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Repairing the long-term damage from Accutane

 
MemberMember
1803
(@guitarman01)

Posted : 03/06/2016 7:25 pm

Herbal Therapy Is Equivalent to Rifaximin for the Treatment of Small Intestinal Bacterial Overgrowth

John Hopkins study.
must read! this could be the key to our gut health!
where all our problems could be coming from.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030608/
READ THIS.........................
imbalances in the gut microbiome (also known as dysbiosis) have been linked to the development of disorders of mood and behavior, Alzheimer's disease, and numerous gastrointestinal and systemic disorders including inflammatory bowel disease, diabetes, obesity, and cardiovascular disease.27,28Bacterial dysbiosis in SIBO can disrupt epithelial tight junctions increasing small intestine paracellular permeability, translocation of endotoxin, and induction of proinflammatory cytokines.2931SIBO can have a number of extraintestinal manifestations such as rosacea, restless legs syndrome,17,32arthralgias, anemia, interstitial cystitis,33chronic prostatitis,34and polyneuropathy.1A large body of work has linked bacterial dysbiosis of the small bowel and endotoxemia to non-alcoholic steatohepatitis and progression of alcoholic liver disease, non-alcoholic fatty liver disease, obesity, and others

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MemberMember
1804
(@truejustice)

Posted : 03/07/2016 1:41 am

Has anyone done the Andreas Moritz Liver flush but skipped the 2 visits to do a colon cleanse??

That part is a pain in the arse - no pun intended :)

This is my third cleanse but I want to know if you can still successfully do the flush minus the colon cleanse part ?

I should learn how to do a home coffee enama - would save me all the hassle!!

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MemberMember
6
(@vicecaz)

Posted : 03/07/2016 10:52 am

On 3/7/2016 at 2:41 PM, TrueJustice said:

Has anyone done the Andreas Moritz Liver flush but skipped the 2 visits to do a colon cleanse??

That part is a pain in the arse - no pun intended [Edited image out]

This is my third cleanse but I want to know if you can still successfully do the flush minus the colon cleanse part ?

I should learn how to do a home coffee enama - would save me all the hassle!!

How do you feel now? Did you a feel a difference before/after have done the two flush ?

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MemberMember
1804
(@truejustice)

Posted : 03/07/2016 4:56 pm

You feel really good just after completing it all - you feel much cleaner and psychologically stronger for at least a month or so.

Id like to do 3-4 flushes in quicker succession to try and get that energy kick that I've heard can happen!!

Is it a cure for tane problems? - maybe, maybe not. All I know is, I feel much better within myself after doing them - certainly ten times better than any supplement I've ever taken, and trust me I've taken more supplements than I care to think about over the last 19 years!

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MemberMember
960
(@tryingtohelp2014)

Posted : 03/07/2016 8:48 pm

On 3/6/2016 at 4:42 PM, macleod said:

Yes, I am looking into Isotretinoin's role in attenuating (reduce the force of) Nitric Oxide production in the body. Reservatrol, which is in red wine, is a huge NO booster which is crucial for endolitheal function. 

In the mean time, follow a healthy diet, exercise, and include some of these listed supplements:

http://www.anabolicmen.com/boost-nitric-oxide-naturally/

heh keeps making connections!!   Lithium orotate might be a sleeper with NO as well

maybe i should put it this way... "If you have a limp dick from accutane, get tested!!!"

[Edited link out]
 

Just Say NO To Copper Deficiency!
headline bar

Jack Saari

What do air pollution, the Nobel prize, Viagra and copper nutrition have in common? The answer: Nitric oxide. Nitric oxide is a deceptively simple molecule (chemical formula -- NO) that has complex and far reaching effects on the body. It is not to be confused with nitrous oxide (N2O), the anesthetic, which is otherwise known as ˜laughing gas'.

