Crank-thanks for dropping the article. I'll have to check it out and bring it to doctors, as I'm going to try again to get a better understanding of my health.

Who knows if we would figure out a cure if we did have more backing behind us but at least we might have more recognition and respect. I think our lack of understanding allows hope for a miracle cure but I think the damage is irreversible. If we had lupus or naturally occurring problems that did not stem from a drug, it would in a way be easier to accept because that's life and the isn't a cure but we hold off hoping that taking a supplement will cure it all because it was a synthetic drug that caused this. I don't know about you but I doubt a supplement will take care of the dry desert my skin has been forced to live with-not to mention the list of others problems.

It's a repetitive cycle on a bike that is stationary. I went on tane in 03. Now I don't consider myself a veteran but I do believe I have struggled long enough to have good insight. We( 10 + years off) have done our research and havE probably come to a place of maturity and understanding life is short and we have a choice to try and live somewhat happy lives and accept the fact our lives were changed and not in the way we envisioned when we were young.

Since I've been on this thread there has hardly ever been any motivation to stand together and organize. Rallies with 1 person attending. Are you fucking kidding me? This is a wake up for me as well. I've since filed it forms reporting my sides and looking into ways to talk to the right people about it. How is anyone going to take us seriously, let alone doctors? For all you young bucks who are new to the forum, you're part of this unfortunate family now-let's work together. I promise you, everything has been researched and tried. I'm not encouraging you to give up our stop researching, but make your voice heard. Life can still be enjoyable and quite fruitful.

Certain people here have a role, such as tryingtohelp. Everyone has a different skill, so use them. I hope this is not taken in a arrogant manner. I'm trying to come from a place of activism and motivation for change. I wish i could be the person to put this on my shoulders and lead the way but Franky I'm too tired and am going to try and evaluate my situation both medically and psychologically - as I have never put forth a valiant effort, due to my own reasons.

I'm going to step away for awhile to work on my health with the info. You all have tediously gathered. I wish everyone good health and a productive, happy and healthy new year.

I guess if we don't do anything else, at least we'll have more people in the future we can research and relate to.

Deebo has a point.

I'm no longer going to argue with someone who wants to try protocols that are completely implausible even by the most rudimentary standards of science.

However, I will get irate when individuals will only think of themselves and not report their sides. I'm not calling anyone out (because I don't know who has and who hasn't reported sides).

As I mentioned, that publication in the PlosOne Journal has been a stepping stone in now getting Doctors taking me seriously (and hopefully others). It has got one of the urologists I saw to report sexual sides effects to the BNF with my research outlining the biological plausibility of this condition. It has also allowed me to be taken seriously enough to be tasked with writing an article for the Journal of Sexual Medicine (which I'm still in the process of drafting). The research I've done has granted me the opportunity for an endo to seek specialist tests at university research facilities to 'prove' some of the theories that myself and others who work more behind the scenes believe to be true. If these tests are actually possible and they confirm some of these cellular-level theories then it may actually open up the door for litigation.

This is the kind of stuff we all need to be working towards. It'll open the door for serious research by educated professionals (like propeciahelp are achieving), which will open the door for possible treatment and perhaps litigation. However, even if those both are out of reach it will hopefully prevent another soul to go through this sh*t. It's not just about us.

The sad fact is, unlike say Propecia afflicted individuals who have the advantage of immediately accessing a database of knowledge available which they can take to the doctors. I'm still largely having to sort the science out myself and with the few others who are seeking progress so as not to be laughed out of the docs office. This is why despite 'tane being out since '82 we're not making huge progress compared to other long-term victims.So I repeat, I don't mind you putting coffee in the wrong hole as long as you spend a few hours reporting sides to every relevant organisation in the meantime.

And Persephina, sadly if you're right ,they're not complaining in the right places. When I attended a protest at the Roche HQ in the UK with the parents of the suicide victims that made national news only one other victim made the journey. That really sucked.

This is the stuff I'm talking about! These are steps in the right direction. Good job brother. Id definitely be interested in your progress. Please keep me posted.

Deebo, I think this thread more often tends to attract those more internal and withdrawn, who reflect and research. Those more external, who do not hesitate to have their 'voice' heard, tend to be off the internet and out in the world complaining (often having been inspired by those more withdrawn, in my experience). I'm sure they're there. We all play our part in the end. No use bashing people for what it is in their nature.

I understand your point, and although it is valid, it doesn't reflect what I see in the world outside of the Internet. I know quite a few people who I attended school with who took tane and suffer from pretty severe fibro, rheumatoid problems. When I spoke to them briefly about some of their problems, they had no idea they might be linked. Rallies are organized with no turnout. So where is this outside activism? II don't see informercials of lawyers taking about tane anymore. Doctors don't link the sides. I'm sure there are some people doing their, but I could care little. I am talking to people here. We have knowledge that many don't. Perhaps were brave enough or suffer enough to be here. It doesn't matter. Everything I say includes me. I haven't done my part enough. If you and others take this as bashing I'm sorry you feel that way. If feathers have to be ruffled to ignite a spark, then that is the price. Everyone wants to heal themselves and research their way their. Why not try another option in addition? This is all I'm saying.

YBLY - Yes cannabis has been shown to be the most consistently helpful treatment modality on this site. As far as I've seen it has led to 3 recoveries (AIP, TA, OttoVisual) or close to it, several others use it for effective symptomatic treatment. That being said there is also evidence for individuals not responding well to it (anxiety etc.).

Indigo - Whilst I agree with the whole 'love thyself and move on' methodology as it will allow you to live whilst feeling less like sh*t. It however does not lead to progress. If this attitude continues to prevail we'll most likely have to tell some 15y/o kid in 20 years time to love themselves because we wanted to move on and not think about negative things. I can only describe it as selfishness not in and of itself but indirectly through a lack of foresight. Thus, I am not saying the notion is inherently wrong I'm just saying we need to widen our focus beyond the present tense. It is possible to come to terms with this condition whilst being pro-active, the two are not mutually exclusive.

how does accutane deplete your body of cannabis??

how does cannabis bind with vitamin A or an accutane metabolite??

how has cannabis been shown to protect cell damage and ROS activity induced by people actively taking accutane?

its just ludicrous to think pot will do anything more than give you a release of dopamine, and lessen some pain receptor somewhere temporarily. Moreover, THC has to to be detoxified by your liver, adding another burden to an already messed up system. Its no different than people temporarily feeling better after a night of drinking. Is drinking every night a long term option??

