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So what's the general consensus nowadays because a few years back it ranged fromcannabis oil as a cure all forpost accutane side effects all the way through tothepreposterous like running barefoot will cure you. That's why i had to walk away because it was non stop infighting in between contextlesspeer review studies on every page and it seemed to be going round in a closed circuitloop.
So what have the brightest minds on thesitegot to offer in terms of new breakthroughs....has there been any? and if so what side effects do they displace? I've got some breakthroughs of my own that may help.
5 hours ago, Chico Esposito said:Who here reacts terribly to Vitamin A in food to the point were it makes your side effects significantly worse,has dry skin, seb derm, cracking aching joints, dry brittle hair, feels like their body is a waste dump, cracked bleeding lips, inability to digest foods properly, dry eyes, light sensitivity wereby youcan't look atbright lights and who has spent a fortune on supplements to no avail, whilst getting continually worse?
Yep - that's me too!!
what am I now - 19 years post treatmentstillwith bad side effects, something like that. I actually thought my problems peaked after about 12 year but the last 5 or so have seen more problems with light sensitivity, thinning hair, aching joints etc. Someof it you can put down to age ( I'm 40 ) but I was once very fit, I still like to workout ( I'm even a qualified yoga teacher but I can't do all the poses anymore so can't teach )
Talk about robbingme of the best years, I take strength though in the fact that I'm still able to work and I own my own home ect -so from that perspective I give the middle finger to anyone whose ever prescribed this poison or who is somehow involved in making it and thus has impacted on my health and others.
There are some really smart people who do a lot of research and have provided plenty of info in this forum - A big thankyou for all the effort!!
Hopefully there's light ahead of this long tunnel for all of us!!
have you guys been tested for nasal allergies btw? the skin prick test. I recently went and am allergic to grass,trees,cats,dogs,dust,mold,pollen, pretty much everything. Have you tried nasal steroids for facial inflammation, flushing, brain fog along with a non sedating antihistimine? Im still figuring this out myself, but my face looks younger when I take claritin. anyone have problems breathing well through their nose? headaches, ear fullness? could have something to do with mast cells and histamine that accutane may have effected. We could be hyper allergic to our envirment. allergies can manifest themselves in surprising ways and not always sneezing ,running nose. facial inflammation can become so bad it cuts off blood flow, hence brain fog,eye and skin sensitivity,lack of nutrients, hair loss? everyone feel pretty good where they know the air is clean? mainly outside in the dead of winter, or on a beach,with the oceans saltin the air. feel like shit more often in doors? more often in the winter with no fresh air inside?
13 hours ago, shadeo14 said:Anyone using cannabis oil have updates? There used to be all kinds of speculation on it all over this forum
I tried using RSO (cannabis oil) for about 6 months, but the benefits were limited. I initially got improved mental clarity, and got intermittent improvements in sensation (at times glimpses of complete normally, but just brief moments), with consistent improvement in orgasm (significantly improved, but not back to normal) suggesting maybe dopamine was increased, but the improvements plateaued quite quickly so the benefits weren't out weighing the stoned effect which is just annoying (I would have no interest in weed otherwise, I was just looking for the medicinal benefit).
I know 2 other guys who also tried this around the same time as me, both taking higher doses than myself, but neither got any lasting benefits either. I also tried RSHO (basically hemp oil, so high CBD but no THC) but I got nothing from that at all and it was probably just expensive snake oil.
There are however 3 documented cannabis oil recoveries on this thread. One guy was in a really bad way and fully recovered, with improvements to night vision in a matter of weeks from starting. One of the others went to a South American country for about 5 months just to take it, and got improvements after 3 months and he was almost fully recovered at the end of his 5 months. Another guy from the Netherlands fully recovered his sexual sides and other sides, but he still gets brain fog. All 3 of them having lasting benefits after stopping.
If I lived in Colorado in the States and could easily get hold of a really good medicinal grade of this stuff I'd probably quit my job and just take it for 6 months straight, but it's not an option for me currently.
Back in 08 (finish tane end 07), I developed congestion in ears and nose . Bloods showed very high total IgE...never followed up on that or did specific allergen testing , but I know I dont have allergies. I had to go on nasal steroids ...still on them.
Have you had IgE tests?
3 hours ago, Mike San said:Back in 08 (finish tane end 07), I developed congestion in ears and nose . Bloods showed very high total IgE...never followed up on that or did specific allergen testing , but I know I dont have allergies. I had to go on nasal steroids ...still on them.