Twenty-five years ago, the only known effect of nitric oxide on human health was as an air pollutant emitted by automobile exhausts. About that time nitric oxide was also found to be the active component of nitroglycerin and other medications that were used to alleviate pain in patients with coronary heart disease. Over the next ten years, extensive study of blood vessel function showed that nitric oxide is naturally produced in the body and is responsible for regulating blood flow and blood pressure. In the last decade research on nitric oxide has mushroomed and shown that the compound plays a role not only in blood vessel function but also in transmission of signals in the nervous system, in heart contraction and in immune function.

So significant are the findings that a major scientific journal named nitric oxide the ˜Molecule of the Year' in 1992. The scientists that discovered the relationship between nitric oxide and blood vessel function earned the 1998 Nobel Prize in Physiology and Medicine. Because so many systems are affected by nitric oxide, potential medical applications of this research are boundless. They include treatments for high blood pressure, septic shock, arteriosclerosis (hardening of the arteries) and cancer. One such application is the development of Viagra, a drug that exaggerates the effect of naturally produced nitric oxide and thus aids men with erectile dysfunction.

What does nitric oxide have to do with copper nutrition? Recent studies performed on rats at the Grand Forks Human Nutrition Research Center, in conjunction with scientists at the University of Louisville, Ky., have shown that restricting the animals' intake of dietary copper impairs the action of nitric oxide on their blood vessels. This suggests that copper deficiency may contribute to reduced blood flow, and hence reduce oxygen delivery to tissues and increase blood pressure.

We have also recently found that, in the heart, nitric oxide production is elevated by reduced copper intake. Whereas nitric acid production in blood vessels is desirable, excess production in the heart can interfere with contractile function. Thus, by two different processes, dietary copper deficiency alters the action of nitric oxide, thereby interfering with functions of the heart and circulation. And because nitric oxide acts in other systems, such as the brain and immune system, it is likely that further research will reveal that known defects caused by copper deficiency in those systems relate to nitric oxide as well.

How do we prevent these undesirable effects of copper deficiency from happening to us? Consume a balanced diet containing foods high in copper -- liver, legumes, shellfish, meats, nuts, seeds and whole grains -- to achieve a copper intake of 1.5 to 3.0 milligrams per day.

and... lower values of cerulosplamin = low blood nitrite=low nitric oxide

Copper and nitric oxide meet in the plasma

Tamika K Samuel1 & Jonathan D Gitlin1

  1. Tamika K. Samuel and Jonathan D. Gitlin are in the Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA. e-mail: [email protected]

 

 

Abstract

Nitrite is an inorganic anion essential in cell signaling and vascular biology. A new study shows that the multicopper oxidase ceruloplasmin is critical for maintaining plasma nitrite, revealing a new link between copper and nitric oxide homeostasis.

Once considered as merely a toxic food additive, inorganic nitrite (NO2ˆ’) is now a molecule of considerable interest as a messenger of cell signaling in health and disease1. Nitric oxide (NO) is an endogenously produced gas that functions as an essential signaling molecule2.

 

 

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MemberMember
960
(@tryingtohelp2014)

Posted : 03/07/2016 9:08 pm

On 3/7/2016 at 5:27 AM, Fchawk said:

The things that I am 99% sure have worked at helping symptoms are:

-creatine
-taurine
-BCAAS

my PWO includes
creatine
taurine
citruline

sidenote ... interesting thread to read: [Edited link out]
high zinc and 5AR symptoms.

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MemberMember
1803
(@guitarman01)

Posted : 03/07/2016 10:59 pm

On 3/8/2016 at 10:08 AM, tryingtohelp2014 said:

my PWO includes
creatine
taurine
citruline

sidenote ... interesting thread to read: [Edited link out]
high zinc and 5AR symptoms.

if your convinced about copper you should be taking copper and copper only, and I would go on a higher dose. hell everything else youve done has been higher dose from sam e to taurine to manganese to tmg. so why you being so shy about copper? stop taking all that other shit with it youll never know whats what. all you need is copper at a higher safe dose. Im not off the copper band wagon yet myself. I dont think any of us have a serious copper deficiency per say, but what i do believe is that this could maybe help push out excess vitamin a in the tissues throughout the body if thats what we are really dealing with. like you said vitamin a vs copper, cells not big enough for the both to coexist. looking at your past post youve taken why too many other supplements with what you thought was "the one" to ever really know what the hell was going on. you need to narrow it down. you got way too many variables. k bye.