its interesting... do you know the theory of why the plant produces THC in the first place? its to stop herbivores from eating it. lol, cant be high in the junglesomehwere, and have some big cat or bear chasing you.

will taking pot lessen my joint pains? fuck yeah it will. am i curing myself by doing this? fuck no im not. YOU ARE ALL TREATING SYMPTOMS!!!!

to the people who think banding together in some demonstration will help...roche stopped selling accutane already, only to be sold by other companies in generic form. have all of the propecia people cured themselves yet with their "togetherness" ?? i would give 10 million dollars to trade for a cure. lawyers are not going to help us do that. im sorry, they wont. its the old joke...doctors havent cured anything since polio...dont look for help by submitting a forum paper for review! We're at an interesting point in time...The information is already out there that will help us...never before has this amount of medical knowledge/studies, been available for the general population to review.

a gagillion dollars being spent on cancer research....and is not stopping cancer from becoming more prevalent. The only thing Its doing is improving survivability, its not treating the root cause though. no money in that.

That being said, I think In 10 years, IBM/deep blue/watson will be able to figure out, thru brute force, the optimal treatments for all diseases by reviewing all known pathways/connections. doctors will be irrelevant soon enough, if not already.

We are all here to find a cure, to treat the root cause.... not win a lawsuit. I think this thread alone, by its 6000+ posts has done more to discourage people from taking this drug than any demonstration could ever do. its an active 24/7/365 demonstration. anybody anywhere in the world, researching accutane side effects, hits this thread on the first page of google.

I learned a long time ago on this thread to not bother with politics or disagreeing with people, but for the record:

Smoking just caused a flare-up for me, which has made all my symptoms worse. I even added concentrated CBD after the flare-up to try to help, but it was only a Band-Aid.

Manganese did not prevent this. It may be helping the side effects a little, but still no cure with it. Have dropped back down to 10mg daily, as 20mg every other day had seemingly no effect for me.

Tryingtohelp: what combination/dosage are you seeing the best results with right now? Choline still makes me feel terrible every time I take it, and very depressed.

I learned a long time ago on this thread to not bother with politics or disagreeing with people, but for the record:

Smoking just caused a flare-up for me, which has made all my symptoms worse. I even added concentrated CBD after the flare-up to try to help, but it was only a Band-Aid.

Manganese did not prevent this. It may be helping the side effects a little, but still no cure with it. Have dropped back down to 10mg daily, as 20mg every other day had seemingly no effect for me.

Tryingtohelp: what combination/dosage are you seeing the best results with right now? Choline still makes me feel terrible every time I take it, and very depressed.

every other day..or every other two days... im using 30 mgs now (20 and 10 in split doses) I feel it a few hours after taking it for sure. I still think we might need to take a lot more than this for shorter periods... but im getting tested soon. there is a doctor out there stating that you need to take 36 mgs to have any effect? and others up to 175 mg! for a few days. ill try and find that post.

if choline is giving you a problem, try TMG or lecithin instead and see if that makes a difference. eat choline rich foods. i think its an important part in moving fat out of the liver...which i think we have. make sure to take a little B2 as well. im still taking all of the methyl Bs .

TTH14: Exceptionally cynical view with a hefty dose of confirmation bias, probably aided by contact with naturopaths and naturalnews. Read a few sceptic sites once in a while. Case in point:

http://www.sciencebasedmedicine.org/big-placebo-says-medicine-never-cures-anything/

Small excerpt:

Evidently American Medicine doesnt cure anything except tuberculosis, pneumonia, bacterial meningitis, gonorrhea, any bacterial illness you care to name. American medicine routinely cures previously deadly conditions like appendicitis, ectopic pregnancies and obstetric hemorrhage. Better yet, it can completely prevent many viral and bacterial scourges through vaccination. Its not a coincidence that American lifespan has increased from 48 years to 77.7 years in slightly more than a century. Much of what routinely killed Americans is now routinely cured.

In fact, cure is so routine that these illnesses rarely enter American consciousness. No one worries about dying from tertiary syphilis, diphtheria or rheumatic heart disease. Those diseases are routinely prevented or cured in their early stages.

Looking at everything from a deficiency point of view again is not surpassing the most rudimentary levels of biology. And the fact this "doctors haven't cured anything since polio" is still getting thrown around means that critical thinking skills are also severely under-developed.

Have you considered the fact that people have to die one day and that we now have more elderly people than ever before by a wide margin thus it makes it more likely people will develop cancer. Sure 200 years ago before modern medicine we would be dead by 40 due to most likely a bacterial disease. We've cured that, added 30 years to the average lifespan and now have to deal with our own internal organs wearing out instead. So by your standards medicine was more functional in the 1800's because less people got cancer, you just miss the point that they died before the age where cancer becomes more common.

Propeciahelp are actually beginning to understand how finasteride screws with their internal biology. This opens the doors for lawsuits and better treatments, a double bonus. Are they there yet? No. Are they making progress? Fuck yes. Parts of their research is what is helping me build my own case as there are strong correlations in certain pathways between 'tane and propecia.

We as Accutaners are left with Roche going "We don't know how it works", thus making it far more difficult to suss out a solution or form a law suit. This thread has gone around in circles over the 300 pages. I just googled 'Accutane side effects', didn't appear on the 1st page. Before I took Accutane I looked at wikipedia there was no mention of 'proven' long lasting effects and reassurance of the temporary nature of sides was given. So I took it, look where I am.

These are just a few reasons actual studies are needed.

Yes we're here to find a solution, people have been trying since the 80's. It's clearly not our most successful venture. So let's explore the other avenues too. This thread is entirely circular and will continue this way for years to come. As is evident by the past few pages, many people have not read the whole thread and to quote George Santayana "Those who cannot remember the past are condemned to repeat it". This thread confirms that quote.

I can even imagine Roche CEO's smiling at our belligerent dismissal of getting recognition or not even remotely aiming for rigorous scientific studies to be done. This is why my endo had to write this:

If there were actually some Randomised placebo controlled trials already done, this would tremendously speed up this process. Yet, unfortunately I've somehow got to figure out alongside a few other individuals dispersed around the world how exactly to go about this!

YBLY - Yes cannabis has been shown to be the most consistently helpful treatment modality on this site. As far as I've seen it has led to 3 recoveries (AIP, TA, OttoVisual) or close to it, several others use it for effective symptomatic treatment. That being said there is also evidence for individuals not responding well to it (anxiety etc.).