Have you had IgE tests?
I havent had a ige blood test but I did see the allergist. I mentioned a blood test and she said the skin prick test were more accurate. so being that I was confirmed allergic to everything I guess no need for the ige tests? So my question if you didnt follow up with a skin allergy test but had high blood levels indicating an allergic reaction, how do you know you dont have allergies? and why would it be high otherwise?
23 hours ago, Chico Esposito said:So what's the general consensus nowadays because a few years back it ranged fromcannabis oil as a cure all forpost accutane side effects all the way through tothepreposterous like running barefoot will cure you. That's why i had to walk away because it was non stop infighting in between contextlesspeer review studies on every page and it seemed to be going round in a closed circuitloop.
So what have the brightest minds on thesitegot to offer in terms of new breakthroughs....has there been any? and if so what side effects do they displace? I've got some breakthroughs of my own that may help.
What are your breakthroughs?
15 hours ago, guitarman01 said:have you guys been tested for nasal allergies btw? the skin prick test. I recently went and am allergic to grass,trees,cats,dogs,dust,mold,pollen, pretty much everything. Have you tried nasal steroids for facial inflammation, flushing, brain fog along with a non sedating antihistimine? Im still figuring this out myself, but my face looks younger when I take claritin. anyone have problems breathing well through their nose? headaches, ear fullness? could have something to do with mast cells and histamine that accutane may have effected. We could be hyper allergic to our envirment. allergies can manifest themselves in surprising ways and not always sneezing ,running nose. facial inflammation can become so bad it cuts off blood flow, hence brain fog,eye and skin sensitivity,lack of nutrients, hair loss? everyone feel pretty good where they know the air is clean? mainly outside in the dead of winter, or on a beach,with the oceans saltin the air. feel like shit more often in doors? more often in the winter with no fresh air inside?
I was allergic to birch tree pollen prior to accutane, now im allergic to anything and everything (mostly foods) but a decent amount of plants. Anti histamines do nothing for me (well a small symptom relief but nowhere near relief)
I'll get some air purifying devices for my apartment, but i do feel pretty decent in the enviroments you mentioned
Too tired to be outside for most of the year, and too thin + thermal regulation is all messed up so i dont handle the severe cold we have here. -20 degrees celcius atm
3 hours ago, Accutainted4ever said:No I've never taken St John's wort. Do you think I should?
Some hypothesis posted earlier that it could help with accutane specific problems, people are looking into it. In the meantime it could offer anti depressant properties if you struggle with that
8 hours ago, guitarman01 said:On 1/6/2016, 6:37:34, Chico Esposito said:So what's the general consensus nowadays because a few years back it ranged fromcannabis oil as a cure all forpost accutane side effects all the way through tothepreposterous like running barefoot will cure you. That's why i had to walk away because it was non stop infighting in between contextlesspeer review studies on every page and it seemed to be going round in a closed circuitloop.
So what have the brightest minds on thesitegot to offer in terms of new breakthroughs....has there been any? and if so what side effects do they displace? I've got some breakthroughs of my own that may help.
What are your breakthroughs?
second this, anything is welcome at this point
16 minutes ago, Accutainted4ever said:Is it ok to take taurine and glycine at the same time or do they compete for absorption?
Should they be taken with food or on an empty stomach, or does it not matter?
I think they actually enhance each other when taken together. But you could space them out if you want. Both at night is good tho
Better absorption on empty stomach. It doesnt matter too much for taurine but glycine with complete protein would possibly hamper its absorption. Just take them with water before bed, enhances your sleep too
On 2 January 2016 at 8:40:19 AM, tryingtohelp2014 said:
17 minutes ago, yetanotheraccutanevictim said:Does anyone know how to obtain some more accutane cheaply? I am looking into homeopathy as a cure. I'm specifically looking for the generic, Claravis. I only need 1 capsule.
Been there and done that - sorry to say but it doesn't work, not for me anyway.
You may have more success though - good luck!!
Not sure where my homeopath obtained pill from, I paid him to do that.
On 1/8/2016 at 8:18 AM, TrueJustice said:Been there and done that - sorry to say but it doesn't work, not for me anyway.
You may have more success though - good luck!!
Not sure where my homeopath obtained pill from, I paid him to do that.
It does work according to some VERY intelligent people (like Dietrich Klinghardt). But, he says traditional homeopathy rarely works anymore. Most people disregard it as quackery due to them not understanding the complex quantum physics behind it.
