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Have you guys with ED issues tried NoFap for 90 days or more?
Is the ED being caused mean that you can't even get hard by manual stimulation?
seems to be that many of the affected can still get hard but the issue is numbness, erections go down very easily, weaker erections and weak orgasms. 5ar inhibition must have something to with it
http://www.google.com/patents/US8481032
accutane increases lipocalin-2 expression by 27 fold in some cases. this in turn keeps retinoic acid levels in the skin permanently high. we need a ppar-y agonist.
natural ppar-y agonists: red clover?!
http://www.sciencedirect.com/science/article/pii/S0006295214004249
Example 1 Lipocalin-2 Production is Increased in Db/Db Diabetic/Obese Mice, but is Suppressed Following Treatment with the PPAR Agonist Rosiglitazone
Have you guys with ED issues tried NoFap for 90 days or more?
Is the ED being caused mean that you can't even get hard by manual stimulation?
I dont try it, it just happens. Weeks pass and I cant remember when I last ejaculated. I have no urge to have sex or no load to ejaculate. It is just how old people live.
I can get an erection with manual stimulation or if I have a little libido I can get it up.
But before accutane I was ready for 7/24. I never had any kind of ED problem, and I had to do it every two or three days. Usually everyday.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090422/
seems we have to downregulate LCN2 and upregulate SCD1
it seems to me that scd activity would decrease lipocalin-2 activity
i think that initialy on accutane there's a chanse that in the begining the scd would work more becuase of a need to fix accutane effects, but later it would collapse, and that once it collapsed it saty collapsed.
data from the link above and another one below support my hypothesis that after accutane the body turn into retinoic acid producing machine, which sustaine an accutane state, which sustaine a foxo state in a continuous loop.
from the above link:
''Lack of skin SCD1 causes an elevation in skin levels of retinol and retinoic acid, which in turn activates the transcription of retinoic acid-induced genes. We speculate that one of these elevated retinoic acid-induced genes, Lcn2(lipocalin-2) results in sebocyte dysfunction and sebaceous gland hypoplasia in the SKO mice''
http://diabetes.diabetesjournals.org/content/57/4/846.full
''Possibly, fatty acid activation of Foxo1 with subsequent inhibition of SCD1 would create a self-sustained cycle with deleterious cellular effects (31,46,48,49).''
and we know about the connection between foxo and the accutane side effects( http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/ )
.
all totally makes sense. we are caught in a loop. we have basically become SKO mice
logically we need to attack this loop from all sides, either the lcn-2 or the SCD-1
for the lcn-2 side..... magnolia extract....red clover tea?
http://www.sciencedirect.com/science/article/pii/S0006295214004249 Natural products prove to be a rich source for the discovery of novel PPAR ligands and many structurally diverse agonists of this receptor were recently identified from traditionally used medicinal plants or food sources. Interestingly, the majority of identified natural compounds are rather weak agonists of PPAR, often activating the receptor as partial agonists, with activation pattern distinct from the full thiazolidinedione agonists and more similar to endogenous ligands with weaker activation potential such as fatty acids and prostanoids. Noteworthy, several PPAR agonists were identified in plants used as culinary spices, beverages or food sources, opening the possibility to consider modulation of the activity of this nuclear receptor through dietary interventions. While most of the identified natural products only activate PPAR as SPPARMs, some are dual agonists able to also activate PPAR (Table 2). An especially interesting activation pattern is observed for the neolignans magnolol and honokiol, which are ligands for both PPAR and its dimer activation partner RXR. The neolignan honokiol and several other natural products have also demonstrated beneficial metabolic effects in diabetic animal models, with reduced side effects in comparison to full thiazolidinedione agonists. Many extracts from medicinal plants reported in the literature as PPAR activators are so far not thoroughly investigated. The identification of their active constituents might provide further interesting ligands in the future.
On 7/3/2015 at 2:40 AM, Ottovisual said:
On 6/26/2015 at 12:47 AM, Trapt said:On 7/4/2014 at 6:18 AM, Ottovisual said:Reporting in.
5 weeks using RSO now.
Total ingested 5 grams.
To be clear, the RSO is still dominating me at this moment. If things are going better/worse, the next week it could be vice versa.
