- Did you ever meet in person with someone who has similar problems to us post tane?

 

- Do you have emotional blunting, derealization, depresonalization, sexual problems, social phobia since starting Accutane?

I have never met (that I am aware of) anyone who has had similar problems. I have talked to people about it who used Accutane without issue, and some that had problems while taking Accutane, or had a friend who had problems, but I have never met anyone face to face that is dealing with long term issues as a result of taking Accutane. There are people out there like us though, and so much more now, I'm kind of relieved that I decided to start poking around again online. It's always a tiny bit reassuring to see that others have had similar experiences, and this isn't something that is just in my head.

I would say yes to all of those except the sexual problems. I believe most of my sexual problems have been related to drugs I was using to try and treat my depression. I think one caused my prostate to swell or something, and I always felt like I had to pee, and ejaculating felt like i was trying to pass a kidney stone or something, not pleasant. Right now, I'm on enough anti-depressants that I do experience some loss of sensitivity, difficulty reaching orgasm, but my wife is very understanding and we try to be honest and communicate with each other about it. I know you have had bad experiences with a lot of these treatment drugs, and I have to, but I did find one that worked for me eventually. Our first daughter was born when I was 22 ( 4 years post Accutane) with serious terminal birth defects. She lived for 12 days, and died in my arms. After that, my depression really took over for a while, until I broke down and started looking for help. 40 mg of fluoxetine daily was enough that I could function, for the most part, and could stand the side effects well. I got by like that for a long time, and every once in a while I would feel good (mentally, gut was always fucked up still) stop taking my fluoxetine, and then 2 weeks later would start careening back towards depression, so I eventually resigned myself to the fact that this was something that was a part of me now, and I would have to live with it and manage it everyday. Which was fine, until last year, independently to one another, my father and another close friend expressed concern to me being on fluoxetine long term (over 10 years daily at this point), and even though it was obviously working for me, they both said that "I should be normal by now". FailFish. So I decided to stop taking my fluoxetine. I knew that I would hit depression after the 2 week half-life ran out, but I lied to myself and said, If I can just power through the first month or two, I can get out of this and be "normal" again. Never happened, my life and depression soon spiralled comepletely out of control. What is worse is that when I finally realized that I would never be the "normal" that they wanted, I got back on fluoxetine....and it had absolutely no effect. It doesn't work anymore. Might as well give me a box of tic tacs. 60 mg daily of name brand Prozac (omg expensive) is just enough to get me out of bed and not constantly thinking about killing myself. I've been trying other things to find something else, but most everything else I try either doesn't work or gives me awful side effects. So that's why I started digging around here. I've learned a lot in the past couple weeks though, and I am hopeful that I can get through this, and I'll just have to keep trying new things until I find something that works. I do however, have a very supportive immediate family, so that helps a lot, and my heart goes out to you that your family doesn't seem quite as supportive (though to be honest, mine was alot more like yours in the beginning).

I'm very worried about how I'm losing my ability to fully follow a thought more and more everyday. I used to be known as a great writer, now I can barely form sentences, let alone paragraphs. I'm hopeful that I will be so motivated to survive that the thoughts I do slowly form will improve my health very slowly, even perhaps miraculously. I don't want to die but everything feels impossibly difficult and I'm too unsupported. Not meaning to be negative, just need to vent. On the bright side, I haven't lost hope thanks to this thread and all you strong people still trying in the face of disaster.

I feel this so much right now. If I am cooking dinner and go the pantry, I might stand there for 2 or 3 minutes trying to remember what I came to get. I was talking to my wife yesterday, and literally just hit a blank wall mid sentence, and couldn't even remember what I was talking about. This brain fog is most definitely from depression. My therapist told me that they are finding that a lack of serotonin production can seriously affect focus, attention, memory, etc. I've definitely had times when fully depressed where I wasn't thinking clearly, but this brain fog is totally new and a bit disconcerting, although I am 36 now, but I just chalk it up to my lack of serotonin production, and I am optimistic that if I can straighten that out a bit, this brain fog will clear up.

Theory: We were heavily toxic before accutane and our acne was a symptom of our body trying to tell us that, now we took accutane and backed up our body with even more toxins. Just like these toxins built up for years, it's going to take years of healthy habits to repair our body and be as toxin free as possible. Healthy eating, supplementation, exercise, and plenty of rest will be needed to heal. It's not going to happen over night and there is no miracle cure.

