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What's different about Lugols??
My Iodine drops are combined with potassium- I'm assuming that's standard for any good quality drops correct?
Im hearing that selenium is good to take whilst on Iodine, what else is recommended?
No links pls - Those who've had success with an Iodine protocol just send me a list of supplements that work in conjunction- I'll guarantee I already have it in my arsenal of supplements stashed in the cupboard.
Thank you
Just thought I would post out of interest.
[Edited link out]
On 3/18/2017 at 6:27 AM, TrueJustice said:What's different about Lugols??
My Iodine drops are combined with potassium- I'm assuming that's standard for any good quality drops correct?
Im hearing that selenium is good to take whilst on Iodine, what else is recommended?
No links pls - Those who've had success with an Iodine protocol just send me a list of supplements that work in conjunction- I'll guarantee I already have it in my arsenal of supplements stashed in the cupboard.
Thank you
Are you joking?
3 minutes ago, hatetane said:Just thought I would post out of interest.
http://propeciahelp.com/endocrinologyAre you joking?
Nope - I've got heaps of stuff, just have to be sure it's still in date.
On 3/18/2017 at 8:58 AM, hatetane said:Just thought I would post out of interest.
[Edited link out]
when I compare the relationship between finasteride and accutane long term side effects, I'd call it a drug induced sickness, a disability, a disease.
you would think they'd figure it out soon with propecia, its more synonymous with its side effects then it is as a hair loss treatment.
On 3/15/2017 at 9:57 PM, hatetane said:http://www.curezone.org/forums/am.asp?i=423167
spine degeneration
Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis.
Abstract
Mutations in copper/zinc superoxide dismutase (SOD1) are responsible for 20% of familial amyotrophic lateral sclerosis through a gain-of-toxic function. We have recently shown that ammonium tetrathiomolybdate, an intracellular copper-chelating reagent, has an excellent therapeutic benefit in a mouse model for amyotrophic lateral sclerosis. This finding suggests that mutant SOD1 might disrupt intracellular copper homeostasis. In this study, we investigated the effects of mutant SOD1 on the components of the copper trafficking pathway, which regulate intracellular copper homeostasis. We found that mutant, but not wild-type, SOD1 shifts intracellular copper homeostasis toward copper accumulation in the spinal cord during disease progression: copper influx increases, copper chaperones are up-regulated, and copper efflux decreases. This dysregulation was observed within spinal motor neurons and was proportionally associated with an age-dependent increase in spinal copper ion levels. We also found that a subset of the copper trafficking pathway constituents co-aggregated with mutant SOD1. These results indicate that the nature of mutant SOD1 toxicity might involve the dysregulation of the copper trafficking pathway, resulting in the disruption of intracellular copper homeostasis.
Anyone else have foamy/bubbly urine? I've read it could be the result of the body not properly absorbing protein. So I've been taking protein powder lately to sort of compensate and I definitely feel much better.
It made me think of that bodybuilder youtuber Brian Turner who never had any sexual side effects despite taking accutane for over a year. Could it be because he probably daily consumes protein powder?
A definite yes for Iodine. Too many hormonal and glandular correlations to Accutane to pass on it. Look, if you've been on Accutane, I just about guarantee your LH/FSH signaling (and therefore Testosterone too) is fried. Your pituitary's fucked. So you better get on Iodine and MAYBE de-calcify a bit from other halogens. I've been taking up to 100mg daily with no sides to speak of, besides vivid dreams/inability to sleep. I view this as a positive though. One MUST stress on the importance of taking Iodine with its co-factors, though:
https://docs.google.com/document/d/1t_6oprpjmDCMqwCXP_6BMf0Mbr9DivmOSALeJTjReuY/edit
I tried 50mg Zinc a second time today. No dryness this time around. I feel just fine. I'm not sure what it was with the first time I tried it, but I'm always curious to briefly experiment with 5-ARIs.