It has to be made in a lab setting (like BioResource). Unfortunately, I'm having a hard time finding a lab that will do custom remedies. BioResource (one of the best) unfortunately does not. But they have a few great products like Apo-Hepat that detoxifies the liver.
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Message I sent back to cyclodex.com regarding cyclodextrin infusions for getting rid of retinoids from the liver:
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The response back to me:
"The answer is yes. Check out Trappsol Cyclo on the internet. This is our endotoxin controlled, sterile product for IV use in the clinical trial we are doing in Europe. Trappsol HPB is also GRAS in Europe.
The product is hydroxypropyl beta cyclodextrin and it has been approved for use in many drugs given IV all over the world including the US."
On 1/8/2016 at 8:36 AM, yetanotheraccutanevictim said:It does work according to some VERY intelligent people (like Dietrich Klinghardt). But, he says traditional homeopathy rarely works anymore. Most people disregard it as quackery due to them not understanding the complex quantum physics behind it.
It has to be made in a lab setting (like BioResource). Unfortunately, I'm having a hard time finding a lab that will do custom remedies. BioResource (one of the best) unfortunately does not. But they have a few great products like Apo-Hepat that detoxifies the liver.
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Message I sent back to cyclodex.com regarding cyclodextrin infusions for getting rid of retinoids from the liver:"You said BCD is not to be used intravenously?Are you saying Trappsol Cyclo (hydroxypropyl BCD) CAN safely be used intravenously?Could you link me to the exact product that can be used intravenously? We need one that will pull isotretinoin from the body, specifically.There are many, MANY people suffering the side effects of using isotretinoin and we are all wondering what the safest method of getting this into our systems to pull retinoids from the liver would be.[Edited link out]From the one study we have on pulling vitamin A out of the liver:"The patient received a continuous intravenous infusion at 470 mg/kg/24hrs for a total of 30 g over 4 day period in the form of 5% aquous solution in water.. Other than generalized irritability and leg pain associated with vitamin A toxicity, no adverse events were reported, although cholesterol levels decreased by 20-30% during the cyclodextrin infusions."I wish there were more studies available that quantified how much came out of the body. Also, we are not sure where the drug is stored but we assume it's in the liver. 80% of retinoids in the body are stored there. Isotretinoin is 13 cis retinoic acid that's converted into all-trans retinoic acid in the body.If something could be taken or injected that would rid the body of this chemical, it would heal SO many people.Any information you could provide is VERY MUCH appreciated!-----------------
The response back to me:"The answer is yes. Check out Trappsol Cyclo on the internet. This is our endotoxin controlled, sterile product for IV use in the clinical trial we are doing in Europe. Trappsol HPB is also GRAS in Europe.
The product is hydroxypropyl beta cyclodextrin and it has been approved for use in many drugs given IV all over the world including the US."
Man, wished you would have asked him about per oral or orally. if its safe, and up to how much per day? and also if it would still have an effect even if not as great on vitamin a toxicy, mainly in the liver. I got this stuff coming tomorrow, but there is no way im going to iv it over a 4 day period. Actually you should ask him you guys are like buddies now.
On 1/8/2016 at 8:44 AM, guitarman01 said:On 1/8/2016 at 8:36 AM, yetanotheraccutanevictim said:@Guitarman, I sent him another response just now:"Thank you again for the quick response. I hate to keep bothering you but I have just a couple more questions.