 

Indigo - Whilst I agree with the whole 'love thyself and move on' methodology as it will allow you to live whilst feeling less like sh*t. It however does not lead to progress. If this attitude continues to prevail we'll most likely have to tell some 15y/o kid in 20 years time to love themselves because we wanted to move on and not think about negative things. I can only describe it as selfishness not in and of itself but indirectly through a lack of foresight. Thus, I am not saying the notion is inherently wrong I'm just saying we need to widen our focus beyond the present tense. It is possible to come to terms with this condition whilst being pro-active, the two are not mutually exclusive.

Hey man.

You know I like you and appreciate your stance in this forum.

You're clearly very intelligent and determined.

But, given the state of most of us, we can't do anything (in my opinion) to run trials.

How many people really speak on here? 10? Based around the world... with no access to expensive tests.

It costs thousands of pounds to run trials. We cannot make it happen.

And getting lawsuits prepared... it'd just be a very stressful and time-consuming event leading to further disappointment.

I'm not even sure there will be records anywhere that I took Accutane 8 years ago, and those with long-term problems won't be considered seriously.

'Oh yeah... 8 years after taking the drug you have anxiety and depression... PROVE IT, YOUNG SIR!'

We've already had all the doc's unhelpful blood tests and they always come back 'normal'.

Unless you want more frustration, you're setting yourself up for failure.

I wasn't telling anybody to love themselves (though, this is something that everyone needs to work on as self-hate can hold you back a lot. I struggle with this a lot). I was talking more of accepting the reality of the situation, and realising the difference between things in and out of our control. As you'll of seen, I tried an

awful lot of things while I was posting regularly on here.

Jmsil (James Silcock) - remember him? - killed himself because he was not willing to accept his life as it was. He was desperate to get well and focused everything on this drug and its side effects. He called me one time, not long before he killed himself. I said, 'Who's this?'

It was early in the morning and I was tired from having just woken up.

He said 'James'.

I couldn't think quickly.

He said 'From the forum'. I'd given him my number in a private message one time.

So, I said 'Hey James. How are you?'

He couldn't talk because he'd become so reclusive and he hung up, messaging me after to say he didn't know why he was calling anyway.

He let this drug take everything from him.

He didn't have a terminal illness like many people get (not just because of their diet, as I stupidly used to believe) but he couldn't stop thinking about how things should be, or could have been. How things were before. 'Everything was perfect, and now I have nothing'... That kind of thinking. over time, is dangerous.

I haven't given up on a cure... or improving my health, may be more accurate ... at all.

I've just recognized that things have become worse over time, because of stress.

Stress can deplete many nutrients (B vitamins come to mind). It's very easy to blame Accutane (very easy indeed) and take the power away from ourselves by saying 'How could I possibly be happy while I have these problems. I'll not have stress only once I have found a cure'.

I was mainly pointing out that we have to deal with our emotions as best we can, and change situations to help us feel happier.

I spent so much time and money trying to get better.

And where did it get me?

I certainly figured out what doesn't help.

Thomas Edison took his time discovering the mechanics of electricity, so maybe one day I'll have it all figured out.

As I've said, I'm focused on Adrenal fatigue and Copper Overload, because having studied both in-depth, they fit me perfectly,

I know the anxious mind is out of my control, and physical for the most part.

I believe that Bipolar and Schizophrenia are often, if not always, physical problems.

Let's not forget that the brain is an organ, just like the heart.

The thyroid comes into A.F + C.O as well, and I often feel so cold that I shake.

My body temperature is always low, but doctor's tests say I'm all gravy.

I went to the hospital last year to see an endocrinologist.

They couldn't find a damn thing wrong.

I still don't trust them...

They said my blood pressure wasn't low.

(I get dizzy often, especially when I go from laying down/sitting to standing and it's very common with A.F)

However, they tested it after I'd be stood for 2 minutes. 'It's perfectly in range'.

Previously, when I've been told I have low blood pressure by nurses, they check as soon as I've gone from sitting to standing.

Do these professionals know what they're doing?

Doesn't seem like it!

Over the last 8 years, I've learned not to waste any more time with doctors.

Clearly there is something about this Gilbert's syndrome, which ties into the liver.

Copper overload worsens things over time, as it gets stored in the liver and then the brain, thus creating anxiety and all sorts.

You may recall that an ex-propecia dude overcame his side effects by treating copper overload (which he discovered on a hair mineral analysis).

It sounds too silly to be the cause of any of our problems, but if zinc becomes low, copper becomes high. And vise versa.

Stress (not necessarily just mental stress) and sugar deplete zinc fast.

As well as Vitamin C (I saw a few of you mention that tests showed you were low in Vitamin C despite supplementing).

Vitamin C and Zinc are the main two supplements you'll see under 'Immunity' in the health stores, like Holland and Barrett over here in the UK.

Hint, hint.

Fact: I have moderate-severe adrenal fatigue (shown in test - doctors however insist that everything is okay and that saliva tests don't work)

Fact: I have yeast overgrowth, a gut infection and low stomach acid (I had a stool analysis done last year) - basically, leaky gut

Fact: I have the symptoms of hypothyroidism and my body temperature is always low.

I'm just going off of facts rather than trying to look into more potential causes. There are enough causes to explain how I feel, and they all require the same things: rest, relaxation and good food. Of course, life is a motherfucker and trying to achieve all three isn't very straightforward.

It's very easy to make the same mistakes again and again.

To summarise: We all need to learn to appreciate that things could be worse and that we've not lost it all. We should concentrate on other things besides this, or else everything will appear bad and we'll feel hopeless 24/7, unless we gain a little hope from another potential 'cure'. I know it's not easy, but we're all stuck in a bad habit and sometimes you need to know when to accept things aren't going to change overnight. If we're not laughing every day, we might as well kill ourselves now. Life is too short to throw away and we can't expect to recover while we abuse other areas of our lives. Going to bed at a good time, taking time out to relax, learning to let go of perfectionism and unrealistic expectations, laying off the coffee and stimulants.. these kinds of things will help to reduce the strain we are feeling.

 

Deebo, I think this thread more often tends to attract those more internal and withdrawn, who reflect and research. Those more external, who do not hesitate to have their 'voice' heard, tend to be off the internet and out in the world complaining (often having been inspired by those more withdrawn, in my experience). I'm sure they're there. We all play our part in the end. No use bashing people for what it is in their nature.