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MemberMember
960
(@tryingtohelp2014)

Posted : 03/07/2016 11:53 pm

On 3/8/2016 at 11:59 AM, guitarman01 said:
On 3/8/2016 at 10:08 AM, tryingtohelp2014 said:
my PWO includes
creatine
taurine
citruline

sidenote ... interesting thread to read: [Edited link out]
high zinc and 5AR symptoms.

if your convinced about copper you should be taking copper and copper only, and I would go on a higher dose. hell everything else youve done has been higher dose from sam e to taurine to manganese to tmg. so why you being so shy about copper? stop taking all that other shit with it youll never know whats what. all you need is copper at a higher safe dose. Im not off the copper band wagon yet myself. I dont think any of us have a serious copper deficiency per say, but what i do believe is that this could maybe help push out excess vitamin a in the tissues throughout the body if thats what we are really dealing with. like you said vitamin a vs copper, cells not big enough for the both to coexist. looking at your past post youve taken why too many other supplements with what you thought was "the one" to ever really know what the hell was going on. you need to narrow it down. you got way too many variables. k bye.

exactly... because of what you just said. taurine, SAM-E and TMG...thats one thing. high doses of these are used for liver dysfunction. hi doses of these are needed to have an even minimal effect on any study ive ever read. they arent minerals, there isnt 6+ months of storage of these in your liver. As far as manganese, i never upped the dose to more than 10mg on more than maybe a few occasions. did you even read that allthingsmale thread you quoted? guy is experiencing PFS symptoms from 10days @50mg of zinc alone, that has lasted for months. months later his copper levels still show below normal in blood. high doses of zinc cause 5AR symptoms. high doses of a lot of things cause 5AR symptoms.

you cant mess with minerals in isolation.. 1. they dont work like that. 2. you can make it worse....you cant read one study about an upper tolerable limit and declare victory. you have to read 100 more studies just to begin to understand what going on. like i said, if you take 8mg... 12% gets absorbed, while messing something else up because your body has to upregulate metallothionein to protect itself.... 1mg, 56% gets absorbed. thats youre bodies way of keeping thing in check.

3. u need other cofactors. RBC zinc copper iron manganese need to be tested by people first. accutane people might be the exception to the rule if things are that messed up. copper is actually a lot safer than zinc. copper at normal doses doesnt have an effect on zinc status. zinc on the other hand is a different story. Zinc induces metallothionein...metallothioneinhas a very high affinity to bind copper more than anything. thats why i cringe, when i see people on this thread drink up "copper toxicity" from websites that have absolutely nothing to do with accutane damaged people.... and start downing zinc and vitamin C in massive doses... and this isafter taking a drug, that rids your bodies cells and liver of copper in 4 different ways! (ATP7A, ceruloplasmin,copper amine oxidase, vitamin A displacement) except for modeaa, nobody in this entire 350+ page thread has even hinted at a copper deficiency!! like i said, this thread was started by a person still believing he is "copper toxic." need many more people to get tested.

4.more important than anything..... if copper is going to push something stored out... you probably dont want to do it overnight!!! otherwise somebody will come on the thread complaining of facial ticks, skin dryness, knee pain and who knows what else and proclaim it worthless. Im taking it slow because i believe in this more than anything else so far. im even "pulsing" doses 3 days on, 1-2 days off. with the safest from of copper available btw. the reason for pulsing is... i think copper is actually moving something... so give your body a few days to deal with what it moved.

so far so good. my brain hasnt felt this good in 10 years.

Edit:

and as long as we're talking about PFS relationships... i think hands down by far the best theory is expressed in this thread by xptriado (just replace finasteride with accutane... same thing)
http://forums.phoenixrising.me/index.php?threads/23andme-chronic-insomnia-and-family-history-of-psychiatric-cns-disorders.28189/page-7

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MemberMember
960
(@tryingtohelp2014)

Posted : 03/08/2016 8:00 am

something else ive kicked around all the way back to a b-12 theory. If we do have a backup of retinoic acid, we could have this negative GR feedback loop still happening. Some theorize this could be the sole reason for postpartum depression in women & the depression/suicides linked to accutane haveany females usedmifepristone (morning after pill?) Men could try low dose lithium orotate.

