Acne.org Products
This thread seems to go around in circles with information that has been brought up in the past. I presume this is partially the reason I don't see older members posting anymore. The methylation issue was brought up in the paSt and died off just as everything else has. I'm sorry to say but we're all fucked. Live your life everyday to the fullest and don't think about the negativity the future may or may not hold. I am no where near this. The anger is to much but I'm going to seek help to work on letting it go and making a difference before my time card is pulled. Often we are treating the secondary causes and not the primary cause because let's face it, no one knows. Fixing b vitamins deficiency is just an effect of the primary cause. Out of all these people on here supposedly one or two healed themselves of I'm guessing some problems but I know everyone is different and some peoples problems are more severe. Did the drug Fuck up all sorts of things in the body like a time bomb poison or did it affect one main thing that shuts down or causes misfunction? For god sakes. What has worked? Anything at all? I mean come on! Anything that most people here can benefit from?
ramp up to 15mg of manganese slowly. start with 5 and eat manganese rich foods. must be taken on empty stomach ...away from other foods or supplements.
Maybe I don't understand something but if we need 300-400 mg of magnese daily so is there a mistake?
manganese.... not magnesium
Tyrosine Phosphorylation Regulates Manganese Superoxide Dismutase (MnSOD) RNA-Binding Protein Activity and MnSOD Protein Expression
All cells tested contain a cytosolic protein that binds to a defined region in the 3 untranslated region of manganese superoxide dismutase (MnSOD) RNA; both the MnSOD RNA-binding protein (MnSOD-BP) and the cis element are required for efficient translation of MnSOD RNA [Chung, D. J., Wright, A. E., and Clerch, L. B. (1997) Biochemistry 37, 1629816306]. This study was designed to test the hypothesis that MnSOD-BP activity is regulated by phosphorylation. When cell extracts from whole rat lung or a rat lung fibroblast cell line, RFL-6, were treated in vitro with a protein tyrosine phosphatase, there was a 4-fold increase in MnSOD-BP activity indicating that MnSOD-BP activity was upregulated by tyrosine dephosphorylation. RFL-6 cells treated in cell culture with herbimycin A or genistein, inhibitors of protein tyrosine kinase, had significantly more MnSOD-BP activity than cells treated with diluent. In RFL-6 cells treated with herbimycin A, the increase in MnSOD-BP activity was associated with an increase in the level of MnSOD protein without a change in MnSOD mRNA concentration. We propose that the modulation of MnSOD protein expression by the tyrosine phosphorylation state of MnSOD-BP is a potential therapeutic target for increasing MnSOD activity during periods of oxidative stress.
Has anybody done the 23andme.com test? If so please let me know or inbox me. I have one simple question that needs answering.
Hey I got my 23andme results yesterday. So its official, I'm about 99% European, which is awesome.
But can anyone tell me how I get my health results, as they dont do that anymore? I remember reading ages ago that there is another website where I put my genetic data and and voila it will tell me my genes. Is that correct?
I had an MRI on my brain done a few weeks ago. Everything was a ok.
I had a $140 salivary cortisol test done which showed elevated cortisol. Instead of going down throughout the day, mine was going up! Amazing. I've been takin relora and feeling much better.
I also had a $400 organic acids test done. Most things there were good. Methylation, neurotransmitters all that were good. I was extremely low in sulfate though which said chronic low glutathione levels. Also elevated suberate levels which means my body is burning fatty acids outside the cells instead of in them? How does that work I do not know. And also a few mitochondrial hiccups which meant low energy levels. I'm waiting for all the necessary supplements to arrive from iherb so I can try them out. Carnitine and NAC and a few others.
Cheers
My cortisol levels revealed the same thing for my adrenals. For a while I was taking Adrenal support and I'm now starting another. I think it helped maintain better energy levels. My sleep schedule is messed up too though, admittedly. Will you be supplementing glutathione?
This whole methylation talk is quite interesting.
