jaundice I got and the fat malabsorption. Feels like my bile isn't flowing.
Also, in the past week I've been closely monitoring my skin and how it reacts to what I eat and I've noticed a clear correlation with eating fruit and the acne, particularly apples. Then I read about fructose malabsorption and FODMAPS. I realized on those nights I ate apple for dessert I had a tendency to eat a bunch of onion rings with my dinner - a big nono for the FODMAPS diet. These symptoms seem to also point to a liver problem.
Anyway, if anyone has similar symptoms and has found something that helps them I'd be glad to hear about it.
Oh and something else interesting: the craziest affect a supplement has ever had on me was Betaine HCL. People love the stuff but I tried it and my folliculitis went nuts. Basically turned me into a scab again. It was super dramatic. My only theories have been it either killed off bacteria growing in my stomach / small intestine and it was "die off" I was experiencing (although why don't antibiotics cause die off?) or my stomach acid has been burning my duodenum due to a lack of bile to neutralize it. And by increasing my stomach acidity I burned myself worse than usual. I especially know my folliculitis is tied to intestinal mucosal wall integrity because it's on a permanent cycle where it gets worse and better like clockwork that seems to match the cycle of intestinal wall replacement that happens every 4 days or so.
18 minutes ago, Recreant said:Hi,
Wanted to sign up for this site to post about my accutane experience. I wrote a big long thing about it and came to register but then realized I already had an account that I'd totally forgot about and apparently posted a somewhat similar account of my drug experience 5 years ago. Damnit! Well, new things have cropped up in the past five years and I spent a while on this and want to post it anyway. I'd be very thankful if anyone actually reads through it and has any advice. Thanks.
As an 18 year old in the year 2000 who suffered from moderate acne I was excited about getting on the drug and finally ending my horrible acne affliction. Things were fine at the beginning but I soon lowered my dose on my own because the skin and lip dryness was insane. I think my doctor had prescribed something along the lines of alternating between 80mg and 40mg each day. I think I ended up taking 40mg every other day to give myself some breathing room from the drug. I still wonder what would have happened if I'd stuck to the original dosage my doctor had prescribed. I'd probably be worse off. I think he's dead now.
I was about a month or so into my course when my heart sank at the sight of some hairloss at the corners of my hairline. That's also when I first noticed a thick, whiteish sludge of sebum on my scalp that I'd never had before. As my hairline receded, something else happened: all the hair on my head began to slowly miniaturize. I used to have very, very thick hair but now it was see-through. My head looked like a mountain in winter, when all the leaves have fallen off the trees and you can see right through to the ground. This drove me kinda nuts and I angrily shaved my head bald. That's when I realized the extent of the sebum on my scalp - it was insane. I would drag my nails across my scalp every day and scrape up huge amounts of the stuff.
Shaving my head may have not been the best idea though, because it triggered one more horrible situation: folliculitis. Not only was my hair now see-through, but I was starting to develop a severe case of folliculitis that was now easily visible! Hats became my friend and unfortunately have been my friend for 17 years. I'm the weird hat guy at all the parties.
Anyway, the folliculitis got really bad and I stupidly agreed with my derm to go on minocycline. I didn't last long on the antibiotic because it gave me horrible dry eyes. Any winter wind would make me look like I was crying. While I kind of hate having dry eyes and still have them, they weren't my worst side and I only saw one optometrist about it a very long time ago. I vaguely remember him claiming I had oily eyes or something. I don't know. After quitting cold turkey the folliculitis came back worse, obviously. The answer? Stupidly agree to go on Doxycycline. Doxycycline took two weeks to give me permanent eye floaters so I dropped it cold turkey too. I still remember the day after quitting. It was about 4 in the afternoon when I could feel the first hints of the folliculitis storm coming. I actually felt feverish. The folliculitis hit me the hardest it ever has and my scalp basically turned into one giant scab. I couldn't sleep it hurt so bad. I'm pretty sure my derm is dead.
My derm then prescribed me topical clindamycin to attack it. I basically soaked my scalp in the stuff, so of course it got into my system. It didn't take too long before it gave me jaundice and I stopped. I then went on Tetracycline which I'd taken previous to Accutane but it eventually gave me jaundice, too. I resorted to giving up on antibiotics and after a while the folliculitis did calm slightly. I was also using a shampoo called Sebulex which really helped. Of course it's now discontinued because life is unfair. He's definitely dead because he was super old and this was all 17 years ago.