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In regards to TRT, today marks 2 months for me. Getting my hormones checked next week. I feel pretty good mentally. Physically, I'm unsure. My joints are much better. It's much easier for me to walk, do yoga, workout, lift heavy stuff, squat. I definitely gained some muscle, though this is not yet a reference as going on TRT mentally made me crash (no fun to be there at 25yo) and I haven't gone to the gym very consistently. That's absolutely my fault, and I'm getting back on track gym/diet wise and I hope to fully benefit from TRT in that sense, very soon.
Libido.. interestingly, nothing to speak about. Like, nothing. I think it's worse since beginning TRT.
I'm much more aggressive, much more sharp, much more able to just do stuff and accomplish my daily goals. I no longer nap. I can live on little sleep where as I used to require 10h+ everyday.
Dryness wise... I'll suggest it has very, very slightly improved. Chronic rhinitis is a bit better. Face skin still pretty dry. The rest of my skin is pretty darn smooth. My hair feels a bit more brittle. Tough to explain, but it's not in a bad way. Its texture has just changed a bit. My eyes are dry as usual.
IBS has improved. My stomachtends to not be as big and inflamed for a skinny athletic person. Foods haven't been hurting me as much. Toilet-wise.. it's been worse, but is it TRT? I'm thinking it might be the Magnesium (malate/oxide) I had been taking so far.
TRT supposedly builds up over time. I'm not taking injections yet, and I understand Androgel might be poorly absorbed by some. I will likely change the administration route upon having my hormone results. I don't believe my T levels are much higher, but I remain very positive that TRT brings about permanent improvements to many issues caused by Accutane.
I've been a bit down lately. Some things sometimes are tougher to accept than others, but I'm back, feeling better, and more than ever prepared to cure myself and get the life I want.
Summing up, here's my life currently:
Daily Supplements
5g androgel
60mg+ Iodine
2g vit C
2000mg vit K2 [Edited link out]
200-400mg Magnesium [Edited link out]
200mg Selenium
500mg Calcium-D-Glucarate [Edited link out]
400 IU vit E
4k IU vit D
250mg Rhodiola (every so often, energy/focus boost)
500mg Phenibut (once a week or so, acts much like alcohol replacement)
Some Nootropics here and there for fun.
After a chaotic restaurant discovery month, back to a strict paleo/bulleproof diet. Very clean. Many veggies, much healthy fat and high quality proteins.
Daily Yoga, Meditation, Acupressure. A/B/C workouts over 8/9 days doing SDeadlift, Squats, Bench, Pullups, Pushups. Walking 1h+ a day outside.
Very strict nofap hard-mode.
This wouldn't be a dietary deficiency but maybe there could be something else going on here.
Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver.
Abstract
We studied the effects of zinc deficiency on hepatic androgen metabolism and aromatization, androgen and estrogen receptor binding, and circulating levels of reproductive hormones in freely fed, pair-fed and zinc deficient rats. Hepatic conversion of testosterone to dihydrotestosterone was significantly less, but formation of estradiol from testosterone was significantly greater in rats fed the zinc-deficient diet compared with freely fed and pair-fed control rats. There were significantly lower serum concentrations of luteinizing hormone, estradiol and testosterone in rats fed the zinc-deficient diet. No difference in the concentration of serum follicle-stimulating hormone was observed between the zinc-deficient group and either control group. Scatchard analyses of the receptor binding data showed a significantly higher level of estrogen receptor in zinc-deficient rats (36.6 +/- 3.4 fmol/mg protein) than in pair-fed controls (23.3 +/- 2.2 fmol/mg protein) and a significantly lower level of androgen binding sites in rats fed the zinc-deficient diet (6.7 +/- 0.7 fmol/mg protein) than in pair-fed control rats (11.3 +/- 1.2 fmol/mg protein). There were no differences in hepatic androgen and estrogen receptor levels between freely fed and pair-fed controls. These findings indicate that zinc deficiency reduces circulating luteinizing hormone and testosterone concentrations, alters hepatic steroid metabolism, and modifies sex steroid hormone receptor levels, thereby contributing to the pathogenesis of male reproductive dysfunction.