Yes I will be supplementing glutathione. I tried it out a month ago, but it was a month out of date. Glutathione apparently has a short shelf life and needs to be used straight away. So I dont know if it was working properly. It was doing something as I felt pretty good. I was taking S acetyl glutathione. But it gave me diarrhoea. I've got a brand new one in the fridge waiting to be taken.
What is a less dangerous way of getting rid of acne - getting a a sex change or taking Accutane?
Hmm its up for debate which ones less worse. Either or.
This thread seems to go around in circles with information that has been brought up in the past. I presume this is partially the reason I don't see older members posting anymore. The methylation issue was brought up in the paSt and died off just as everything else has. I'm sorry to say but we're all fucked. Live your life everyday to the fullest and don't think about the negativity the future may or may not hold. I am no where near this. The anger is to much but I'm going to seek help to work on letting it go and making a difference before my time card is pulled. Often we are treating the secondary causes and not the primary cause because let's face it, no one knows. Fixing b vitamins deficiency is just an effect of the primary cause. Out of all these people on here supposedly one or two healed themselves of I'm guessing some problems but I know everyone is different and some peoples problems are more severe. Did the drug Fuck up all sorts of things in the body like a time bomb poison or did it affect one main thing that shuts down or causes misfunction? For god sakes. What has worked? Anything at all? I mean come on! Anything that most people here can benefit from?
Methylation is not where its at for us. I went down the methylation route for a while. Both promethyl and antimethyl routes both made me worse. The recent organic acids test I did showed my mehtylation was normal. So I'm not interested in playing around with methylation anymore. Doesnt work for me.
Mostly I've found things only help side effects but no permament cure. The day we find a permanent cure for Accutane is the day we find the elixer to eternal life.
But increasing sulfur in my diet through more cruciferous vegies has helped my mood.
Has anybody done the 23andme.com test? If so please let me know or inbox me. I have one simple question that needs answering.
Hey I got my 23andme results yesterday. So its official, I'm about 99% European, which is awesome.
But can anyone tell me how I get my health results, as they dont do that anymore? I remember reading ages ago that there is another website where I put my genetic data and and voila it will tell me my genes. Is that correct?
I had an MRI on my brain done a few weeks ago. Everything was a ok.
I had a $140 salivary cortisol test done which showed elevated cortisol. Instead of going down throughout the day, mine was going up! Amazing. I've been takin relora and feeling much better.
I also had a $400 organic acids test done. Most things there were good. Methylation, neurotransmitters all that were good. I was extremely low in sulfate though which said chronic low glutathione levels. Also elevated suberate levels which means my body is burning fatty acids outside the cells instead of in them? How does that work I do not know. And also a few mitochondrial hiccups which meant low energy levels. I'm waiting for all the necessary supplements to arrive from iherb so I can try them out. Carnitine and NAC and a few others.
Cheers
My cortisol levels revealed the same thing for my adrenals. For a while I was taking Adrenal support and I'm now starting another. I think it helped maintain better energy levels. My sleep schedule is messed up too though, admittedly. Will you be supplementing glutathione?
This whole methylation talk is quite interesting.
Yes I will be supplementing glutathione. I tried it out a month ago, but it was a month out of date. Glutathione apparently has a short shelf life and needs to be used straight away. So I dont know if it was working properly. It was doing something as I felt pretty good. I was taking S acetyl glutathione. But it gave me diarrhoea. I've got a brand new one in the fridge waiting to be taken.
>What is a less dangerous way of getting rid of acne - getting a a sex change or taking Accutane?
Hmm its up for debate which ones less worse. Either or.
