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1 hour ago, Chico Esposito said:The only way to specifically isolate the retinoic acid content of the blood would be a High Performance Liquid Chromatography test or a HPLC test for short.
Thx for info. My question is though once determined that our Retinoic Acid blood levels are high - what comes next??
Has anyone hit Vit E with high levels? I read once in a medical book that to combat Vit A you should take E. I guess in our case though our prob isn't spec with A , it's with the synthetic version!?
1 hour ago, TrueJustice said:Thx for info. My question is though once determined that our Retinoic Acid blood levels are high - what comes next??Has anyone hit Vit E with high levels? I read once in a medical book that to combat Vit A you should take E. I guess in our case though our prob isn't spec with A , it's with the synthetic version!?
I started looking up vit E yesterday. It seems interesting if anything. I've begun 400IU a day yesterday. I'll keep at it for a couple days.
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Vitamin E stops retinol from being oxidized to retinoic acid?
Co-ingestion of high doses of vit E along with vit A has been shown to preven vit A toxicity. Question is, does taking vit E after the fact help?
Sources
Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity.
Influence of excess vitamin E on vitamin A toxicity in rats. - During co-ingestion; increase in liver vit A with increasing levels of vit E in the diet. Might mean more is getting handled through the liver, so less accumulates elsewhere?
A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients. - Patients treated with dietary supplement had lower side effects, with a less degree of erythema and dryness, and greater degree of hydration; a greater adherence to therapy was also reported.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Traber%20MG%5BAuthor%5D&cauthor=true&cauthor_uid=19019024 255 studies by someone named Traber. She knows vit E.
'Excess' vitamin E intake is not a health concern: Linus Pauling expert - Traber says no concerns about vit E toxicity. 90%+ americans are deficient in vit E.
https://raypeatforum.com/community/threads/vitamin-e-tocopherol-is-a-potent-aromatase-inhibitor.3106/
http://www.acne.org/messageboard/topic/295030-repairing-the-long-term-damage-from-accutane/?do=findComment&comment=3516004
2 hours ago, TrueJustice said:Thx for info. My question is though once determined that our Retinoic Acid blood levels are high - what comes next??Has anyone hit Vit E with high levels? I read once in a medical book that to combat Vit A you should take E. I guess in our case though our prob isn't spec with A , it's with the synthetic version!?
Well it'd just be a way of showing that the drug is still in our bodies, which would disprove the claim by Roche that it leaves the body in 3-6 months. It'd confirm what a lot of us have been saying for years.
Personally i wouldn't waste your money on Vitamin E. It doesn't work to cure sides and high levels (of supplemental Vitamin E) are toxic in itself and increase all cause mortality rates in various studies. Get your Vitamin E from food.
Roche CEO 'sleeps better' as risk to drugmaker's growth recedes
His time at the top is lengthy by the standards of the Swiss group's peers but hardly an anomaly at Roche, which has had only seven chief executives in 120 years.
http://www.reuters.com/article/us-roche-ceo-idUSKCN0Z8226
Well, at least someone is getting a good nights sleep. Kind of been a tad difficult for me the past 8 years with this Tinnitus ringing in my head....but, I digress.
I just find it amusing that these companies compete financially on an international level over peoples cancer and they put out a PR video once or twice a year, telling the patient that they do it for them, when its so obvious it's primarily for the share holders and themselves. I dunno Severin, maybe if you weren't the highest paid CEO in Switzerland and put some of those francs towards R&D. If you weren't also a part time board member of CreditSuisseAG, I'd maybe say Roche was in it for the Science, but its clear its all about the $.
Hi everyone.
Long time reader of this thread, first time poster. I'm 18, was 17 when I started taking accutane. I also have had some issues after taking accutane and would like some help recovering and to try and help others to recover as well. Here's my story (sorry it's pretty long!)
My story:
Got minor sexual effects during the course, and these worsened as it went on (probably should've stopped it right then but hindsight is great right?!)
Got even worse soon after I stopped the course - to the point where an erection was impossible.
Been 4 months since I finished the course now, and I have fluctuated a lot. Basically on my very good days an erection is pretty easy to get - don't even have to touch it, I can just watch some porn or fantasize. But on my very bad days I struggle to get one. I usually need porn, physical stimulation and a few minutes of effort, and even then it's only 80% strength I would say. And there are obviously 'in-between' days where I feel it's ok but not satisfactory.
Don't have a gf at the moment but on the bad days I'm sure it'd be very difficult to get it up for sex. On the good days I'm sure I'd have little problem.
Long term my recovery is trending upwards I think, but it's gradual progress. Often I'll have a few amazing days in a row where I feel close to normal again, but then followed by several bad days as described above. 2 steps forward, 1 step backward.
Other than this I have no other persistent side effects. In fact I feel in very good health:
I hit the gym 4 days a week to do heavy weight training and a little cardio.
I don't feel fatigued, depressed, etc.
Recently had my testosterone checked and it came back at 21.9 (the normal rangeis between 8 and30 so no problems there).
Just have this one problem of diminished sexual function.
