Acne.org Products
1 hour ago, TrueJustice said:Aren't all the side effects known by now?
I'm more into reporting on Doctors and Specialists ignorance or general inability to know what to do with the side effects - that's what needs reporting more than anything but who the hell do you tell that to??It's the bullshit theory that once you stop taking tane any side effects will go away, that's the lie that needs reporting.
This is what I tell any 'expert' who disagrees, and it shuts them up real quick. Clear skin was a 'side effect' of the original purpose of Tane, yet my clear skin has persisted 8 + years after stopping. So why is that the only side effect that's 'allowed' to persist years later?
12 hours ago, TrueJustice said:Aren't all the side effects known by now?
I'm more into reporting on Doctors and Specialists ignorance or general inability to know what to do with the side effects - that's what needs reporting more than anything but who the hell do you tell that to??It's the bullshit theory that once you stop taking tane any side effects will go away, that's the lie that needs reporting.
So you haven't reported then - thanks a lot. Maybe if you and others bothered to report their side effects many young people might have been saved from taking this poison.
If you got the time to visit this forum you have the time to report your sides.
50 minutes ago, hatetane said:So you haven't reported then - thanks a lot. Maybe if you and others bothered to report their side effects many young people might have been saved from taking this poison.
If you got the time to visit this forum you have the time to report your sides.
I've seen over 20 different doctors, tons of specialists, naturopaths, counselor's, that's just off the top of my head.
How many people do I need to tell??
You sound like a crusader for getting this drug banned - all power to you!!, no doubt we all feel that way but my approach is to continue to talk to people ( doctors/specialists) about issues rather than fill out some form trying to explain I've got side effects 20 years after the fact.
I respect your approach, I ask that you respect mine too.
4 hours ago, TrueJustice said:I've seen over 20 different doctors, tons of specialists, naturopaths, counselor's, that's just off the top of my head.How many people do I need to tell??
You sound like a crusader for getting this drug banned - all power to you!!, no doubt we all feel that way but my approach is to continue to talk to people ( doctors/specialists) about issues rather than fill out some form trying to explain I've got side effects 20 years after the fact.
I respect your approach, I ask that you respect mine too.
No, i am not out to get acc banned - i want permanent sexual side effects listed in the packet just like propecia.
You have nothing to lose by filling in a form - have you asked you doctors if they reported you claims or if they automatically report all reported adversesides of drugs?
If you can't see your part of the problem not much else I can say.
I want everyone to be able to make informed choices - wouldn't you have liked that opportunity?
By the way - do you know why propecia have researchers trying to find a cure - it's because of the amount of guys who reported it
to the respective bodies!
Send me the best link that us Aussies should fill out in reporting side effects. I'm assuming you don't need to mention when you actually took it, otherwise I might get laughed off if I say 1997.
I'm also assuming there's a form more suitable for us over say US or U.K. victims.
9 hours ago, TrueJustice said:I've seen over 20 different doctors, tons of specialists, naturopaths, counselor's, that's just off the top of my head.How many people do I need to tell??
You sound like a crusader for getting this drug banned - all power to you!!, no doubt we all feel that way but my approach is to continue to talk to people ( doctors/specialists) about issues rather than fill out some form trying to explain I've got side effects 20 years after the fact.
I respect your approach, I ask that you respect mine too.
No, i am not out to get acc banned - i want permanent sexual side effects listed in the packet just like propecia.
You have nothing to lose by filling in a form - have you asked you doctors if they reported you claims or if they automatically report all reported adversesides of drugs?
If you can't see your part of the problem not much else I can say.
I want everyone to be able to make informed choices - wouldn't you have liked that opportunity?
By the way - do you know why propecia have researchers trying to find a cure - it's because of the amount of guys who reported it
to the respective bodies!
On 3/26/2017 at 1:24 PM, TrueJustice said:Send me the best link that us Aussies should fill out in reporting side effects. I'm assuming you don't need to mention when you actually took it, otherwise I might get laughed off if I say 1997.
I'm also assuming there's a form more suitable for us over say US or U.K. victims.
https://www.tga.gov.au/reporting-medicine-and-vaccine-adverse-events-0
Fill out the report form and you can also ask them for all reported adverse side effects from accutane
under theFreedom of Information Act.
