http://www.sciencedirect.com/science/article/pii/S0022347687801099

http://www.sciencedirect.com/science/article/pii/0002934386907266

http://www.sciencedirect.com/science/article/pii/S0022347652800587

Idk if this is long term vitamin a toxicity. Strictly vitamin a toxicity doesn't cause all these effects.

Looking at cerebral atrophy for example, I don't see any relation to vitamin a.
But simply looking at other nutrients from what I ve looked into so far, vitamin B6, vitamin B12, zinc deficiency and copper toxicity are capable of inducing cerebral atrophy. I've seen a exact case where B6 deficiency also caused thinning of the corpus callous. I've seen reversible atrophy with zinc deficiency. But I've seen nothing related to vitamin a so far.

I don't think it's an ongoing toxicity issue like you are thinking. this is why the effects are seemingly permanent. Rather, like many have mentioned here before it may be a receptor issue. For instance, in the case involving the 16 year old Indian boy who lost his night vision completely after 7 daysof isotretinoin treatment, doctors protocol was to stop treatment, and begin supplementing with Vitamin A retinal for a monthheven if Vitamin A serum tests indicated normal levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533586/

Another article here for those with permanent impaired night vision like me and insomnia and sleep disorders (day night reversal, insomnia) Melatonin may be a good supplement we should try.

https://www.ncbi.nlm.nih.gov/pubmed/17512125

deleted

This didnt copy and paste correctly(but its still in order) but definitely check out the source pdf. Now if a dermatologist was like this is how accutane might work in erasing your acne forever and showed you these gene changes, Most  rational people would definitely think more then twice. id be thinking (now anyways), thats really fucked up. because it is. This is where you maybe get in touch with a genealogist that could possibly look into this. This is where a massive lawsuit might be hiding. 
https://etda.libraries.psu.edu/files/final_submissions/284
Just a couple things i noticed that might pertain to myself at least, Zinc transporter protein affected.
possible SOD2 mutation.
and a whole lot more.
This is also what might floor any doctor if you were to show them this and they might take you alot more seriously.