[Edited link out]

Clinical reports have highlighted a role for retinoids in the etiology of mood disorders. Although we had shown that recruitment of the nuclear receptor retinoic acid receptor-(RAR-) to corticotropin-releasing hormone (CRH) promoter is implicated in activation of the hypothalamuspituitaryadrenal (HPA) axis, further insight into how retinoids modulate HPA axis activity is lacking. Here we show that all-transretinoic acid (RA)-induced HPA activation involves impairments in glucocorticoid receptor (GR) negative feedback. RA was applied to rats chronically through intracerebroventricular injection. A 19-day RA exposure induced potent HPA axis activation and typical depression-like behavior. Dexamethasone failed to suppress basal corticosterone (CORT) secretion, which is indicative of a disturbed GR negative feedback. In the hypothalamic paraventricular nucleus, increased CRH+and c-fos+cells were found while a negative R2+/ER+correlation was present between the number of RAR-+and GR+cells. This was paralleled by increased RAR-and decreased GR protein expression in the hypothalamus. Additionalin vitrostudies confirmed that RA abolished GR-mediated glucocorticoid-induced suppression of CRH expression, indicating a negative cross-talk between RAR-and GR signaling pathways. Finally, the above changes could be rapidly normalized by treatment with GR antagonist mifepristone. We conclude that in addition to the classic RAR--mediated transcriptional control of CRH expression, disturbances in GR negative feedback constitute a novel pathway that underlies RA-induced HPA axis hyperactivity. The rapid normalization by mifepristone may be of potential clinical interest in this respect.

The GR isexpressedin almost every cell in the body and regulatesgenescontrolling thedevelopment,metabolism, andimmune response. Because the receptor gene is expressed in several forms, it has many different (pleiotropic) effects in different parts of the body.

When the GR binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription.[1][2]The unbound receptor resides in thecytosolof the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol (by preventing the translocation of othertranscription factorsfrom the cytosol into the nucleus).

In humans, the GR protein is encoded byNR3C1genewhich is located onchromosome 5(5q31).[3][4]

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MemberMember
2
(@matysek145)

Posted : 03/08/2016 6:41 pm

Hi guys

I've been reading this thread for more than a year now.

Short story of me:
I was on Izotek (polish isotretinoin medicine) since October 2010 to about April/May 2011. Don't remember the dosage. My only symptoms during the course were only a little dry skin and pain in groins during the excercise, nothing special.

After the course i felt really good. About half year after stopping the course i started to feel pain in my left knee after excercises. Later on i started to feel pain in right knee as well. Didn't correlate to isotretinoin yet. Had RTG and USG tests done, doctors didn't see anything there. I was at the physiotherapy twice (autumn 2012 and autumn 2014) - didn't help.

With time other joints began to ache and this is my main side effect.
Furthermore i have dry and stuffy nose all the time (few weeks ago i was on antibiotics because of some infection and it surprisingly made my nose clear, i could breath again :)). Also from time to time i have cold feet (especially when laying in bed) and rather rare i feel throbbing in the ears and am sensitive to sounds.

Some days are better, some are worse, it isn't that bad yet, but it is generally getting worse with time. And of course i can't tell for 100% it is caused by isotretinoin, but there must be something i can cling to :)

And now maybe something more interesting for @tryingtohelp2014 (i don't know hot to tag you :()  - i have done copper tests you wanted (actually instead of RBC copper i got serum copper, but anyway...):
Ceruloplasmin: 18.3 mg/dl (15 - 30 is good range, but according to wikipedia 20-40 is good range).
Copper (serum i suppose): 69.86 ug/dl (70 - 140)  = 0.6986 ug/ml
These seem to be comparable to yours, guys.