If you could give your thoughts on oral vs intravenous administration of HPBCD, it would be incredibly useful. Perhaps you could remark about safety, dosage, and effectiveness for treating hypervitaminosis A in the liver.Currently, we are going to try the same dosage Dr. Carpenter used:"The patient received a continuous intravenous infusion at 470 mg/kg/24hrs for a total of 30 g over 4 day period in the form of 5% aquous solution in water.. Other than generalized irritability and leg pain associated with vitamin A toxicity, no adverse events were reported, although cholesterol levels decreased by 20-30% during the cyclodextrin infusions.""Clinical observations and those laboratory results which were related to the disease and which were collected at the time of infusion therapy had been published previously;6J8 the distribution of retinoids in lipoproteins was described later.15 Table 2 displays the clinical chemistry data documenting the lack of short-term adverse effects of the infusion. The data show that in spite of a badly balanced injection solution, no hemolysis was seen."Some information about safety from this link:[Edited link out]"At 100 mg/Kg some minimal histological changes were found in the epithelial cells of the urinary bladder, kidney tubular cells and in the liver.""At 400 mg/Kg, there was a decreased body weight and food consumption, increased water consumption, decreased hematocrit, hemoglobin and erythrocyte levels, increased creatinine, total bilirubin and aspartate and alanine aminotransferase levels. Some organ weights also increase. Most of these changes were reversible after one month except for slightly elevated aspartate and alanine aminotransferase levels and histological changes in the lung and urinary tract that were only partially reversible.""In subchronic toxicity studies, no adverse effects were found in rats treated intravenously with 50mg/Kg or in dogs receiving 100 mg/KG HPBCD. At 400 mg/Kg in dogs there were slight increases in serum alanine and aspartate aminotransferase and total bilirubin. Histological changes werefound in the lung and epithelial cells of the urinary bladder and renal pelvis. All of the changes were reversed within a month after treatment except for incomplete re- versibility of the swollen renal plevis epithelium. Teratogenicity and embryotoxicity studies have been done in rats and rabbits at doses up to 400mg/Kg per day. Slight maternal toxicity was observed in rats at 400mg/Kg but there were no primary adverse effects in the offspring. No adverse effects were observed in the rabbits."Seems that at about 400 mg/kg per hour is about the tolerable limit. Not entirely sure, though. We may do less just as a precaution. We want to get the most bang for the buck, though.I appreciate your time and kindness."
18 minutes ago, yetanotheraccutanevictim said:"At 400 mg/Kg, there was a decreased body weight and food consumption, increased water consumption, decreased hematocrit, hemoglobin and erythrocyte levels, increased creatinine, total bilirubin and aspartate and alanine aminotransferase levels. Some organ weights also increase. Most of these changes were reversible after one month except for slightly elevated aspartate and alanine aminotransferase levels and histological changes in the lung and urinary tract that were only partially reversible."
lol. Idk does that all sound ok to you?
you order this stuff too yet?
http://www.unboundmedicine.com/medline/citation/1522488/Hydroxypropylcyclodextrins_in_parenteral_use__II:_Effects_on_transport_and_disposition_of_lipids_in_rabbit_and_humans_
Intravenous infusion of hydroxypropyl-beta-cyclodextrin into a patient with hypervitaminosis A led to a release of liver-stored retinoids into serum in quantities much higher than those that could be directly solubilized by hydroxypropyl-beta-cyclodextrin.
What does that mean? directly solubilized? orally?
@guitarman01Concerning the possible side effects from using HPBCD, you have to decide for yourself if your accutane side effects are worth living with. I personally am going to try the HP-cyclodextrin. I'll probably do a lower dose just for extra precaution. Maybe 200mg per kg (slow drip).
And I think the above statement you posted means that IV HPBCDcaused moreretinoid release from the liver into the serum than could be handled by the CD (by "handled" I mean grabbed and carried out of the body). That's why the kid being treated with cyclodextrin had symptoms of vitamin A overdose for a while. Some of the stored retinoids were released into circulation and not all of them could be gathered up quickly enough. Still, this is a great method for getting retinoids out of the liver it seems. Maybe we could do even smaller dosages just spread out over longer periods of time.
Edit: Or it means that the CD could not make it water-soluble at the rate at which is was coming out. So some remained fat-soluble. (and perhaps got carried into fat-cells or lymph). Not entirely sure though
2 minutes ago, guitarman01 said:orally seems pretty safe up to 4 to 8 grams per day for up to two weeks. thats the route i would go first.
I would think it would still have some effectand 8 grams is actually alot
Also, oral administration could possibly be better in our case due to it going straight to the liver. However, I'm sure a lot of it is degraded via digestion. If you do this, do it on an empty stomach in the morning with a huge glass of water.
1 hour after ingesting, I'd take binders like charcoal or chlorella
7 minutes ago, yetanotheraccutanevictim said:Also, oral administration could possibly be better in our case due to it going straight to the liver. However, I'm sure a lot of it is degraded via digestion. If you do this, do it on an empty stomach in the morning with a huge glass of water.1 hour after ingesting, I'd take binders like charcoal or chlorella
and after all this, trying these methods. if none of this works/feel no effects. I think we can put to bed the theory that accutane is stored in our liver still. but if it does. we should get blood test that show its there and sue roche save lives and live happily ever after. Rich and healthy.