All significantly changed genes after 8 weeks isotretinoin therapy
Some genes may be listed twice; indicates separate probe sets on Affymetrix gene array chips.
Fold
Change Gene Title Gene Symbol
2.54 microseminoprotein, beta- MSMB
2.03 microseminoprotein, beta- MSMB
2.00 kraken-like dJ222E13.1
1.98 --- ---
1.85 coagulation factor C homolog, cochlin (Limulus polyphemus) COCH
1.77
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte
protein of 76kDa) LCP2
1.73 fibulin 1 FBLN1
1.71 hypothetical protein MGC27165 MGC27165
1.68 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 CHST6
1.67 KIAA0527 protein KIAA0527
1.67 fibulin 1 FBLN1
1.66 collagen, type VI, alpha 2 COL6A2
1.64 collagen, type V, alpha 1 COL5A1
1.63 SAM domain, SH3 domain and nuclear localisation signals, 1 SAMSN1
1.63 filamin A, alpha (actin binding protein 280) FLNA
1.62 butyrophilin, subfamily 3, member A3 BTN3A3
1.61 collagen, type V, alpha 1 COL5A1
1.61 protein phosphatase 1, regulatory (inhibitor) subunit 16B PPP1R16B
1.60 tryptase beta 2 TPSB2
1.60 insulin-like growth factor binding protein 4 IGFBP4
1.60 microfibrillar-associated protein 2 MFAP2
1.59 tryptase beta 2 TPSB2
1.59 tryptase beta 2 TPSB2
1.57 --- ---
1.57 slit homolog 3 (Drosophila) SLIT3
1.56 Rho-related BTB domain containing 3 RHOBTB3
1.56 insulin-like growth factor binding protein 5 IGFBP5
1.56 microfibrillar-associated protein 4 MFAP4
1.56 tryptase beta 2 TPSB2
1.55 collagen, type VI, alpha 2 COL6A2
1.55 collagen, type IV, alpha 2 COL4A2
1.55 fibulin 1 FBLN1
1.54 natural killer cell transcript 4 NK4
1.54 hematopoietic cell-specific Lyn substrate 1 HCLS1
1.53 tenascin N TNN
162
1.53 fibronectin 1 /// fibronectin 1 FN1
1.53 collagen, type VI, alpha 1 COL6A1
1.53 protease, serine, 11 (IGF binding) PRSS11
1.52 collagen, type V, alpha 2 COL5A2
1.52 procollagen C-endopeptidase enhancer PCOLCE
1.51 protein tyrosine phosphatase, receptor type, C PTPRC
1.51
integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated
antigen 1; macrophage antigen 1 (mac-1) beta subunit) ITGB2
1.51 collagen, type V, alpha 1 COL5A1
1.51 laminin, alpha 2 (merosin, congenital muscular dystrophy) LAMA2
1.51 tryptase beta 2 TPSB2
1.50 tryptase beta 2 TPSB2
1.50
matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa
type IV collagenase) MMP2
1.49 FLJ00133 protein FLJ00133
1.49 protein phosphatase 1, regulatory (inhibitor) subunit 16B PPP1R16B
1.49 WNT inhibitory factor 1 WIF1
1.49 --- ---
1.48 prostaglandin D2 synthase 21kDa (brain) PTGDS
1.48 fibronectin 1 FN1
1.48 thrombospondin 4 THBS4
1.48 complement component 1, s subcomponent C1S
1.48 protein tyrosine phosphatase, receptor type, G PTPRG
1.47 dynamin 1 DNM1
1.47 complement component 3 C3
1.47
serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member
1, (angioedema, hereditary) SERPING1
1.47 DKFZP586K1520 protein DKFZP586K1520
1.47
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte
protein of 76kDa) LCP2
1.46 fibronectin 1 FN1
1.46 insulin-like growth factor binding protein 5 IGFBP5
1.46 forkhead box D1 FOXD1
1.46 platelet-derived growth factor receptor, beta polypeptide PDGFRB
1.46 DKFZP564J102 protein DKFZP564J102
1.46 KIAA1102 protein KIAA1102
1.46 collagen, type XIV, alpha 1 (undulin) COL14A1
1.45 CDW52 antigen (CAMPATH-1 antigen) CDW52
1.45 ribonuclease T2 RNASET2
1.44
colony stimulating factor 1 receptor, formerly McDonough feline
sarcoma viral (v-fms) oncogene homolog CSF1R
1.44 ankyrin 2, neuronal ANK2
1.44 major histocompatibility complex, class II, DP alpha 1 HLA-DPA1
1.44 huntingtin interacting protein 1 HIP1
1.43 collagen, type VI, alpha 3 COL6A3
1.43 CD3Z antigen, zeta polypeptide (TiT3 complex) CD3Z
1.43 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog LYN
1.43 major histocompatibility complex, class II, DP beta 1 HLA-DPB1
1.43 matrix metalloproteinase 23B MMP23B
1.42 fibronectin 1 FN1
1.42 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 TBC1D1
1.42 Ras association (RalGDS/AF-6) domain family 2 RASSF2
163
1.42 tenascin XB TNXB
1.42 lysyl oxidase-like 2 LOXL2
1.42 mannosidase, alpha, class 1A, member 1 MAN1A1
1.42 insulin-like growth factor binding protein 5 IGFBP5
1.42 LIM domain only 2 (rhombotin-like 1) LMO2
1.42 Src-like-adaptor SLA
1.41 G protein-coupled receptor 124 GPR124
1.41
tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy,
pseudoinflammatory) TIMP3
1.41 chondroitin sulfate proteoglycan 2 (versican) CSPG2
1.41 TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator T3JAM
1.41 neurotrophic tyrosine kinase, receptor, type 2 NTRK2
1.40 phosphatidic acid phosphatase type 2B PPAP2B
1.40
tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy,
pseudoinflammatory) TIMP3
1.39 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) CXCL12
1.39 KIAA1102 protein KIAA1102
1.39 RNA binding protein with multiple splicing RBPMS
1.39
Homo sapiens cDNA FLJ36690 fis, clone UTERU2008707, highly
similar to COMPLEMENT C1R COMPONENT PRECURSOR (EC
3.4.21.41). ---
1.38 CD3D antigen, delta polypeptide (TiT3 complex) CD3D
1.38 lymphocyte-specific protein tyrosine kinase LCK
1.38 BTB (POZ) domain containing 3 BTBD3
1.37
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric
dwarfism) FGFR3
1.37 lipase, hepatic LIPC
1.37 slit homolog 3 (Drosophila) SLIT3
1.37 polymerase I and transcript release factor PTRF
1.37 nuclear receptor subfamily 2, group F, member 1 NR2F1
1.37 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 ARHGEF6
1.37 reticulon 1 RTN1
1.37 --- ---
1.37 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) FUT8
1.37 cystatin C (amyloid angiopathy and cerebral hemorrhage) CST3
1.36
Homo sapiens T cell receptor beta chain BV20S1 BJ1-5 BC1 mRNA,
complete cds ---
1.36 up-regulated in liver cancer 1 UPLC1
1.36 protein S (alpha) PROS1
1.35
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2,
Pfeiffer syndrome) FGFR1
1.35 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) PKP1
1.35 CUG triplet repeat, RNA binding protein 2 CUGBP2
1.35 major histocompatibility complex, class I, E HLA-E
1.35 --- ---
1.35 CD2 antigen (p50), sheep red blood cell receptor CD2
1.35 up-regulated in liver cancer 1 UPLC1
1.35 HLA-G histocompatibility antigen, class I, G HLA-G
1.35 adrenergic, alpha-2A-, receptor ADRA2A
1.34 Rho GDP dissociation inhibitor (GDI) beta ARHGDIB
1.34 discs, large homolog 5 (Drosophila) DLG5
1.34 major histocompatibility complex, class I, F HLA-F
164
1.34 CD37 antigen CD37
1.34 interferon-induced protein 35 IFI35
1.34 major histocompatibility complex, class II, DQ beta 2 HLA-DQB2
1.34 likely ortholog of mouse IRA1 protein IRA1
1.34 hypothetical protein FLJ10770 KIAA1579
1.33 laminin, gamma 1 (formerly LAMB2) LAMC1
1.33 cat eye syndrome chromosome region, candidate 1 CECR1
1.33 collagen, type IV, alpha 2 COL4A2
1.33 phospholipase C-like 2 PLCL2
1.33 immunoglobulin superfamily containing leucine-rich repeat ISLR
1.33 KIAA1102 protein KIAA1102
1.33
Homo sapiens T cell receptor beta chain BV20S1 BJ1-5 BC1 mRNA,
complete cds ---
1.33 FK506 binding protein 10, 65 kDa FKBP10
1.33 Lysosomal-associated multispanning membrane protein-5 LAPTM5
1.33 CD97 antigen CD97
1.33 drebrin 1 DBN1
1.32 biglycan BGN
1.32 latent transforming growth factor beta binding protein 1 LTBP1
1.32 sprouty-related, EVH1 domain containing 2 SPRED2
1.32 dihydropyrimidinase-like 2 DPYSL2
1.32 protein tyrosine phosphatase, receptor type, M PTPRM
1.32 SET and MYND domain containing 3 SMYD3
1.32 HLA-G histocompatibility antigen, class I, G HLA-G
1.32 zinc finger protein FLJ10697
1.32 CD81 antigen (target of antiproliferative antibody 1) CD81
1.32 EGF-containing fibulin-like extracellular matrix protein 2 EFEMP2
1.31 lipoma HMGIC fusion partner LHFP
1.31
MADS box transcription enhancer factor 2, polypeptide C (myocyte
enhancer factor 2C) MEF2C
1.31 F-box and leucine-rich repeat protein 7 FBXL7
1.31 hypothetical gene BC008967 BC008967
1.31 CD34 antigen CD34
1.31
S100 calcium binding protein A4 (calcium protein, calvasculin,
metastasin, murine placental homolog) S100A4
1.31
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP
binding protein Rac2) RAC2
1.31 alpha-2-macroglobulin A2M
1.30 major histocompatibility complex, class II, DQ beta 1 HLA-DQB1
1.30 receptor tyrosine kinase-like orphan receptor 1 ROR1
1.30 potassium channel tetramerisation domain containing 12 KCTD12
1.30 chondroitin sulfate proteoglycan 2 (versican) CSPG2
1.30 interferon induced transmembrane protein 1 (9-27) IFITM1
1.30 transforming growth factor, beta receptor II (70/80kDa) TGFBR2
1.29 adaptor-related protein complex 2, beta 1 subunit AP2B1
1.29 KIAA1518 protein KIAA1518
1.29 RAB6 interacting protein 1 RAB6IP1
1.29 hypothetical protein FLJ21868 FLJ21868
1.29 protein tyrosine phosphatase, receptor type, B PTPRB
1.28 hypothetical protein FLJ11588 FLJ11588
1.28 caldesmon 1 CALD1
1.28 protein tyrosine phosphatase, non-receptor type substrate 1 PTPNS1
165
1.28 selectin P ligand SELPLG
1.27 chromosome 1 open reading frame 21 C1orf21
1.27 phosphoglycerate dehydrogenase PHGDH
1.27 quaking homolog, KH domain RNA binding (mouse) QKI
1.27 phospholipid transfer protein PLTP
1.26 intercellular adhesion molecule 2 ICAM2
1.26 fms-related tyrosine kinase 3 ligand FLT3LG
1.26 hypothetical protein DKFZp564K0822 DKFZP564K0822
1.25 ATPase, Ca++ transporting, plasma membrane 4 ATP2B4
1.25 microtubule-associated protein 4 MAP4
1.25 caldesmon 1 CALD1
1.25 brain abundant, membrane attached signal protein 1 BASP1
1.24 DIX domain containing 1 DIXDC1
1.24 A kinase (PRKA) anchor protein 11 AKAP11
1.23 solute carrier family 39 (zinc transporter), member 14 SLC39A14
1.23 CDC14 cell division cycle 14 homolog B (S. cerevisiae) CDC14B
1.23
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen
CD51) ITGAV
1.22 transducer of ERBB2, 2 TOB2
1.22 ring finger protein 38 RNF38
1.21 fasciculation and elongation protein zeta 2 (zygin II) FEZ2
1.21 myocardin-related transcription factor B MRTF-B
1.20 glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A GRINL1A
-7.92 hydroxyacid oxidase 2 (long chain) HAO2
-7.88
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid deltaisomerase
1 HSD3B1
-6.91 hypothetical protein FLJ11106 FLJ11106
-6.78 solute carrier organic anion transporter family, member 4C1 SLCO4C1
-6.58 fatty acid desaturase 1 FADS1
-6.39 fatty acid desaturase 1 FADS1
-6.25 PDZ domain containing 1 PDZK1