Anyway, I finally ended up doing a ton of research in 2006 and began to realize intestinal permeability and food allergies were the culprit behind my aggressive folliculitis. By cutting out dairy, excess sugar, and wheat, while taking supplements like L-Glutamine, I was able to really keep my scalp clear. Unfortunately I had to stop the L-Glutamine after I upped my dose one night and woke up the next morning with Multiple Sclerosis type symptoms. Terrible balance, speech stuttering and involuntary muscle spasms that lasted a year. So... I may have MS since L-Glutamine is something that would be very bad for someone with MS to take.
In 2007 I took a stool analysis test that showed bizarre fat malabsorption. The presence of fat in my stool was highly elevated and my triglycerides were literally off the chart.
Despite the knowledge of malabsorption I didn't really do anything about it. I kind of got wrapped up in work and since I'd healed my gut a little I kind of forgot about it all - though I still had the dry eyes, floaters, and hairloss. My sebulex shampoo was working quite well controlling the crazy dandruff I now had. Although I did have, and still do, an annoying amount of seborrheic dematitis around my nose and in my beard area.
Fast forward to the past couple of years where I started experiencing GERD and IBS. My stomach would make the most insane gurgling sounds when I'd drink a can of coke. My stool changed. It started to become looser and looser until one day I saw a bit of blood and freaked out a little. Despite my concern I really procrastined in getting it checked out. I'd also moved to a new province (I'm in Canada) and didn't have a health card so it took a long time to see a doctor and by then my stool was mostly blood and mucus. I had to start wearing extra pairs of underwear to bed in case of accidents. 😡I got a colonoscopy done last month and was diagnosed with Colitis. Doctors aren't sure if it's Ulcerative Colitis or Crohn's. I was prescribed Mesalamine but stopped due to fear of side effects. I'm prone to permanent sides and at this point rarely risk adding to my collection. I've managed to normalize my bowel movements relatively well without the drug via diet and supplements. No more blood and my bowel movements are sort of formed. Just not quite what they used to be. Although I still often get stool that is pale and floats on the surface.
This whole colon thing was a real nuisance, but something else has cropped up in the past month: acne.
So now I'm wondering if my recent drinking impaired my liver more than it already was. While on accutane I never got my liver enzymes tested. Then there's all that jaundice I got and the fat malabsorption. Feels like my bile isn't flowing.
Also, in the past week I've been closely monitoring my skin and how it reacts to what I eat and I've noticed a clear correlation with eating fruit and the acne, particularly apples. Then I read about fructose malabsorption and FODMAPS. I realized on those nights I ate apple for dessert I had a tendency to eat a bunch of onion rings with my dinner - a big nono for the FODMAPS diet. These symptoms seem to also point to a liver problem.
Anyway, if anyone has similar symptoms and has found something that helps them I'd be glad to hear about it.Oh and something else interesting: the craziest affect a supplement has ever had on me was Betaine HCL. People love the stuff but I tried it and my folliculitis went nuts. Basically turned me into a scab again. It was super dramatic. My only theories have been it either killed off bacteria growing in my stomach / small intestine and it was "die off" I was experiencing (although why don't antibiotics cause die off?) or my stomach acid has been burning my duodenum due to a lack of bile to neutralize it. And by increasing my stomach acidity I burned myself worse than usual. I especially know my folliculitis is tied to intestinal mucosal wall integrity because it's on a permanent cycle where it gets worse and better like clockwork that seems to match the cycle of intestinal wall replacement that happens every 4 days or so.
Have you been tested for any autoimmune issues? Folliculitis is inflammation of the hair follicles...
Could explain your hairloss and bowel issues...
Is a drug used to treat acne making teens suicidal?
Roaccutane, a drug commonly used to treat the skin problem, has been linked to depression and suicidal thoughts
.
Interesting read right here...
https://chriskresser.com/is-depression-a-disease-or-a-symptom-of-inflammation/
Could really be be onto something.
I mean how many people have even experimented with prednisone? Elohel? That's one. And he was back to his normal self almost instantly. And then maybe one other dude tried hydrocortisone a while back. If you've tried prednisone and it didn't do anything for you please speak up. But I really think we are dealing with full on systemic inflammation.
This blood clotting test I mentioned was absolutely normal.
PT and PTT INR 1.0 0.8 - 1.2
Reference interval is for non-anticoagulated patients. Suggested INR therapeutic range for Vitamin K antagonist therapy: Standard Dose (moderate intensity therapeutic range): 2.0 - 3.0 Higher intensity therapeutic range 2.5 - 3.5
Prothrombin Time 10.7 sec 9.1 - 12.0
aPTT 30 sec 24 - 33
One of the last b12 tests I had. As you can see its sitting pretty low on the scale.