This thread seems to go around in circles with information that has been brought up in the past. I presume this is partially the reason I don't see older members posting anymore. The methylation issue was brought up in the paSt and died off just as everything else has. I'm sorry to say but we're all fucked. Live your life everyday to the fullest and don't think about the negativity the future may or may not hold. I am no where near this. The anger is to much but I'm going to seek help to work on letting it go and making a difference before my time card is pulled. Often we are treating the secondary causes and not the primary cause because let's face it, no one knows. Fixing b vitamins deficiency is just an effect of the primary cause. Out of all these people on here supposedly one or two healed themselves of I'm guessing some problems but I know everyone is different and some peoples problems are more severe. Did the drug Fuck up all sorts of things in the body like a time bomb poison or did it affect one main thing that shuts down or causes misfunction? For god sakes. What has worked? Anything at all? I mean come on! Anything that most people here can benefit from?
Methylation is not where its at for us. I went down the methylation route for a while. Both promethyl and antimethyl routes both made me worse. The recent organic acids test I did showed my mehtylation was normal. So I'm not interested in playing around with methylation anymore. Doesnt work for me.
Mostly I've found things only help side effects but no permament cure. The day we find a permanent cure for Accutane is the day we find the elixer to eternal life.
But increasing sulfur in my diet through more cruciferous vegies has helped my mood.
how can something that doesnt have anything to do with your side-effects make it worse?! did you goto genetic genie and put in your 23andme results? what did it say? were you homozygous in anything? if you dont know that part, you probably didnt do the methylation protocol correctly.
Has anybody done the 23andme.com test? If so please let me know or inbox me. I have one simple question that needs answering.
Hey I got my 23andme results yesterday. So its official, I'm about 99% European, which is awesome.
But can anyone tell me how I get my health results, as they dont do that anymore? I remember reading ages ago that there is another website where I put my genetic data and and voila it will tell me my genes. Is that correct?
I had an MRI on my brain done a few weeks ago. Everything was a ok.
I had a $140 salivary cortisol test done which showed elevated cortisol. Instead of going down throughout the day, mine was going up! Amazing. I've been takin relora and feeling much better.
I also had a $400 organic acids test done. Most things there were good. Methylation, neurotransmitters all that were good. I was extremely low in sulfate though which said chronic low glutathione levels. Also elevated suberate levels which means my body is burning fatty acids outside the cells instead of in them? How does that work I do not know. And also a few mitochondrial hiccups which meant low energy levels. I'm waiting for all the necessary supplements to arrive from iherb so I can try them out. Carnitine and NAC and a few others.
Cheers
My cortisol levels revealed the same thing for my adrenals. For a while I was taking Adrenal support and I'm now starting another. I think it helped maintain better energy levels. My sleep schedule is messed up too though, admittedly. Will you be supplementing glutathione?
This whole methylation talk is quite interesting.
Yes I will be supplementing glutathione. I tried it out a month ago, but it was a month out of date. Glutathione apparently has a short shelf life and needs to be used straight away. So I dont know if it was working properly. It was doing something as I felt pretty good. I was taking S acetyl glutathione. But it gave me diarrhoea. I've got a brand new one in the fridge waiting to be taken.
&gt
;
What is a less dangerous way of getting rid of acne - getting a a sex change or taking Accutane?
lockquote>
Hmm its up for debate which ones less worse. Either or.
>This thread seems to go around in circles with information that has been brought up in the past. I presume this is partially the reason I don't see older members posting anymore. The methylation issue was brought up in the paSt and died off just as everything else has. I'm sorry to say but we're all fucked. Live your life everyday to the fullest and don't think about the negativity the future may or may not hold. I am no where near this. The anger is to much but I'm going to seek help to work on letting it go and making a difference before my time card is pulled. Often we are treating the secondary causes and not the primary cause because let's face it, no one knows. Fixing b vitamins deficiency is just an effect of the primary cause. Out of all these people on here supposedly one or two healed themselves of I'm guessing some problems but I know everyone is different and some peoples problems are more severe. Did the drug Fuck up all sorts of things in the body like a time bomb poison or did it affect one main thing that shuts down or causes misfunction? For god sakes. What has worked? Anything at all? I mean come on! Anything that most people here can benefit from?