3 months after my last dosage I can give a objective review on side effects.
I started a new job this week which involves a lot of driving so I had to quit the daytime dose because I can't risk having a fuckup with dosing and driving.
What happens is the RSO produces massive amounts of melatonin which is a big healer but also a big sleeper. If someone is ill, the first thing they advise is to take a good night of sleep right ? Imagine having a week of sleep pushed into 1 night.
Also like some already posted, your short term memory is pretty much in standby modus when the RSO is active ( probably its easier to induce sleeping this way ).
If I take a night (big) dose at 8 oclock I feel the melatonin 24 hours and feel quite sleepy the whole 24 hours.
If I dont take a dose, I will get massive amounts of energy, to the point where I want to run over the whole world. I feel like a little boy again playing in the woods with no energy limit. ( maybe to rebound the massive melatonin wearing off ).
The second week there was I point where I got random "new" youth memories. It felt like a door opened to a part of the brain which was locked due to depression.
The moment when I got these memories it felt like synchronizing with my old me, I remembered who I was, I felt empathy again. Instead of black & white I felt colors.
Today I also skipped the daytime dose and I can feel it wearing off when I stop my shift in the afternoon.
I got home and I really really wanted to have sex with my girlfriend. I wanted to touch her body. I am looking for subtle words to explain this. I felt like a Greek god [Edited link out]
I cannot emphasize this enough though: Moments happen, they make me smile but whether its permanent or not I cannot tell at this point, I need to be off RSO for quite some time.
Currently I'm fixing the dosing issue, the key is consistency and tolerance. There comes a point where you ingest 1 gram a day and the only side effect is a good night rest. If I ingest 1 gram at my current tolerance point, I will be in lalaland for some days.
As for ingestion, I read somewhere Rick ( or one of his associates ) said the goal is to get the RSO to the stomach. I put my RSO in a vitamin like capsule and swallow it. About 1 hour later I feel it kicking in and then I can pull 12 - 16 hours of sleep.
I tried different ways of ingestion, but this one is the easiest and most potent for me on top of that it follows the same route as accutane did so it can repair the whole accutane route. Rectal is said to be the most potent because of all the large blood vessels there and direct absorption into the blood.
Recommended is 1 small daytime dose in the morning and a big sleeper for the evening.
All the best,
Ottovisual,
Can you give us an update with the RSO? What were your post-Accutane side effects? What side effects disappeared with the RSO? What side effects still remain? Are you still using it? Thanks.
Hey everybody,
Dig in my archive of posts and you will find my full symptons.
I have been doing great, I would lie if I said I'm 100% cured but the good days outnumber the bad days.
Symptons that remained positive after a low protocol of RSO:
- Weight: I lost about 6-7 KG's after accutane. I was unable to regain those Kg's no matter how hard I trained, no matter what I ate. This is fully restored, I'm currently doing weightlifting and the muscles grow and grow.
- Gum/Dental Health: My gums remain perfectly in shape, my dentist has 0 complains. Before the RSO treatment it was rubbish, retreating and irritated.
- Skin: No more dry skin.
- Libido: So, my libido went from 100 to 60 - 70 post accutane. At this point I would say I'm 90 again. Inmediatly after accutane I got a girlfriend and we are six years together. If I was single I would be 100 again I'm sure. What I noticing now is when I'm flirting with a girl I feel the blood charging my penis and a instant boner is following. Pre-RSO this wasn't the case.
- GI tract: RSO did alot for my GI-Tract, only thing I'm doing now is a probiotic and good fermented food. I have regular bowels and the texture and everything is perfect.
This that still remained negative / midly negative.
- Brain fog. Although people said my personality positively changed when I took RSO ( and they didnt know I took it ) my brain didn't returned back to the extreme sharpness I had before accutane.
Pre-accutane all these verbally options shooted from my sub-councious into my counsciousness when I was discussing something. Post-accutane I felt like a child, just following other people and no input from my side. After the RSO my memory improved ALOT, these random youth memories were shooting through my brain and that made me very very happy.
But the brain fog / alertness pretty much remained the same.