Of course we know not enough people are reporting, still it would be interesting if we all gathered this information.
On the UK form it asks if your doctor reported the side effect - you can see why this information is important.
If it is shown that doctors are not reporting very serious adverse side effects - criminal really - there may in future be a change
that would make sure ALL reported adverse side effects do get reported whether the doctor believes it or not!
This may or may not help us or others in the future but it can't hurt.
As for time frame that is totally irrelevant and the fact that you have seen so many doctors in the past 30 could go a long way in
providing info that will lead to better patient care.
Can everyone get on board with this - it is so simple and it will also help anyone who tries to bring a legal case.
Dubya is a great advocate of REPORTING and he lists many addresses in his tagline. http://www.nomorepanic.co.uk/showthread.php?t=129912 Don't be part of the problem!
Report your side effects through the following links:
Rxisk -[Edited link out]
FDA - https://www.accessdata.fda.gov/scripts/medwatch/index.cfm?action=consumer.reporting1
NHS - http://yellowcard.mhra.gov.uk/
Roche -[Edited link out]
Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin.
Abstract
Acne vulgaris is a skin disorder of the sebaceous follicles, involving hyperkeratinization and perifollicular inflammation. Matrix metalloproteinases (MMP) have a predominant role in inflammatory matrix remodeling and hyperproliferative skin disorders. We investigated the expression of MMP and tissue inhibitors of MMP (TIMP) in facial sebum specimens from acne patients, before and after treatment with isotretinoin. Gelatin zymography and Western-blot analysis revealed that sebum contains proMMP-9, which was decreased following per os or topical treatment with isotretinoin and in parallel to the clinical improvement of acne. Sebum also contains MMP-1, MMP-13, TIMP-1, and TIMP-2, as assessed by ELISA and western blot, but only MMP-13 was decreased following treatment with isotretinoin. The origin of MMP and TIMP in sebum is attributed to keratinocytes and sebocytes, since we found that HaCaT keratinocytes in culture secrete proMMP-2, proMMP-9, MMP-1, MMP-13, TIMP-1, and TIMP-2. SZ95 sebocytes in culture secreted proMMP-2 and proMMP-9, which was also confirmed by microarray analysis. Isotretinoin inhibited the arachidonic acid-induced secretion and mRNA expression of proMMP-2 and -9 in both cell types and of MMP-13 in HaCaT keratinocytes. These data indicate that MMP and TIMP of epithelial origin may be involved in acne pathogenesis, and that isotretinoin-induced reduction in MMP-9 and -13 may contribute to the therapeutic effects of the agent in acne.
MMP9 Functions
Proteins of thematrix metalloproteinase(MMP) family are involved in the breakdown ofextracellular matrixin normal physiological processes, such asembryonic development,reproduction,angiogenesis,bone development,wound healing, cell migration,learningandmemory, as well as in pathological processes, such asarthritis,intracerebral hemorrhage,[5]andmetastasis.[6]Most MMPs are secreted as inactiveproproteinswhich are activated when cleaved by extracellularproteinases. The enzyme encoded by this gene degrades type IV and Vcollagensand other extracellular matrix proteins.[7]Studies in rhesus monkeys suggest that the enzyme is involved inIL-8-induced mobilization ofhematopoieticprogenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.[3]
Molecular function
collagen binding
zinc ion binding
metal ion binding
peptidase activity
protein binding
identical protein binding
hydrolase activity
metallopeptidase activity
endopeptidase activity
serine-type endopeptidase activity
metalloendopeptidase activity
Cellular component
extracellular matrix
proteinaceous extracellular matrix
extracellular region
extracellular exosome
extracellular space
tertiary granule lumen
ficolin-1-rich granule lumen
Biological process skeletal system development
negative regulation of cation channel activity
positive regulation of protein phosphorylation
endodermal cell differentiation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
ossification
negative regulation of intrinsic apoptotic signaling pathway
ephrin receptor signaling pathway
extracellular matrix disassembly
negative regulation of apoptotic process
proteolysis
macrophage differentiation
positive regulation of keratinocyte migration
positive regulation of apoptotic process
collagen catabolic process
positive regulation of release of cytochrome c from mitochondria
positive regulation of receptor binding
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
embryo implantation
leukocyte migration
positive regulation of vascular smooth muscle cell proliferation
extracellular matrix organization
positive regulation of cell migration
neutrophil degranulation
Inhibition of human gingival gelatinases (MMP-2 and MMP-9) by metal salts.