I understand your point, and although it is valid, it doesn't reflect what I see in the world outside of the Internet. I know quite a few people who I attended school with who took tane and suffer from pretty severe fibro, rheumatoid problems. When I spoke to them briefly about some of their problems, they had no idea they might be linked. Rallies are organized with no turnout. So where is this outside activism? II don't see informercials of lawyers taking about tane anymore. Doctors don't link the sides. I'm sure there are some people doing their, but I could care little. I am talking to people here. We have knowledge that many don't. Perhaps were brave enough or suffer enough to be here. It doesn't matter. Everything I say includes me. I haven't done my part enough. If you and others take this as bashing I'm sorry you feel that way. If feathers have to be ruffled to ignite a spark, then that is the price. Everyone wants to heal themselves and research their way their. Why not try another option in addition? This is all I'm saying.

Reading back on my posts I do probably come across as too idealistic. Too optimistic. I have actually read 2/3s of the thread (being new, it may have not all sunk in yet though), I'm well aware of how screwed we all are, with all this circling, lack of confirmation on possible 'cures' and doctors not believing us. Despite all this hopelessness, I still believe, have to believe, we did do enough, including you with what we were given. And we are given so little. When I said those who are external are off the internet, I didn't actually mean completely. I think I was subconsciously referring to you and cranky. That's why you guys are so frustrated, because you guys are driven a different direction than the majority in this thread, who are more internal. Possibly. I don't want you guys to grow bitter and give up :c

Tryingtohelp: I think we need to be very careful with this, and I think you're right in saying we need breaks- manganese madness, or manganese toxicity, is a real thing that supposedly happens when the established dosage (11mg) is exceeded.

Tryingtohelp: I think we need to be very careful with this, and I think you're right in saying we need breaks- manganese madness, or manganese toxicity, is a real thing that supposedly happens when the established dosage (11mg) is exceeded.

manganese madness happens thru inhaled fumes. thats only in the mining and steel industry. not thru oral supplementation. they have studies where women have taken 20 mgs daily for 6 months, no problems. only 3-5% of the chelated manganese you take gets absorbed. I just worry about our livers and bile being impaired to begin with. excess is removed by way of the bile...so its important to get that working as well.

IndigoRush you seem to me very intelligent from first time i see you and your post you prfectly seem like me.you put things so good ! Only difference between me and you my health it s not as bad as yours.I take test for adrenal fatigue and i have mild-moderate adrenal fatigue.I just find this on a website.

THE PUPILLARY REFLEX TEST

Materials needed: a flashlight.

To do this test, one shines a flashlight into one of the patients eyes. The light can be shined from the side so as cause minimum discomfort to the patient.

If the oxidation rate is fast (acute stage of stress), upon shining the flashlight, the pupil of the eye will constrict and remain constricted for at least 30 to 45 seconds.

If the oxidation rate is slow (exhaustion stage of stress), the pupil will constrict, but will then quickly dilate once again and remain dilated, or it may fluctuate between constricted and dilated.

When i do the test my pupil fluctuate.After this i search slow oxiders and what i found.Slow Oxidizers

A slow oxidizer is an individual who's Thyroid and Adrenal glands are underactive, resulting in a slower metabolism.

Slow Oxidizers are more prone to chronic fatigue, weight gain, Copper toxicity!!!!!!!!!,hypoglycemia and a slower digestive system leading to fewer bowel movements.

Perfect describing ! The things fit perfectly i am so happy we know what the problems are.1 Week ago I start to treat the adrenals and the leaky gut with this things :

1.A good diet

2.Coconut oil (for a good function of thyroid and adrenals and for healing the gut

3.Now's Probiotic (For healing the gut and restore intestinal flora

4.Adrenal Supplement

5.B complex

6.Vitamin C over 1000 mg/day

7.Digestive enzymes

8.Zinc 15 mg /day (not enough for chopper toxicity ?)

Can you please tell me what is your strategy for restore your health ?

Good bless you and A healthy life !

Hi, first time here. Just wanted to say that this thread really opened my eyes about what was going on with me, so thanks for that. I have been struggeling for about 6 months now and cant imagine how it would be to live with this for years like many here have. Sadly though after reading alot here, I understand now that its probably what I have to look forward to. What is strange though is that my problems started almost a year after I ended the treatment.

The first thing that happened to me was a blody stool, around 8 months ago. I called the doctor, and they said hemoroides. Everything felt normal after that, until I took a vaccine. The next day my heart was beating out of my chest, i had trouble breathing, intense pain in the forhead. My doctor gave me antibiotics, he thought maybe lung infection. After the first day I got massive diarrhea. It stopped after 2 weeks and I had lost 10 kg. After this my body just seems out of balance somehow. Doctor said no way its the vaccine, the only way is if my immune system is badly compromised, and my bloodwork showed otherwise.

When I read what some of you say I instantly recognise lots of it. I went from beeing full of energy and training all the time to falling asleep after taking a 10 minute walk. And my heart would not stop beating out of my chest. Incredible mood swings like the most hopeless depression, and the feeling that there was nothing to live for. Anxiety could take control and not let go for a long time. I could also suddenly start to cry without knowing why.

After the diarrhea I got constipated, and still am. My BM now hurt like hell, and consist of floaters, black and beige poop, blood, you name it. Every day is a new surprise. Bloating, muscle and joint aces, headaces, blurred vision, brain fog, dark urine and hair loss is some of the things my life is blessed with now.

I actually asked my doctor if it could be the isotretinoin treatment that caused this but he thinks its to long ago to have that kind of effect on my body now. The doctors dont know what to do with me, so far they are labeling it ME, but I have always had a feeling it was the iso that did it. And from what it seems Im not alone. From the very first pill i knew it was bad for me, and now i guess I have to pay the price.

Luckily im not as ill now as I was 6 months ago. I actually thought for a while that I had gotten lyme disease, so started following a diet very similar to what I have read here. At the same time I had to drop out of school and focus on getting better.

I went to a chiropractor several times a month, meditating each day and went from 5 minutes with yoga (all I could manage) to now some very light training. I hope to one day return to school where i major in sports but for the time beeing im stuck at a place between sick and healthy. After reading the posts about the liver might beeing the culprit, Im very ready to try a liver cleanse. Thank you all, its nice to know one is not alone. I will be watching this thread for sure.

IndigoRush you seem to me very intelligent from first time i see you and your post you prfectly seem like me.you put things so good ! Only difference between me and you my health it s not as bad as yours.I take test for adrenal fatigue and i have mild-moderate adrenal fatigue.I just find this on a website.

THE PUPILLARY REFLEX TEST

 

 

Materials needed: a flashlight.