Theory: We were heavily toxic before accutane and our acne was a symptom of our body trying to tell us that, now we took accutane and backed up our body with even more toxins. Just like these toxins built up for years, it's going to take years of healthy habits to repair our body and be as toxin free as possible. Healthy eating, supplementation, exercise, and plenty of rest will be needed to heal. It's not going to happen over night and there is no miracle cure.

Can we please talk about these ludicrous baseless presumptions elsewhere?

This one has been discussed to death in this thread already.

Thanks.

 

Theory: We were heavily toxic before accutane and our acne was a symptom of our body trying to tell us that, now we took accutane and backed up our body with even more toxins. Just like these toxins built up for years, it's going to take years of healthy habits to repair our body and be as toxin free as possible. Healthy eating, supplementation, exercise, and plenty of rest will be needed to heal. It's not going to happen over night and there is no miracle cure.

Can we please talk about these ludicrous baseless presumptions elsewhere?

This one has been discussed to death in this thread already.

Thanks.

No need to be rude. they aren't baseless either. I sure am speaking from my own experience and what I've experienced seems very similar to the users who are posting. I didn't think I was on to anything, and I just thought it should be restated considering the amount of new users who have posted in this thread recently with their symptoms becoming so unbearable making life seem not worth living anymore. Like i said there's hope, but it will take time

I think its more gene transcription and cellular apoptosis. I don't know if it was just random genetic susceptibility, ignorance of retinoid effects on humans, or planned on Roche's part to target certain genes in people (the drug may have masked other ingredients with ulterior motives). It's a bit farfetched, but I can't just rule it out. I do believe there have been "successful" therapies with isotretinoin, but I'm willing to bet that ultimately it will speed up the process of your body, and all of the susceptibilities that our genetic makeup would yield in the future. In some people's cases their joints, some their digestive organs, reproductive organs, neurology weaknesses..

 

Theory: We were heavily toxic before accutane and our acne was a symptom of our body trying to tell us that, now we took accutane and backed up our body with even more toxins. Just like these toxins built up for years, it's going to take years of healthy habits to repair our body and be as toxin free as possible. Healthy eating, supplementation, exercise, and plenty of rest will be needed to heal. It's not going to happen over night and there is no miracle cure.

Can we please talk about these ludicrous baseless presumptions elsewhere?

This one has been discussed to death in this thread already.

Thanks.

No need to be rude. they aren't baseless either. I sure am speaking from my own experience and what I've experienced seems very similar to the users who are posting. I didn't think I was on to anything, and I just thought it should be restated considering the amount of new users who have posted in this thread recently with their symptoms becoming so unbearable making life seem not worth living anymore. Like i said there's hope, but it will take time

Stating that ambiguous toxins were the root cause of our acne is as much baseless conjecture as saying the sun revolves around the earth because it "feels" like a valid idea. There is zero evidence of what you say and you are insinuating the ill health of everyone here is the fault of their poor lifestyle choices.

I find it rude.

If you want to talk about hopelessness, I wake up daily wondering if this will ever end and it is the type of fantasy you are peddling that makes me lose hope we'll ever get out of this, or at least stop it from happening to others.

i wonderd if a Blood transfusions can do somthing, i once listened to a podcast on how it can make old mice younger(don't remmber on what peremeters but it was quite wide if i remember correctly) . maybe it can do something to our body to cahnge some defect reaction to the drug which acording to one study persist even 6 month after accutane been stopped when they chacked the study subjucts (TLR2 reduction) i also always wonder if the foxo study checked people after long cessation from the drug)

I had an email exchange with the author of the foxo research paper. According to him the foxo level goes back to the initial basis shortly after isotretinoin intake is stopped. he mentioned a couple of weeks.

Hi there,

New here.I heard about this forum on a facebook page, I've heard it's very useful.

So I came of Roccutane two weeks ago after being on it for two months. 1 month on twenty mg. and another month on 50mg (the max for my body weight). I've gone of it after I started to experience severe anxiety and sleeplessness as well as kidney pain and constant urine infections/ constipation as well as vaginal dryness and pain during sex. Almost all of this started when the dosage increased (apart from the constipation which started a couple of days into starting it). So I decided it just wasn't worthit anymore. In those two months I had no initial breakout and my adult acne cleared up a lot, but even still, it wasn't worth the side-effects for me.