Autoimmune diseases have shown to have some things in common, such as thyroid antibodies,
parietal cell antibodiesand intrinsic factor antibodies.
intrinsic factor antibodies can give a false normal b12 serum reading.
Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing.
https://www.ncbi.nlm.nih.gov/pubmed/15466926
It is concluded that Cbl, MMA, and HCys levels fluctuate with time and neither predict nor preclude the presence of Cbl-responsive hematologic or neurologic disorders.
Autoimmuneatrophicgastritisis a chronic inflammatory disease in which the immune system mistakenly destroys a special type of cell (parietal cells) in the stomach. Parietal cells make stomach acid (gastric acid) and a substance our body needs to help absorb vitamin B12(called intrinsic factor).
This could be wrong though. Just like that last poster was saying, especially if he had a bad reaction to betaine hcl, there is also this.
Bile. After thestomach, food travels to the small intestine. The enzymes in the small intestine work best in alkaline conditions, but the food is acidic after being in thestomach. A substance calledbileneutralises theacidto provide the alkaline conditions needed in the small intestine.
18 hours ago, Recreant said:Hi,
Wanted to sign up for this site to post about my accutane experience. I wrote a big long thing about it and came to register but then realized I already had an account that I'd totally forgot about and apparently posted a somewhat similar account of my drug experience 5 years ago. Damnit! Well, new things have cropped up in the past five years and I spent a while on this and want to post it anyway. I'd be very thankful if anyone actually reads through it and has any advice. Thanks.
As an 18 year old in the year 2000 who suffered from moderate acne I was excited about getting on the drug and finally ending my horrible acne affliction. Things were fine at the beginning but I soon lowered my dose on my own because the skin and lip dryness was insane. I think my doctor had prescribed something along the lines of alternating between 80mg and 40mg each day. I think I ended up taking 40mg every other day to give myself some breathing room from the drug. I still wonder what would have happened if I'd stuck to the original dosage my doctor had prescribed. I'd probably be worse off. I think he's dead now.
I was about a month or so into my course when my heart sank at the sight of some hairloss at the corners of my hairline. That's also when I first noticed a thick, whiteish sludge of sebum on my scalp that I'd never had before. As my hairline receded, something else happened: all the hair on my head began to slowly miniaturize. I used to have very, very thick hair but now it was see-through. My head looked like a mountain in winter, when all the leaves have fallen off the trees and you can see right through to the ground. This drove me kinda nuts and I angrily shaved my head bald. That's when I realized the extent of the sebum on my scalp - it was insane. I would drag my nails across my scalp every day and scrape up huge amounts of the stuff.
Shaving my head may have not been the best idea though, because it triggered one more horrible situation: folliculitis. Not only was my hair now see-through, but I was starting to develop a severe case of folliculitis that was now easily visible! Hats became my friend and unfortunately have been my friend for 17 years. I'm the weird hat guy at all the parties.
Anyway, the folliculitis got really bad and I stupidly agreed with my derm to go on minocycline. I didn't last long on the antibiotic because it gave me horrible dry eyes. Any winter wind would make me look like I was crying. While I kind of hate having dry eyes and still have them, they weren't my worst side and I only saw one optometrist about it a very long time ago. I vaguely remember him claiming I had oily eyes or something. I don't know. After quitting cold turkey the folliculitis came back worse, obviously. The answer? Stupidly agree to go on Doxycycline. Doxycycline took two weeks to give me permanent eye floaters so I dropped it cold turkey too. I still remember the day after quitting. It was about 4 in the afternoon when I could feel the first hints of the folliculitis storm coming. I actually felt feverish. The folliculitis hit me the hardest it ever has and my scalp basically turned into one giant scab. I couldn't sleep it hurt so bad. I'm pretty sure my derm is dead.
My derm then prescribed me topical clindamycin to attack it. I basically soaked my scalp in the stuff, so of course it got into my system. It didn't take too long before it gave me jaundice and I stopped. I then went on Tetracycline which I'd taken previous to Accutane but it eventually gave me jaundice, too. I resorted to giving up on antibiotics and after a while the folliculitis did calm slightly. I was also using a shampoo called Sebulex which really helped. Of course it's now discontinued because life is unfair. He's definitely dead because he was super old and this was all 17 years ago.