Methylation is not where its at for us. I went down the methylation route for a while. Both promethyl and antimethyl routes both made me worse. The recent organic acids test I did showed my mehtylation was normal. So I'm not interested in playing around with methylation anymore. Doesnt work for me.
Mostly I've found things only help side effects but no permament cure. The day we find a permanent cure for Accutane is the day we find the elixer to eternal life.
But increasing sulfur in my diet through more cruciferous vegies has helped my mood.
how can something that doesnt have anything to do with your side-effects make it worse?! did you goto genetic genie and put in your 23andme results? what did it say? were you homozygous in anything? if you dont know that part, you probably didnt do the methylation protocol correctly.
Tryingtohelp
How far are you right now with supplementing Manganese ? And what are your improvements ?
Do you think acne also returns ?
Has anybody done the 23andme.com test? If so please let me know or inbox me. I have one simple question that needs answering.
Hey I got my 23andme results yesterday. So its official, I'm about 99% European, which is awesome.
But can anyone tell me how I get my health results, as they dont do that anymore? I remember reading ages ago that there is another website where I put my genetic data and and voila it will tell me my genes. Is that correct?
I had an MRI on my brain done a few weeks ago. Everything was a ok.
I had a $140 salivary cortisol test done which showed elevated cortisol. Instead of going down throughout the day, mine was going up! Amazing. I've been takin relora and feeling much better.
I also had a $400 organic acids test done. Most things there were good. Methylation, neurotransmitters all that were good. I was extremely low in sulfate though which said chronic low glutathione levels. Also elevated suberate levels which means my body is burning fatty acids outside the cells instead of in them? How does that work I do not know. And also a few mitochondrial hiccups which meant low energy levels. I'm waiting for all the necessary supplements to arrive from iherb so I can try them out. Carnitine and NAC and a few others.
Cheers
My cortisol levels revealed the same thing for my adrenals. For a while I was taking Adrenal support and I'm now starting another. I think it helped maintain better energy levels. My sleep schedule is messed up too though, admittedly. Will you be supplementing glutathione?
This whole methylation talk is quite interesting.
Yes I will be supplementing glutathione. I tried it out a month ago, but it was a month out of date. Glutathione apparently has a short shelf life and needs to be used straight away. So I dont know if it was working properly. It was doing something as I felt pretty good. I was taking S acetyl glutathione. But it gave me diarrhoea. I've got a brand new one in the fridge waiting to be taken.
&gt
;
What is a less dangerous way of getting rid of acne - getting a a sex change or taking Accutane?
lockquote>
Hmm its up for debate which ones less worse. Either or.
>This thread seems to go around in circles with information that has been brought up in the past. I presume this is partially the reason I don't see older members posting anymore. The methylation issue was brought up in the paSt and died off just as everything else has. I'm sorry to say but we're all fucked. Live your life everyday to the fullest and don't think about the negativity the future may or may not hold. I am no where near this. The anger is to much but I'm going to seek help to work on letting it go and making a difference before my time card is pulled. Often we are treating the secondary causes and not the primary cause because let's face it, no one knows. Fixing b vitamins deficiency is just an effect of the primary cause. Out of all these people on here supposedly one or two healed themselves of I'm guessing some problems but I know everyone is different and some peoples problems are more severe. Did the drug Fuck up all sorts of things in the body like a time bomb poison or did it affect one main thing that shuts down or causes misfunction? For god sakes. What has worked? Anything at all? I mean come on! Anything that most people here can benefit from?
Methylation is not where its at for us. I went down the methylation route for a while. Both promethyl and antimethyl routes both made me worse. The recent organic acids test I did showed my mehtylation was normal. So I'm not interested in playing around with methylation anymore. Doesnt work for me.
Mostly I've found things only help side effects but no permament cure. The day we find a permanent cure for Accutane is the day we find the elixer to eternal life.