Also:
Bilirubin: 1.5 mg/dl (0 - 1.2) HIGH - tryingtohelp2014, you mentioned you have HIGH bilirubin too (coincidence? :))

Hope these results will help you in your research

And at the end maybe something useless, but maybe you will see something interesting there:
Last year at the begining of August i got (the results are in two units thousand/ul and in %):
neutrophils at 2.09 t(housands)/ul (2.5 - 7) LOW (36.9%, where 40-70 is good range - LOW)
eosinophils at 0.53 t/ul (0.1 - 0.5) HIGH (9.4%, 1 - 7 - HIGH)
Then at the begining of September i started to feel stomach pains after meals, later even without any meals
On 21 September my results were:
neutrophils: 2.11LOW, very similar result to previous (28%, 40 - 70 - LOWER)
eosinophils: 2.39 HIGH growth (31.8%, 1 - 7 - HIGHER)

I got some medicines for this, doctor was suspecting helicobacter pylori. I was taking medicines for about week, wasn't really helping, one day pain was that bad i didn't get out of bed. Then i quit medicines was fasting for three days. Pains passed and didn't come back (it was in October)
My recent blood test:
neutrophils 1.85 - even lower (35.7%, 40 - 70 - LOW)
eosinophils 0.38t/ul (0.1 - 0.5, so it seems to be good, but i %: 7.4, in range 1- 7 - HIGH)
lymphocytes 2.37t/ul (1 - 3.5 - good, but in %: 45.8, in range 20 - 45)

I think there can be something with SIBO/parasites/allergies/good-bad bacteries imbalances in gut according to recent discussions here.
I want to do some tests, but some of them are quite expensive so i need to investigate more and talk to my doctor, which of them could be worth of doing.

Sorry for my english, after putting this into translator to find mistakes, translation in my language (polish) sounds really primitive and funny, i hope it's not that bad for you :)

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MemberMember
1803
(@guitarman01)

Posted : 03/08/2016 6:51 pm

i want to post this from the florastor website. this is kind of a funny one but maybe not.

Florastor increases the production of three digestive enzymes: lactase, maltase, and sucrase. When Florastor is present, there is a 77% increase in lactase, 75% increase in maltase, and 82% increase in sucrase. An increase in these digestive enzymes helps break down dietary sugars, which improves the absorption of water and nutrients in your small intestine.5

Helps absorb Water. Really? Yes, Water.

Short-chain fatty acids are produced when healthy bacteria break down indigestible carbs and fibers in the colon. More short-chain fatty acids reflect healthier activity of bacteria in the colon. Florastor improves levels of fecal butyratethe short-chain fatty acid preferred by colon cells for energyby 60%. Healthy colon cells help your body stay hydrated by re-absorbing water in the colon.6

Again, Helps absorb Water.

I can get oily skin,Hair. Maybe we dont have a oil problem. We have a Water problem.

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MemberMember
223
(@gladiatoro)

Posted : 03/08/2016 10:47 pm

It's called chronic cellular dehydration.

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MemberMember
960
(@tryingtohelp2014)

Posted : 03/08/2016 11:05 pm

4 hours ago, matysek145 said:

And now maybe something more interesting for @tryingtohelp2014 (i don't know hot to tag you :() - i have done copper tests you wanted (actually instead of RBC copper i got serum copper, but anyway...):
Ceruloplasmin: 18.3 mg/dl (15 - 30 is good range, but according to wikipedia 20-40 is good range).
Copper (serum i suppose): 69.86 ug/dl (70 - 140) = 0.6986 ug/ml
These seem to be comparable to yours, guys.