I'm currently just letting time go by and (hopefully!) letting my body readjust itself - I think that's what it's doing as that would explain this fluctuation.I'm also cutting out porn completely from now on to see if that helps.
Those of you who have also experienced sexual problems, do you have any tips on dealing with this? Any supplements to speed up recovery maybe? Been looking at zinc, as there's a lot about it on the misc in relation to erections and testosterone etc.Let me know.
Sorry that was pretty long but thanks for reading if you did manage to get this far!
5 hours ago, t981 said:Hi everyone.
Long time reader of this thread, first time poster. I'm 18, was 17 when I started taking accutane. I also have had some issues after taking accutane and would like some help recovering and to try and help others to recover as well. Here's my story (sorry it's pretty long!)My story:
Got minor sexual effects during the course, and these worsened as it went on (probably should've stopped it right then but hindsight is great right?!)Got even worse soon after I stopped the course - to the point where an erection was impossible.
Been 4 months since I finished the course now, and I have fluctuated a lot. Basically on my very good days an erection is pretty easy to get - don't even have to touch it, I can just watch some porn or fantasize. But on my very bad days I struggle to get one. I usually need porn, physical stimulation and a few minutes of effort, and even then it's only 80% strength I would say. And there are obviously 'in-between' days where I feel it's ok but not satisfactory.
Don't have a gf at the moment but on the bad days I'm sure it'd be very difficult to get it up for sex. On the good days I'm sure I'd have little problem.
Long term my recovery is trending upwards I think, but it's gradual progress. Often I'll have a few amazing days in a row where I feel close to normal again, but then followed by several bad days as described above. 2 steps forward, 1 step backward.
Other than this I have no other persistent side effects. In fact I feel in very good health:
I hit the gym 4 days a week to do heavy weight training and a little cardio.
I don't feel fatigued, depressed, etc.
Recently had my testosterone checked and it came back at 21.9 (the normal rangeis between 8 and30 so no problems there).
Just have this one problem of diminished sexual function.
I'm currently just letting time go by and (hopefully!) letting my body readjust itself - I think that's what it's doing as that would explain this fluctuation.I'm also cutting out porn completely from now on to see if that helps.
Those of you who have also experienced sexual problems, do you have any tips on dealing with this? Any supplements to speed up recovery maybe? Been looking at zinc, as there's a lot about it on the misc in relation to erections and testosterone etc.Let me know.
Sorry that was pretty long but thanks for reading if you did manage to get this far!
Dosage?
35 minutes ago, Gladiatoro said:6 hours ago, t981 said:Hi everyone.
Long time reader of this thread, first time poster. I'm 18, was 17 when I started taking accutane. I also have had some issues after taking accutane and would like some help recovering and to try and help others to recover as well. Here's my story (sorry it's pretty long!)My story:
Got minor sexual effects during the course, and these worsened as it went on (probably should've stopped it right then but hindsight is great right?!)Got even worse soon after I stopped the course - to the point where an erection was impossible.
Been 4 months since I finished the course now, and I have fluctuated a lot. Basically on my very good days an erection is pretty easy to get - don't even have to touch it, I can just watch some porn or fantasize. But on my very bad days I struggle to get one. I usually need porn, physical stimulation and a few minutes of effort, and even then it's only 80% strength I would say. And there are obviously 'in-between' days where I feel it's ok but not satisfactory.
Don't have a gf at the moment but on the bad days I'm sure it'd be very difficult to get it up for sex. On the good days I'm sure I'd have little problem.
Long term my recovery is trending upwards I think, but it's gradual progress. Often I'll have a few amazing days in a row where I feel close to normal again, but then followed by several bad days as described above. 2 steps forward, 1 step backward.
Other than this I have no other persistent side effects. In fact I feel in very good health:
I hit the gym 4 days a week to do heavy weight training and a little cardio.
I don't feel fatigued, depressed, etc.
Recently had my testosterone checked and it came back at 21.9 (the normal rangeis between 8 and30 so no problems there).
Just have this one problem of diminished sexual function.
I'm currently just letting time go by and (hopefully!) letting my body readjust itself - I think that's what it's doing as that would explain this fluctuation.I'm also cutting out porn completely from now on to see if that helps.
Those of you who have also experienced sexual problems, do you have any tips on dealing with this? Any supplements to speed up recovery maybe? Been looking at zinc, as there's a lot about it on the misc in relation to erections and testosterone etc.Let me know.
Sorry that was pretty long but thanks for reading if you did manage to get this far!
Dosage?
Started at 20mg, upped to 40mg after a couple of weeks and then up to 60mg for about the last month.
7 hours ago, QuietSoldier said:Has anyone had any success with beta carotene? I've tried supplementing vitamin A in the past (bad idea), but recently started taking beta carotene, and my body reacts much more favorably to it.
I did it for a week or two off and on. In the hopes of curing my night blindness and other ailments. Around 33,000iu. I believe beta carotene's measurements are different from other forms of vit-A. Roughly 2 measurements of beta carotene is equal to one IU of vit A or something of the likes. I didn't really notice anything, maybe bouts of euphoria (which means a lot for someone with depression, but could be placebo) I did start to notice the nasal passage drying and eyeballs get stuck more often. So clearly it has that drying out effect still, which we all felt firsthand with Accutane.