But increasing sulfur in my diet through more cruciferous vegies has helped my
mood.
how can something that doesnt have anything to do with your side-effects make it worse?! did you goto genetic genie and put in your 23andme results? what did it say? were you homozygous in anything? if you dont know that part, you probably didnt do the methylation protocol correctly.
Tryingtohelp
How far are you right now with supplementing Manganese ? And what are your improvements ?
Do you think acne also returns ?
2 weeks in. joints feel better..which is kind of scary. yes i believe when you really start to turn stuff back on, you will get a clearing effect. i took this drug 20 years ago for moderate acne...which was stupid. i dont believe i will still have acne....but i think when the oil glands turn back on, youll see pores that have been shut off start to unplug?! ive had a few weird ones already on my legs of all places.
http://www.landesbioscience.com/supplement/NelsonDE1-3-Sup1.pdf
''Complete list: Significantly Changed genes after 8 weeks isotretinoin treatment''
i suppose that the positive numbers mean upregulation and the minus mean downregulation
this is a good catch.
maybe try to cross reference the biggest ++ and biggest -- on that list.... and find influences with different enzymes and what minerals are used up by those being used up faster or slower.
Hi, so do you believe taking manganese is majorly important for us accutane sufferers? I've tried almost everything. My next step is to do some major detoxing through liver flushing and colon hydrotherapy. Also, this is my first post. Hello everyone... 20 year old who took accutane when I was 17. Severely messed me up. Would love to have some input from others about what has worked. - Alan
Trying to find this study... help:
A Polish study found that certain cancer-fighting drugs that impair collagen synthesis and delay wound healing work by immobilizing manganese, so that it cant activate the collagen-building enzyme.
Trying to find this study... help:
A Polish study found that certain cancer-fighting drugs that impair collagen synthesis and delay wound healing work by immobilizing manganese, so that it cant activate the collagen-building enzyme.
So, supplementing with Manganese would not help. Because there is a mechanism inside of us that handles it differently after accutane.
Or because you have to take accutane for some months it has made a habit out of the mechanism after we stopped accutane. Supplementing with an "overdose" manganese will return the balance?
Also, people are reporting brain fog. Is there any link with manganese ?
TO MEMBER DUUL.
if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you
http://ghr.nlm.nih.gov/gene/SUOX
''Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain.''
iron problem from accutane been broth up . the iron might be deficient acording to some science reported cases, or another option (according to internet forum info which might be wrong. messege 32- http://forums.phoenixrising.me/index.php?threads/b2-i-love-you.15209/page-2 ) iron can be unusable because of an manganese deficency ,this manganese is needed for iron to be relase from the liver,and the manganese deficincy can be beucase of b2 deficency.
so is it the manganese and b2 that being more needed, or the molybdenum itself is deficient also?
TO MEMBER DUUL.
if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you
some of DUULs sides were interesting... all to me indicate collagen/Mn thyroid/Mn deficiency:
-Minor Tintinitus (slight ringing of ears) Ears tested: Hearing is fine.
- TMJ / Jaw clicking (hurts to yawn sometimes)
- Cracking joints such as Knees and thumbs. (loud knee cracks, thumbs always want to crack)
- Low Libido
-Eye floaters (happened 3 years after accutane)
-Dry Eyes (sometimes they are in the way, my eyes are never white - always some pinkness or eye irritation)
-Changes in Body Temperature, Sometimes feet are ice cold, other parts of my body are warm.
Modeaa:
Taurine.....
Some studies suggest humans are dependent upon dietary taurine to maintain "adequate" taurine reserves. Females tend toward lower taurine levels than males as their production pathways don't work as efficiently.
Taurine is closely bound to zinc & manganese so deficiencies of either of these can interfere with its' utilization. Likewise, zinc & manganese enhance the effects of taurine.