 

To do this test, one shines a flashlight into one of the patients eyes. The light can be shined from the side so as cause minimum discomfort to the patient.

 

If the oxidation rate is fast (acute stage of stress), upon shining the flashlight, the pupil of the eye will constrict and remain constricted for at least 30 to 45 seconds.

 

If the oxidation rate is slow (exhaustion stage of stress), the pupil will constrict, but will then quickly dilate once again and remain dilated, or it may fluctuate between constricted and dilated.

 

When i do the test my pupil fluctuate.After this i search slow oxiders and what i found.Slow Oxidizers

 

A slow oxidizer is an individual who's Thyroid and Adrenal glands are underactive, resulting in a slower metabolism.

 

Slow Oxidizers are more prone to chronic fatigue, weight gain, Copper toxicity!!!!!!!!!,hypoglycemia and a slower digestive system leading to fewer bowel movements.

 

Perfect describing ! The things fit perfectly i am so happy we know what the problems are.1 Week ago I start to treat the adrenals and the leaky gut with this things :

1.A good diet

2.Coconut oil (for a good function of thyroid and adrenals and for healing the gut

3.Now's Probiotic (For healing the gut and restore intestinal flora

4.Adrenal Supplement

5.B complex

6.Vitamin C over 1000 mg/day

7.Digestive enzymes

8.Zinc 15 mg /day (not enough for chopper toxicity ?)

 

Can you please tell me what is your strategy for restore your health ?

 

Good bless you and A healthy life !

Yeah man, my hair mineral analysis advised I was a slow oxidiser.

It sounds like you have a good plan on it.

I take 22mg of zinc (1 a day).

If you take too much at once, copper is released from the brain/liver and ends up entering the bloodstream and staying there for a bit if it can't be released.

This then leads to terrible anxiety and overall worsening of symptoms.

I tried taking a couple of zinc's for 2 days while I was working a couple of months back.

I felt worse than ever.

Definitely a connection there.

I'd advise you check out a book called 'Depression Free, Naturally'.

It's really good, if not a little confusing with it's supplementation recommendations.

However, you'll find many things to back up how you're feeling.

There are chapters on anxiety and chronic fatigue.

There seems to be growing evidence that Chronic fatigue is caused by A.F and C.O.

Copper overload can occur more often in woman, as the pill and IUD (for contraception) are high in it.

Overall, the modern diet promotes copper overload, and zinc deficiency.

For anyone with chronic stress, it's pretty much guaranteed.

http://drlwilson.com/articles/copper_toxicity_syndrome.htm

to tryingtohelp:

Q: how does accutane deplete your body of cannabis??

A: What? What does that even mean. There is the Endocannabinoid System in the human body... http://en.wikipedia.org/wiki/Endocannabinoid_system

Not cannabis.

Q: how does cannabis bind with vitamin A or an accutane metabolite??

A: It doesn't because accutane metabolite or left over residue is just a theory around here (and only here) not a Fact.

It certainly wouldn't bind to Vitamin A, that would be harmful.

I personally believe accutane, isotretinoin is not in our bodies anymore. It's long gone. We are just left with damage control.

Many people have been off accutane for many years, no side effects for them. It's a DOSAGE issue.

Many of us that took it, took WAY to much of it for the issues we had.

Bodybuilders who do nothing but drink whey protein (have tons of oil production), take 10mg of Accutane before a trade show to clean up their skin.

Than it just returns back to normal with no side effects.

Q: how has cannabis been shown to protect cell damage and ROS activity induced by people actively taking accutane?

its just ludicrous to think pot will do anything more than give you a release of dopamine,

and lessen some pain receptor somewhere temporarily. Moreover, THC has to to be detoxified by your liver, adding another burden to an already messed up system. Its no different than people temporarily feeling better after a night of drinking. Is drinking every night a long term option??

A: Pot doesn't just focus on dopamine, it heals and helps relief pain, especially Crohn's and Ulcerative colitis.

http://www.marijuanagrowing.com/showthread.php?3142-Rick-Simpson-Oil-Me-Crohn%92s-Disease-90-days

Wow I can't believe you compared drinking alcohol to a very beneficial plant that cures cancer. You don't shine to bright.

If our livers are as burdened as you say, you would be VERY ILL and in the hospital bed ridden.

I believe our livers are working just fine. Like I said, we are left with chemical damage control.

Also how much research have you done into Rick Simpson Oil? Try looking it up more, it helps repair DNA and turn on genes.

to: crank92

YBLY - Yes cannabis has been shown to be the most consistently helpful treatment modality on this site. As far as I've seen it has led to 3 recoveries (AIP, TA, OttoVisual) or close to it, several others use it for effective symptomatic treatment. That being said there is also evidence for individuals not responding well to it (anxiety etc.).

Well than, THREE PEOPLE made massive improvement in their side effects. And anyone here has the gall to shoot down cannabis oil?

Seems like it does work. The only people that are upset, can't get it.

I'll tell you what, if you can't get it where you live. Maybe it's time to migrate, no money? Save some up than move.

to tryingtohelp:

Q: how does accutane deplete your body of cannabis??

A: What? What does that even mean. There is the Endocannabinoid System in the human body... http://en.wikipedia.org/wiki/Endocannabinoid_system

Not cannabis.

Q: how does cannabis bind with vitamin A or an accutane metabolite??

A: It doesn't because accutane metabolite or left over residue is just a theory around here (and only here) not a Fact.

It certainly wouldn't bind to Vitamin A, that would be harmful.

I personally believe accutane, isotretinoin is not in our bodies anymore. It's long gone. We are just left with damage control.

Many people have been off accutane for many years, no side effects for them. It's a DOSAGE issue.

Many of us that took it, took WAY to much of it for the issues we had.

Bodybuilders who do nothing but drink whey protein (have tons of oil production), take 10mg of Accutane before a trade show to clean up their skin.

Than it just returns back to normal with no side effects.

Q: how has cannabis been shown to protect cell damage and ROS activity induced by people actively taking accutane?

its just ludicrous to think pot will do anything more than give you a release of dopamine,

and lessen some pain receptor somewhere temporarily. Moreover, THC has to to be detoxified by your liver, adding another burden to an already messed up system. Its no different than people temporarily feeling better after a night of drinking. Is drinking every night a long term option??