I've just been diagnosed with severe sinus disease and vasculitis. Trying prednisolone and amoxicillin going forward. Does anyone else have enlarged lacrimal glands / dacryoadenitis and swollen vasculature around the orbit?
Additionally, I've noticed that my symptoms seem to be getting way worse recently. I can't figure out what I'm doing. I recently stopped weight training as I tore my left shoulder labrum/rotator cuff and need surgery. I am absolutely convinced accutane weakened my cartilage.
I am currently trying proviron, nofap hard mode, taking CoQ10, zinc, biotin, and 10mg cialis. I have recently also developed peyronie's. My DHT continues to test very low, as well as very low SHBG.
Hope my next update is more positive.
1 hour ago, Weltschmerz47 said:I've just been diagnosed with severe sinus disease and vasculitis.
Sorry to hear this. How were these diagnosed? Did they have a cause for Vasculitus? How long ago and what was your duration and dosage of accutane? Have you had your copper serum, ceruloplasmin and zinc serum tested? Maybe we should start to consider getting a 24hr copper urine and zinc. I still think there might be something abnormal going on with Copper and zinc. Something going on with connective tissues.
Maybe there is something going on with systemic calcification or misuse of calcium.
Anyone else who has their 23andme data have any pathogenic mutations at the atp7a or atp7b genes?
So, BBC just came out with an articleadvocating not retinoid therapy in general, mind you, but ROACCUTANE in particular. Cue the before and after shots of perfection. Ahhh so beautiful.
[Edited link out]
I think it's sad tbh. they think they are "doing the right thing"by advocating these new age drugsunder the guise of "we care about you" "we want to help".Roche is the same way with their Cancer awareness tweets. And that's all fine and dandy if treatment is successful, but what happens if it's not? Will they still have your back? These people are really low. I think its partly due to their willingful ignorance ofadverse effects. We as a societydon't want to hear about set backs or failures, we just want to make our quota at the end of the day, because in our mind that is progress. The fact that this drugs mechanisms of action are unknown and altering certain internal parts of the body could lead to issues later on down the road is not a concern. Let's be honest, we humans just want the quick fix. Companies want the quick quarterly profits. Your life later on down the road means very little to them if anything at all.
" Roche's rising haemophilia star emicizumab is far from untarnished on the safety front, but news of a patient death in its ongoing pivotal programme takes concerns to a new level. The big question is whether the apparent thrombosis risk is a threat to approval."
http://www.ehc.eu/roche-issues-statement-on-emicizumab-clinical-trial/
The statement is the best part. "Not our fault. Safety is our number 1 priority."
Honestly, if you arean investor, I would bet big on emicizumab getting approval and becoming one of the biggest sellers by 2022. Roche will get the FDA to clear it. It will hit the market. We know better than anyone. There will be commercials airing around 2027, and a couple hundred deaths, but so what, we turned a profit. Just be sure to get in and out quick.
5 hours ago, Colinboko said:Guys, we need to stop switching subjects so quickly on this thread. Makes it feel like we're getting absolutely nowhere. We were discussing hormones and then in comes a post about BBC... it makes it really difficult to follow
This thread is an unorganized mess, everyone's just doing their own thing and there are multiple theories that people swear by.
I disagree with these last posts. The more information, research, news, and studies people post pertaining to accutane the better. Also how accutane has affected their health in multiple ways so we can try to pin down what's going on here. I'd rather have a team of people looking at multiple possibilities simultaneously then to just stagnant on one idea or theory. There is some very serious stuff here going on with some people many years post accutane and I want to know why. No this is not going to fit into a pretty package for everyones viewing pleasure, but for people really paying attention, I think we can piece it together.
I still have fairly dry skin and it is VERY thin and I have rosacea and pretty severe flushing. Many people have taken mepacrine (quinacrine) for the flushing and had success but I also have hormonal problems and some digestive issues and was thinking about LDN. Could I take them together? Would that be too much going on? They are both very safe drugs so it would probably be fine?
I am also going to get blood tests today. I am going to get hormones, vitamin d and thyroid checked. Anything else I should get done? Anything specific or any advice for me?