These months I supplemented with some nootropics and Astaxanthin. Now the Astaxanthin pretty much clears my brain fog and give me ALOT of clarity and when I add a nootropic like Piracetam or Noopept I'm 100% myself again. I also firmly believe these nootropics can restore our disrupted brain networks. I'm making 17 hours a day again just like pre accutane and have alot of energy.
Eye-Floaters: Now I speak alot of people who smoked weed and they reported that the floaters increased when using and it took them some years to get some relieve again. Also when I use Astaxanthin and a Nootropic it decreases alot. Also, the only thing we can change about floaters is the perception of floaters. They are always there.
Tinnitus: Decreased from 100 to 60. Again I think this is a brain thing, I dont think it's my ears, I think there are some nerves in my brain over-sensitive or over-simulating.
Sleep: While on RSO you sleep like a baby. I think sleep is a big focus area for us. I dont think we sleep like we should, and we dont recover like normal people do. So while on the RSO the sleep was perfect, but after it was crap.
Just a quick summary of my current health.
My current stack
Astaxanthin - for brain fog
Piracetam or Noopept or Aniracetam - To stimulate my brain again and repairing the disrupted brain networks
ZMA - before bed, to improve the quality of my sleep. This is one the most important supplements I take and very cost effective. Make me dream again so I know I'm doing quality sleep
There are days where I have the full access to my intelligence, where all the suggestions are shooting through my counciousness and the words just roll out my mouth. Where I have full control of the words I'm saying and where I can plan the sentence visually in my head so I can choose the strategy in a discussion. I also can predict people's reaction based on their personality. Just like pre-tane. So things look very good.
These last years are basically years of detoxifying and then years of rebuilding my body and soul. And I'm current;y rebuilding my body and soul.
Still there are days where I have full blown brain fog but this is always followed on a bad night of sleep.
I'm off to get some food.
If you have any questions, just Pm me.
Oh yeah, for the nootropics, some people experience lowered libido for the first weeks. Just read the reports on reddit.
- Otto.
Great to hear you're still doing well Otto! With regards the mental clarity/brain fog, I would suggest trying pine pollen. It's been one of the most effective things for me to improve mental clarity (not to mention reduces ED too), however I found that after taking it for 3-4 weeks I started to get symptoms of excessive estrogen like sensitive nipples. I've been taking an aromatase inhibitor for about 6 weeks now however, and I've started on the pine pollen again now so hopefully that will prevent my e levels going through the roof!
Hey guys, I have found an interesting article on Internet. Its about the androgen metabolism in the Skin. The only hard Problem we have is not working metabolism of androgens in the Skin. I list all Skin enzymes:
1. Steroid sulfatase: Metabolizes DHEA-S to DHEA (many of us have very high DHEA-S, because this Enzyme is low)
2. 3beta hsd: DHEA to Androstenedione
3. 17beta hsd: Androstenedione to Testosterone
4. 5 Alpha reductase: Testosterone to Dihydrotestosterone
5. Only ''good'' working Enzyme in us is the aromatase: Testosterone to Estradiol
Greetings to you guys stay strong 
Hey guys, I have found an interesting article on Internet. Its about the androgen metabolism in the Skin. The only hard Problem we have is not working metabolism of androgens in the Skin. I list all Skin enzymes:
1. Steroid sulfatase: Metabolizes DHEA-S to DHEA (many of us have very high DHEA-S, because this Enzyme is low)
2. 3beta hsd: DHEA to Androstenedione
3. 17beta hsd: Androstenedione to Testosterone
4. 5 Alpha reductase: Testosterone to Dihydrotestosterone
5. Only ''good'' working Enzyme in us is the aromatase: Testosterone to Estradiol
Greetings to you guys stay strong
ok so you suggest?????
"Allopregnanolone formed in peripheral tissues readily enters the brain where it acts to enhance activation of GABA. A receptors" (William H. Theodore, MD; Clinical Epilepsy Section NIH Bethesda, MD).
^ A reasonable explanation of how Accutane's effects of lowering steroid metabolism in peripheral tissues can cause anxiety and depressive side effects in acne patients receiving the drug, and lead to decreased neurogenesis obversed in studies of rats given Accutane/isotretinoin.