A: Pot doesn't just focus on dopamine, it heals and helps relief pain, especially Crohn's and Ulcerative colitis.

http://www.marijuanagrowing.com/showthread.php?3142-Rick-Simpson-Oil-Me-Crohn%92s-Disease-90-days

Wow I can't believe you compared drinking alcohol to a very beneficial plant that cures cancer. You don't shine to bright.

If our livers are as burdened as you say, you would be VERY ILL and in the hospital bed ridden.

I believe our livers are working just fine. Like I said, we are left with chemical damage control.

Also how much research have you done into Rick Simpson Oil? Try looking it up more, it helps repair DNA and turn on genes.

to: crank92

YBLY - Yes cannabis has been shown to be the most consistently helpful treatment modality on this site. As far as I've seen it has led to 3 recoveries (AIP, TA, OttoVisual) or close to it, several others use it for effective symptomatic treatment. That being said there is also evidence for individuals not responding well to it (anxiety etc.).

Well than, THREE PEOPLE made massive improvement in their side effects. And anyone here has the gall to shoot down cannabis oil?

Seems like it does work. The only people that are upset, can't get it.

I'll tell you what, if you can't get it where you live. Maybe it's time to migrate, no money? Save some up than move.

Reading is a skill i guess. Thats my point... cannabis/THC has absolutely nothing to do with 13 cis retinoic acid.... but i guess you want to treat some "chemical" damage with another totally unrelated complex chemical compound. That makes perfect sense! *eyes roll*

Now pot cures cancer huh? OKAAAAAY ... and you quote a marijuanagrowing.com site as a reference.... all kinds of LOL there.

Burdened liver = bed ridden? where the fuck do you get that? There are more people actively posting on this thread with Gilberts syndrome, than have been supposedly "cured" by pot. read up on it. you dont shine too bright do you?

You seem very manic. change your name 3 more times, and change what youre trying 30 more times....you might find that cure.

 

Reading is a skill i guess. Thats my point... cannabis/THC has absolutely nothing to do with 13 cis retinoic acid.... but i guess you want to treat some "chemical" damage with another totally unrelated complex chemical compound. That makes perfect sense! *eyes roll*

Now pot cures cancer huh? OKAAAAAY ... and you quote a marijuanagrowing.com site as a reference.... all kinds of LOL there.

Burdened liver = bed ridden? where the fuck do you get that? There are more people actively posting on this thread with Gilberts syndrome, than have been supposedly "cured" by pot. read up on it. you dont shine too bright do you?

Your seem very manic. change your name 3 more times, and change what youre trying 30 more times....you might find that cure.

Dude, you're not a scientist. You're just as manic with your theories.

13 cis retinoic acid is not inside of you anymore. get over it. Many studies are shown that accutane leaves the body very quickly.

What evidence can you provide that isotretinoin is still in the body.

And it's obvious you are anti-weed. anti-pot. You sound like you need cannabis.

"Reading is a skill i guess. Thats my point... cannabis/THC has absolutely nothing to do with 13 cis retinoic acid.... but i guess you want to treat some "chemical" damage with another totally unrelated complex chemical compound. That makes perfect sense! *eyes roll*"

^TTH14 - This statement again shows your complete ignorance for anything above basic level science. I'm presuming you haven't studied biology and/or chemistry past the age of 16 for you to be so naive? Seriously, I end up wanting to throw textbooks at some of you.

Here's some studies on MJ's anti-tumor effects in reputable journals. Now will you stop pretending you have an all encompassing knowledge of the internet and develop some critical thinking skills. Feels like I'm arguing with religious zealots, protecting ideas based on faith and ignorance and dismiss evidence and knowledge.

• Guzman M, Duarte MJ, Blazquez C, et al.: A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. Br J Cancer 95 (2): 197-203, 2006. [PUBMED Abstract]
• Velasco G, Sanchez C, Guzman M: Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer 12 (6): 436-44, 2012. [PUBMED Abstract]

Now I'll point out despite all the research I've linked below I can fully acknowledge that cannabis won't benefit everyone, just like any medication. However, there is more evidence for it than most other treatment modalities I've come across for this shit situation we got ourselves into.

Cannabinoids & Neurogenesis

Shohami, E., CohenYeshurun, A., Magid, L., Algali, M., & Mechoulam, R. (2011). Endocannabinoids and traumatic brain injury. British journal of pharmacology, 163(7), 1402-1410.

There is a large body of evidence showing that the endocannabinoid (eCB) system are markedly increased in response to pathogenic events. This fact, as well as numerous studies on experimental models of brain toxicity, neuroinflammation and trauma supports the notion that the eCB are part of the brain's compensatory or repair mechanisms.

This review is focused on the role the eCB system plays as a self-neuroprotective mechanism and its potential as a basis for the development of novel therapeutic modality for the treatment of CNS pathologies.

Steiner, M. A., & Wotjak, C. T. (2008). Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis. Progress in brain research, 170, 397-432.

The endocannabinoid system has been recognized as a major neuromodulatory system, which functions to maintain brain homoeostasis.

Rubio-Araiz, A., Arevalo-Martin, A., Gomez-Torres, O., Navarro-Galve, B., Garcia-Ovejero, D., Suetterlin, P., ... & Molina-Holgado, F. (2008). The endocannabinoid system modulates a transient TNF pathway that induces neural stem cell proliferation. Molecular and Cellular Neuroscience, 38(3), 374-380.

Found that CB1 or CB2 agonists induce neural stem cell (NSC) proliferation coupled to a significant increase in both TACE/ADAM 17 and TNF- levels. Overall these data suggest a novel mode of action for the endocannabinoid system in NSC proliferation that is coupled to TNF signalling and that may be of therapeutic interest in the emerging field of brain repair.

Gowran, A., Noonan, J., & Campbell, V. A. (2011). The multiplicity of action of cannabinoids: implications for treating neurodegeneration. CNS neuroscience & therapeutics, 17(6), 637-644.

The CB system is emerging as a key regulator of neuronal cell fate and is capable of conferring neuroprotection by the direct engagement of prosurvival pathways and the control of neurogenesis.

treatment of certain neurological diseases that feature a neurodegenerative component.

Kim, S. H., Won, S. J., Mao, X. O., Ledent, C., Jin, K., & Greenberg, D. A. (2006). Role for neuronal nitric-oxide synthase in cannabinoid-induced neurogenesis. Journal of Pharmacology and Experimental Therapeutics, 319(1), 150-154.

Cannabinoids also stimulate neurogenesis in the adult brain through activation of CB1R.