Abstract
OBJECTIVES:
The interaction between metal ions and the oral environment is a major subject matter in dental research. Matrix metalloproteinases (MMPs) have been implicated in several pathologic oral processes such as periodontal tissue destruction, root caries, tumour invasion and temporomandibular joint disorders. The aim of this work was to test the effect of Zn, Cu, Sn and Hg ions on the activity of the major gingival gelatinolytic MMPs.
METHODS:
Gingival explants were cultured overnight in DMEM and the activity of secreted enzymes was analyzed by gelatin zymography in buffers containing different metal ion concentrations. The major gelatinolytic proteinases present in the conditioned media were characterized as MMP-2 and MMP-9 by immunoprecipitation with specific antibodies. The eletrophoretic bands were scanned and the transmittance values were analyzed with the Sigmagel software (Sigma).
RESULTS:
ZnSO4 was a strong inhibitor of MMP-2 (I50 = 15 microM) and MMP-9 (I50 = 40 microM), whereas CuSO4, HgSO4 and SnCl2 showed less efficient inhibition potential.
SIGNIFICANCE:
Our findings show that the activity of oral tissue MMPs may be modulated by metal ions present in the oral environment. Therefore, the accumulation of metals in connective tissue may interfere with the formation and resorption of the extracellular matrix components.
On 3/25/2017 at 9:56 PM, TrueJustice said:Aren't all the side effects known by now?
I'm more into reporting on Doctors and Specialists ignorance or general inability to know what to do with the side effects - that's what needs reporting more than anything but who the hell do you tell that to??It's the bullshit theory that once you stop taking tane any side effects will go away, that's the lie that needs reporting.
Yep, I was told by the doctor that the side-effects would all go away as soon as I stopped taking the drug....obviously wrong 
some of this is looking pretty interesting, that may pertain to more then just oral health.
Zinc reduces collagen degradation in demineralized human dentin explants.
Author information
- 1
- Department of Dental Materials, School of Dentistry, Campus de Cartuja s/n, University of Granada, E-18071 Granada, Spain. [email protected]
Abstract
OBJECTIVES:
Dentin matrix metalloproteinases are implicated in the pathogenesis of caries and contribute to collagen degradation in resin-dentin interfaces. The objective was to determine if collagen degradation may be modulated by an excess of zinc or zinc chelators.
METHODS:
Mineralized and phosphoric acid demineralized human dentin specimens were tested. Chlorhexidine digluconate, doxycycline or ZnCl were added to the media. In half of the groups, active exogenous metalloproteinase-2 was incorporated into the solution. C-terminal telopeptide determinations (radioimmunoassay) were performed after 24 h, 1 and 3 weeks.
RESULTS:
Collagen degradation was prominent in demineralized dentin. Doxycycline fully blocked dentin proteolysis. Chlorhexidine digluconate reduced the degradation at the 24-h period. Zinc in excess strongly inhibits hydrolysis of collagen and its effect was maintained for 3 weeks.
CONCLUSIONS:
Zinc in excess reduces MMP-mediated collagen degradation. The hypothesis that binding of zinc to collagen results in protection of sensitive cleavage sites of metalloproteinases requires further validation.
I'd like to pin down if anything abnormal is going on with zinc, people have seemed to have some issues with zinc supplements, So is more zinc a good or bad thing? I've seen blood levels fluctuate down to as low as in the 50s with people post accutane but also as high as 100, where 100 seems to be the mean average in healthy populations. I might consider getting a 24 zinc urine test to see if that reveals anything.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836234/
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases involved in the breakdown of the extracellular matrix (ECM) and basement membrane components such as aggrecan, collagen, elastin, fibronectin, gelatin, and laminin.[13] In normal physiology, MMPs are responsible for ECM homeostasis, tissue remodeling, wound healing, angiogenesis, and apoptosis amongst other important processes.[1,46] However, MMPs can also participate in the pathophysiology of diseases such as arthritis, multiple sclerosis, periodontal disease, cancer metastasis, atherosclerosis, and cardiac injury and remodeling.[712] MMPs have therefore been an important therapeutic target for over two decades, with growing interest to-wards the design of inhibitors that are highly specific against different MMP isoforms and possess a high therapeutic index over older generation compounds.[1319]
Normal serum level of Zn is 84-159 g/dl. Also, the serum level of Zn under 83 g/dl is considered as Zn deficiency (6)
A prominent feature of Zn deficiency is the broad range of produced pathologies and a spectrum of clinical manifestations, including impaired growth, alopecia, anemia, dwarfism, impaired sexual development, dermatitis, loss of hair, poor appetite, abnormal dark adaptation, delayed wound healing and mental lethargy (3,4,8-13).