I was warned of the side effects before, however my dermatologist told me that anxiety and depression etc was just a precaution they have to put down and that nobody she has treated ever had it and that as I have no history of mental illness I would be fine. I was also told that any side effects are short term and would go away after stopping treatment. I was told the same by my doctor who advised me not to look at 'scare stories' online, and that it really is a wonderful drug. Well, after reading the so called 'scare stories' online, I'm beginning to think that they just had it out like sweets on the NHS (it's free over here): my acne was mild with the occasional moderate flare-up and has given me some scars, but I think they rushed into prescribing it. I don't want to blame my GP or dermatologist, I'm sure they were doing what they thought was best for me, but I do regret taking the drug.

So now, after two weeks being of it the anxiety has stopped as has the pain I was experiencing has too, which is a good sign. I'm also sleeping better although I still feel more tired than usual. However, I'm still constantly constipated which has me worried that I could have IBS from the Roaccutane. My doctor days it's probably the birth control (Dianette...which I need to keep taking for another two weeks) and has just prescribed me laxatives to take for a month. I really don't want to go down that road though. I'm hoping that this is not a longterm thing. Another, slightly embarrassing issue (although what I've said already is embarrassing enough, but hey, I guess we are all going through similar issues or we wouldn't be here) is that my urine is a funny greenish colour and sometimes smells. Which again started when the dosage increased and still hasn't gone away. Anyone else had this?

Wondering if there is anyone here who has had similar problems on the drug which has continued for them? And if they have any advice or tips on how to get Roaccutane out of my body quicker. I've been making milk thistle every day but not sure what else to do. Also if anyone has any advice on some natural remedies for constipation I would appreciate some tips. I want to avoid putting more drugs in my body until it's clean.

Thank you and hope everyone is doing better

 

thanks. just to make sure,you meant to this paper http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/ by Bodo C Melnik , right?

 

assuming you did, did he mentioned acording to what he say foxo will normalized after accutane been stopped,.like did he mention it was tested on accutnae long term suffers or non suffers? or animals?

did he had an explanation for the long term side affects? anything else he said?

thank you very much

Yes it is this research paper. Melnik is a dermatologist and professor in Osnabruck. A small city, only 200km away from where I live. He did not mention that it was tested on long term sufferers. Melnik said, that in 25 years of experience as a dermatologist, he has seen not one single case of a patient who has long term, irreversible side effects from isotretinoin. I described all my problems, that I have after the accutane treatment. And he responded, it is very unlikely, that those symptoms are linked to isotretinoin in any way.

I wanted to add, if the community here thinks, it would be helpful to bring up our problems to Prof. Melnik and get his feedback, I can meet him in person and get his feedback. Please let me know.

 

Melnik said, that in 25 years of experience as a dermatologist, he has seen not one single case of a patient who has long term, irreversible side effects from isotretinoin. I described all my problems, that I have after the accutane treatment. And he responded, it is very unlikely, that those symptoms are linked to isotretinoin in any way.

The fact that he never met any of us doesn't mean we don't exist. And there are many of us with very similar pattern of symptoms.

I wanted to add, if the community here thinks, it would be helpful to bring up our problems to Prof. Melnik and get his feedback, I can meet him in person and get his feedback. Please let me know.

Well you can try, but I don't think he will believe you. He's probably one of the old date doctors who never changes his mind, he thinks something is impossible, so its impossible. Even if a hundred of us would meet him, he would still be in denial. What we need is a team of open minded young scientists who are willing to resarch our cases with a newest methods and technology. It's not even about finding the cure, but making the society aware of a problem. But of course it would take a huge amount of money and will never happen. I was thinking about writing an article to Vice or something like that, but probably they wouldn't post it. The true is that no one really cares, except the people who are suffering post tane. And we're not doctors, scientist, journalists, public figures, millionaires. No one cares and no one will. For now we're on our own.

The medical journals online would disagree with his experience. There are many of us with the same problems. I've met hundreds online. I wonder what the correlation is between us all. This is why we need our own website to petition and demand research into this. Believe me, if even 100 or more gathered in a group. Any Government has no choice but to take notice. I recommend everyone complete a full report of their symptoms post tane. Keep that report ready and handy at all times. We need to be more organized. This is what I am hoping for once our website is complete.