-5.91
glycine dehydrogenase (decarboxylating; glycine decarboxylase,
glycine cleavage system protein P) GLDC
-5.83 fatty acid binding protein 7, brain FABP7
-5.62 hypothetical protein FLJ10462 FLJ10462
-5.52
phospholipase A2, group VII (platelet-activating factor acetylhydrolase,
plasma) PLA2G7
-5.47 fatty acid desaturase 2 FADS2
-4.90 galanin GAL
-4.79 arachidonate 15-lipoxygenase, second type ALOX15B
-4.79 fatty acid binding protein 7, brain FABP7
-4.77 fatty acid desaturase 1 FADS1
-4.23 histone 1, H1c /// histone 1, H1c HIST1H1C
-4.21 mucin 1, transmembrane MUC1
-3.99 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) HMGCS1
-3.92 insulin induced gene 1 INSIG1
-3.91 lipidosin BG1
-3.84
sterol O-acyltransferase (acyl-Coenzyme A: cholesterol
acyltransferase) 1 SOAT1
-3.80 lipidosin BG1
-3.73 dehydrogenase/reductase (SDR family) member 9 DHRS9
-3.72 variable charge, Y-linked, 2 VCY2
166
-3.71 apolipoprotein C-I APOC1
-3.71 carnitine acetyltransferase CRAT
-3.67 SA hypertension-associated homolog (rat) SAH
-3.65 UDP glycosyltransferase 2 family, polypeptide A1 UGT2A1
-3.59 hypothetical protein MAC30 MAC30
-3.54
hyperpolarization activated cyclic nucleotide-gated potassium channel
3 HCN3
-3.49 phosphodiesterase 6A, cGMP-specific, rod, alpha PDE6A
-3.48 ureidopropionase, beta UPB1
-3.48 hypothetical protein MAC30 MAC30
-3.40 mucin 1, transmembrane MUC1
-3.38 hypothetical protein MAC30 MAC30
-3.37 SA hypertension-associated homolog (rat) SAH
-3.34 transitional epithelia response protein TERE1
-3.34 hydroxysteroid (11-beta) dehydrogenase 1 HSD11B1
-3.34 peroxisomal long-chain acyl-coA thioesterase ZAP128
-3.24
Homo sapiens mRNA; cDNA DKFZp564P142 (from clone
DKFZp564P142) ---
-3.24 insulin induced gene 1 INSIG1
-3.20 solute carrier family 26, member 3 SLC26A3
-3.17 homogentisate 1,2-dioxygenase (homogentisate oxidase) HGD
-3.11 NAD(P) dependent steroid dehydrogenase-like H105E3
-3.11
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase,
dimethylallyltranstransferase, geranyltranstransferase) FDPS
-3.06 solute carrier family 27 (fatty acid transporter), member 2 SLC27A2
-3.05 peroxisomal trans 2-enoyl CoA reductase PECR
-3.04 DESC1 protein DESC1
-3.02 cytochrome P450, family 4, subfamily F, polypeptide 8 CYP4F8
-3.02 cell death-inducing DFFA-like effector a CIDEA
-2.97 fatty acid 2-hydroxylase FA2H
-2.97 chitinase 3-like 1 (cartilage glycoprotein-39) CHI3L1
-2.95 chitinase 3-like 1 (cartilage glycoprotein-39) CHI3L1
-2.91
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid
delta 4-dehydrogenase alpha 1) SRD5A1
-2.83 glycerol kinase GK
-2.83 malic enzyme 1, NADP(+)-dependent, cytosolic ME1
-2.78
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A
thiolase) ACAT2
-2.78 insulin induced gene 1 INSIG1
-2.78 7-dehydrocholesterol reductase DHCR7
-2.76 --- ---
-2.75 hypoxia-inducible protein 2 HIG2
-2.74 fructose-1,6-bisphosphatase 1 FBP1
-2.64 fatty acid synthase FASN
-2.64 --- ---
-2.63 chromosome 6 open reading frame 105 C6orf105
-2.62 histone 1, H2bc HIST1H2BC
-2.60 3-hydroxy-3-methylglutaryl-Coenzyme A reductase HMGCR
-2.59 arginase, type II ARG2
-2.54 abhydrolase domain containing 5 ABHD5
-2.53
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid
delta 4-dehydrogenase alpha 1) SRD5A1
167
-2.51 abhydrolase domain containing 5 ABHD5
-2.50 sterol-C4-methyl oxidase-like SC4MOL
-2.50 acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain ACADM
-2.50 glycerol kinase GK
-2.49
ELOVL family member 5, elongation of long chain fatty acids
(FEN1/Elo2, SUR4/Elo3-like, yeast) ELOVL5
-2.49 B-cell receptor-associated protein 29 BCAP29
-2.48 solute carrier family 27 (fatty acid transporter), member 2 SLC27A2
-2.48 glycerol kinase GK
-2.48 chromosome 14 open reading frame 137 C14orf137
-2.45 myogenic factor 3 /// myogenic factor 3 MYOD1
-2.45 malic enzyme 1, NADP(+)-dependent, cytosolic ME1
-2.44 apolipoprotein C-I APOC1
-2.44 CGI-100 protein CGI-100
-2.43
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-
Coenzyme A thiolase) ACAA2
-2.42 glycerol kinase GK
-2.42 deoxyribonuclease I-like 2 DNASE1L2
-2.42 cut-like 2 (Drosophila) CUTL2
-2.42 NAD(P) dependent steroid dehydrogenase-like H105E3
-2.39 nuclear receptor binding factor 1 CGI-63
-2.38 cystathionase (cystathionine gamma-lyase) CTH
-2.35 paraoxonase 3 PON3
-2.33 emopamil binding protein (sterol isomerase) EBP
-2.33 melanocortin 5 receptor MC5R
-2.32 7-dehydrocholesterol reductase DHCR7
-2.32 mevalonate (diphospho) decarboxylase MVD
-2.30 dopa decarboxylase (aromatic L-amino acid decarboxylase) DDC
-2.30 branched chain aminotransferase 2, mitochondrial BCAT2
-2.29 superoxide dismutase 2, mitochondrial SOD2
-2.29 fatty-acid-Coenzyme A ligase, long-chain 2 FACL2
-2.29 intraflagellar transport protein IFT20 LOC90410
-2.27 carnitine acetyltransferase CRAT
-2.27 retinol dehydrogenase 11 (all-trans and 9-cis) RDH11
-2.27 G protein-coupled receptor 64 GPR64
-2.26 adipose differentiation-related protein ADFP
-2.25 phosphatidylcholine transfer protein PCTP
-2.25 steroid-5-alpha-reductase, alpha polypeptide 1 SRD5A1
-2.23 lysophosphatidic acid phosphatase ACP6
-2.22 acyl-Coenzyme A oxidase 2, branched chain ACOX2
-2.22
ELOVL family member 5, elongation of long chain fatty acids
(FEN1/Elo2, SUR4/Elo3-like, yeast) ELOVL5
-2.21 Krueppel-related zinc finger protein H-plk
-2.20 abhydrolase domain containing 5 ABHD5
-2.20 molybdenum cofactor sulfurase MOCOS
-2.20 dual specificity phosphatase 4 DUSP4
-2.20 cytochrome b-5 CYB5
-2.20 retinol dehydrogenase 11 (all-trans and 9-cis) RDH11
-2.18 potassium inwardly-rectifying channel, subfamily J, member 15 KCNJ15
-2.17
branched chain keto acid dehydrogenase E1, beta polypeptide (maple
syrup urine disease) BCKDHB
-2.16 transmembrane 7 superfamily member 2 TM7SF2
168
-2.15 cytochrome b-5 CYB5
-2.15 cytochrome P450, family 4, subfamily F, polypeptide 2 CYP4F2
-2.15
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A
thiolase) ACAT2
-2.13 emopamil binding protein (sterol isomerase) EBP
-2.12 zinc finger protein 43 (HTF6) ZNF43
-2.11 cytochrome b-5 CYB5
-2.11 propionyl Coenzyme A carboxylase, beta polypeptide PCCB
-2.11 acyl-Coenzyme A dehydrogenase family, member 8 ACAD8
-2.11 phosphomevalonate kinase PMVK
-2.10 serum/glucocorticoid regulated kinase 2 SGK2
-2.09 N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) NPL
-2.09
Homo sapiens cDNA FLJ16053 moderately similar to MITOGENACTIVATED
PROTEIN KINASE KINASE KINASE 5 (EC 2.7.1.-) ---
-2.08 peroxisomal membrane protein 2, 22kDa PXMP2
-2.08 histone 1, H2ae HIST1H2AE
-2.06 selenoprotein X, 1 SEPX1
-2.06 histone 1, H2bg HIST1H2BG
-2.06 sorbitol dehydrogenase SORD
-2.06
Homo sapiens transcribed sequence with moderate similarity to protein
ref:NP_084526.1 (M.musculus) h ---
-2.05 chromosome 22 open reading frame 20 C22orf20
-2.05 aldehyde dehydrogenase 3 family, member B2 ALDH3B2
-2.04
1-acylglycerol-3-phosphate O-acyltransferase 3 /// 1-acylglycerol-3-
phosphate O-acyltransferase 3 AGPAT3
-2.03
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane
protein, 34kDa), member 17 SLC25A17
-2.02 peroxisomal membrane protein 4, 24kDa PXMP4
-2.02 alpha-methylacyl-CoA racemase AMACR
-2.01 isopentenyl-diphosphate delta isomerase IDI1
-2.01 glucose-6-phosphate dehydrogenase G6PD
-1.99 pyruvate kinase, liver and RBC PKLR
-1.98 isopentenyl-diphosphate delta isomerase IDI1
-1.97 transketolase (Wernicke-Korsakoff syndrome) TKT
-1.96 calcium binding protein P22 CHP
-1.95 KIAA0626 gene product KIAA0626
-1.95 aconitase 1, soluble ACO1
-1.94 mevalonate kinase (mevalonic aciduria) MVK
-1.92 ras homolog gene family, member I ARHI
-1.92 hypothetical protein MGC4172 MGC4172
-1.92 hypothetical protein FLJ22679 FLJ22679
-1.92
acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-
Coenzyme A thiolase) ACAA1
-1.92 acetoacetyl-CoA synthetase AACS
-1.92 3-hydroxy-3-methylglutaryl-Coenzyme A reductase HMGCR
-1.92 peroxisomal biogenesis factor 11A PEX11A
-1.91 peroxisomal biogenesis factor 11A PEX11A
-1.91 carnitine palmitoyltransferase II CPT2
-1.91 LAG1 longevity assurance homolog 4 (S. cerevisiae) LASS4
-1.91 hypothetical protein LOC283537 LOC283537
-1.90 glutathione peroxidase 3 (plasma) GPX3
-1.90 hypothetical protein DKFZp547M236 DKFZp547M236
169
-1.90 gamma-aminobutyric acid (GABA) A receptor, alpha 4 GABRA4
-1.90 --- ---
-1.89
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3,
yeast)-like 4 ELOVL4
-1.89 pyruvate dehydrogenase (lipoamide) alpha 1 PDHA1
-1.89 farnesyl-diphosphate farnesyltransferase 1 FDFT1
-1.89 3-hydroxyisobutyryl-Coenzyme A hydrolase HIBCH
-1.89 lipin 1 LPIN1
-1.88 peroxisomal biogenesis factor 3 PEX3
-1.87
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane
protein, 34kDa), member 17 SLC25A17
-1.86 hypothetical protein HSPC111 HSPC111
-1.86 glutathione peroxidase 3 (plasma) GPX3
-1.85 2',5'-oligoadenylate synthetase 1, 40/46kDa OAS1
-1.85 progesterone receptor membrane component 1 PGRMC1
-1.85 sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like SC5DL
-1.85 --- ---
-1.85 electron-transferring-flavoprotein dehydrogenase ETFDH
-1.85 chitinase 3-like 2 CHI3L2
-1.85 zinc finger protein 254 ZNF254
-1.85 superoxide dismutase 2, mitochondrial SOD2
-1.84 farnesyl-diphosphate farnesyltransferase 1 FDFT1
-1.84 brain expressed, associated with Nedd4 BEAN
-1.84 synapsin II SYN2
-1.83
zinc finger protein 145 (Kruppel-like, expressed in promyelocytic
leukemia) ZNF145
-1.82 zinc finger protein 91 (HPF7, HTF10) ZNF91
-1.82 --- ---
-1.82 transketolase (Wernicke-Korsakoff syndrome) TKT
-1.81 enoyl Coenzyme A hydratase domain containing 1 ECHDC1
-1.81
phosphogluconate dehydrogenase /// phosphogluconate
dehydrogenase PGD
-1.81 ATP citrate lyase ACLY
-1.80 electron-transferring-flavoprotein dehydrogenase ETFDH
-1.79 isocitrate dehydrogenase 1 (NADP+), soluble IDH1
-1.79 peroxisome biogenesis factor 13 PEX13
-1.79 zinc finger protein 43 (HTF6) ZNF43
-1.78 peroxisomal biogenesis factor 3 PEX3
-1.78 aminolevulinate, delta-, synthase 1 ALAS1
-1.78 glyceronephosphate O-acyltransferase GNPAT
-1.77 aldehyde dehydrogenase 3 family, member B2 ALDH3B2
-1.77 sorbitol dehydrogenase SORD
-1.77 ATP citrate lyase ACLY
-1.77 solute carrier family 15 (oligopeptide transporter), member 1 SLC15A1
-1.77 pleckstrin homology-like domain, family A, member 2 PHLDA2
-1.76 NAD kinase FLJ13052
-1.76 histone 1, H2bk HIST1H2BK