Accutane decreases levels of other 5-alpha and 3-alpha metabolized steroids, implying it effects these enzymes. These enzymes function in concert to produce allopregnanolone.
Allopregnanolone promotes neurogenesis, has an anxiolytic (anti-anxiety) effect, and increases pro-sexual behavior.
Just to let you guys know, if you want to specifically discuss erection problems from accutane, you could go to this thread here. I posted to it a couple of times.
They have someone who claimed doing a water fast helped him out quite a bit, but doing that is out of the question for me.
www.acne.org/messageboard/topic/272480-accutane-and-erectile-dysfunction/
Hey guys like many of you I am experiencing prolonged side effects from an accutane course over 2 years ago, and I am trying to understand what can be done to repair/reverse the damage. However, as much I would like to read through 347 pages I simply do not have that time, so I was hoping if someone could be kind enough to summarize the most effective solutions that this thread has produced. Thanks!
Hey Marlin, I don't know what to suggest you, because I don't know your Hormone tests.. But I think they are similar to all of us.. I think we should restore our sebum production. IGF-1 stimulates sebum and is the culprit of acne because it lowers SHBG, with lowering SHBG it increases Free Testosterone and is one of the most potent 5 Alpha reductase Stimulators. I think the bad hormones for us are the estrogens especially Estradiol. Do not take supplements like DIM or other anti andogenic herbs. They will lower Estrogens but also your estrogen receptor activity and active DHT.
Hey guys like many of you I am experiencing prolonged side effects from an accutane course over 2 years ago, and I am trying to understand what can be done to repair/reverse the damage. However, as much I would like to read through 347 pages I simply do not have that time, so I was hoping if someone could be kind enough to summarize the most effective solutions that this thread has produced. Thanks!
Here's a quick summary of what works- nothing
Hello users.
I've took Accutane approximately 8 months ago, a full dose of it. I do not regret it because it literally gave life to me again. I was falling into a severe depression due to my acne, i didn't even do nothing for my 18's, just stayed at home crying. Also i knew that Accutane is kinda of a "poison" and really messes with your body.
I had a normal course, with the normal expected side effects. Unfortunately, minor - sometimes moderate when bending, laying on bed, lifting heavy- lower back pain have stayed with me, also with dry lips (not closely as bad as in Accutane) and dry eyes.
For my luck (not trying to sound like a douche bag) these side effects are really minimal compared to the ones some of you guys have. and i'm really sorry about it.
I don't actually have the time to read all +300 pages from the thread, so my question is:
Is there any supplement that can,at least, band aid the lower back pain?. The pain doesn't interfere with my normal life, but you know, is kinda scary having this weird pain at 19 years old. I don't know if it going to cause any serious problem in the future, so it would be good if i start doing something now about it.
A thing that helped me was going to a gym. I'm really into it, but i have a "black list" of exercises that i can't do due to the pain.
I've just tried Glucosamine with no relief or help.
Also i think that it haves something to do with dryness of the Hyaluronic Acid on my body right ?. Since i've read that this relates with dryness in the lips,eyes,skin and even bones.
Hey guys like many of you I am experiencing prolonged side effects from an accutane course over 2 years ago, and I am trying to understand what can be done to repair/reverse the damage. However, as much I would like to read through 347 pages I simply do not have that time, so I was hoping if someone could be kind enough to summarize the most effective solutions that this thread has produced. Thanks!
Here's a quick summary of what works- nothing
Pretty much, lol. However, if you change your diet, exercise, and find supplements that work for you, you can look at a 2-3% better quality of life.
Hey guys like many of you I am experiencing prolonged side effects from an accutane course over 2 years ago, and I am trying to understand what can be done to repair/reverse the damage. However, as much I would like to read through 347 pages I simply do not have that time, so I was hoping if someone could be kind enough to summarize the most effective solutions that this thread has produced. Thanks!
Here's a quick summary of what works- nothing
brutal but true
Hey guys like many of you I am experiencing prolonged side effects from an accutane course over 2 years ago, and I am trying to understand what can be done to repair/reverse the damage. However, as much I would like to read through 347 pages I simply do not have that time, so I was hoping if someone could be kind enough to summarize the most effective solutions that this thread has produced. Thanks!