Also:
Bilirubin: 1.5 mg/dl (0 - 1.2) HIGH - tryingtohelp2014, you mentioned you have HIGH bilirubin too (coincidence? :))

Hope these results will help you in your research

And at the end maybe something useless, but maybe you will see something interesting there:
Last year at the begining of August i got (the results are in two units thousand/ul and in %):
neutrophils at 2.09 t(housands)/ul (2.5 - 7) LOW (36.9%, where 40-70 is good range - LOW)
eosinophils at 0.53 t/ul (0.1 - 0.5) HIGH (9.4%, 1 - 7 - HIGH)
Then at the begining of September i started to feel stomach pains after meals, later even without any meals
On 21 September my results were:
neutrophils: 2.11LOW, very similar result to previous (28%, 40 - 70 - LOWER)
eosinophils: 2.39 HIGH growth (31.8%, 1 - 7 - HIGHER)

I got some medicines for this, doctor was suspecting helicobacter pylori. I was taking medicines for about week, wasn't really helping, one day pain was that bad i didn't get out of bed. Then i quit medicines was fasting for three days. Pains passed and didn't come back (it was in October)
My recent blood test:
neutrophils 1.85 - even lower (35.7%, 40 - 70 - LOW)
eosinophils 0.38t/ul (0.1 - 0.5, so it seems to be good, but i %: 7.4, in range 1- 7 - HIGH)
lymphocytes 2.37t/ul (1 - 3.5 - good, but in %: 45.8, in range 20 - 45)

thanks. yes high bilirubin here as well.joint ache is my main side, along with dry skin(we are both polish as well! :). a few others with long term effects have the same thing. gilberts's disease stops bilirubin from breaking down. but whats interesting is, the same UGT enzyme that breaks down bilirubin, is also used to break down accutane. and if 80% of this enzyme is impaired while on accutane ( i think accutane actually causes this by itself, i never had high bilirubin before taking the drug) you will have a hard time getting rid of anything.

thank you for the copper test. low neutrophils are a leading indicator of copper deficiency!!!! some say this is an even more accurate/sensitivethan any serum test. you have to remember, by the time it gets low in the blood, its depleted everything else in your body.

The deficiency in copper can cause many hematological manifestations, such asmyelodysplasia,anemia,leukopenia(low white blood cell count) andneutropenia(low count ofneutrophils, a type of white blood cell that is often called "the first line of defense" for the immune system).[3]
https://en.wikipedia.org/wiki/Copper_deficiency

well. we're definitely not copper toxic, thats for sure. even if you go by the "free" copper mumbo jumbo... we have none.

serum copper RBC copper ceruloplasmin 24hr copper urine
tryingtohelp * .77 (.80-1.75ug/ml)L .48 (.50-1.00ug/ml)L 19.2 (16-31)
Bobbydigital 10.7 (11-22)L .14(.15-.60)L .13(.24-.94umol/d)L
Koikoi 24 (4-116) 19 (15-30)
Matysek * #
69.86 (70 - 140)L 18.3 (15 - 30)

*high bilirubin #low neutrophils

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MemberMember
1803
(@guitarman01)

Posted : 03/08/2016 11:31 pm

18 minutes ago, tryingtohelp2014 said:
thanks. yes high bilirubin here as well. a few others with long term effects have the same thing. gilberts's disease stops bilirubin from breaking down. but whats interesting is, the same UGT enzyme that breaks down bilirubin, is also used to break down accutane. and if 80% of this enzyme is impaired while on accutane ( i think accutane actually causes this by itself, i never had high bilirubin before taking the drug) you will have a hard time getting rid of anything.

thank you for the copper test. low neutrophils are a leading indicator of copper deficiency!!!! some say this is an even more accurate/sensitivethan any serum test. you have to remember, by the time it gets low in the blood, its depleted everything else in your body.

The deficiency in copper can cause many hematological manifestations, such asmyelodysplasia,anemia,leukopenia(low white blood cell count) andneutropenia(low count ofneutrophils, a type of white blood cell that is often called "the first line of defense" for the immune system).[3]
https://en.wikipedia.org/wiki/Copper_deficiency

serum copper RBC copper ceruloplasmin 24hr copper urine
tryingtohelp .77 (.80-1.75ug/ml)L .48 (.50-1.00ug/ml)L 19.2 (16-31)
Bobbydigital 10.7 (11-22)L .14(.15-.60)L .13(.24-.94umol/d)L
Koikoi 24 (4-116) 19 (15-30)
Matysek * #
69.86 (70 - 140)L 18.3 (15 - 30)

*high bilirubin #low neutrophils

stop the copper madness! and lets stop telling people to get blood tested for this. what copper might be telling me though is its revealing a underlining deficiency at relatively low doses(10mgs and under) and im thinking it might be manganese. im going to look at this again without taking 10 other supplements with it and i plan on taking 30mgs a day divided by 3. ive noticed a few things with this that seem to counter the copper and its got me wondering atm.