Thanks a lot! Y'all are all awesome.
13 minutes ago, helpmeoutbuddies11 said:I am also going to get blood tests today. I am going to get hormones, vitamin d and thyroid checked. Anything else I should get done? Anything specific or any advice for me?
If it's easy enough to add id tac on zinc serum, ceruloplasmin and copper serum. To see if there is any abnormalities. These both have alot to do with skin health,immunity and mental function
12 hours ago, ehohel said:18 hours ago, Colinboko said:Guys, we need to stop switching subjects so quickly on this thread. Makes it feel like we're getting absolutely nowhere. We were discussing hormones and then in comes a post about BBC... it makes it really difficult to follow
This thread is an unorganized mess, everyone's just doing their own thing and there are multiple theories that people swear by.
I understand what you're saying but it's always going to be that way given tane can fuck up multiple organs, cause anything from brain damage to ulcerative colitis....the list goes on hence the posts jump from one topic to the next.
I used to hold out for the post that says "guys I've got the answer, you just need to take this".....this is never going to happen I'm afraid.
Theres plenty of stuff on this forum though that you could print off and take to your doctor, spec if you're having to debate stuff and deal with ignorant bullshit.
Print stuff off and leave with the GP - that's the only way some of them will learn how horrific Accutane is!!
This forum is great for that alone in my book.
On 3/19/2017 at 3:29 PM, guitarman01 said:Sorry to hear this. How were these diagnosed? Did they have a cause for Vasculitus? How long ago and what was your duration and dosage of accutane? Have you had your copper serum, ceruloplasmin and zinc serum tested? Maybe we should start to consider getting a 24hr copper urine and zinc. I still think there might be something abnormal going on with Copper and zinc. Something going on with connective tissues.Maybe there is something going on with systemic calcification or misuse of calcium.
Anyone else who has their 23andme data have any pathogenic mutations at the atp7a or atp7b genes?
I also have hypercalcemia and elevated LDH.. posted about this previously..
i took 120mg for 4 mos before stopping when i noticed ED during intercourse
2 hours ago, Weltschmerz47 said:I also have hypercalcemia and elevated LDH.. posted about this previously..i took 120mg for 4 mos before stopping when i noticed ED during intercourse
what is resting pulse and temp?Noncancerous conditions that can raise
LDH levelsinclude heart failure, hypothyroidism, anemia, pre-eclampsia, meningitis, encephalitis, acute pancreatitis, HIV and lung or liver disease. Tissue breakdown releasesLDH, and thereforeLDHcan be measured as a surrogate for tissue breakdown, e.g. hemolysis.
Iodine deficiency produces hypercalcemia and hypercalcitonemia in rats.
Abstract
To determine the effect of thyroid-stimulating hormone (TSH) on secretion of calcitonin by the thyroid, 50 male Sprague-Dawley rats were randomly separated into seven groups. The groups received different diets, medications, or operations [propylthiouracil (PTU), iodine-deficient diet, (LID), acute or chronic thyroxine treatment, sham operation (SO), hemithyroidectomy (Htx), and total thyroidectomy (Ttx)]. two weeks to six months later, serum TSH concentrations were increased in the Htx, Ttx, and LID groups when compared with SO animals. Serum calcitonin concentrations were increased in the LID- and PTU-treated groups and were decreased in animals that chronically received thyroxine. Serum calcium concentrations were increased in the LID animals, decreased in the Ttx animals, and were similar in the other groups. These findings suggest that TSH stimulates both follicular and parafollicular cells in the rat thyroid and that iodine deficiency causes hypercalcemia and hypercalcitonemia.
1 hour ago, Weltschmerz47 said:I also have hypercalcemia and elevated LDH.. posted about this previously..i took 120mg for 4 mos before stopping when i noticed ED during intercourse
What about the Vasculitus, is this systemic? How was this diagnosed?
And did you have a sinus ct scan?
Any damage to the sinus structure?
Other people might have similar things going on, so just trying to get the most information, thanks.