Here's a quick summary of what works- nothing
Pretty much, lol. However, if you change your diet, exercise, and find supplements that work for you, you can look at a 2-3% better quality of life.
There is no 100% cure, but recovery up to 50-75% is possible in my oppinion.
Hey guys like many of you I am experiencing prolonged side effects from an accutane course over 2 years ago, and I am trying to understand what can be done to repair/reverse the damage. However, as much I would like to read through 347 pages I simply do not have that time, so I was hoping if someone could be kind enough to summarize the most effective solutions that this thread has produced. Thanks!
Here's a quick summary of what works- nothing
Pretty much, lol. However, if you change your diet, exercise, and find supplements that work for you, you can look at a 2-3% better quality of life.
There is no 100% cure, but recovery up to 50-75% is possible in my oppinion.
Shiet. Sign me up.
Hi I want to joint this discussion cuz I suffer accutane post side effects.
in the beggining of 2014. I took a pretty low dose (5/10mg) for 3 months. The treatment
was stopped cuz I was having extreme facial flushing and tons of little red dots (petechiae) around my eyes.
Here today I can say that Im free of the rosacea but my acne came back "normal" and those petechiae still comes and goes around my eyes. Do you guys have some similar experience? I can get them from crying to much or removing my eye makeup too brutally.
Can accutane give this side effect??? I never hear of it. Will this go away one day?
Porswis
Hey guys like many of you I am experiencing prolonged side effects from an accutane course over 2 years ago, and I am trying to understand what can be done to repair/reverse the damage. However, as much I would like to read through 347 pages I simply do not have that time, so I was hoping if someone could be kind enough to summarize the most effective solutions that this thread has produced. Thanks!
Here's a quick summary of what works- nothing
Pretty much, lol. However, if you change your diet, exercise, and find supplements that work for you, you can look at a 2-3% better quality of life.
There is no 100% cure, but recovery up to 50-75% is possible in my oppinion.
Shiet. Sign me up.
I managed to revert the damage from worse to bad.
I assume that as 50-75% recovery.
Mental issues were the worst for me. I did nothing special, but it took 1 year to get to the point where I dont have panic attacks, suicidal thoughts anymore. I still feel depressed but it is different.
I still suffer from many problems but they are bearable. Keep fighting.
Accutane decreases levels of other 5-alpha and 3-alpha metabolized steroids, implying it effects these enzymes. These enzymes function in concert to produce allopregnanolone.
Allopregnanolone promotes neurogenesis, has an anxiolytic (anti-anxiety) effect, and increases pro-sexual behavior.
I still don't understand why I became so depressed (let alone extremely fatigued and problems remembering) while on 20mg Isotretinoin in just 2 days. What's weirder is that before becoming depressed on the second day, I actually became extremely irritable and had uncontrollable anger within half an hour of taking 20mg Isotretinoin on the first day and I don't know if that has happened to anyone before.
I thought the reason why it causes these mental side effects in some people is because it decreases neurogenesis by causing cell apoptosis throughout the body (one area being the hypothalamus). Here's the quote from Wikipedia:
Isotretinoin's exact mechanism of action is unknown, but several studies have shown that isotretinoin induces apoptosis (cell death) in various cells in the body. Cell death may be instigated in the meibomian glands,[56][57] hypothalamic cells,[58] hippocampus cells[59][60]andimportant for treatment of acnein sebaceous gland cells.
I really hope my brain isn't permanently damaged from taking 20mg Isotretinoin for 5 days and while it most likely isn't, it did severely affect my mental health while I was on it even though it was just for 5 days which is why I got off it so early.
just a little update
been travelling for just over a month now and havent really had time to try anything substantial.
but ive noticed that when im consistently drinking and smoking cigarettes my stutter decreases and memory decreases, and i feel more at home in my body.
also took some mdma a few weeks ago and got the same result.
I was on a plane also and happened to look at my pupils under those bright lights and noticed a very evident ring of gold around each pupil.
So now im defiantly thinking low dopamine as drinking and what not increases dopamine as does smoking cigarettes.
copper toxicity i think is defiantly the culprit here.
I have been taking St johns wort in attempts to raise dopamine and i think it works to some extent but probably not as good as L-tyrosine