Fernandez-Lopez, D., Lizasoain, I., Moro, M. A., & Martinez-Orgado, J. (2013). Cannabinoids: Well-Suited Candidates for the Treatment of Perinatal Brain Injury. Brain Sciences, 3(3), 1043-1059.

The modulation of the endocannabinoid system has proven to be an effective neuroprotective strategy to prevent and reduce neonatal brain injury in different animal models and species. Also, the beneficial role of the endocannabinoid system on the control of the endogenous repairing responses (neurogenesis and white matter restoration) to neonatal brain injury has been described in independent studies.

Oudin, M. J., Hobbs, C., & Doherty, P. (2011). DAGLdependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis. European Journal of Neuroscience, 34(10), 1634-1646.

control of adult neurogenesis in the hippocampus and subventricular zone.

Epigenetics

Epigenetic control of neurogenesis by the brain endocannabinoid system: Involvement of mitogen-activated protein kinases - Francisco Molina-Holgado1, Pranali Pose1, Catherine Kollikho1, Daniel Garcia-Ovejero2, Uyen Le2, Eduardo Molina-Holgado2. 1Department of Life Sciences, University of Roehampton, London SW15 4JD, UK, 2Laboratory of Neuroinflammation, Unidad de Neurologia Experimental, Hospital Nacional de Paraplejicos, 45071 Toledo, Spain

Emerging evidence suggests that cannabinoid signaling regulates gene expression by inducing epigenetic modification such as DNA methylation or histone modification in the regulation of a range of neurobiological processes in the brain, including CNS development, learning, memory and neurodegeneration associated with ageing.

These studies therefore indicate a novel mode of epigenetic modification for the endocannabinoid system in neurogenesis that may be of therapeutic interest in the emerging field of brain repair.

D'Addario, C., Di Francesco, A., Pucci, M., Finazzi Agro, A., & Maccarrone, M. (2013). Epigenetic mechanisms and endocannabinoid signalling. FEBS Journal,280(9), 1905-1917.

The endocannabinoid system, composed of endogenous lipids, their target receptors and metabolic enzymes, has been implicated in multiple biological functions in health and disease, both in the central nervous system and in peripheral organs.

Possibility of an 'epigenetic therapy' that could possibly be applied also to endocannabinoids

Sometimes people remain blocked on an ideea . Me and IndigoRush and another guy from here give what is wrong with us but you not even discuss about it.Continue to sleep is a good thing

"Reading is a skill i guess. Thats my point... cannabis/THC has absolutely nothing to do with 13 cis retinoic acid.... but i guess you want to treat some "chemical" damage with another totally unrelated complex chemical compound. That makes perfect sense! *eyes roll*"

 

^TTH14 - This statement again shows your complete ignorance for anything above basic level science. I'm presuming you haven't studied biology and/or chemistry past the age of 16 for you to be so naive? Seriously, I end up wanting to throw textbooks at some of you.

 

Here's some studies on MJ's anti-tumor effects in reputable journals. Now will you stop pretending you have an all encompassing knowledge of the internet and develop some critical thinking skills. Feels like I'm arguing with religious zealots, protecting ideas based on faith and ignorance and dismiss evidence and knowledge.

• Guzman M, Duarte MJ, Blazquez C, et al.: A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. Br J Cancer 95 (2): 197-203, 2006. [PUBMED Abstract]
• Velasco G, Sanchez C, Guzman M: Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer 12 (6): 436-44, 2012. [PUBMED Abstract]

Now I'll point out despite all the research I've linked below I can fully acknowledge that cannabis won't benefit everyone, just like any medication. However, there is more evidence for it than most other treatment modalities I've come across for this shit situation we got ourselves into.

Cannabinoids & Neurogenesis

Shohami, E., CohenYeshurun, A., Magid, L., Algali, M., & Mechoulam, R. (2011). Endocannabinoids and traumatic brain injury. British journal of pharmacology, 163(7), 1402-1410.

There is a large body of evidence showing that the endocannabinoid (eCB) system are markedly increased in response to pathogenic events. This fact, as well as numerous studies on experimental models of brain toxicity, neuroinflammation and trauma supports the notion that the eCB are part of the brain's compensatory or repair mechanisms.

This review is focused on the role the eCB system plays as a self-neuroprotective mechanism and its potential as a basis for the development of novel therapeutic modality for the treatment of CNS pathologies.

Steiner, M. A., & Wotjak, C. T. (2008). Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis. Progress in brain research, 170, 397-432.

The endocannabinoid system has been recognized as a major neuromodulatory system, which functions to maintain brain homoeostasis.

Rubio-Araiz, A., Arevalo-Martin, A., Gomez-Torres, O., Navarro-Galve, B., Garcia-Ovejero, D., Suetterlin, P., ... & Molina-Holgado, F. (2008). The endocannabinoid system modulates a transient TNF pathway that induces neural stem cell proliferation. Molecular and Cellular Neuroscience, 38(3), 374-380.

Found that CB1 or CB2 agonists induce neural stem cell (NSC) proliferation coupled to a significant increase in both TACE/ADAM 17 and TNF- levels. Overall these data suggest a novel mode of action for the endocannabinoid system in NSC proliferation that is coupled to TNF signalling and that may be of therapeutic interest in the emerging field of brain repair.

Gowran, A., Noonan, J., & Campbell, V. A. (2011). The multiplicity of action of cannabinoids: implications for treating neurodegeneration. CNS neuroscience & therapeutics, 17(6), 637-644.

The CB system is emerging as a key regulator of neuronal cell fate and is capable of conferring neuroprotection by the direct engagement of prosurvival pathways and the control of neurogenesis.

treatment of certain neurological diseases that feature a neurodegenerative component.

Kim, S. H., Won, S. J., Mao, X. O., Ledent, C., Jin, K., & Greenberg, D. A. (2006). Role for neuronal nitric-oxide synthase in cannabinoid-induced neurogenesis. Journal of Pharmacology and Experimental Therapeutics, 319(1), 150-154.

Cannabinoids also stimulate neurogenesis in the adult brain through activation of CB1R.

Fernandez-Lopez, D., Lizasoain, I., Moro, M. A., & Martinez-Orgado, J. (2013). Cannabinoids: Well-Suited Candidates for the Treatment of Perinatal Brain Injury. Brain Sciences, 3(3), 1043-1059.

The modulation of the endocannabinoid system has proven to be an effective neuroprotective strategy to prevent and reduce neonatal brain injury in different animal models and species. Also, the beneficial role of the endocannabinoid system on the control of the endogenous repairing responses (neurogenesis and white matter restoration) to neonatal brain injury has been described in independent studies.