Anyway, I finally ended up doing a ton of research in 2006 and began to realize intestinal permeability and food allergies were the culprit behind my aggressive folliculitis. By cutting out dairy, excess sugar, and wheat, while taking supplements like L-Glutamine, I was able to really keep my scalp clear. Unfortunately I had to stop the L-Glutamine after I upped my dose one night and woke up the next morning with Multiple Sclerosis type symptoms. Terrible balance, speech stuttering and involuntary muscle spasms that lasted a year. So... I may have MS since L-Glutamine is something that would be very bad for someone with MS to take.
In 2007 I took a stool analysis test that showed bizarre fat malabsorption. The presence of fat in my stool was highly elevated and my triglycerides were literally off the chart.
Despite the knowledge of malabsorption I didn't really do anything about it. I kind of got wrapped up in work and since I'd healed my gut a little I kind of forgot about it all - though I still had the dry eyes, floaters, and hairloss. My sebulex shampoo was working quite well controlling the crazy dandruff I now had. Although I did have, and still do, an annoying amount of seborrheic dematitis around my nose and in my beard area.
Fast forward to the past couple of years where I started experiencing GERD and IBS. My stomach would make the most insane gurgling sounds when I'd drink a can of coke. My stool changed. It started to become looser and looser until one day I saw a bit of blood and freaked out a little. Despite my concern I really procrastined in getting it checked out. I'd also moved to a new province (I'm in Canada) and didn't have a health card so it took a long time to see a doctor and by then my stool was mostly blood and mucus. I had to start wearing extra pairs of underwear to bed in case of accidents. 😡I got a colonoscopy done last month and was diagnosed with Colitis. Doctors aren't sure if it's Ulcerative Colitis or Crohn's. I was prescribed Mesalamine but stopped due to fear of side effects. I'm prone to permanent sides and at this point rarely risk adding to my collection. I've managed to normalize my bowel movements relatively well without the drug via diet and supplements. No more blood and my bowel movements are sort of formed. Just not quite what they used to be. Although I still often get stool that is pale and floats on the surface.
This whole colon thing was a real nuisance, but something else has cropped up in the past month: acne.
So now I'm wondering if my recent drinking impaired my liver more than it already was. While on accutane I never got my liver enzymes tested. Then there's all that jaundice I got and the fat malabsorption. Feels like my bile isn't flowing.
Also, in the past week I've been closely monitoring my skin and how it reacts to what I eat and I've noticed a clear correlation with eating fruit and the acne, particularly apples. Then I read about fructose malabsorption and FODMAPS. I realized on those nights I ate apple for dessert I had a tendency to eat a bunch of onion rings with my dinner - a big nono for the FODMAPS diet. These symptoms seem to also point to a liver problem.
Anyway, if anyone has similar symptoms and has found something that helps them I'd be glad to hear about it.Oh and something else interesting: the craziest affect a supplement has ever had on me was Betaine HCL. People love the stuff but I tried it and my folliculitis went nuts. Basically turned me into a scab again. It was super dramatic. My only theories have been it either killed off bacteria growing in my stomach / small intestine and it was "die off" I was experiencing (although why don't antibiotics cause die off?) or my stomach acid has been burning my duodenum due to a lack of bile to neutralize it. And by increasing my stomach acidity I burned myself worse than usual. I especially know my folliculitis is tied to intestinal mucosal wall integrity because it's on a permanent cycle where it gets worse and better like clockwork that seems to match the cycle of intestinal wall replacement that happens every 4 days or so.
You should read up on LDN and opt. your doctor(s) for trying it out. The symptoms which you describe in terms of your bowel and liver health is things that LDN specifically helps out with. In my opinion you are a prime candidate. Get on it as soon as possible.
For the folliculitis and acne try out a carb free paleo diet (ketogenic paleo) for a week and see if it helps you out.
Right here . I have a mutation.
| GIF | rs35211634 | 59612859 | C or T | C / T |
| Risk | rs35211634(C;C) |
|---|---|
| Alt | rs35211634(C;C) |
| Reference | rs35211634(T;T) |
| Significance | Other |
| Disease | Intrinsic factor deficiency |
| Variation | info |
| Gene | GIF |
| CLNDBN | Intrinsic factor deficiency, congenital, susceptibility to |
| Reversed | 0 |
| HGVS | NC_000011.9:g.59612859T>C |
| CLNSRC | OMIM Allelic VariantUniProtKB (protein) |
| CLNACC | RCV000001812.2, |
Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients.
Abstract
Introduction. Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment.
Lack ofintrinsic factoris most commonly due to anautoimmuneattack on the cells that make it in the stomach.