Yeah, communicating with this doctor is the last thing we need. He will set us back decades. Probably never even followed up any of his patients long term.

I wanted to add, if the community here thinks, it would be helpful to bring up our problems to Prof. Melnik and get his feedback, I can meet him in person and get his feedback. Please let me know.

Absolutely, you should meet with him! This is an awesome idea to open dialogue with a dermatologist who has a scientific background.

A good way to let the world know we exist, so to speak.

 

I wanted to add, if the community here thinks, it would be helpful to bring up our problems to Prof. Melnik and get his feedback, I can meet him in person and get his feedback. Please let me know.

 

Absolutely, you should meet with him! This is an awesome idea to open dialogue with a dermatologist who has a scientific background.

A good way to let the world know we exist, so to speak.

I would agree, meeting with him would be great.

 

Hi Indigo. Your story makes absolute sense. In my research of accutane, witnessing friends and family using it and using it myself, I am not surprised at all to hear your story and I'm so sorry you are still suffering.

 

The drug isn't even for acne- its specific function is to cause apoptosis, or cell death, and that could be used for a number of different things. Such as DESTROYING CELLS AND A PART OF YOUR SYSTEM. I'm sure you know this. I suspect it is an experimental drug and they are using it on people with Acne to gain lots of information about it and see what else it may do to its users. Also it takes forever to "work" and does not treat the scarring as only topical solutions can repair acne scars. Accutane is a truly awful drug and I feel so much grief for all who use it.

 

The only way I got rid of my acne was by using Secretly Obvious. Its made of only 100% essential plant oils from the most healing plants in the world. I have PCOS and got rid of my hormonal cystic acne in like 12 weeks. Now the scarring is gone. Its been 4 months of using the Intense Acne Formula. The side effects have only been amazing mood elevation, and my PCOS is actually improving. I found out I'm able to get pregnant after all! It is my saving grace, and I truly believe in the power of mother nature now. I am so glad to be off of chemicals, acids, peroxides, peels, etc. I only use the soap and formula, no other steps.

 

Thats the only thing I can help you with topically. I hope this helps others on here struggling with acne and scarring and skin issues.

 

 

 

Poor taste to use this forum to peddle your company's product.

Yea wtf, Lol. Post this in the other threads. I don't think acne is a big worry for us at this point.

How much does sleep impact on detoxification?

I mean, if we were capable of going to sleep voluntarily and we prolonged that state for a very very long time would the body detox entirely or would we need to set the stage for it first?

I think I learnt a meditation technique to be able to do just that.

Hi Indigo. Your story makes absolute sense. In my research of accutane, witnessing friends and family using it and using it myself, I am not surprised at all to hear your story and I'm so sorry you are still suffering.

 

The drug isn't even for acne- its specific function is to cause apoptosis, or cell death, and that could be used for a number of different things. Such as DESTROYING CELLS AND A PART OF YOUR SYSTEM. I'm sure you know this. I suspect it is an experimental drug and they are using it on people with Acne to gain lots of information about it and see what else it may do to its users. Also it takes forever to "work" and does not treat the scarring as only topical solutions can repair acne scars. Accutane is a truly awful drug and I feel so much grief for all who use it.

 

The only way I got rid of my acne was by using Secretly Obvious. Its made of only 100% essential plant oils from the most healing plants in the world. I have PCOS and got rid of my hormonal cystic acne in like 12 weeks. Now the scarring is gone. Its been 4 months of using the Intense Acne Formula. The side effects have only been amazing mood elevation, and my PCOS is actually improving. I found out I'm able to get pregnant after all! It is my saving grace, and I truly believe in the power of mother nature now. I am so glad to be off of chemicals, acids, peroxides, peels, etc. I only use the soap and formula, no other steps.

 

Thats the only thing I can help you with topically. I hope this helps others on here struggling with acne and scarring and skin issues.

lol eat shit and die.

Just posting an update here as I might as well really.

So ive been taking 5-htp for what feels like a week or two now, not really bothered to remember the date, its not my saving grace obviously, but its a little experiment Im trying.

My mood has defiantly increased over the last week and if that due to 5htp then hoorah.

Ive also been taking zinc as well and i really cant say what works and what works and what doesnt work as speculation and general mood observation seem to vague for me to draw conclusions on, but it is defiantly having some effect on my health.