-1.75 FLJ23311 protein FLJ23311
-1.75 sorting nexin 13 SNX13
-1.75 aminoacylase 1 ACY1
-1.75 TRAF6-inhibitory zinc finger protein TIZ
-1.75 thiosulfate sulfurtransferase (rhodanese) TST
170
-1.75 lipin 1 LPIN1
-1.74 fatty-acid-Coenzyme A ligase, long-chain 5 FACL5
-1.74 2',5'-oligoadenylate synthetase 1, 40/46kDa OAS1
-1.73 cytochrome P450, family 4, subfamily F, polypeptide 3 CYP4F3
-1.73 chromosome 21 open reading frame 5 C21orf5
-1.73 anterior gradient 2 homolog (Xenopus laevis) AGR2
-1.72 fatty-acid-Coenzyme A ligase, long-chain 2 FACL2
-1.72 creatine kinase, mitochondrial 1 (ubiquitous) CKMT1
-1.72 zinc finger protein 165 ZNF165
-1.72 YDD19 protein YDD19
-1.71 --- ---
-1.71 H2B histone family, member S H2BFS
-1.71 acetyl-Coenzyme A carboxylase alpha ACACA
-1.71 alpha-methylacyl-CoA racemase AMACR
-1.71 ATP citrate lyase ACLY
-1.71 dicarbonyl/L-xylulose reductase DCXR
-1.70 calsyntenin 3 CLSTN3
-1.70 desmocollin 2 DSC2
-1.69
solute carrier family 31 (copper transporters), member 1 /// solute
carrier family 31 (copper transporters), member 1 SLC31A1
-1.69 calmodulin-like 3 CALML3
-1.69
solute carrier family 25 (mitochondrial carrier; Graves disease
autoantigen), member 16 SLC25A16
-1.69 SAR1a gene homolog 2 (S. cerevisiae) SARA2
-1.68 interleukin 1, beta IL1B
-1.68 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain HADHSC
-1.68 KIAA0626 gene product KIAA0626
-1.68 peroxiredoxin 2 PRDX2
-1.67 cytochrome P450, family 51, subfamily A, polypeptide 1 CYP51A1
-1.67
dihydrolipoamide branched chain transacylase (E2 component of
branched chain keto acid dehydrogenase complex; maple syrup urine
disease) DBT
-1.67 silver homolog (mouse) SILV
-1.66 peroxiredoxin 2 /// peroxiredoxin 2 PRDX2
-1.66 transmembrane 4 superfamily member 6 TM4SF6
-1.66 nudix (nucleoside diphosphate linked moiety X)-type motif 4 NUDT4
-1.65 cyclin-dependent kinase 5 CDK5
-1.65 hypothetical protein FLJ20574 FLJ20574
-1.64 N-terminal Asn amidase LOC123803
-1.64 hypothetical protein FLJ13263 FLJ13263
-1.64 transferrin receptor (p90, CD71) TFRC
-1.63 peroxisomal biogenesis factor 16 PEX16
-1.63 low density lipoprotein receptor (familial hypercholesterolemia) LDLR
-1.63 N-terminal Asn amidase LOC123803
-1.63 neuronal protein NP25
-1.63 DnaJ (Hsp40) homolog, subfamily C, member 3 DNAJC3
-1.62 homogentisate 1,2-dioxygenase (homogentisate oxidase) HGD
-1.62
solute carrier family 7 (cationic amino acid transporter, y+ system),
member 5 SLC7A5
-1.62 hypothetical protein FLJ22649 similar to signal peptidase SPC22/23 FLJ22649
-1.62 immediate early response 3 IER3
-1.62 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary CEACAM1
171
glycoprotein)
-1.62 brain protein 44-like BRP44L
-1.61 histone 1, H2ag HIST1H2AG
-1.61 Wiskott-Aldrich syndrome-like WASL
-1.60 phosphoinositide-3-kinase, class 2, gamma polypeptide PIK3C2G
-1.60 chromosome 9 open reading frame 16 C9orf16
-1.60 RNA-binding protein FLJ20273
-1.60
holocarboxylase synthetase (biotin-[proprionyl-Coenzyme Acarboxylase
(ATP-hydrolysing)] ligase) HLCS
-1.60 24-dehydrocholesterol reductase DHCR24
-1.60
ems1 sequence (mammary tumor and squamous cell carcinomaassociated
(p80/85 src substrate) EMS1
-1.59
acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-
Coenzyme A thiolase) ACAA1
-1.59 CGI-111 protein CGI-111
-1.58
Homo sapiens transcribed sequence: basic leucine-zipper protein
BZAP45; ---
-1.58 peptidylprolyl isomerase F (cyclophilin F) PPIF
-1.58 FBJ murine osteosarcoma viral oncogene homolog B FOSB
-1.58 cytidine deaminase CDA
-1.58 aldo-keto reductase family 1, member A1 (aldehyde reductase) AKR1A1
-1.58 solute carrier family 16 (monocarboxylic acid transporters), member 7 SLC16A7
-1.57 transmembrane 4 superfamily member 6 TM4SF6
-1.56 progesterone receptor membrane component 1 PGRMC1
-1.56 inositol polyphosphate-4-phosphatase, type II, 105kDa INPP4B
-1.56 3-hydroxyisobutyryl-Coenzyme A hydrolase HIBCH
-1.56
Homo sapiens RAB15, member RAS onocogene family, mRNA (cDNA
clone IMAGE:4866926), with apparent retained intron ---
-1.56 peroxisomal biogenesis factor 16 PEX16
-1.55 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain HADHSC
-1.54
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary
glycoprotein) CEACAM1
-1.54 AAIR8193 UNQ8193
-1.54 geranylgeranyl diphosphate synthase 1 GGPS1
-1.54 hypothetical protein HSPC111 HSPC111
-1.54 stromal cell protein LOC55974
-1.54
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3,
yeast)-like 1 ELOVL1
-1.54 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) MCCC1
-1.53 DKFZP564B167 protein DKFZP564B167
-1.53 multiple coagulation factor deficiency 2 MCFD2
-1.52 transferrin receptor (p90, CD71) TFRC
-1.52 etoposide induced 2.4 mRNA EI24
-1.52 chromosome 20 open reading frame 24 C20orf24
-1.52 guanine nucleotide binding protein (G protein), gamma 4 GNG4
-1.52
protein phosphatase 1B (formerly 2C), magnesium-dependent, beta
isoform PPM1B
-1.52 Pirin PIR
-1.52 --- ---
-1.51 melan-A MLANA
-1.51 peptidylprolyl isomerase F (cyclophilin F) PPIF
-1.51 keratin 16 (focal non-epidermolytic palmoplantar keratoderma) KRT16
172
-1.51 G antigen 5 GAGE5
-1.51 serine hydroxymethyltransferase 1 (soluble) SHMT1
-1.51 hypothetical protein FLJ20152 FLJ20152
-1.50 CGI-51 protein CGI-51
-1.50 chromosome 21 open reading frame 33 C21orf33
-1.50 ribonuclease P1 RNASEP1
-1.50 progestin and adipoQ receptor family member III PAQR3
-1.50 translational inhibitor protein p14.5 UK114
-1.49 histone 2, H2aa HIST2H2AA
-1.49 hypothetical protein BC016005 LOC129642
-1.49 putative protein similar to nessy (Drosophila) C3F
-1.49 fatty-acid-Coenzyme A ligase, long-chain 3 FACL3
-1.49 histone 3, H2a HIST3H2A
-1.49 RAB27A, member RAS oncogene family RAB27A
-1.48 solute carrier organic anion transporter family, member 4C1 SLCO4C1
-1.48
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier),
member 11 SLC25A11
-1.48 biotinidase BTD
-1.48 acyl-Coenzyme A dehydrogenase, very long chain ACADVL
-1.48 cystatin B (stefin CSTB
-1.47 CGI-100 protein CGI-100
-1.47 G protein-coupled receptor 143 GPR143
-1.47 DNA segment, Chr 15, Wayne State University 75, expressed D15Wsu75e
-1.47 interleukin 13 receptor, alpha 1 IL13RA1
-1.47
mitochondrial carrier homolog 2 (C. elegans) /// mitochondrial carrier
homolog 2 (C. elegans) MTCH2
-1.47 uncharacterized hypothalamus protein HT009 HT009
-1.47 c-Mpl binding protein LOC113251
-1.47 dihydrofolate reductase DHFR
-1.47 RAR-related orphan receptor A RORA
-1.47
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADHcoenzyme
Q reductase) NDUFS1
-1.47 platelet-activating factor acetylhydrolase 2, 40kDa PAFAH2
-1.47 pyridoxal (pyridoxine, vitamin B6) kinase PDXK
-1.47 ubiquitin carrier protein E2-EPF
-1.46 hydroxysteroid (17-beta) dehydrogenase 7 HSD17B7
-1.46 v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog KRAS2
-1.46 low molecular mass ubiquinone-binding protein (9.5kD) QP-C
-1.46 pre-B-cell colony-enhancing factor PBEF
-1.46 DKFZP566O084 protein DKFZp566O084
-1.46 hypothetical protein FLJ10525 FLJ10525
-1.46 fumarate hydratase FH
-1.46 ring finger protein 128 RNF128
-1.45 biotinidase BTD
-1.45 histone 2, H2aa HIST2H2AA
-1.45 histone 1, H2bg HIST1H2BG
-1.45 sushi-repeat protein SRPUL
-1.45 nudix (nucleoside diphosphate linked moiety X)-type motif 4 NUDT4
-1.45 mitochondrial ribosomal protein S16 MRPS16
-1.45 Nijmegen breakage syndrome 1 (nibrin) NBS1
-1.45 pyruvate dehydrogenase complex, component X PDHX
-1.45 CGI-65 protein CIA30
173
-1.44 ethanolamine kinase EKI1
-1.44 histone 1, H2bh HIST1H2BH
-1.44
sialyltransferase 7D ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-
1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) SIAT7D
-1.44 tumor protein D52-like 1 TPD52L1
-1.44 --- ---
-1.44 GrpE-like 1, mitochondrial (E. coli) GRPEL1
-1.44 RNA terminal phosphate cyclase domain 1 RTCD1
-1.44 protease, serine, 8 (prostasin) PRSS8
-1.44 CGI-90 protein CGI-90
-1.44
3-hydroxybutyrate dehydrogenase (heart, mitochondrial) /// 3-
hydroxybutyrate dehydrogenase (heart, mitochondrial) BDH
-1.44 family with sequence similarity 3, member C FAM3C
-1.44 glycine cleavage system protein H (aminomethyl carrier) GCSH
-1.44
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c
(subunit 9) isoform 3 ATP5G3
-1.44 membrane-associated nucleic acid binding protein MNAB
-1.44 platelet-activating factor acetylhydrolase 2, 40kDa PAFAH2
-1.43 hypothetical protein FLJ11011 FLJ11011
-1.43 solute carrier family 35 (UDP-galactose transporter), member A2 SLC35A2
-1.43
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3,
yeast)-like 1 ELOVL1
-1.43 --- ---
-1.43 peroxisomal biogenesis factor 7 PEX7
-1.43 Nit protein 2 NIT2
-1.43 gamma-glutamyl carboxylase GGCX
-1.43 activated leukocyte cell adhesion molecule ALCAM
-1.43 FLJ20202 protein FLJ20202
-1.43 NAD(P)H dehydrogenase, quinone 2 NQO2
-1.43 geranylgeranyl diphosphate synthase 1 GGPS1
-1.42 chloride channel 3 CLCN3
-1.42 lactamase, beta 2 CGI-83
-1.42 signal-transducing adaptor protein-2 STAP2
-1.42
excision repair cross-complementing rodent repair deficiency,
complementation group 1 (includes overlapping antisense sequence) ERCC1
-1.42
Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen
SS-A/Ro) SSA2
-1.41 KIAA0186 gene product KIAA0186
-1.41 uracil-DNA glycosylase UNG
-1.41 histone 1, H2bd HIST1H2BD
-1.41 cytosolic nonspecific dipeptidase (EC 3.4.13.18) CN2
-1.41 sortilin 1 SORT1
-1.41 MRS2-like, magnesium homeostasis factor (S. cerevisiae) MRS2L
-1.41 pyruvate dehydrogenase (lipoamide) beta PDHB
-1.41 pre-B-cell colony-enhancing factor PBEF
-1.41 v-raf murine sarcoma viral oncogene homolog B1 BRAF
-1.40 Nijmegen breakage syndrome 1 (nibrin) NBS1
-1.40 hypothetical protein FLJ10849 FLJ10849
-1.40 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) MCCC2
-1.40 ubiquitin specific protease 2 USP2
-1.40 tumor rejection antigen (gp96) 1 TRA1
-1.40 RAB27A, member RAS oncogene family RAB27A
174
-1.40 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain HADHSC
-1.40 thioesterase superfamily member 2 THEM2
-1.40 chromosome 14 open reading frame 1 C14orf1
-1.40 KIAA0626 gene product KIAA0626
-1.40 mediator of RNA polymerase II transcription, subunit 8 homolog (yeast) MED8
-1.40 chromosome 1 open reading frame 27 C1orf27
-1.40 DnaJ (Hsp40) homolog, subfamily D, member 1 DNAJD1
-1.40 cleavage and polyadenylation specific factor 5, 25 kDa CPSF5