Eye floaters and taurine hmmm.
http://www.earthclinic.com/cures/eye-floaters_questions.html
and of course the taurine conjugates:
DETOXIFICATION: Taurine conjugates & detoxifies various internal & external toxic compounds & may help chemical sensitivities.
cross referencing brain fog and manganese i got two blogs i havent seen before
http://www.socialanxietysupport.com/forum/f11/is-manganese-the-solution-70691/
Trying to find this study... help:
A Polish study found that certain cancer-fighting drugs that impair collagen synthesis and delay wound healing work by immobilizing manganese, so that it cant activate the collagen-building enzyme.
So, supplementing with Manganese would not help. Because there is a mechanism inside of us that handles it differently after accutane.
Or because you have to take accutane for some months it has made a habit out of the mechanism after we stopped accutane. Supplementing with an "overdose" manganese will return the balance?
Also, people are reporting brain fog. Is there any link with manganese ?
read first review
http://www.amazon.com/Source-Naturals-Manganese-Chelate-elemental/product-reviews/B000EQ2S28
some here have also theorized that intrahepatic cholestasis is a reason for the continued side effects years after stopping this drug....
"Intrahepatic cholestasis is defined as a disturbance of bile secretion without anatomic obstruction (Feur and Difonzo, 1992). This situation results most often as an adverse consequence of drug therapy * think accutane here *(Chan et al., 1998; Plaa and Priestly, 1976; Stieger et al., 2000)"
http://toxsci.oxfordjournals.org/content/73/2/378.full
"An interesting feature of the present study is that only the Mn-BR combination induces cholestasis. Injection of Mn alone leads to significant increase in the activities of cholesterol metabolism key enzymes, HMG-CoA reductase, and cholesterol 7-hydroxylase."
"These findings may help to further elucidate the biochemical mechanisms of drug-induced cholestasis in human and lead to possible therapeutic maneuvers to prevent or treat the cholestasis induced by drug interactions."
when Mn is taken alone, it showed to increase the bile flow?!
You're very good at finding interesting studies. I wonder what the mechanism is that Mn plays in resolving the cholestasis. Also this video comes to mind:
[Edited video out]
(he believes liver flushing cured him. related to intrahepatic cholestasis perhaps...)
Also, here is an article about accutane and Vit A: http://www.westonaprice.org/health-topics/the-pursuit-of-happiness/
I can confirm that I was indeed very deficient in Vitamin A 1 year post accutane (according to Spectracell Labs Micronutrient Testing). I took the accutane for 5 months. During the entire treatment and after, I ate incredibly high amounts of beta carotene through sweet potatoes each and every day. My actual Vit A intake was not high however. Just some more thoughts..
On 12/7/2014 at 2:23 AM, tryingtohelp2014 said:some here have also theorized that intrahepatic cholestasis is a reason for the continued side effects years after stopping this drug....
"Intrahepatic cholestasis is defined as a disturbance of bile secretion without anatomic obstruction (Feur and Difonzo, 1992). This situation results most often as an adverse consequence of drug therapy * think accutane here *(Chan et al., 1998; Plaa and Priestly, 1976; Stieger et al., 2000)"
http://toxsci.oxfordjournals.org/content/73/2/378.full
"An interesting feature of the present study is that only the Mn-BR combination induces cholestasis. Injection of Mn alone leads to significant increase in the activities of cholesterol metabolism key enzymes, HMG-CoA reductase, and cholesterol 7-hydroxylase."
"These findings may help to further elucidate the biochemical mechanisms of drug-induced cholestasis in human and lead to possible therapeutic maneuvers to prevent or treat the cholestasis induced by drug interactions."
when Mn is taken alone, it showed to increase the bile flow?!
Hello everone. First let me start out by saying i am extremely appreciative of everyone in here who contributes and has a general concern for overcoming all of these accutane induced symptoms.
From what I understand, the dry eyes, ED's, joint pain and digestion issues seem to be the stand outs of long term side effects. I was hoping someone could point me in the right direction for my symptoms which like all of you i am sure that accutane has caused.