In 2007, Orbak reported, for the first time, that yhyperkeratinization was more prominent in Zn-deficient rats. They suggested that Zn deficiency is a potential risk factor for oral and periodontal diseases (19).
I am on LDN since wednesday. I was interested in it because of digestive issues, it's only few days so I don't expect it to help so quick but holy cow it helped. Not for digestive issues, but for mental part and energy levels. I feel sooo much better, normally at last. I still have pain in my body, but I can actually concentrate on other things, and brain fog is no more.
Dubta says:
Do your part to raise awareness:
For new individuals PM'ing me, I will reply IF you report all your side effects to the links below and screenshot each one once you have completed it. PM me with your email and I will message you and you can send the screenshots over with whatever questions you like.
Report side effects to organisations here:
Rxisk
[Edited link out]
FDA
https://www.accessdata.fda.gov/scripts/medwatch/index.cfm?action=consumer.reporting1
NHS
http://yellowcard.mhra.gov.uk/
Roche
[Edited link out]
Report side effects to accutane sympathetic MP's here (UK):
[email protected]
[email protected]
I encourage people to copy this signature into their own.
4 hours ago, guitarman01 said:I'd like to pin down if anything abnormal is going on with zinc, people have seemed to have some issues with zinc supplements, So is more zinc a good or bad thing? I've seen blood levels fluctuate down to as low as in the 50s with people post accutane but also as high as 100, where 100 seems to be the mean average in healthy populations. I might consider getting a 24 zinc urine test to see if that reveals anything.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836234/
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases involved in the breakdown of the extracellular matrix (ECM) and basement membrane components such as aggrecan, collagen, elastin, fibronectin, gelatin, and laminin.[
13] In normal physiology, MMPs are responsible for ECM homeostasis, tissue remodeling, wound healing, angiogenesis, and apoptosis amongst other important processes.[1,46] However, MMPs can also participate in the pathophysiology of diseases such as arthritis, multiple sclerosis, periodontal disease, cancer metastasis, atherosclerosis, and cardiac injury and remodeling.[712] MMPs have therefore been an important therapeutic target for over two decades, with growing interest to-wards the design of inhibitors that are highly specific against different MMP isoforms and possess a high therapeutic index over older generation compounds.[1319]
On numerous tests my Zinc levels are fine, Copper was an abnormality on a couple of them.
If we can work out the relationship between Zinc/Copper/Vit A we might be on to something.
We still don't know if the Liver after tane has been altered in some way with how it processes Vit A etc, meaning we can supplement all we want but if the liver can't process correctly that's the problem ahead of everything else.
19 hours ago, Umas said:I am on LDN since wednesday. I was interested in it because of digestive issues, it's only few days so I don't expect it to help so quick but holy cow it helped. Not for digestive issues, but for mental part and energy levels. I feel sooo much better, normally at last. I still have pain in my body, but I can actually concentrate on other things, and brain fog is no more.
What is LDN?
3 hours ago, ehohel said:Anyone ever consider HGH for joint and tendon repair?
Out of all the people that have come through here has anyone actually been diagnosed( ie, x-rays, bone scans, tissue samples ) with any degenerative joint or muscle disease? if this happened because of accutane you think this would be turning into lawsuits, but you never hear of anything.
I'm curious myself about getting a bone density scan and having a specialist specifically look at joint tissue and cartilage and possibly a muscle biopsy, maybe which might reveal some things.
its also hard to distinguish sometimes, between muscle pain, nerve pain, joint pain, and bone pain.