-1.40 glycoprotein, synaptic 2 GPSN2
-1.40 riboflavin kinase FLJ11149
-1.40 histone 1, H2be HIST1H2BE
-1.39 dual specificity phosphatase 4 DUSP4
-1.39 stromal cell-derived factor 2-like 1 SDF2L1
-1.39 KIAA0033 protein KIAA0033
-1.39 enoyl Coenzyme A hydratase 1, peroxisomal ECH1
-1.39 programmed cell death 8 (apoptosis-inducing factor) PDCD8
-1.39 hypothetical protein FLJ22353 FLJ22353
-1.39 proteasome (prosome, macropain) subunit, alpha type, 5 PSMA5
-1.39 biliverdin reductase B (flavin reductase (NADPH)) BLVRB
-1.39 chromosome 14 open reading frame 87 C14orf87
-1.39 phosphoglucomutase 1 PGM1
-1.38 secretory carrier membrane protein 1 SCAMP1
-1.38 CGI-04 protein CGI-04
-1.38 testis enhanced gene transcript (BAX inhibitor 1) TEGT
-1.38 interferon-related developmental regulator 1 IFRD1
-1.38 uncharacterized hematopoietic stem/progenitor cells protein MDS031 MDS031
-1.38 ribokinase RBSK
-1.38 tumor protein D52-like 1 TPD52L1
-1.37 dystrophin related protein 2 DRP2
-1.37 pyruvate dehydrogenase (lipoamide) beta PDHB
-1.37 hypothetical protein dJ473B4 DJ473B4
-1.37 myosin, light polypeptide 4, alkali; atrial, embryonic MYL4
-1.37
dihydrolipoamide dehydrogenase (E3 component of pyruvate
dehydrogenase complex, 2-oxo-glutarate complex, branched chain
keto acid dehydrogenase complex) DLD
-1.37 solute carrier family 39 (zinc transporter), member 8 SLC39A8
-1.37 basigin (OK blood group) BSG
-1.37 interleukin 1 receptor, type II IL1R2
-1.36 nasopharyngeal epithelium specific protein 1 NESG1
-1.36 --- ---
-1.36 HUS1 checkpoint homolog (S. pombe) HUS1
-1.36 --- ---
-1.36 biotinidase BTD
-1.36 PRKC, apoptosis, WT1, regulator PAWR
-1.36 RAS protein activator like 1 (GAP1 like) RASAL1
-1.36 heat shock 70kDa protein 9B (mortalin-2) HSPA9B
-1.36 ubiquinol-cytochrome c reductase core protein I UQCRC1
-1.36 chromosome 9 open reading frame 16 C9orf16
-1.35 hydroxysteroid (17-beta) dehydrogenase 12 HSD17B12
-1.35 solute carrier family 39 (zinc transporter), member 8 SLC39A8
-1.35
UDP glycosyltransferase 2 family, polypeptide B28 /// UDP
glycosyltransferase 2 family, polypeptide B28 UGT2B28
175
-1.35 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa NDUFV2
-1.35 ethanolamine kinase EKI1
-1.35 cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A
-1.35 carboxypeptidase D CPD
-1.35 transaldolase 1 TALDO1
-1.35 interleukin 1 receptor, type II IL1R2
-1.35 malonyl-CoA:acyl carrier protein transacylase (malonyltransferase) MT
-1.35 v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) MAFF
-1.35 cytochrome c oxidase subunit Vb COX5B
-1.35 carboxypeptidase D CPD
-1.35
solute carrier family 25 (mitochondrial carrier; ornithine transporter)
member 15 SLC25A15
-1.35 putative L-type neutral amino acid transporter KIAA0436
-1.35
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c'' /// ATPase,
H+ transporting, lysosomal 21kDa, V0 subunit c'' ATP6V0B
-1.35
solute carrier family 11 (proton-coupled divalent metal ion transporters),
member 2 SLC11A2
-1.34 hypothetical protein DKFZp434G0522 DKFZp434G0522
-1.34 CDK5 regulatory subunit associated protein 1 CDK5RAP1
-1.34 solute carrier family 35, member B1 SLC35B1
-1.34 peroxisomal farnesylated protein PXF
-1.34 fumarate hydratase FH
-1.34 proteasome (prosome, macropain) subunit, alpha type, 4 PSMA4
-1.34
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADHcoenzyme
Q reductase) NDUFS8
-1.34 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa EIF2B3
-1.33 --- ---
-1.33 proteasome (prosome, macropain) subunit, alpha type, 7 PSMA7
-1.33 associated molecule with the SH3 domain of STAM AMSH
-1.33 elongation factor, RNA polymerase II, 2 ELL2
-1.33 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa NDUFB3
-1.33 transcription factor Dp-2 (E2F dimerization partner 2) TFDP2
-1.33
excision repair cross-complementing rodent repair deficiency,
complementation group 1 (includes overlapping antisense sequence) ERCC1
-1.33 Niemann-Pick disease, type C1 NPC1
-1.33 hypothetical protein MGC2574 MGC2574
-1.33 proteasome (prosome, macropain) subunit, alpha type, 3 PSMA3
-1.33 ORM1-like 2 (S. cerevisiae) ORMDL2
-1.33 GrpE-like 1, mitochondrial (E. coli) GRPEL1
-1.33
proteasome (prosome, macropain) subunit, beta type, 5 /// proteasome
(prosome, macropain) subunit, beta type, 5 PSMB5
-1.33
solute carrier family 11 (proton-coupled divalent metal ion transporters),
member 2 SLC11A2
-1.33 solute carrier family 22 (organic cation transporter), member 1-like SLC22A1L
-1.33
sorbin and SH3 domain containing 1 /// sorbin and SH3 domain
containing 1 SORBS1
-1.33 fructose-1,6-bisphosphatase 2 FBP2
-1.32
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2,
14.5kDa NDUFC2
-1.32 translocase of inner mitochondrial membrane 13 homolog (yeast) TIMM13
-1.32 cytochrome c oxidase subunit VIIb COX7B
-1.32 --- ---
176
-1.32
likely ortholog of mouse exocyst component protein 70 kDa homolog
(S. cerevisiae) Exo70: exocyst component protein 70 kDa homolog (S.
cerevisiae) EXO70
-1.32 dipeptidylpeptidase 3 DPP3
-1.32 RAB38, member RAS oncogene family RAB38
-1.32 popeye domain containing 2 POPDC2
-1.32 heat shock 70kDa protein 9B (mortalin-2) HSPA9B
-1.32 secretory carrier membrane protein 1 SCAMP1
-1.32 glutamate-cysteine ligase, modifier subunit GCLM
-1.32 erythroid associated factor ERAF
-1.32 hypothetical protein FLJ10375 FLJ10375
-1.31 early growth response 3 EGR3
-1.31
solute carrier family 5 (sodium-dependent vitamin transporter), member
6 SLC5A6
-1.31 malignant T cell amplified sequence 1 MCTS1
-1.31 interferon-related developmental regulator 1 IFRD1
-1.31 H2A histone family, member X H2AFX
-1.31 DnaJ (Hsp40) homolog, subfamily A, member 3 DNAJA3
-1.31 recombination protein REC14 REC14
-1.31
glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme,
Andersen disease, glycogen storage disease type IV) GBE1
-1.31 CGI-51 protein CGI-51
-1.31
dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme
A isomerase) DCI
-1.31 glutathione transferase zeta 1 (maleylacetoacetate isomerase) GSTZ1
-1.31 --- ---
-1.30 eukaryotic translation initiation factor 4E EIF4E
-1.30 growth hormone inducible transmembrane protein GHITM
-1.30
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADHcoenzyme
Q reductase) NDUFS7
-1.30 mitochondrial ribosomal protein S33 MRPS33
-1.30 B-cell receptor-associated protein 31 BCAP31
-1.30 chromosome 14 open reading frame 2 C14orf2
-1.30 HSPC171 protein HSPC171
-1.30 D-dopachrome tautomerase DDT
-1.30 potassium channel, subfamily K, member 1 KCNK1
-1.29 ubiquitin-conjugating enzyme E2A (RAD6 homolog) UBE2A
-1.29 D-aspartate oxidase DDO
-1.29 histone 2, H2be HIST2H2BE
-1.29 --- ---
-1.29 solute carrier family 30 (zinc transporter), member 1 SLC30A1
-1.29 --- ---
-1.29 Nijmegen breakage syndrome 1 (nibrin) NBS1
-1.28 Krueppel-related zinc finger protein H-plk
-1.28 ClpX caseinolytic protease X homolog (E. coli) CLPX
-1.28 FLJ20288 protein FLJ20288
-1.28 hypothetical protein MGC4276 similar to CG8198 MGC4276
-1.28 translocase of inner mitochondrial membrane 23 homolog (yeast) TIMM23
-1.28 c-myc binding protein MYCBP
-1.28 trefoil factor 2 (spasmolytic protein 1) TFF2
-1.28 translocase of outer mitochondrial membrane 70 homolog A (yeast) TOMM70A
-1.27 cytochrome c oxidase subunit Va COX5A
177
-1.27 mitochondrial ribosomal protein S18A MRPS18A
-1.27 polyposis locus protein 1 DP1
-1.27
Homo sapiens transcribed sequence with strong similarity to protein
pir:A32800 (H.sapiens) A32800 chaperonin GroEL precursor - human ---
-1.27 pantothenate kinase 3 PANK3
-1.26 --- ---
-1.26 glutaredoxin 2 GLRX2
-1.26
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c
(subunit 9) isoform 3 ATP5G3
-1.26 unc-5 homolog B (C. elegans) UNC5B
-1.26 mitochondrial translation optimization 1 homolog (S. cerevisiae) MTO1
-1.26 ganglioside-induced differentiation-associated protein 1-like 1 GDAP1L1
-1.26 huntingtin interacting protein 2 HIP2
-1.26 integral type I protein P24B
-1.26 AUT-like 2, cysteine endopeptidase (S. cerevisiae) AUTL2
-1.26 cytochrome c oxidase subunit Vb COX5B
-1.26 T-cell leukemia translocation altered gene TCTA
-1.26 mitochondrial ribosomal protein L33 MRPL33
-1.26
diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme
A binding protein) DBI
-1.25 ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c ATP6V0C
-1.25
likely ortholog of rat vacuole membrane protein 1 /// likely ortholog of rat
vacuole membrane protein 1 VMP1
-1.25 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) COX7A2
-1.25 metaxin 1 MTX1
-1.25 fatty acid binding protein 6, ileal (gastrotropin) FABP6
-1.25 postsynaptic protein CRIPT CRIPT
-1.25 aspartylglucosaminidase AGA
-1.25
diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme
A binding protein) DBI
-1.25 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa NDUFA3
-1.25
succinate dehydrogenase complex, subunit C, integral membrane
protein, 15kDa SDHC
-1.25
Homo sapiens transcribed sequence with weak similarity to protein
pir:PC4369 (H.sapiens) PC4369 olfactory receptor, HT2 - human
(fragment) ---
-1.24 6-pyruvoyltetrahydropterin synthase PTS
-1.24 succinate-CoA ligase, GDP-forming, alpha subunit SUCLG1
-1.24 adaptor-related protein complex 3, sigma 2 subunit AP3S2
-1.24 cytochrome c oxidase subunit Vb /// cytochrome c oxidase subunit Vb COX5B
-1.24 zinc finger protein 430 ZNF430
-1.24 chromosome 6 open reading frame 79 C6orf79
-1.23 recombination protein REC14 REC14
-1.23 ras homolog gene family, member E ARHE
-1.23 F-box only protein 9 FBXO9
-1.23 ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D ATP6V1D
-1.22 peptidase (mitochondrial processing) beta PMPCB
-1.22 DNA segment on chromosome X (unique) 9879 expressed sequence DXS9879E
-1.21 CGI-147 protein CGI-147
-1.21 malate dehydrogenase 1, NAD (soluble) MDH1
-1.21 synaptogyrin 1 SYNGR1
-1.21 proteasome (prosome, macropain) subunit, alpha type, 1 PSMA1
178
-1.21 chromosome 14 open reading frame 2 C14orf2
-1.20
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f,
isoform 2 ATP5J2
-1.20 ubiquitin specific protease 3 USP3
-1.20 cytochrome c oxidase subunit VIa polypeptide 1 COX6A1
-1.20
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADHcoenzyme
Q reductase) NDUFS3
-1.20 ubiquinol-cytochrome c reductase core protein II UQCRC2
-1.18
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma
polypeptide 1 ATP5C1
A