Quote
MemberMember
960
(@tryingtohelp2014)

Posted : 03/08/2016 11:39 pm

14 hours ago, guitarman01 said:
14 hours ago, tryingtohelp2014 said:
thanks. yes high bilirubin here as well. a few others with long term effects have the same thing. gilberts's disease stops bilirubin from breaking down. but whats interesting is, the same UGT enzyme that breaks down bilirubin, is also used to break down accutane. and if 80% of this enzyme is impaired while on accutane ( i think accutane actually causes this by itself, i never had high bilirubin before taking the drug) you will have a hard time getting rid of anything.

thank you for the copper test. low neutrophils are a leading indicator of copper deficiency!!!! some say this is an even more accurate/sensitivethan any serum test. you have to remember, by the time it gets low in the blood, its depleted everything else in your body.

The deficiency in copper can cause many hematological manifestations, such asmyelodysplasia,anemia,leukopenia(low white blood cell count) andneutropenia(low count ofneutrophils, a type of white blood cell that is often called "the first line of defense" for the immune system).[3]
https://en.wikipedia.org/wiki/Copper_deficiency

serum copper RBC copper ceruloplasmin 24hr copper urine
tryingtohelp .77 (.80-1.75ug/ml)L .48 (.50-1.00ug/ml)L 19.2 (16-31)
Bobbydigital 10.7 (11-22)L .14(.15-.60)L .13(.24-.94umol/d)L
Koikoi 24 (4-116) 19 (15-30)
Matysek * #
69.86 (70 - 140)L 18.3 (15 - 30)

*high bilirubin #low neutrophils

stop the copper madness! and lets stop telling people to get blood tested for this. what copper might be telling me though is its revealing a underlining deficiency at relatively low doses(10mgs and under) and im thinking it might be manganese. im going to look at this again without taking 10 other supplements with it and i plan on taking 30mgs a day divided by 3. ive noticed a few things with this that seem to counter the copper and its got me wondering atm.

why would i want people to stop getting tested? tests cant hurt you. im 3 for 3 in low serum tests! seems like a trend. what if i go 10 for 10? wait youre going to do what?? take 30mg of manganese?? please dont, u can fuck up your brain

protip: why dont you stop taking EVERYTHING for a week, and get tested first, before pure guessing with high doses of antagonistic minerals!

edit:

let me drop some simple math on you guitarman..... blood reference ranges = 95% of the population falls within said range.
the odds of 3 random people getting tested (for serum copper), and all falling outside the the range in a row, would be .05x.05x.05=0.000125%
or to put it another way... trying to do something with a 5% success rate 3x in a row = 857,375 to 1

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MemberMember
16
(@bobby-digital-2)

Posted : 03/09/2016 1:16 am

On 07/03/2016 at 1:56 PM, TrueJustice said:

You feel really good just after completing it all - you feel much cleaner and psychologically stronger for at least a month or so.

Id like to do 3-4 flushes in quicker succession to try and get that energy kick that I've heard can happen!!

Is it a cure for tane problems? - maybe, maybe not. All I know is, I feel much better within myself after doing them - certainly ten times better than any supplement I've ever taken, and trust me I've taken more supplements than I care to think about over the last 19 years!

I'm starting liver flushing in the next week or two now that all my stomach issues are taken care of. What symptoms where you experiencing post accutane? And how do those symptoms improve post flush? Thanks!!

Quote
MemberMember
1804
(@truejustice)

Posted : 03/09/2016 2:53 am

1 hour ago, Bobby.Digital said:
I'm starting liver flushing in the next week or two now that all my stomach issues are taken care of. What symptoms where you experiencing post accutane? And how do those symptoms improve post flush? Thanks!!