With the zinc I got headaches for a couple of days in a row, and I never have them. Whether or not that is some sort of reaction occurring with copper I dont know. This is what I want to think so yeah I sticking with that.

Ive actually been crazy loud over the last couple of days, but in a good sort of way where I'm more confident to say the stupid funny things that pop into my brain.

I have also been a little more affectionate and can fit it a litttttle easier when confronted with loud personalities in a room.

Im a quiet guy and generally prefer discussing ideas 1 on 1 but over the last week Ive been able to adapt which is interesting to see. My boss and a few other people have actually said this to me. For you reading this you could be like ok yes I see but you have to understand for me this is a pretty gnarly change. So yes thats very interesting none the less. Ive also been able to hold thoughts for way longer, like my mind can blurt out at least 3 or 4 sentences and just dwell on them easier. Before it was like words fighting for a place and then once they got there if they so chose to take form in a sentence then happy days.

I think theres some really good things out there that any one on this board can do to see at least some change. The stupid shit i hate seeing is always crazy theories on the tiniest of chemical reactions and what not. Its like yeah ok science, but I really dont care for theory, i like the practical approach. If more people here could just be like hey Im trying this, update in 2 weeks and discuss the reaction and then state where you want to go from there things would have way more momentum. I get that this drug has fugged a lot of people over but just take your emotions out of it and persist with different approaches to healing.

You will get better, that is a fact, please please please believe me when I say this. Head down the natural path, try not to get caught up in stuff like tries to harness emotions for the greater good or whatever, meditation springs to mind when I say this. I think yeah if your a super grounded healthy person and you just want to chill your mind for a few mintues a day in order to become more sharp or whatever then do it. But when your mind is a washing machine post accutane then hold back. Save it for another day when things are better.

Again rabble rabble rabble. my disclaimer as always is weird stuff has happened to everyone post accutane. I dont want to preach anything, I hope Im right obviously, but I possibly am not, more discussion and defiantly please more momentum. Write your post about being fucked over and now having to deal with it and then start working on fixing it, update using this board, or hopefully that website people are talking about creating. Sorry if that was blunt, but remember you are not your emotions, they are just a little fucked right now.

I dunno what the topic of conversation is these days and as it's my birthday, I won't be reading the forum... but did anyone see this:

Has anyone tried IF (Intermittent Fasting) as that'd be much more doable than a long-term fast.

I dunno what the topic of conversation is these days and as it's my birthday, I won't be reading the forum... but did anyone see this:

 

 

 

Has anyone tried IF (Intermittent Fasting) as that'd be much more doable than a long-term fast.

Seems like that guy recommends just taking the time off work and smashing out a 5 week fast / cleanse.

Im at the same place where you are in regards to not really being able to quit my job and just drop everything.

But if it needs to be done then it needs to be done. Try ask for 4 weeks unpaid, and then if thats not an option straight away, see how long it will take to accrue the time off.

I thought I read about a guy on here that fasted in order to cleanse 'soft tissue'. Dont think it really went anywhere though? Was his name Chico something...?

So I just did a littler research into my own question and the guys name is Chico Espositio. If you search his content he really has some solid theories on what is going on to those affected post-accutane.

As i mentioned he also has dwindled on the idea of using the fasting method to remove potential accutane left over after first taking it. I believe he states he has used only IF fasting, and while he did see results doing this, I couldnt find anything more about him doing anything else for a longer amount of time. I have PM'd him so hopefully I get some info back there.

If the fast does indeed burn the fat cells and get accutane flowing into the blood stream again then from what I have read there are a few things to pick it up and carry it away.

Zeolite

Bentonite Clay

Chlorella

Cilantro

Magnesium

I use french green clay but might make the switch to bentonite.

It seems also that it is possible to detoxify fat cells and purge the accutane out using Niacin (vit b3).

Perhaps you could that Stefan and see what the results are instead of doing the fast?

I might actually try this as it all doesn't seem overwhelming. And it could atleast give me closure on this theory.

A good approach could be.

Starting to fast

Wait a few days

Niacin flush

Sauna (FIR perhaps)

Heavy metal binding agents I discussed, zeolite etc.

Just building off other theories, would be great to hear what people think.

Hey folks! Not really related to Accutane directly, but Tamiflu is another fine example of Roche bettering humanity through corporate responsibility and polished ethics.

http://www.theguardian.com/business/2014/apr/10/tamiflu-saga-drug-trials-big-pharma

And if you think the clinical trial data on Accutane will ever see the light of day, you'll be surprised.