Please forgive me if any of this is redundant. I came into this search because my daughters friend started struggling with depression and suicidal inclinations. Turns out she was on Accutane a few months ago, and Im sure thats the genesis of her symptoms. In researching side effects, Im horrified by the long-term, wide ranging destruction to so many physical systems that can result from this drug. Even today with all the info available online, it is easy not to know how scary possible side effects of a drug are, and end up taking something that is very damaging. My dad is a PhD in analytical chemistry. He worked on asthma medications for years. He distrusts a lot of medications because he knows possible risks. Doctors often dont; either they dont understand it or dont keep up with the warnings, or just dont pay attention to the ingredients and what they can do. (Like, asthma inhalers with high alcohol content will irritate the airways, not open them. Seems obvious, but if youre not paying attention to the ratios of ingredients ) I still avoid fake sugars because Dad banned saccharine when I was a kid. I avoid Cipro (ciprofloxacin) because it can cause deadly nerve damage. There are basic, safer options like erythromycin, amoxicillin, or azithromycin. So I still call and ask Dad about anything we are prescribed, or supplements to consider. When I asked him what might help with our friends depression, he said zinc. Drinking enough water to flush your system, and zinc. I have seen zinc mentioned in some posts here, but I wanted to pass it along specifically too. Recent studies have indicated it helps with depression in solid physiological ways. Heres one article:

https://www.psychologytoday.com/blog/evolutionary-psychiatry/201309/zinc-antidepressant

And because zinc is a mineral your body will always need, its something you can take long term, unlike some of the herbs or purges that you are only supposed to use for short lengths of time. Recommended daily allowances on zinc supplements are usually pretty conservative. I would start there and see if it helps. Dad did studies years ago on zinc deficiency in kids who were way behind on the growth curve. Proper zinc levels normalized growth in these kids. It helps other systems in your body work efficiently, and it helps in absorption of antioxidants.
Another reason I want to mention it is that zinc also helps increase taste acuity and appetite,fight hair loss, improve skin issues, and improve libido. (Oysters are high in zinc, which is why they're effective as an aphrodesiac.) Each of these match up to combat some of Accutanes long term side effects. I dont know if zinc will cure the massive side effects some people are suffering with, but it might help. Honestly, I believe it cant hurt. So I wanted to post that in case it helps someone to heal. And I'm praying - for improvement, for success in finding treatments, and healing for all of you dealing with horrible damages.

So, from what I remember someone on here said they felt SIGNIFICANTLY better while taking prednisone. For those who don't catch colds/viruses anymore, I wonder if this could be our golden ticket...

I'm truly convinced it has a lot to do with a modulation of the immune system. At least for some of us. I'm going to bring up prednisone to my doc and see if I could sample some just for shits and giggles.

4 hours ago, Redslippers said:

Please forgive me if any of this is redundant. I came into this search because my daughters friend started struggling with depression and suicidal inclinations. Turns out she was on Accutane a few months ago, and Im sure thats the genesis of her symptoms. In researching side effects, Im horrified by the long-term, wide ranging destruction to so many physical systems that can result from this drug. Even today with all the info available online, it is easy not to know how scary possible side effects of a drug are, and end up taking something that is very damaging. My dad is a PhD in analytical chemistry. He worked on asthma medications for years. He distrusts a lot of medications because he knows possible risks. Doctors often dont; either they dont understand it or dont keep up with the warnings, or just dont pay attention to the ingredients and what they can do. (Like, asthma inhalers with high alcohol content will irritate the airways, not open them. Seems obvious, but if youre not paying attention to the ratios of ingredients ) I still avoid fake sugars because Dad banned saccharine when I was a kid. I avoid Cipro (ciprofloxacin) because it can cause deadly nerve damage. There are basic, safer options like erythromycin, amoxicillin, or azithromycin. So I still call and ask Dad about anything we are prescribed, or supplements to consider. When I asked him what might help with our friends depression, he said zinc. Drinking enough water to flush your system, and zinc. I have seen zinc mentioned in some posts here, but I wanted to pass it along specifically too. Recent studies have indicated it helps with depression in solid physiological ways. Heres one article:

https://www.psychologytoday.com/blog/evolutionary-psychiatry/201309/zinc-antidepressant

And because zinc is a mineral your body will always need, its something you can take long term, unlike some of the herbs or purges that you are only supposed to use for short lengths of time. Recommended daily allowances on zinc supplements are usually pretty conservative. I would start there and see if it helps. Dad did studies years ago on zinc deficiency in kids who were way behind on the growth curve. Proper zinc levels normalized growth in these kids. It helps other systems in your body work efficiently, and it helps in absorption of antioxidants.
Another reason I want to mention it is that zinc also helps increase taste acuity and appetite,fight hair loss, improve skin issues, and improve libido. (Oysters are high in zinc, which is why they're effective as an aphrodesiac.) Each of these match up to combat some of Accutanes long term side effects. I dont know if zinc will cure the massive side effects some people are suffering with, but it might help. Honestly, I believe it cant hurt. So I wanted to post that in case it helps someone to heal. And I'm praying - for improvement, for success in finding treatments, and healing for all of you dealing with horrible damages.

 

 

 

Well with Accutane you've got everything from those who took it with no side effects to those who've gotten bowel cancer, and inbetween all that you have all of us on this forum with a multitude of problems.

I'd love to say taking zinc is the answer but unfortunately it's not, you may benefit from it slightly but that's about it - it's no cure for someone with ongoing head pressure and light sensitivity and that sort of thing.

The long post about genes getting altered above kinda suggests that zinc isn't a cure yeah??!

44 minutes ago, Colinboko said:

I'm truly convinced it has a lot to do with a modulation of the immune system. At least for some of us. I'm going to bring up prednisone to my doc and see if I could sample some just for shits and giggles.

So it could be a overactive immune system and you would suppress this with steroids. Well to use arthritis as a example(immune system attacking own tissue) a long term maintenance dose would prob be in the realm of 5mg, maybe start with that to be safe.

24 minutes ago, TrueJustice said:

The long post about genes getting altered above kinda suggests that zinc isn't a cure yeah??!

The long post on altered genes is the equivalent of a needle in a haystack. Someone could spend their whole life trying to decipher that and still not have a answer.
I treat this forum maybe differently then some people. I could relate that long post on gene changes to a math equation. These posts are the chalkboard trying to work out the equation. Looking at that you can see how things could go in so many different directions. To clarify, mentioning something numerous times dosnt mean thats the answer. Im just trying to work through the problems and showing my work in a way.
Some things I also post because you never know who might come through here that has unlimited funds and numerous connections to be able to take things farther then anyone has been able to in the past.

13 hours ago, guitarman01 said:

solute carrier family 39 (zinc transporter), member 14 SLC39A14

This gene for example, could cause a disruption in zinc homeostasis. This could stop growth.
I could also make a case for excess zinc possibly inducing some types of mmps that can cause tissue destruction. As in the case with periodontal disease. its all very conflicting.
So everything I say should come with a disclaimer in that im just trying to post what might be useful information to keep the ball rolling. If it favors zinc for instance, that is just something that Im looking into atm. Process of elimination.

2 hours ago, Colinboko said:

So, from what I remember someone on here said they felt SIGNIFICANTLY better while taking prednisone. For those who don't catch colds/viruses anymore, I wonder if this could be our golden ticket...

I'm truly convinced it has a lot to do with a modulation of the immune system. At least for some of us. I'm going to bring up prednisone to my doc and see if I could sample some just for shits and giggles.

This would be good to know for sure, but who can tell us for sure if Accutane effects immune system or not?

I went to see a top gastroenterologist last year and did colon and gastro examination - at the end he dismissed it all saying nothing wrong with gut even though I think there is - no mention of immune system impairment which would be gut related correct?, so if a gastroenterologist can't help than who can when it comes to immune system issues??

I'm fucken sick of experimenting - I just want someone to come back with conclusive evidence ofsomething so we know exactly what to take, what immune system drug to take!

If anyone knows the name of any particular tests that would be a good starting point, that way I could go back to this specialist and ask more questions, insist on certain tests etc.

9 hours ago, Redslippers said:

Please forgive me if any of this is redundant. I came into this search because my daughters friend started struggling with depression and suicidal inclinations. Turns out she was on Accutane a few months ago, and Im sure thats the genesis of her symptoms. In researching side effects, Im horrified by the long-term, wide ranging destruction to so many physical systems that can result from this drug. Even today with all the info available online, it is easy not to know how scary possible side effects of a drug are, and end up taking something that is very damaging. My dad is a PhD in analytical chemistry. He worked on asthma medications for years. He distrusts a lot of medications because he knows possible risks. Doctors often dont; either they dont understand it or dont keep up with the warnings, or just dont pay attention to the ingredients and what they can do. (Like, asthma inhalers with high alcohol content will irritate the airways, not open them. Seems obvious, but if youre not paying attention to the ratios of ingredients ) I still avoid fake sugars because Dad banned saccharine when I was a kid. I avoid Cipro (ciprofloxacin) because it can cause deadly nerve damage. There are basic, safer options like erythromycin, amoxicillin, or azithromycin. So I still call and ask Dad about anything we are prescribed, or supplements to consider. When I asked him what might help with our friends depression, he said zinc. Drinking enough water to flush your system, and zinc. I have seen zinc mentioned in some posts here, but I wanted to pass it along specifically too. Recent studies have indicated it helps with depression in solid physiological ways. Heres one article:

https://www.psychologytoday.com/blog/evolutionary-psychiatry/201309/zinc-antidepressant

And because zinc is a mineral your body will always need, its something you can take long term, unlike some of the herbs or purges that you are only supposed to use for short lengths of time. Recommended daily allowances on zinc supplements are usually pretty conservative. I would start there and see if it helps. Dad did studies years ago on zinc deficiency in kids who were way behind on the growth curve. Proper zinc levels normalized growth in these kids. It helps other systems in your body work efficiently, and it helps in absorption of antioxidants.
Another reason I want to mention it is that zinc also helps increase taste acuity and appetite,fight hair loss, improve skin issues, and improve libido. (Oysters are high in zinc, which is why they're effective as an aphrodesiac.) Each of these match up to combat some of Accutanes long term side effects. I dont know if zinc will cure the massive side effects some people are suffering with, but it might help. Honestly, I believe it cant hurt. So I wanted to post that in case it helps someone to heal. And I'm praying - for improvement, for success in finding treatments, and healing for all of you dealing with horrible damages.