I feel like sometimes there is a type of inflammation coming from the gi tract no matter what we try to do or supplements we take. If there was a underlying issue here maybe this would have to be addressed first above all else. Something that is triggering a immune response.
here's what i've mentioned before about ppis possibly having benefit outside of just reducing acid secretion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035917/
Potential Anti-inflammatory Effects of Proton Pump Inhibitors: A Review and Discussion of the Clinical Implications
Proton pump inhibitors (PPIs) are potent blockers of gastric acid secretion, and are widely regarded as the agents of choice for the treatment of acid-peptic disorders. For patients with upper gastrointestinal symptoms of uncertain etiology, improvement with PPI therapy is considered prima facie evidence of a pathogenetic role for acid-peptic disease. In addition to anti-secretory effects, however, PPIs have been found to have anti-oxidant properties and direct effects on neutrophils, monocytes, endothelial, and epithelial cells that might prevent inflammation. Those anti-inflammatory effects of the PPIs might influence a variety of inflammatory disorders, both peptic and non-peptic, within and outside of the gastrointestinal tract. The purpose of this report is to review the mechanisms whereby PPIs might exert anti-inflammatory effects exclusive of gastric acid inhibition, to discuss the clinical implications of those effects, and to emphasize that a clinical response to PPIs should not be construed as proof for an underlying acid-peptic disorder.
2 hours ago, guitarman01 said:I feel like sometimes there is a type of inflammation coming from the gi tract no matter what we try to do or supplements we take. If there was a underlying issue here maybe this would have to be addressed first above all else. Something that is triggering a immune response.
here's what i've mentioned before about ppis possibly having benefit outside of just reducing acid secretion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035917/
Potential Anti-inflammatory Effects of Proton Pump Inhibitors: A Review and Discussion of the Clinical Implications
Proton pump inhibitors (PPIs) are potent blockers of gastric acid secretion, and are widely regarded as the agents of choice for the treatment of acid-peptic disorders. For patients with upper gastrointestinal symptoms of uncertain etiology, improvement with PPI therapy is considered prima facie evidence of a pathogenetic role for acid-peptic disease. In addition to anti-secretory effects, however, PPIs have been found to have anti-oxidant properties and direct effects on neutrophils, monocytes, endothelial, and epithelial cells that might prevent inflammation. Those anti-inflammatory effects of the PPIs might influence a variety of inflammatory disorders, both peptic and non-peptic, within and outside of the gastrointestinal tract. The purpose of this report is to review the mechanisms whereby PPIs might exert anti-inflammatory effects exclusive of gastric acid inhibition, to discuss the clinical implications of those effects, and to emphasize that a clinical response to PPIs should not be construed as proof for an underlying acid-peptic disorder.
Its interesting what you're saying here. I asked recently about anyone taking on the "Gut Thrive now 5" program - given there was no response I'll assume no one has done it. I'm not an expert so I don't know if this program will clean up our gut or GI like we want it to but the program looks to be quiet detailed with some pretty good products involved from what I can tell.
Im also not sure if it would combat the inflammation issue many of us have?
We may very well just need the right antibiotic to tackle this gut issue.
last year I did Rifaximin and Vancomycin with no success but that's not to say something else might work. Someone mentioned something else recently that slips my mind at the moment.
If anyone can mention other antibiotics or anti inflammatory products ( not LDN ) please do!!
On 3/20/2017 at 7:57 AM, ehohel said:On 3/20/2017 at 2:06 AM, Colinboko said:Guys, we need to stop switching subjects so quickly on this thread. Makes it feel like we're getting absolutely nowhere. We were discussing hormones and then in comes a post about BBC... it makes it really difficult to follow
This thread is an unorganized mess, everyone's just doing their own thing and there are multiple theories that people swear by.
I'm reading some of the earlier posts in the 100's pages, and we actually go in circles a lot, lol. I feel like unless we are able to make a breakthrough in a lab, or by trial and error on ourselves, we kind of posted and shared every online isotretinoin resource available to us.