- IBD/Chrons I haven't had a normal poo since the week before I started accutane. (2 years)
- Incredibly dry irritated skin.
- lots of hairloss and extremely dry hair!
I have tried oodles and oodles of supplements, fasting etc and have had no success. From my skimming of the 292 pages (which took almost 2 weeks 
) it seems like a maganese supplement would be a good idea?
Im just wondering if maganese is now the best approach for my symptoms, or maybe I missed something while reading.
Id be happy to report back as I try new things.
Kind Regards,
Aaron
On 12/7/2014 at 4:12 AM, yetanotheraccutanevictim said:You're very good at finding interesting studies. I wonder what the mechanism is that Mn plays in resolving the cholestasis. Also this video comes to mind:
[Edited video out]
(he believes liver flushing cured him. related to intrahepatic cholestasis perhaps...)
Also, here is an article about accutane and Vit A: http://www.westonaprice.org/health-topics/the-pursuit-of-happiness/
I can confirm that I was indeed very deficient in Vitamin A 1 year post accutane (according to Spectracell Labs Micronutrient Testing). I took the accutane for 5 months. During the entire treatment and after, I ate incredibly high amounts of beta carotene through sweet potatoes each and every day. My actual Vit A intake was not high however. Just some more thoughts..
On 12/7/2014 at 2:23 AM, tryingtohelp2014 said:some here have also theorized that intrahepatic cholestasis is a reason for the continued side effects years after stopping this drug....
"Intrahepatic cholestasis is defined as a disturbance of bile secretion without anatomic obstruction (Feur and Difonzo, 1992). This situation results most often as an adverse consequence of drug therapy * think accutane here *(Chan et al., 1998; Plaa and Priestly, 1976; Stieger et al., 2000)"
http://toxsci.oxfordjournals.org/content/73/2/378.full
"An interesting feature of the present study is that only the Mn-BR combination induces cholestasis. Injection of Mn alone leads to significant increase in the activities of cholesterol metabolism key enzymes, HMG-CoA reductase, and cholesterol 7-hydroxylase."
"These findings may help to further elucidate the biochemical mechanisms of drug-induced cholestasis in human and lead to possible therapeutic maneuvers to prevent or treat the cholestasis induced by drug interactions."
when Mn is taken alone, it showed to increase the bile flow?!
i saw this....
I think its the utilization of choline by way of Mn that helps with the cholestasis problem. Trimethylglycine will help with this as well. Mn also helps to produce stomach acid...and if you watch that video...his digestion was all messed up. he was low on iron...again this is an indirect symptom. starts with stomach acid, then goes onto the intestines and your gut...thats where probiotics will come into play. liver and gall bladder flushes... i really dont know about that. its very vague, and most studies ive seen say they dont do a thing. we basically took a highly potent acid for an extended period of time...and our body robbed our stores of mineral (s) to combat this.
im a 2300 rated chess player. im good at connecting dots. now that im committed to this, i WILL figure it out.
im a 2300 rated chess player. im good at connecting dots. now that im committed to this, i WILL figure it out.
I'm very happy you are determined and extremely grateful to have you here. I will definitely be sharing what ends up helping me.
little video on epigenetics. She mentions accutane at 36:45:
So you don't think the drug is still in our system? I've heard another person say they got over symptoms just from doing simple oxygen based colon cleansers. Seems too good to be true haha. And as for the liver/gallbladder flush, I don't think it would hurt. I will be attempting it this month along with many colonics, colemas, and enemas (After I get tested for small intestinal bacterial overgrowth)
Edit: Going to be getting NOW Foods TMG 1000mg along with the manganese you recommend
im a 2300 rated chess player. im good at connecting dots. now that im committed to this, i WILL figure it out.