Oudin, M. J., Hobbs, C., & Doherty, P. (2011). DAGLdependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis. European Journal of Neuroscience, 34(10), 1634-1646.

control of adult neurogenesis in the hippocampus and subventricular zone.

Epigenetics

Epigenetic control of neurogenesis by the brain endocannabinoid system: Involvement of mitogen-activated protein kinases - Francisco Molina-Holgado1, Pranali Pose1, Catherine Kollikho1, Daniel Garcia-Ovejero2, Uyen Le2, Eduardo Molina-Holgado2. 1Department of Life Sciences, University of Roehampton, London SW15 4JD, UK, 2Laboratory of Neuroinflammation, Unidad de Neurologia Experimental, Hospital Nacional de Paraplejicos, 45071 Toledo, Spain

Emerging evidence suggests that cannabinoid signaling regulates gene expression by inducing epigenetic modification such as DNA methylation or histone modification in the regulation of a range of neurobiological processes in the brain, including CNS development, learning, memory and neurodegeneration associated with ageing.

These studies therefore indicate a novel mode of epigenetic modification for the endocannabinoid system in neurogenesis that may be of therapeutic interest in the emerging field of brain repair.

D'Addario, C., Di Francesco, A., Pucci, M., Finazzi Agro, A., & Maccarrone, M. (2013). Epigenetic mechanisms and endocannabinoid signalling. FEBS Journal,280(9), 1905-1917.

The endocannabinoid system, composed of endogenous lipids, their target receptors and metabolic enzymes, has been implicated in multiple biological functions in health and disease, both in the central nervous system and in peripheral organs.

Possibility of an 'epigenetic therapy' that could possibly be applied also to endocannabinoids

Cool studies.... not one of these even remotely comes close to showing how our bodies physically detoxify and conjugate accutane, or its metabolites during or after ingestion. THC is not involved in this process! Its not related at all....at all ... AT ALL. We know this phase II pathway for a fact already. theres only one. We know what enzyme is used....theres only one. we know this enzyme can become down regulated to the point of shutting off from the cumulative effect of taking this drug, hence the toxicity. Ive read study after study after study.... theres only one divalent cation needed for this system... and its not weed.

For all of you that believe there is no residue in your body, answer me this .... If we know the actual pathway for elimination, and that pathway becomes blocked while taking this drug(already proven to happen in the intestines btw), where does the accutane metabolite go? does it magically vanish into thin air, or does it get stored somewhere? your body will do whatever is has to do to remove it from the bloodstream, not from the body.

Again, your body doesnt incorporate THC for this cellular detoxification....IGF-1 isnt needed.... positive thinking isnt used up.

With the amount of people that have taken accutane, and the amount of people that smoke weed, we shouldve heard of 30 or 300, or 3000 people being cured of the side effects over the last 30 years.... NOT 3!!!!! my God... talk about correlation does not imply causation! Is that critical thinking??

If you get a nail(accutane) stuck in your tire(your body), and develop a leak.... no matter what you try inflating that tire with wont work until you remove the nail. youre all trying to find a substance to re-inflate that tire, without fixing the nail problem first. Just look at how many people start developing more severe side effects years after taking this drug. Theyre seemingly fine after completion, only to start deteriorating much later. something is actively making them worse. Its the same story over and over and over.

im done with this thread. where is annoyy when you need him? to think, he actually spoke of the glucurodination.

bye.

Hey guys, let me help give you some fresh perspective.

Just got back from the doctor, more tests done, all normal. Given my symptoms and lack of other abnormalities, doctor strongly suspects IBS (despite not having any real issues with diarrhea or the like).

I think you're all on the right track in suspecting that a lot of these problems originate from the gut (from anxiety to ED to joint pain). The cumulative stress resulting from these gut and liver problems then (for reasons beyond my understanding, I don't pretend to be a scientist) trigger adrenal fatigue and fibro-like symptoms.

"Reversing" the effects of Accutane is a misleading term. Damage is done, there's obviously no reset. That said, I think there are measures we can take to help our bodies heal themselves.

Supplements won't do shit if we're ingesting things that harm us. Caffeine, alcohol, and the majority of the western dietary staples are poison to us (regardless of whether or not we took Accutane). We need INSANELY HEALTHY DIETS in order to prevent further stressing our liver and guts. Supplements are there to, well, supplement the vitamins and nutrients our bodies are lacking due to dietary restrictions and possible malabsorption. Accutane has been linked to celiac, so if nothing else, cut gluten. Probiotics certainly can't hurt either.

Exercise is truly a panacea, as is sunlight. Maximize upon these.

Marijuana is good for the digestive system (look at testimonials from people with Crohn's). If the majority of our problems to originate in the gut, pot certainly can't hurt. It won't make our hair grow back or fix our hyperpigmented skin, but in addition to dietary changes and exercise, it might help alleviate pain and fatigue.

Heal the mind, heal the body. Stress will make everything worse. Everyone on this thread is, if my own experience is any indication, chronically hyper-stressed and anxious. Do what you need to do to reach your happy place and stay there (anti-depressants might be beneficial when combined with other strategies).

No one pill or approach will solve everything. A holistic, all-encompassing approach to this is the only way to best manage our health. I doubt our hair will EVER return to normal in spite of all our best efforts. But depression, sexual dysfunction, fatigue, anxiety, joint pain, and digestive issues can all be ALLEVIATED (note: we should ban the word "cure" around here). Be positive, stay strong, and count your blessings. Dwelling on what's "lost" will only make things worse.

Whats this CYP26A1 enzyme that keeps showing up whenever a study is talking about accutane or retinoic acid? seems to be the enzyme responsible for drug metabolism specifically of all trans retinoic acid and retinoic acid. What is it? and how can we up regulate it?

Good video on A.F

Nothing works for me thus far. still feel shot

even with paleo my memory and emotion is toast

We are all here to find a cure, to treat the root cause.... not win a lawsuit. I think this thread alone, by its 6000+ posts has done more to discourage people from taking this drug than any demonstration could ever do. its an active 24/7/365 demonstration. anybody anywhere in the world, researching accutane side effects, hits this thread on the first page of google.

Surprisingly, this thread isn't on the first page of google, or second, or third, etc, for many side effect related searches. Try it!

accutane side effects, accutane joint pains, accutane dry skin, accutane erectile dysfuntion, accutane ibs, accutane depression

Results were mostly attorneys and health product storefronts, with a few links to other threads on this site.