 

Thank you so much for trying to help us out. Please get your daughters's friend to report her side effects to Yellow Card - MHRA, Roche, or FDA.

 

2 Things:
1- for the third time, what is the most someone has recovered from this semi-dead state?
2- I have been able to convince my psychologist that accutane can mess up your brain. I showed him a few studies I found, and he told me he was able to find some decent stuff after doing a little bit of searchingon his own.

If you respong to either, please answer #1 as well

11 hours ago, TrueJustice said:

This would be good to know for sure, but who can tell us for sure if Accutane effects immune system or not?

I went to see a top gastroenterologist last year and did colon and gastro examination - at the end he dismissed it all saying nothing wrong with gut even though I think there is - no mention of immune system impairment which would be gut related correct?, so if a gastroenterologist can't help than who can when it comes to immune system issues??

I'm fucken sick of experimenting - I just want someone to come back with conclusive evidence ofsomething so we know exactly what to take, what immune system drug to take!

If anyone knows the name of any particular tests that would be a good starting point, that way I could go back to this specialist and ask more questions, insist on certain tests etc.

I was going to try and get an antibodies test. But I've also been experiencing some vocal cord inflammation and prednisone is often given to help reduce this. So I wonder if I'll feel any affects from it.

16 hours ago, Colinboko said:

So, from what I remember someone on here said they felt SIGNIFICANTLY better while taking prednisone. For those who don't catch colds/viruses anymore, I wonder if this could be our golden ticket...

I'm truly convinced it has a lot to do with a modulation of the immune system. At least for some of us. I'm going to bring up prednisone to my doc and see if I could sample some just for shits and giggles.

This was me, high dose prednisone made me feel 100% normal. I was taking it as a 15 day taper for what a doc thought was asthma. Currently doing the opposite of cortisol, blasting testosterone and NPP. I feel good, but NOTHING made me ever feel as great as prednisone. Perfect sleep, perfect energy, perfect digestion, immense mental clarity. (even though I think I read somewhere that cortisol worsens memory?) but that wasn't the case for me, if I was bored I could plan out my whole week and have 5 days go by and still remember all the planning for that day that I had made.

I would certainly do it again if it wasn't counterproductive to what I'm trying to physically achieve considering it breaks down muscle. And if I knew that some long term high dose trial of this stuff would be a permanent fix, I wouldn't hesitate to quit my steroids, start PCT, and afterwards run prednisone again.

Who can share any results about short or longterm LDN usage?

1 hour ago, ehohel said:

This was me, high dose prednisone made me feel 100% normal. I was taking it as a 15 day taper for what a doc thought was asthma. Currently doing the opposite of cortisol, blasting testosterone and NPP. I feel good, but NOTHING made me ever feel as great as prednisone. Perfect sleep, perfect energy, perfect digestion, immense mental clarity. (even though I think I read somewhere that cortisol worsens memory?) but that wasn't the case for me, if I was bored I could plan out my whole week and have 5 days go by and still remember all the planning for that day that I had made.

I would certainly do it again if it wasn't counterproductive to what I'm trying to physically achieve considering it breaks down muscle. And if I knew that some long term high dose trial of this stuff would be a permanent fix, I wouldn't hesitate to quit my steroids, start PCT, and afterwards run prednisone again.

Here you go everyone ^

Not 40% better, not 80% better...

100% better...

Doesn't hurt to try..

http://eczemacure.info/2008/10/17/my-21st-liver-flush-was-i-a-victim-of-accutane/

1 hour ago, Colinboko said:

Here you go everyone ^

Not 40% better, not 80% better...

100% better...

Doesn't hurt to try..

Are you saying you only feel 100% better when you're on it?

What happens when you're off it? Do you go back to feeing crap again? If that's the case it's not curing anything yeah, just masking the side effects!

Im just asking so I can gather all the info.

15 minutes ago, TrueJustice said:

Are you saying you only feel 100% better when you're on it?

What happens when you're off it? Do you go back to feeing crap again? If that's the case it's not curing anything yeah, just masking the side effects!

Im just asking so I can gather all the info.

It's not masking anything. It's significantly reducing the constant inflammation accutane has set upon our bodies. If you think there is some magic pill that will ultimately and permanently reduce the inflammation that this pill has caused then by all means chuck up some options. But if prednisone is going to make me feel better, you can bet your ass I'm going to take it regardless of what it may bring down the road. I have a life to live. I have things I wish to accomplish. And I sure as hell don't want to have a life dependent on constantly checking an out dated blog.

if you were looking between ldn and a oral steroid I would say ldn would be the safer option long term. Prednisone is a immune suppressant but its also one of the most powerful anti inflammatories you can take. LDN is a immune stimulant or regulator but it also has central nervous system anti inflammatory properties. So it would be hard to say what part of the drugs were having the greater effect. Taking a immunosuppressant for a long period of time is probably not a good idea. I have also had various immune type blood tests or markers of systemic inflammation that have all come back normal. If it was me I would definitely trial LDN before prednisone. Both of these might just be masking a underlining issue, but for people that just want relief I definitely understand.

2 minutes ago, guitarman01 said:

if you were looking between ldn and a oral steroid I would say ldn would be the safer option long term. Prednisone is a immune suppressant but its also one of the most powerful anti inflammatories you can take. LDN is a immune stimulant or regulator but it also has central nervous system anti inflammatory properties. So it would be hard to say what part of the drugs were having the greater effect. Taking a immunosuppressant for a long period of time is probably not a good idea. I have also had various immune type blood tests or markers of systemic inflammation that have all come back normal. If it was me I would definitely trial LDN before prednisone. Both of these might just be masking a underlining issue, but for people that just want relief I definitely understand.

It's just so strange to me that both elohel and I have not caught a cold/flu since the onset of our symptoms. If I feel a sore throat coming on, it's gone within an hour. Something is in overdrive. There is some sort of inflammatory response. Probably why the acne doesn't return either... because even that bacteria gets instantly destroyed. I also don't have slow wound healing that most post accutane sufferers have. My wounds heal normally, and to be honest maybe even faster than before. This could be it for me.

If any of you live in Europe and care even a little bit about making sure your side effects are recognized and others are properly warned, please follow the links to report your experience with Accutane to your European Medicines Agency PRAC representative:

https://www.lastingsides.org/roaccutane/european-medicines-agency-to-review-roaccutane

They are holding a committee meeting in June to discuss increasing warnings on the drug, especially regarding depression, and possibly adding sexual side effects to the information.

was just looking at that list of changed genes I posted. lead me to this.

phosphatidylcholine transfer protein PCTP Changed( now looking at these its hard to say if anything would result in a actual mutation you could see on 23andme or just altered function, alot of these processes prob revert back to normal after accutane as seen in the countless blood tests we've had, but maybe there are some tucked away/harder to investigate that dont.)

Choline Metabolism Provides Novel Insights into Non-alcoholic Fatty Liver Disease and its Progression

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486/

Humans eating low choline diets develop fatty liver and liver damage,. This dietary requirement for choline is modulated by estrogen and by single nucleotide polymorphisms (SNPs) in specific genes of choline and folate metabolism.

Choline, folate and methionine metabolism are interrelated as all influence the production ofS-adenosylmethionine, the universal donor of methyl-groups in biological reactions [5] (Figure 1). Deficiency in one nutrient is associated with an increase in flux of the other nutrients towards methyl donation [5].

An especially important choline metabolite in liver is phosphatidylcholine, which is necessary for the packaging and export of triglycerides in very low density lipoprotein (VLDL) [15] and for the solubilization of bile salts for secretion [16]. Aberrant VLDL mediated secretion of triglycerides is a central mechanism in hepatic steatosis [17]. The role of bile homeostasis in liver physiology is also quite evident, and mostly relates to the causes of gallstones, fibrosis, and hepatocarcinomas [18]. However, new functions attributed to bile salts, including regulation of energy and glucose metabolism [1921], makes it likely that phosphatidylcholine plays a role in modulating these functions as well.

Heres a different one as a example. If that list I posted means anything, and some changes still might be relevant, there are alot of possibilities.

solute carrier family 39 (zinc transporter), member 8 SLC39A8 Changed

We conclude that Zip8(slc39a8) is unique, relative to other Zip proteins, by functioning as an essential zinc importer at the onset of inflammation
http://ajplung.physiology.org/content/294/6/L1127