I'm very happy you are determined and extremely grateful to have you here. I will definitely be sharing what ends up helping me.
little video on epigenetics. She mentions accutane at 36:45:
So you don't think the drug is still in our system? I've heard another person say they got over symptoms just from doing simple oxygen based colon cleansers. Seems too good to be true haha. And as for the liver/gallbladder flush, I don't think it would hurt. I will be attempting it this month along with many colonics, colemas, and enemas (After I get tested for small intestinal bacterial overgrowth)
Edit: Going to be getting NOW Foods TMG 1000mg along with the manganese you recommend
i am 1000% certain there is still a residue or metabolite still residing in us. something is causing a constant epigenetic change. something is suppressing. everyone can say what they will, but of this im certain... albeit purely anecdotal. 4 or 5 years after stopping the course of accutane, i went on a massive weight loss program in order to flush this stuff out. while i wasnt overweight to begin with, i lost about 30 lbs...and towards the end i was just racked with the same side effects x100, as when i was on the drug, to the point where my joints were screaming in pain with the palms and soles of my feet literally peeling from dryness! i had to stop. but while this was happening...i would get a day where my oil glands would turn on 100% again...just like before taking the drug, only to shut off when i started to eat normally. I definitely think i stirred it up, but i didnt have the cofactors/enzymes to take it out.
you have to take more than the TMG.... TMG was just a part of the methylation protocol. the methylation is an attempt to epigenetically repair ourselves.
im sure accutane metabolites replace/mimic natural vitamin A, but also prevents normal vitamin A status.
you have to take more than the TMG.... TMG was just a part of the methylation protocol. the methylation is an attempt to epigenetically repair ourselves.
im sure accutane metabolites replace/mimic natural vitamin A, but also prevents normal vitamin A status.
I spent $1500 in the past 2 months. I only have about $400 left. I'm just trying to get a couple things that I think might help without being too expensive. I'm pretty sure I am taking most of the required methyl donors in my current supp regimen. If you could provide some requirements that need to go along with TMG and manganese that'd be much appreciated. I may already be taking them.
you have to take more than the TMG.... TMG was just a part of the methylation protocol. the methylation is an attempt to epigenetically repair ourselves.
im sure accutane metabolites replace/mimic natural vitamin A, but also prevents normal vitamin A status.
I spent $1500 in the past 2 months. I only have about $400 left. I'm just trying to get a couple things that I think might help without being too expensive. I'm pretty sure I am taking most of the required methyl donors in my current supp regimen. If you could provide some requirements that need to go along with TMG and manganese that'd be much appreciated. I may already be taking them.
with manganese... you need to add B1 B2 and Choline ... but these are taken at different times. manganese is taken by itself, away from food.
the three supplements that ive noticed actually doing something, besides the initial energy rush of the B12.....
TMG ... noticed in my eye whites....and skin changes. i thnik this will take many months to have a greater effect.
probiotics NOW 25 bil 10 strain.... vast improvement in all stomach issues within days. ive been on other probiotics before... nothing compared to this though
Manganese .... noticeable joint pain relief, especially in my shoulders after a few weeks of supplementation at 10 mg a day. dosages will need to be played with. eat foods high in Mn. dont take everyday. skip a day or 3 and then come back with a 20 mg dose and see if that helps or produces something different. we're all different.
start slow....watch for any signs/side effects. dont get out of balance.
Sorry one more comment...slightly off topic I guess. I kind of squeaked my way into this thread. Hi I am Aaron btw.
I am aware this is likely a huge stretch, but if anyone waned to connect the dots... feel free. I've been off accutane for 2 years now. Several occasions over the past 2 years have resulted in large amounts of liquor being consumed.
In every occasion, the following morning has resulted in clear and hydrated skin... ( the red "scars" all over my temples would be 90% faded). The terrible dry irritated red disgusting skin would be no more. This would usually last for 1 day and then things would go back to normal. Is it too much of a stretch to say that the alcohol put some sort of stress on my liver that resulted in beautiful skin the next day? Or is probably blood sugar related? Oh god do I have diabetes? hehe.
Has anyone else noticed a vast improvement in their skin health the morning after drinking?
Thanks for any insights.