Hi there,

 

New here.I heard about this forum on a facebook page, I've heard it's very useful.

So I came of Roccutane two weeks ago after being on it for two months. 1 month on twenty mg. and another month on 50mg (the max for my body weight). I've gone of it after I started to experience severe anxiety and sleeplessness as well as kidney pain and constant urine infections/ constipation as well as vaginal dryness and pain during sex. Almost all of this started when the dosage increased (apart from the constipation which started a couple of days into starting it). So I decided it just wasn't worthit anymore. In those two months I had no initial breakout and my adult acne cleared up a lot, but even still, it wasn't worth the side-effects for me.

I was warned of the side effects before, however my dermatologist told me that anxiety and depression etc was just a precaution they have to put down and that nobody she has treated ever had it and that as I have no history of mental illness I would be fine. I was also told that any side effects are short term and would go away after stopping treatment. I was told the same by my doctor who advised me not to look at 'scare stories' online, and that it really is a wonderful drug. Well, after reading the so called 'scare stories' online, I'm beginning to think that they just had it out like sweets on the NHS (it's free over here): my acne was mild with the occasional moderate flare-up and has given me some scars, but I think they rushed into prescribing it. I don't want to blame my GP or dermatologist, I'm sure they were doing what they thought was best for me, but I do regret taking the drug.

So now, after two weeks being of it the anxiety has stopped as has the pain I was experiencing has too, which is a good sign. I'm also sleeping better although I still feel more tired than usual. However, I'm still constantly constipated which has me worried that I could have IBS from the Roaccutane. My doctor days it's probably the birth control (Dianette...which I need to keep taking for another two weeks) and has just prescribed me laxatives to take for a month. I really don't want to go down that road though. I'm hoping that this is not a longterm thing. Another, slightly embarrassing issue (although what I've said already is embarrassing enough, but hey, I guess we are all going through similar issues or we wouldn't be here) is that my urine is a funny greenish colour and sometimes smells. Which again started when the dosage increased and still hasn't gone away. Anyone else had this?

Wondering if there is anyone here who has had similar problems on the drug which has continued for them? And if they have any advice or tips on how to get Roaccutane out of my body quicker. I've been making milk thistle every day but not sure what else to do. Also if anyone has any advice on some natural remedies for constipation I would appreciate some tips. I want to avoid putting more drugs in my body until it's clean.

 

Thank you and hope everyone is doing better

Probiotics will definitely help your IBS/digestive issues, but get something decent not just yackult (although that's probably better than nothing). Making your own kefir milk is probably worth looking into as well, I've never done it myself but it looks pretty simple to do once you've got some kefir grains from a health shop or eBay or something

 

I dunno what the topic of conversation is these days and as it's my birthday, I won't be reading the forum... but did anyone see this:

 

 

 

Has anyone tried IF (Intermittent Fasting) as that'd be much more doable than a long-term fast.

 

Seems like that guy recommends just taking the time off work and smashing out a 5 week fast / cleanse.

 

Im at the same place where you are in regards to not really being able to quit my job and just drop everything.

But if it needs to be done then it needs to be done. Try ask for 4 weeks unpaid, and then if thats not an option straight away, see how long it will take to accrue the time off.

 

I thought I read about a guy on here that fasted in order to cleanse 'soft tissue'. Dont think it really went anywhere though? Was his name Chico something...?

Probably... I'm sure someone has tried it.

I stopped Accutane in May 2010 and within a week or two developed pain in my ankles, knees and hands (not severe, but bad enough to stop me running). I then started to get a dry mouth, which was quite nasty at first, but became more manageable after a while. I had developed dry eyes whilst on Accutane and this seemed to continue. Now 5 years down the line I have a mouth dry enough to make it difficult to talk for too long without drinking or chewing gum, and dry eyes. The musculoskeletal problems luckily cleared up within 6 months. I did wonder if I might have developed something like Sjogren's disease, but my sicca symptoms have not really progressed and they are pretty much the same as they were 5 years ago. There is occasional variation though, with bad days. I am now beginning to think these symptoms may be related to Accutane. This is positive as far as I'm concerned as at least it means that my symptoms are unlikely to get much worse, and may even get slightly better over time. I have no other problems and my acne is pretty much resolved.