7 hours ago, Gladiatoro said:11 hours ago, t981 said:Started at 20mg, upped to 40mg after a couple of weeks and then up to 60mg for about the last month.So total dosage?
Somewhere around 7200mg I think. That's an estimate as I can't remember the exact dates I changed dosage etc. but it's pretty close to that.
5 hours ago, t981 said:Somewhere around 7200mg I think. That's an estimate as I can't remember the exact dates I changed dosage etc. but it's pretty close to that.
That's a typical dose , I would be careful with ingesting too much vitamin A or retinol , our bodies don't like either too much . Basically our whole system has been screwed over same goes with alcohol limit it , that's how I got rid of the severe lower back pain . That and I increased my lemon water intake .
Thanks for volunteering to mod, Chico. Sea of tangents is apt. Glad someone else sees the vision.
I've got an unrelated major forum migration to do tonight, and plenty of work after that.
My mod requirement is satisfied, so the accutane forum project has moved from "maybe" to "someday". If someone buys a Xenforo license, that will upgrade it to "< 1 week".
Still cured thanks to LDN, btw. Someone mentioned night blindness; I had that at my worst due to low vitamin A.
My understanding is that I'm the first in this community to use or think about using LDN. Updated my sig with some basic LDN instructions.
I would recommend that those living in the same country pool resources, have one person get an LDN script, and then that person can mail a few pills to each member. You only need a very small amount to test whether it will work, since for most of the first month you are taking much smaller than normal doses. A prescription is typically for 6 months. A proper trial might last 5 weeks. You could do a mini 3 day trial just to see whether you get an initial "rested" bump. LDN destabilizes when dissolved into water for metered dosing,so a minimum quantity would be 1 pill per 3 days of trial period.
I think my gut is still more reactive than when this began, but it's within normal familial ranges so that might just be aging and hard living. I could probably improve it further if I focused on it. Not caring much is the strongest sign that I'm cured, since I'm a very utilitarian person. If it were getting in my way, I'd still be obsessed.
Www.buyldn.com
ordered with paypal and shipped to europe, no problems. Recieved it in 7 bussiness days.
Goong to test it tomorrow.
i already gained alot of weight since my first accutane pill 7 years ago.
im now struggelingto lose weight so thats a good sign. For the last 6 months my bowels are firm again and I gained a total of 10 kg.
twice a week I dosed 50000 ui of vitamin D. I already ate a lot of liver (trough sausage) whoch helped me woth my vitamin A
so right now i stop with the vitamine D and A and focus on LDN.
I feel like im 90% back just want to see my hair regrow again. Hope ldn cures the inflammation and with some help of biotin kickstart my hair growth again.
( its typical mbp with little island on top)
good luck everybody
2 hours ago, Ruvik said:testosterone level don't mean anything, I'm impotence from 2010 and i don't remember what is a full erection. Now I'm 27 years old... my testosterone level checked is High, yes is funny.
check your estrogen?
A lot of libido ED symptoms match up with "Estrogen Dominance" google it
you can have a normal testosterone reading.. yes be very high in other free hormones. This calcium D glucarate helps with that as well.
2 hours ago, Ruvik said:testosterone level don't mean anything, I'm impotence from 2010 and i don't remember what is a full erection. Now I'm 27 years old... my testosterone level checked is High, yes is funny.
I'm sorry to hear that Ruvik. From what I've read it seems to be the androgen receptors that are the problem. There are androgens going round the body but androgen receptors have been desensitised. But I don't know enough about this to know whether that is the true reason or if that is just a theory.
On 9/16/2016 at 4:08 AM, Ruvik said:testosterone level don't mean anything, I'm impotence from 2010 and i don't remember what is a full erection. Now I'm 27 years old... my testosterone level checked is High, yes is funny.
What are your SHBG (Sex Hormone-Binding Globulin) levels like? Everyone has always been worried about having really high levels of that because it binds to testosterone and reduces levels of free testosterone, but low levels of it are actually perhaps even worse. Having low SHBG could explain what's wrong with you even though your T numbers are high.
[Edited link out]
Do you drink a lot of soda? Apparently high fructose corn syrup can severely decrease your SHBG to an unhealthy level. Recently I cut out regular soda (decided to switch to diet), and all my side effects that I'm concerned about have improved. My skin is noticeably healthier (less of a dehydrated mess), bloating is way down, bowel movements are better, and my penis is more responsive.
This might have been an unrelated issue to the accutane, but it's worth a shot if your diet does have a lot of sugar in it currently.
On 9/15/2016 at 9:08 PM, Ruvik said:testosterone level don't mean anything, I'm impotence from 2010 and i don't remember what is a full erection. Now I'm 27 years old... my testosterone level checked is High, yes is funny.
Can you post all your blood tests. You definitely need a full sex hormone panel test.
As Tryingtohelp says - Estrogen level is very important.
Too high or low will definitely cause problems.