Fatigue, depression, general sadness. In a nutshell the flush gives you more energy and a clearer mind for a couple of weeks at least.

This time round I'd like that feeling to last longer. Some people have done upwards of 12 flushes so it's a process and it takes time. At the end of the day I want a clean liver so I'm prepared to do that many flushes if that's what it takes!!

Good luck

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MemberMember
0
(@abi72)

Posted : 03/09/2016 9:07 am

has anyone used wellbutrin/bupropion for anxiety - any sides, good or bad?

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10
(@kokodu)

Posted : 03/09/2016 9:20 am

4 minutes ago, hatetane said:

has anyone used wellbutrin/bupropion for anxiety - any sides, good or bad?

I took wellbutrin to check that can dopamine booster do. I didn't notice any good or bad effects.

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223
(@gladiatoro)

Posted : 03/09/2016 12:26 pm

Derms don't even know how this synthetic drug works yet they hand it out to kids like candy WTF.

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16
(@bobby-digital-2)

Posted : 03/09/2016 1:15 pm

10 hours ago, TrueJustice said:
Fatigue, depression, general sadness. In a nutshell the flush gives you more energy and a clearer mind for a couple of weeks at least.

This time round I'd like that feeling to last longer. Some people have done upwards of 12 flushes so it's a process and it takes time. At the end of the day I want a clean liver so I'm prepared to do that many flushes if that's what it takes!!

Good luck

Good to hear man. Do you suffer from chronic brain fog? That's my biggest issue.

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299
(@macleod)

Posted : 03/09/2016 2:44 pm

2 hours ago, Gladiatoro said:

Derms don't even know how this synthetic drug works yet they hand it out to kids like candy WTF.

It's a very perverse industry. But, to their defense, the majority (85%) of people are able to tolerate this drug well enough. The problem with the FDA and the industry is, if the benefits outweigh the negatives, and going by a standard bell curve, they could give less of a shit. If treatment has gone well, they are behind you 100%. If something goes wrong, "piss off, we don't even know you, and are not Liable".

That is what has to change. Responsibility. Accountability. Compassion. And at the very least, for the sake of science. That is worth fighting for.

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223
(@gladiatoro)

Posted : 03/09/2016 4:11 pm

One derm said it correctly , it's a controlled poisoning nothing more nothing less that's why 1/3 of dems wont even prescribe it in there practice because they don't know the long term outcome of these patients.

If you think about it chemotherapy for a harmlesscondition as acne is TRUELY an insane treatment as acne is harmless but chemo is NOT I got the worst side effects years later all over mild acne which btw Accutane did nothing for .

We TRUELY are living in the dark ages of medicine . In fact they will look back in the not too distant. future and say WTF were these people doing.

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1804
(@truejustice)

Posted : 03/09/2016 5:50 pm

3 hours ago, Bobby.Digital said:
Good to hear man. Do you suffer from chronic brain fog? That's my biggest issue.

Yes - brain fog is bad - it's getting progressively worse which worries me.

Id love the liver flush to lift it, maybe after doing 4 or 5 of them it will.

while on the subject of brain fog, what would be people's 5 best products to use? Not looking to take all 5 at once but if anyone's taking something that's easy to get and healthy to take long term please share??

I've got st Johns wort sitting in cupboard waiting to use as I've heard good things about it for fog.

Currently taking copper looking for some results!!

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1803
(@guitarman01)

Posted : 03/09/2016 6:56 pm

Asthma drug could rejuvenate ageing brains, study suggests

Scientists hope to start trials in dementia patients after rat study suggests drug reduces brain inflammation and encourages neuron growth

https://www.theguardian.com/science/2015/oct/27/asthma-drug-could-rejuvenate-ageing-brains-study-suggests

Researchers found that a six week course of the drug, montelukast, improved memory and learning in older rodents, with their performance in cognitive tests nearly matching that of much younger animals.

The drug seems to work through a combination of effects that reduce inflammation in the brain and encourage the growth of fresh neurons in a key region called the hippocampus.

I have this. not going on it until i look into some other things first. but of course il let you guys know if i become limitless.

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